Vertebrate cyclodiene insecticide resistance: role of gamma-aminobutyric acid and diazepam binding sites.

abstract：:We studied the incorporation of cocaine (COC), benzoylecgonine (BE) and ecgonine methyl ester (EME) into hair from blood. At first, the time courses of three drugs in rat plasma following i.p. administration of cocaine were investigated over 360 min. AUCs of COC, BE and EME in plasma were 14.2, 60.7 and 53.4 microgram...

journal_title：Archives of toxicology

authors： Nakahara Y,Ochiai T,Kikura R

更新日期：1992-01-01 00:00:00

abstract：:Millions of tons of all kind of munitions, including mines, bombs and torpedoes have been dumped after World War II in the marine environment and do now pose a new threat to the seas worldwide. Beside the acute risk of unwanted detonation, there is a chronic risk of contamination, because the metal vessels corrode and...

journal_title：Archives of toxicology

authors： Strehse JS,Brenner M,Kisiela M,Maser E

更新日期：2020-12-01 00:00:00

abstract：:To explain the mechanism of renal injury caused by liver ischemia-reperfusion, we investigated biochemical and morphological changes in the liver and kidney in rats. After reperfusion following 60 min of liver ischemia, numerous changes were found. The level of serum transaminases and lipid peroxide formation in the l...

journal_title：Archives of toxicology

authors： Kudo Y,Egashira T,Takayama F,Yamanaka Y,Shimada T

更新日期：1993-01-01 00:00:00

abstract：:Cyclin-dependent kinases (CDKs) are a family of kinases associated predominantly with cell cycle control, making CDK inhibitors interesting candidates for anti-cancer therapeutics. However, retinal toxicity (loss of photoreceptors) has been associated with CDK inhibitors, including the pan-CDK inhibitor AG-012896. The...

journal_title：Archives of toxicology

authors： Wright P,Kelsall J,Healing G,Sanderson J

更新日期：2019-03-01 00:00:00

abstract：:Many carcinogens and mutagens are electrophilic in nature and will react with nucleophilic sites in protein and nucleic acid. Determination of the extent of formation of these adducts of genotoxic agents with protein provides a practical method of monitoring human exposure and of determining the possible risk associat...

journal_title：Archives of toxicology

authors： Bailey E,Farmer PB,Shuker DE

更新日期：1987-01-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is a late-onset retinal disease and the leading cause of central vision loss in the elderly. Degeneration of retinal pigment epithelial cells (RPE) is a crucial contributing factor responsible for the onset and progression of AMD. The toxic fluorophore N-retinyl-N-retinylidene et...

journal_title：Archives of toxicology

authors： Alaimo A,Di Santo MC,Domínguez Rubio AP,Chaufan G,García Liñares G,Pérez OE

更新日期：2020-02-01 00:00:00

abstract：:The effects of small repeated oral doses of mono-2-cresyl diphenyl phosphate (MOCP, 2.5 mg/kg/day) on hen brain and spinal cord neurotoxic esterase (NTE) were measured. The enzyme levels were depressed to about 40% and 55% of normal respectively and maintained at that level for 8 weeks. No clinical and only doubtful h...

journal_title：Archives of toxicology

authors： Lotti M,Johnson MK

更新日期：1980-10-01 00:00:00

abstract：:Monolayers of L6 rat skeletal myoblast cells formed surface binding isotherms with the purified tobacco leaf glycoprotein TGP1 and the enriched cigarette tar glycoprotein TGP2. Scatchard analysis showed that the binding in the range of the limited concentrations tested was to a single class molecule and the calculated...

journal_title：Archives of toxicology

authors： Santos-Buch CA,Hall HR,Farfan F,Orlow I,Firpo A,von Kreuter BF,Becker CG

更新日期：1995-01-01 00:00:00

abstract：:The first step in the oxidative metabolism of cocaine is N-demethylation to norcocaine, which is further N-hydroxylated to more toxic N-hydroxynorcocaine. In this study we examined the kinetics of norcocaine N-hydroxylation mediated by cytochrome P450 (CYP) in mouse and human liver microsomes. N-hydroxynorcocaine was ...

journal_title：Archives of toxicology

authors： Pellinen P,Kulmala L,Konttila J,Auriola S,Pasanen M,Juvonen R

更新日期：2000-11-01 00:00:00

abstract：:Tributyltin (TBT) has been shown to disrupt the ability of natural killer (NK) cells to destroy tumor targets in vitro even at exposures of 25 nM for 24 h, but cell viability was not significantly impacted. Thus, evaluation of intracellular molecular events that regulate cell viability in TBT exposed NK cells are of i...

