Differential expression of cyclin-dependent kinases in the adult human retina in relation to CDK inhibitor retinotoxicity.

abstract：:For ethical and regulatory reasons, in vitro tests for scoring potential toxicities of cosmetics are essential. A test strategy for investigating potential skin sensitization using two human keratinocytic and two human dendritic cell lines has been developed (Mehling et al. Arch Toxicol 86:1273–1295, 2012). Since proh...

journal_title：Archives of toxicology

authors： Fabian E,Vogel D,Blatz V,Ramirez T,Kolle S,Eltze T,van Ravenzwaay B,Oesch F,Landsiedel R

更新日期：2013-09-01 00:00:00

abstract：UNLABELLED:An overdose of acetaminophen (APAP) causes hepatotoxicity due to its metabolite, N-acetyl-p-benzoquinone imine. NAD(P)H:quinone oxidoreductase 1 (NQO1) is an important enzyme for detoxification, because it catabolizes endogenous/exogenous quinone to hydroquinone. Although various studies have suggested the ...

journal_title：Archives of toxicology

authors： Hwang JH,Kim YH,Noh JR,Gang GT,Kim KS,Chung HK,Tadi S,Yim YH,Shong M,Lee CH

更新日期：2015-11-01 00:00:00

abstract：:Hibiscus protocatechuic acid (PCA), a phenolic compound found in the dried flowers of Hibiscus sabdariffa L. (Malvaceae), was demonstrated to have an antioxidant effect in vitro and in vivo, and an antitumor property in our previous study. In the present study, we used lipopolysaccharide (LPS, an endotoxin) to induce ...

journal_title：Archives of toxicology

authors： Lin WL,Hsieh YJ,Chou FP,Wang CJ,Cheng MT,Tseng TH

更新日期：2003-01-01 00:00:00

abstract：:Treatment of cats with acrylamide, either 7.5 or 15 mg/kg IM, once a day for 10 days, resulted in increases of 31 and 47% in the phospholipid content of sciatic nerve, respectively, from a control level of 41.1 +/- 2.7 mg/kg wet weight. Determination of the distribution of individual phospholipids indicated no signifi...

journal_title：Archives of toxicology

authors： Howland RD,Lowndes HE

更新日期：1984-09-01 00:00:00

abstract：:False-negative judgment due to poor chemical solubility is a problem with in vitro skin sensitisation tests. Water-insoluble chemicals are typically dissolved in DMSO in most sensitisation tests but precipitate when diluted with medium beyond their solubility in water. Such tests lack procedures to rule out false-nega...

journal_title：Archives of toxicology

authors： Kimura Y,Fujimura C,Aiba S

更新日期：2020-10-17 00:00:00

abstract：:Many in the welding industry suffer from bronchitis, lung function changes, metal fume fever, and diseases related to respiratory damage. These phenomena are associated with welding fumes; however, the mechanism behind these findings remains to be elucidated. In this study, the lungs of cynomolgus monkeys were exposed...

journal_title：Archives of toxicology

authors： Heo JD,Oh JH,Lee K,Kim CY,Song CW,Yoon S,Han JS,Yu IJ

更新日期：2010-03-01 00:00:00

abstract：:Using human neuroblastoma SH-SY5Y cells, effects of acrylamide on p53 protein and intracellular signal transducting pathways were examined. Acrylamide increased p53, phosphorylated p53, and p53-associated protein murine double minute 2 (MDM2). The phosphorylation of p53 was specific for the Ser15 site. Among mitogen-a...

journal_title：Archives of toxicology

authors： Okuno T,Matsuoka M,Sumizawa T,Igisu H

更新日期：2006-03-01 00:00:00

abstract：:The mycotoxin deoxynivalenol (DON) has a high global prevalence in grain-based products. Biomarkers of exposure are detectable in most humans and farm animals. Considering the acute emetic and chronic anorexigenic toxicity of DON, maximum levels for food and feed have been implemented by food authorities. The tolerabl...

journal_title：Archives of toxicology

authors： Faeste CK,Pierre F,Ivanova L,Sayyari A,Massotte D

更新日期：2019-07-01 00:00:00

abstract：:New strategies are needed to address the data gap between the bioactivity of chemicals in the environment versus existing hazard information. We address whether a high-throughput screening (HTS) system using a vertebrate organism (embryonic zebrafish) can characterize chemical-elicited behavioral responses at an early...

journal_title：Archives of toxicology

authors： Reif DM,Truong L,Mandrell D,Marvel S,Zhang G,Tanguay RL

更新日期：2016-06-01 00:00:00

abstract：:Pregnant C3H mice were exposed to a teratogenic dose of cyclophosphamide (CP, 20 mg/kg body weight) on the 10th day after copulation. Embryos or fetuses were examined 2-9 days later for gross abnormalities, weighed, and assayed for cephalic acetylcholinesterase (EC 3.1.1.7, AChE) activity, and haemoglobin content. In ...

