DNA methylation profiling of asbestos-treated MeT5A cell line reveals novel pathways implicated in asbestos response.

abstract：:Etoposide (ETP) and anthracyclines are applied for wide anti-cancer treatments. However, the ETP-induced cardiotoxicity remains to be a major safety issue and the underlying cardiotoxic mechanisms are not well understood. This study is aiming to unravel the cardiotoxicity profile of ETP in comparison to anthracyclines...

journal_title：Archives of toxicology

authors： Nemade H,Chaudhari U,Acharya A,Hescheler J,Hengstler JG,Papadopoulos S,Sachinidis A

更新日期：2018-04-01 00:00:00

abstract：:To reveal the molecular mechanism of deficit in learning and memory induced by chronic fluorosis, the expression of muscarinic acetylcholine receptors (mAChRs) and oxidative stress were investigated. Sixty Sprague-Dawley (SD) rats were divided randomly into two groups (30 cases in each), i.e., the control group (<0.5 ...

journal_title：Archives of toxicology

authors： Dong YT,Wang Y,Wei N,Zhang QF,Guan ZZ

更新日期：2015-11-01 00:00:00

abstract：:As previously demonstrated, chronic administration of phenobarbital (0.05% in the drinking water) and of nafenopin (0.1% in the diet) increases the incidence and the kinetics of appearance of liver cancers. If bile acids play a key role in liver carcinogenesis, it might thus be expected that treatments like phenobarbi...

journal_title：Archives of toxicology

authors： Delzenne NM,Taper HS,Roberfroid M

更新日期：1994-01-01 00:00:00

abstract：:Cadmium-induced metallothionein (MT) synthesis was investigated in male rats of three ages, 3, 12 and 24 months. Physiological levels of MT in kidney, liver and lung measured simultaneously in untreated animals were found to be within the same range in all three age groups. Following 3-day treatment with CdCl2 equival...

journal_title：Archives of toxicology

authors： Wormser U,Nir I

更新日期：1988-01-01 00:00:00

abstract：:The elevations of blood urea nitrogen and serum creatinine caused by cis-platinum in rats can be prevented by a combination of procedures centered around the administration of sodium N-methyl-N-dithiocarboxyglucamine (NaG), before and very soon after the cis-platinum is administered in hypertonic (4.5%) saline. Elevat...

journal_title：Archives of toxicology

authors： Jones MM,Basinger MA,Craft WD,Domingo JL,Llobet JM

更新日期：1986-10-01 00:00:00

abstract：:Phenethyl isothiocyanate is a chemopreventive phytochemical present in cruciferous vegetables where it exists as the glucosinolate gluconasturtiin. It is a mechanism-based inhibitor of both rat and human cytochrome P450 enzymes. The principal objective of the present study was to ascertain whether phenethyl isocyanate...

journal_title：Archives of toxicology

authors： Konsue N,Ioannides C

更新日期：2010-10-01 00:00:00

abstract：:Mycotoxins are the most frequently occurring natural contaminants in human and animal diet. Among them, deoxynivalenol (DON), produced by Fusarium, is one of the most prevalent and thus represents an important health risk. Recent detection methods revealed new mycotoxins and new molecules derivated from the "native" m...

journal_title：Archives of toxicology

authors： Payros D,Alassane-Kpembi I,Pierron A,Loiseau N,Pinton P,Oswald IP

更新日期：2016-12-01 00:00:00

abstract：:Organotin compounds such as tributyltin (TBT) and triphenyltin can induce diabetes and insulin resistance. However, the development of diabetes caused by organotins and its underlying mechanisms remain unclear. In the present study, male KM mice were orally administered with TBT (0.5, 5, and 50 μg/kg) once every 3 day...

journal_title：Archives of toxicology

authors： Li B,Guo J,Xi Z,Xu J,Zuo Z,Wang C

更新日期：2017-10-01 00:00:00

abstract：:Several studies have explored the negative effects of cigarette smoke on bone healing; however, the complex pathogenesis still remains unclear. One crucial and primary factor determining effective fracture repair is the recruitment and differentiation of mesenchymal stem cells (MSCs) into bone-forming cells. Recently,...

journal_title：Archives of toxicology

authors： Sreekumar V,Aspera-Werz R,Ehnert S,Strobel J,Tendulkar G,Heid D,Schreiner A,Arnscheidt C,Nussler AK

更新日期：2018-04-01 00:00:00

abstract：:Liquorice [main ingredient, glycyrrhizin (GL)] is widely used as a food sweetener and herbal medicine. Occasionally, liquorice consumption causes pseudoaldosteronism as a side effect which causes oedema, hypokalaemia, and hypertension due to hyperactivity of mineral corticoid receptor. We aimed to detect GL metabolite...