journal_title：Archives of toxicology

authors： Aluoch AO,Odman-Ghazi SO,Whalen MM

更新日期：2007-04-01 00:00:00

abstract：:Chemical formation of dichlorvos (2, 2-dichlorovinyl dimethyl phosphate) was found to occur in mouse brain after i.p. injection of metrifonate (2, 2, 2-trichloro-1-hydroxyethyl dimethyl phosphonate). A mass fragmentographic technique was used. Different isotopic variants were used both as internal standards and to com...

journal_title：Archives of toxicology

authors： Nordgren I,Bergström M,Holmstedt B,Sandoz M

更新日期：1978-10-13 00:00:00

abstract：:Certain bisphenols (BPs) have been regarded as endocrine-disrupting chemicals due to their structural similarities to bisphenol A (BPA), a well-known weak estrogenic chemical. However, very limited data are currently available on the relationship between estrogenic activity and the structure of BP analogs. Therefore, ...

journal_title：Archives of toxicology

authors： Cao H,Wang F,Liang Y,Wang H,Zhang A,Song M

更新日期：2017-12-01 00:00:00

abstract：:Milacemide (2-n-pentylaminoacetamide) hydrochloride was administered by continuous i.v. infusion for up to 7 days, at 300 and 600 mg/kg per day to male Sprague-Dawley rats. This was intended to provide high and sustained exposure to evaluate the effect of a preterminal 24-h fast on liver lipid content. Liver lipid con...

journal_title：Archives of toxicology

authors： Rakotoamboa JL,Masson M,Palate B,Carleer J,Roba J

更新日期：1994-01-01 00:00:00

abstract：:The assay of neurotoxic esterase (NTE) in brains taken from dosed hens enables potential neurotoxicity of organophosphate pesticides, plasticers, etc. to be assessed. The original assay [Johnson, M.K. Biochem. J. 114, 711-717 (1969)] has been simplified to eliminate centrifugation and transfer steps and both the selec...

journal_title：Archives of toxicology

authors： Johnson MK

更新日期：1977-06-18 00:00:00

abstract：:The effect of methantheline, a quaternary ammonium compound, on the reactivation by HI 6 of soman-inhibited human erythrocyte acetylcholinesterase (AChE) was investigated in vitro using purified human erythrocyte AChE or washed human erythrocytes. Methantheline itself was found to be a mixed competitive/non-competitiv...

journal_title：Archives of toxicology

authors： Hallek M,Szinicz L

更新日期：1995-01-01 00:00:00

abstract：:Quinolone-induced arthropathy is probably caused by a lack of functionally available magnesium in immature joint cartilage. We used an in vitro assay to study the effects of fluoroquinolones on cartilage formation in mouse limb buds from 12-day-old mouse embryos in regular and in magnesium-deficient medium. Omission o...

journal_title：Archives of toxicology

authors： Förster C,Rücker M,Shakibaei M,Baumann-Wilschke I,Vormann J,Stahlmann R

更新日期：1998-06-01 00:00:00

abstract：:Since teratogenicity testing in mammals is a particular challenge from an animal welfare perspective, there is a great need for the development of alternative test systems. In this context, the zebrafish (Danio rerio) embryo has received increasing attention as a non-protected embryonic vertebrate in vivo model. The p...

journal_title：Archives of toxicology

authors： Brotzmann K,Wolterbeek A,Kroese D,Braunbeck T

更新日期：2020-10-27 00:00:00

abstract：:A method is described for the determination of lorazepam plasma levels involving extraction from the sample and analysis of the intact lorazepam by electron capture gas-liquid chromatography. Using mass spectrometry it is demonstrated, that lorazepam shows a thermal rearrangement under gas chromatographic conditions. ...

journal_title：Archives of toxicology

authors： de Groot G,Maes RA,Lemmens HH

更新日期：1976-06-08 00:00:00

abstract：:Chlorpyrifos (CPF) is a widely used organophosphorus pesticide. Earlier work from our laboratory and others has demonstrated that the sensitivity to CPF exposure changes markedly during maturation. A number of studies suggest that in addition to inhibiting acetylcholinesterase (AChE), CPF oxon may also interact direct...

journal_title：Archives of toxicology

authors： Zhang H,Liu J,Pope CN

更新日期：2002-01-01 00:00:00

abstract：:The aim of this study was to investigate the genotoxic potential of DNA adducts and to compare DNA adduct levels and patterns in petroleum vacuum distillates, coal tar distillate, bitumen fume condensates, and related substances that have a wide range of boiling temperatures. An in vitro assay was used for DNA adduct ...

journal_title：Archives of toxicology

authors： Akkineni LK,Zeisig M,Baranczewski P,Ekström LG,Möller L

更新日期：2001-01-01 00:00:00

abstract：:Ethylenediaminetetraacetic acid (EDTA) is widely used in food and other industries to sequester metal ions and to prevent their disadvantageous effects. The objective of the current study was to evaluate the protective effect of Panax ginseng extract standardized with ginsenoside Rg3 (ginsenoside Rg3 content was 3.6% ...