journal_title：Archives of toxicology

authors： Pillans PI,Stephenson BA,Folb PI

更新日期：1988-01-01 00:00:00

abstract：:There is considerable epidemiological evidence that workers exposed to carbon disulfide (CS2) develop premature atherosclerosis leading to increased rates of coronary heart disease (CHD), but mechanisms underlying this association remain obscure. The present study documents that occupational exposure to CS2 modifies t...

journal_title：Archives of toxicology

authors： Wronska-Nofer T,Chojnowska-Jezierska J,Nofer JR,Halatek T,Wisniewska-Knypl J

更新日期：2002-04-01 00:00:00

abstract：:The effects of six iv infusions of an emulsion containing the plasticizer di(2-ethylhexyl) phthalate (DEHP) on the liver and testes were investigated in 40-day-old rats. Groups of five to six animals received the emulsion every other day in doses of 0, 5, 50 or 500 mg DEHP/kg body weight. Liver effects were studied by...

journal_title：Archives of toxicology

authors： Sjöberg P,Lindquist NG,Montin G,Plöen L

更新日期：1985-12-01 00:00:00

abstract：:The results from a survey of the expert information that is publicly accessible on the use of the dog as test species during the regulatory evaluation of agricultural chemicals and pesticides are reported. Methods that are being used or considered in order to reduce the number of dogs used for this purpose are describ...

journal_title：Archives of toxicology

authors： Box RJ,Spielmann H

更新日期：2005-11-01 00:00:00

abstract：:The studies presented were designed to investigate the effects of cytochrome P450 inhibition on tetrahydrofuran-induced hepatocellular proliferation in female B6C3F(1) mice. Groups of female B6C3F(1) mice were exposed to dynamic atmospheres containing tetrahydrofuran (THF) concentrations of 0, 5,400 or 15,000 mg/m(3) ...

journal_title：Archives of toxicology

authors： van Ravenzwaay B,Gamer AO,Leibold E,Kaufmann W

更新日期：2003-08-01 00:00:00

abstract：:N-methylformamide (NMF) produced dose-dependent zone 3 haemorrhagic necrosis in mice; the threshold dose was 100-200 mg/kg. In rats a dose of 1000 mg/kg caused hepatic damage in some animals and slight elevations of plasma transaminases. A species difference in susceptibility to NMF-induced hepatotoxicity is clearly i...

journal_title：Archives of toxicology

authors： Tulip K,Timbrell JA

更新日期：1988-01-01 00:00:00

abstract：:Rat embryos (9.5-day-old) were cultured for 48 h in the presence of nifedipine (NIF), nimodipine (NIM), nitrendipine (NIT), gallopamil HCl (GAL), verapamil HCl (VER) and diltiazem HCl (DIL). The effects on growth and morphogenetic differentiation in vitro were monitored. Dose-response relationships were evaluated, inc...

journal_title：Archives of toxicology

authors： Stein G,Srivastava MK,Merker HJ,Neubert D

更新日期：1990-01-01 00:00:00

abstract：:The present study was performed to investigate the potential toxic effects of prenatal exposure to 4-tert-octylphenol (OP) on liver, kidney, spleen, and hematologic parameters of male and female rats in adult life. The rats were treated with OP subcutaneously in utero at doses of control (vehicle, corn oil), 100 or 25...

journal_title：Archives of toxicology

authors： Barlas N,Aydoğan M

更新日期：2009-04-01 00:00:00

abstract：:The oxidizing capacity of phagocytic cells is suspected to play a major role in the generation of immunogenic drug metabolites, in particular those that cause extrahepatic immunopathological lesions. In the case of the antirheumatic drug gold(I) disodium thiomalate (Na2Au(I)TM), oxidation of the Au(I) ion to Au(III) a...

journal_title：Archives of toxicology

authors： Goebel C,Kubicka-Muranyi M,Tonn T,Gonzalez J,Gleichmann E

更新日期：1995-01-01 00:00:00

abstract：:Rats were exposed to single periods of inhalation of fumes generated by arc welding. Two processes were compared: either manual metal arc (MMA) using flux-coated mild steel (MS) electrodes or metal inert-gas (MIG) welding with stainless steel (SS). Widespread but small deposits of fume particles were cleared effective...

journal_title：Archives of toxicology

authors： Hicks R,Lam HF,Al-Shamma KJ,Hewitt PJ

更新日期：1984-03-01 00:00:00

abstract：:Certain bisphenols (BPs) have been regarded as endocrine-disrupting chemicals due to their structural similarities to bisphenol A (BPA), a well-known weak estrogenic chemical. However, very limited data are currently available on the relationship between estrogenic activity and the structure of BP analogs. Therefore, ...