journal_title：Archives of toxicology

authors： Takahashi K,Yoshino T,Maki Y,Ishiuchi K,Namiki T,Ogawa-Ochiai K,Minamizawa K,Makino T,Nakamura T,Mimura M,Watanabe K

更新日期：2019-11-01 00:00:00

abstract：:To explain the mechanism of renal injury caused by liver ischemia-reperfusion, we investigated biochemical and morphological changes in the liver and kidney in rats. After reperfusion following 60 min of liver ischemia, numerous changes were found. The level of serum transaminases and lipid peroxide formation in the l...

journal_title：Archives of toxicology

authors： Kudo Y,Egashira T,Takayama F,Yamanaka Y,Shimada T

更新日期：1993-01-01 00:00:00

abstract：:The present study was performed to investigate the potential toxic effects of prenatal exposure to 4-tert-octylphenol (OP) on liver, kidney, spleen, and hematologic parameters of male and female rats in adult life. The rats were treated with OP subcutaneously in utero at doses of control (vehicle, corn oil), 100 or 25...

journal_title：Archives of toxicology

authors： Barlas N,Aydoğan M

更新日期：2009-04-01 00:00:00

abstract：:Volunteers inhaled a constant concentration of 50 ppm trichloroethylene (Tri) for 6 hrs per day on 5 consecutive days. Simultaneous ethanol (EtOH) ingestion (blood level 0.6%) inhibits the metabolization of Tri to trichloroethanol (TCE) and trichloroacetic acid (TCA) by 40% on the average. Oxidation of Tri to TCA does...

journal_title：Archives of toxicology

authors： Müller G,Spassowski M,Henschler D

更新日期：1975-01-01 00:00:00

abstract：:Conventional in vitro toxicity studies have focused on identifying IC50 and the underlying mechanisms, but how toxicants influence biophysical and biomechanical changes in human cells, especially during developmental stages, remain understudied. Here, using an atomic force microscope, we characterized changes in bioph...

journal_title：Archives of toxicology

authors： Mahajan G,Lee MY,Kothapalli C

更新日期：2019-10-01 00:00:00

abstract：:The aim of this study was to assess the neurotoxicity of diazinon oxon (DZO), a major in vivo metabolite of the phosphorothionate insecticide diazinon (DZ), on differentiating mouse N2a neuroblastoma cells. When used at concentrations of 1, 5 and 10 microM, DZO did not cause cell death but it impaired the outgrowth of...

journal_title：Archives of toxicology

authors： Sidiropoulou E,Sachana M,Flaskos J,Harris W,Hargreaves AJ,Woldehiwet Z

更新日期：2009-04-01 00:00:00

abstract：:Zearalenone, a cereal mycotoxin with mycoestrogen activity and effect on fertility, is known to trigger apoptosis of a variety of nucleated cell types including hematopoietic progenitor cells. In analogy to apoptosis of nucleated cells, eryptosis, the suicidal death of erythrocytes, leads to cell shrinkage and cell me...

journal_title：Archives of toxicology

authors： Jilani K,Lang F

更新日期：2013-10-01 00:00:00

abstract：: ...

journal_title：Archives of toxicology

authors： Deng Y,Zhang Y

更新日期：2019-01-01 00:00:00

abstract：:The cadmilm-induced (Cd) damage of mammalian testes is thought to be correlated with an inhibition of carbonic anhydrase (CAH) by Cd. Since Cd causes dose-dependent changes in blood flow of the testes, an inhibition of CAH in the testes could be simulated by a decrease of CAH-rich erythrocytes. Therefore, CAH activiti...

journal_title：Archives of toxicology

authors： Alsen C,Köpcke C,Ohnesorge FK,Schneider J

更新日期：1976-12-23 00:00:00

abstract：:Chemical formation of dichlorvos (2, 2-dichlorovinyl dimethyl phosphate) was found to occur in mouse brain after i.p. injection of metrifonate (2, 2, 2-trichloro-1-hydroxyethyl dimethyl phosphonate). A mass fragmentographic technique was used. Different isotopic variants were used both as internal standards and to com...

journal_title：Archives of toxicology

authors： Nordgren I,Bergström M,Holmstedt B,Sandoz M

更新日期：1978-10-13 00:00:00

abstract：:The antidepressants, imipramine and mianserin, have been reported to cause liver damage. We investigated a role of cytochrome P450 (CYP)-mediated formation of a reactive metabolite in antidepressant-induced acute cell injury using hepatocytes isolated from male and female Wistar rats, and male Dark Agouti rats, which ...

journal_title：Archives of toxicology

authors： Masubuchi Y,Konishi M,Horie T

更新日期：1999-04-01 00:00:00

abstract：:The aim of our study was to determine the period of maximum sensitivity for the induction of characteristic malformations with thalidomide (TH) in Himalayan rabbits. TH was administered orally in different doses (50, 100, 150 and 200 mg/kg) four times at 24-h intervals starting at 192 h of gestation. The malformations...