journal_title：Archives of toxicology

authors： Khalil WK,Ahmed KA,Park MH,Kim YT,Park HH,Abdel-Wahhab MA

更新日期：2008-03-01 00:00:00

abstract：:Organophosphate-induced delayed polyneuropathy (OPIDP) is initiated by inhibition/aging of more than 70-75% of neuropathy target esterase (NTE). Di-n-butyl-2,2-dichlorovinyl phosphate (DBDCVP) (1 mg/kg s.c.) inhibited 96%, 86% and 83% of NTE in brain, spinal cord and peripheral nerve, respectively, and induced a typic...

journal_title：Archives of toxicology

authors： Moretto A,Lotti M,Spencer PS

更新日期：1989-01-01 00:00:00

abstract：:Renal papillary necrosis (RPN) was induced in Fischer 344 (F344) rats (n = 4) using 2-bromoethanamine hydrobromide (BEA) dosed at 150 mg/kg, and in multimammate desert mice (Mastomys natalensis) at 150 and 250 mg/kg (n = 4 per group). Control rats and Mastomys were dosed with 0.9% saline (n = 4 per group). Urine was c...

journal_title：Archives of toxicology

authors： Holmes E,Bonner FW,Nicholson JK

更新日期：1995-01-01 00:00:00

abstract：:The amphetamine-derived designer drugs have been illegally used worldwide as recreational drugs, some of which are known to be hepatotoxic in humans. To compare their cytotoxic effects, 3,4-methylenedioxy-N-methamphetamine (MDMA) and its related analogues, N-methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine (MBDB), 3,4...

journal_title：Archives of toxicology

authors： Nakagawa Y,Suzuki T,Tayama S,Ishii H,Ogata A

更新日期：2009-01-01 00:00:00

abstract：:Perfluorocarboxylic acids (PFCAs) including perfluorooctanoic acid (PFOA) are environmental pollutants showing high accumulation, thermochemical stability and hepatocarcinogenicity. Peroxisome proliferator-activated receptor α is suggested to mediate their toxicities, but the precise mechanism remains unclear. Previou...

journal_title：Archives of toxicology

authors： Abe T,Takahashi M,Kano M,Amaike Y,Ishii C,Maeda K,Kudoh Y,Morishita T,Hosaka T,Sasaki T,Kodama S,Matsuzawa A,Kojima H,Yoshinari K

更新日期：2017-06-01 00:00:00

abstract：:The responsiveness of the hepatic supernatant NAD+-dependent aldehyde dehydrogenase with a high Km value (high Km-AldDH) to phenobarbital (PB) and 3-methylcholanthrene (3-MC) treatment was studied in male rats of three strains; Wistar, Long-Evans, and Sprague-Dawley. A remarkable strain difference in the response of t...

journal_title：Archives of toxicology

authors： Nakanishi S,Shiohara E,Tsukada M,Yamazaki H,Nishiguchi K,Saladin R

更新日期：1979-12-01 00:00:00

abstract：:Neutrophils infiltrate tissues during inflammation, and when activated, they release β-glucuronidase. Since inflammation is associated with carcinogenesis, we investigated how extracellular β-glucuronidase changed the in vitro cellular response to the chemical carcinogen benzo(a)pyrene (B[a]P). For this we exposed hum...

journal_title：Archives of toxicology

authors： Shi Q,Haenen GR,Maas L,Arlt VM,Spina D,Vasquez YR,Moonen E,Veith C,Van Schooten FJ,Godschalk RWL

更新日期：2016-09-01 00:00:00

abstract：:Retinoids, derivatives of vitamin A, are essential for many vertebrate functions. Furthermore, several drugs of this class of compounds are valuable in the treatment of certain forms of skin disorders and cancer. However, the therapeutic application of retinoids is limited by their teratogenic potency. The limbs are i...

journal_title：Archives of toxicology

authors： Sass JO,Zimmermann B,Rühl R,Nau H

更新日期：1997-01-01 00:00:00

abstract：:Amygdalin (D-mandelonitrile-beta-D-gentiobioside) is a cyanogenic glycoside claimed to show anti-cancer activity, sold under the incorrect name "Laetrile". For a sensible discussion of its alleged activity and its established toxicity it is necessary that its fate in the organism is known. The pharmacokinetics of amyg...

journal_title：Archives of toxicology

authors： Rauws AG,Olling M,Timmerman A

更新日期：1982-03-01 00:00:00

abstract：:The effects of acetone on liver, kidney, and lung monooxygenases were studied using hamsters administered 8% acetone in drinking water. Binding of aniline to liver microsomes induced a type II difference spectrum, and the spectral binding was enhanced in hamsters pretreated with acetone. Administration of acetone caus...

journal_title：Archives of toxicology

authors： Ueng TH,Tsai JN,Ju JM,Ueng YF,Iwasaki M,Guengerich FP

更新日期：1991-01-01 00:00:00