journal_title：Archives of toxicology

authors： Cao H,Wang F,Liang Y,Wang H,Zhang A,Song M

更新日期：2017-12-01 00:00:00

abstract：:This study was conducted to determine the functional role of phospholipase D (PLD) involved in testicular Leydig cell damage caused by di (2-ethylhexyl) phthalate (DEHP) in Sprague-Dawley rats. DEHP (500 mg/kg/day) was administered orally to prepubertal rats for 1, 7, 14, 21 or 28 days. After 7 days of exposure, DEHP ...

journal_title：Archives of toxicology

authors： Lee YJ,Ahn MY,Kim HS,Kwack SJ,Park KL,Yoon S,Min D

更新日期：2011-08-01 00:00:00

abstract：:Cadmium-induced metallothionein (MT) synthesis was investigated in male rats of three ages, 3, 12 and 24 months. Physiological levels of MT in kidney, liver and lung measured simultaneously in untreated animals were found to be within the same range in all three age groups. Following 3-day treatment with CdCl2 equival...

journal_title：Archives of toxicology

authors： Wormser U,Nir I

更新日期：1988-01-01 00:00:00

abstract：:Phenethyl isothiocyanate is a chemopreventive phytochemical present in cruciferous vegetables where it exists as the glucosinolate gluconasturtiin. It is a mechanism-based inhibitor of both rat and human cytochrome P450 enzymes. The principal objective of the present study was to ascertain whether phenethyl isocyanate...

journal_title：Archives of toxicology

authors： Konsue N,Ioannides C

更新日期：2010-10-01 00:00:00

abstract：:Female C57/BL/6 x DBA/2 hybrid mice were exposed to two concentrations (270 and 135 ppm) of tetrachloroethylene (PER) in inhalation chambers for 6 h/day, 5 days per week, up to 11.5 weeks (270 ppm) and 7.5 weeks (135 ppm), respectively, followed by a 3-week exposure-free period. In the peripheral blood a reduction of ...

journal_title：Archives of toxicology

authors： Seidel HJ,Weber L,Barthel E

更新日期：1992-01-01 00:00:00

abstract：:Doppler and M-mode echocardiography (EC) were used to investigate the effects of minoxidil on the cardiac function of the dog and potentially to clarify the pathogenesis of cardiac lesions, in particular the necrotic lesion in the left ventricle and the haemorrhagic lesion in the right atrium. Groups of three dogs wer...

journal_title：Archives of toxicology

authors： Hanton G,Gautier M,Bonnet P

更新日期：2004-01-01 00:00:00

abstract：:Boric acid and sodium borates are currently classified as being toxic to reproduction under "Category 1B" with the hazard statement of "H360 FD" in the European CLP regulation. This has prompted studies on boron-mediated reprotoxic effects in male workers in boron mining areas and boric acid production plants. By cont...

journal_title：Archives of toxicology

authors： Duydu Y,Başaran N,Üstündağ A,Aydın S,Yalçın CÖ,Anlar HG,Bacanlı M,Aydos K,Atabekoğlu CS,Golka K,Ickstadt K,Schwerdtle T,Werner M,Meyer S,Bolt HM

更新日期：2018-08-01 00:00:00

abstract：:Initially, mice were pretreated with atropine (17.4 mg/kg; IP) and the oxime reactivator HI-6 (50 mg/kg; IP) 5 min prior to an injection of soman (287 micrograms/kg, SC); approximately 2.1 x LD50 dose). More than 95% of the mice survived this dose of soman with atropine and HI-6 pretreatment. In these survivors of som...

journal_title：Archives of toxicology

authors： Clement JG

更新日期：1989-01-01 00:00:00

abstract：:Delta 9-THC at the dose of 1 mg/kg/die was administered subcutaneously in growing rats, from the second to the 30th day of life. A statistically significant myeloid hyperplasia was demonstrated, which persisted up to 4 months after the end of the treatment, together with significant blood granulocytosis. ...

journal_title：Archives of toxicology

authors： Giusti GV,Carnevale A

更新日期：1975-10-20 00:00:00

abstract：:Second order rate constants for the initial reaction of 12 mammalian oxyhemoglobins (Hb) with equimolar phenylhydrazine (PHZ), a compound inducing Heinz body hemolytic anemia, were determined by recording continuous changes in absorbance with time at 577 nm. The rate constants were varied in a range from 43 m-1.s-1 wi...

journal_title：Archives of toxicology

authors： Kinuta M,Matteson JL,Itano HA

更新日期：1995-01-01 00:00:00

abstract：:Heat shock proteins (HSPs) are a group of proteins that are rapidly induced in response to physiological stress, including hyperthermia and exposure to toxicants. Thus they may provide a useful index of toxicity in in vitro systems for screening for toxicity. We have recently developed a rat nasal explant system for i...

journal_title：Archives of toxicology

authors： Simpson SA,Alexander DJ,Reed CJ

更新日期：2004-06-01 00:00:00