journal_title：Archives of toxicology

authors： Sterz H,Nothdurft H,Lexa P,Ockenfels H

更新日期：1987-07-01 00:00:00

abstract：:Prudhoe Bay crude oil (PBCO) and its aliphatic, aromatic and heterocyclic fractions were tested on the developing chick embryo for (i) embryotoxicity (ii) their ability to induce hepatic and renal cytochrome P450 levels as well as hepatic, renal and pulmonary aryl hydrocarbon hydroxylase activities. On the basis of it...

journal_title：Archives of toxicology

authors： Walters P,Khan S,O'Brien PJ,Payne JF,Rahimtula AD

更新日期：1987-08-01 00:00:00

abstract：:The reversibility of quinolone-induced cartilage lesions has not been studied in detail. We treated five groups of five to seven juvenile Wistar rats (male and female; age: 5 weeks) with 2 x 600 mg ofloxacin/kg by gastric intubation on 1 day only (9:00 a.m. and 5:00 p.m.) and studied the knee joints histologically 3 d...

journal_title：Archives of toxicology

authors： Förster C,Kociok K,Shakibaei M,Merker HJ,Stahlmann R

更新日期：1996-01-01 00:00:00

abstract：:As a potential endocrine disruptor, tris(2,3-dibromopropyl) isocyanurate (TBC) has previously been demonstrated to reduce expression of estrogen-dependent vitellogenin (vtg) mRNA in adult zebrafish. However, the underlying toxicity pathways and molecular mechanisms involved in TBC-induced endocrine disruption remain e...

journal_title：Archives of toxicology

authors： Cao H,Li X,Zhang W,Wang L,Pan Y,Zhou Z,Chen M,Zhang A,Liang Y,Song M

更新日期：2018-04-01 00:00:00

abstract：:The goal of the present study was to obtain an in vivo relevant prioritization method for the endocrine potencies of different polycarbonate monomers, by combining in vitro bioassay data with physiologically based kinetic (PBK) modelling. PBK models were developed for a selection of monomers, including bisphenol A (BP...

journal_title：Archives of toxicology

authors： Punt A,Aartse A,Bovee TFH,Gerssen A,van Leeuwen SPJ,Hoogenboom RLAP,Peijnenburg AACM

更新日期：2019-07-01 00:00:00

abstract：:Aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor, has been studied extensively in carcinogenesis through the genomic pathway. In recent years, AHR has also been reported to exert positive or negative effects on epithelial-mesenchymal transition (EMT), the crucial step in tumor malignant progres...

journal_title：Archives of toxicology

authors： Li CH,Liu CW,Tsai CH,Peng YJ,Yang YH,Liao PL,Lee CC,Cheng YW,Kang JJ

更新日期：2017-05-01 00:00:00

abstract：:A single dose of 10 mg methylmercury chloride per kg body weight was given to 30 days old rats and to adult rats (180-200g)(. This resulted in brain levels of 1.4-2.2 micrograms Hg/g wet weight. In the young rats electron microscopic morphometry showed swelling of the granule cells. The extent of changes was more pron...

journal_title：Archives of toxicology

authors： Syversen TL,Totland G,Flood PR

更新日期：1981-04-01 00:00:00

abstract：:Certain bisphenols (BPs) have been regarded as endocrine-disrupting chemicals due to their structural similarities to bisphenol A (BPA), a well-known weak estrogenic chemical. However, very limited data are currently available on the relationship between estrogenic activity and the structure of BP analogs. Therefore, ...

journal_title：Archives of toxicology

authors： Cao H,Wang F,Liang Y,Wang H,Zhang A,Song M

更新日期：2017-12-01 00:00:00

abstract：:Cyclic AMP (c-AMP), added on its own to rat hepatocyte cultures, caused a marked accumulation of coproporphyrin III. The results obtained by comparing the effect of c-AMP to that of exogenous 5-aminolevulinate (ALA), and from adding c-AMP and ALA together, indicated that the coproporphyrinogen III metabolism was block...

journal_title：Archives of toxicology

authors： De Matteis F,Harvey C

更新日期：2005-07-01 00:00:00

abstract：:The reliable analytical method for total morphine in hair was established by GC/MS-SIM. The calibration curve for morphine in hair showed linear over 0.5-100 ng/mg hair. Though the limit of detection was 0.1 ng/mg hair with an S/N > 3 of the base ion(m/z 429) for morphine, the limit of confirmation by detection of thr...

journal_title：Archives of toxicology

authors： Nakahara Y,Takahashi K,Shimamine M,Saitoh A

更新日期：1992-01-01 00:00:00