Birth weights of newborns and pregnancy outcomes of environmentally boron-exposed females in Turkey.

abstract：:Sertoli cells play a critical role in spermatogenesis, and in adults, they are terminally differentiated with loss of proliferative activity. This study revealed Sertoli cell proliferation in 17-week-old Sprague-Dawley rats whose dams had been intragastrically administered 250 ng of 3,3',4,4',5-pentachlorobiphenyl/kg ...

journal_title：Archives of toxicology

authors： Wakui S,Muto T,Suzuki Y,Takahashi H,Hano H

更新日期：2012-01-01 00:00:00

abstract：:The US Environmental Protection Agency's ToxCast program has generated toxicity data for thousands of chemicals but does not adequately assess potential neurotoxicity. Networks of neurons grown on microelectrode arrays (MEAs) offer an efficient approach to screen compounds for neuroactivity and distinguish between com...

journal_title：Archives of toxicology

authors： Kosnik MB,Strickland JD,Marvel SW,Wallis DJ,Wallace K,Richard AM,Reif DM,Shafer TJ

更新日期：2020-02-01 00:00:00

abstract：:Rats were exposed to single periods of inhalation of fumes generated by arc welding. Two processes were compared: either manual metal arc (MMA) using flux-coated mild steel (MS) electrodes or metal inert-gas (MIG) welding with stainless steel (SS). Widespread but small deposits of fume particles were cleared effective...

journal_title：Archives of toxicology

authors： Hicks R,Lam HF,Al-Shamma KJ,Hewitt PJ

更新日期：1984-03-01 00:00:00

abstract：:The associations of four single nucleotide polymorphisms (p.Arg194Trp, p.Arg280His, p.Pro206Pro, and p.Arg399Gln) in X-ray repair cross-complementing group 1 with urinary arsenic metabolites and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were investigated in a Vietnamese population (n = 100). Individuals with genotype AA in...

journal_title：Archives of toxicology

authors： Fujihara J,Yasuda T,Iwata H,Tanabe S,Takeshita H

更新日期：2016-04-01 00:00:00

abstract：:Metabolic activation of the heterocyclic amine 3-amino -1,4-dimethyl-5 H-pyrido[4,3-b]indole (Trp-P-1) and 7-ethoxyresorufin O-deethylase (EROD) activity were examined in the chorioallantoic membrane (CAM) of 15-day-old chicken and 18-day-old eider duck embryos. The embryos were pretreated with an Ah receptor agonist,...

journal_title：Archives of toxicology

authors： Annas A,Brunström B,Brittebo EB

更新日期：2000-08-01 00:00:00

abstract：:Whether pregnancy-induced immunosuppression when combined with exposure to 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) could exacerbate immunotoxicity has not been previously investigated. The current study evaluated the immune status of C57BL/6 pregnant and virgin mice following exposure to TCDD. To this end, syngene...

journal_title：Archives of toxicology

authors： Camacho IA,Nagarkatti M,Nagarkatti PS

更新日期：2004-05-01 00:00:00

abstract：UNLABELLED:An overdose of acetaminophen (APAP) causes hepatotoxicity due to its metabolite, N-acetyl-p-benzoquinone imine. NAD(P)H:quinone oxidoreductase 1 (NQO1) is an important enzyme for detoxification, because it catabolizes endogenous/exogenous quinone to hydroquinone. Although various studies have suggested the ...

journal_title：Archives of toxicology

authors： Hwang JH,Kim YH,Noh JR,Gang GT,Kim KS,Chung HK,Tadi S,Yim YH,Shong M,Lee CH

更新日期：2015-11-01 00:00:00

abstract：:Acetaminophen (APAP) overdose is the leading cause of acute liver failure. Yet the mechanisms underlying adaptive tolerance toward APAP-induced liver injury are not fully understood. To better understand molecular mechanisms contributing to adaptive tolerance to APAP is an underpinning foundation for APAP-related prec...

journal_title：Archives of toxicology

authors： Yu D,Wu L,Gill P,Tolleson WH,Chen S,Sun J,Knox B,Jin Y,Xiao W,Hong H,Wang Y,Ren Z,Guo L,Mei N,Guo Y,Yang X,Shi L,Chen Y,Zeng L,Dreval K,Tryndyak V,Pogribny I,Fang H,Shi T,McCullough S,Bhattacharyya S,S

更新日期：2018-02-01 00:00:00

abstract：:Cytotoxic effects of cyclophosphamide (CPA), paclitaxel (PCT), and docetaxel (DTX) and their modulation by cytochrome P450 (CYP) metabolism were studied by incubating cell lines L929 and P388D1 with or without rat liver microsomes. The microsomes themselves were not cytotoxic. P388D1 cells were more sensitive to CPA, ...

journal_title：Archives of toxicology

authors： Gut I,Danielová V,Holubová J,Soucek P,Klucková H

更新日期：2000-10-01 00:00:00

abstract：:Although carbon nanotubes (CNTs) are promising nanomaterials, their potential carcinogenicity is a major concern. We previously established a genetic method of analyzing genotoxicity of chemical compounds, where we evaluated their cytotoxic effect on the DT40 lymphoid cell line comparing DNA-repair-deficient isogenic ...

journal_title：Archives of toxicology

authors： Mohiuddin,Keka IS,Evans TJ,Hirota K,Shimizu H,Kono K,Takeda S,Hirano S

更新日期：2014-01-01 00:00:00

abstract：:A series of experiments was set up to elucidate the effects of pollution on marine and estuarine fish health, since the European flounder (Platichthys flesus) has shown a relatively high prevalence of (pre)neoplastic liver lesions and lymphocystis virus disease in Dutch coastal and estuarine waters. The hypothesis of ...

journal_title：Archives of toxicology

authors： Grinwis GC,van den Brandhof EJ,Engelsma MY,Kuiper RV,Vaal MA,Vethaak AD,Wester PW,Vos JG

更新日期：2001-04-01 00:00:00

abstract：:Previously we reported that exposure of mouse and human mast cells to aryl hydrocarbon receptor (AhR) ligands resulted in reactive oxygen species (ROS)- and calcium (Ca2+)-dependent activation of mast cells in vitro and in vivo. However, the mechanisms through which the AhR-ligand axis mediates stress response, Ca2+ s...

journal_title：Archives of toxicology

authors： Wang HC,Zhou Y,Huang SK

更新日期：2017-04-01 00:00:00

abstract：:The effect of various hepatotoxicants on urinary taurine and urinary creatine has been studied in the rat. Several hepatotoxic agents, carbon tetrachloride, thioacetamide, galactosamine and allyl alcohol which all caused hepatic necrosis (sometimes accompanied by steatosis), resulted in a rise in urinary taurine and i...

journal_title：Archives of toxicology

authors： Waterfield CJ,Turton JA,Scales MD,Timbrell JA

更新日期：1993-01-01 00:00:00

abstract：:Rats were administered a sublethal dose of thallium (12.35 mg/kg as aqueous thallous sulfate, Tl2SO4, equivalent to 10 mg Tl+/kg per os) on day 0. Urine and feces were collected separately every day for 8 days and analyzed by atomic absorption spectroscopy. Based on information in the literature, five antidotal treatm...

journal_title：Archives of toxicology

authors： Lehmann PA,Favari L

更新日期：1985-04-01 00:00:00

abstract：:The in vitro DNA strand breaking activity of metallothionein (MT) containing Cd2+ and Zn2+ in a molar ratio of 5:2 is described. Studies with radical scavengers and electron paramagnetic resonance spectroscopy indicate that the DNA damage might be caused by a radical species formed by the native protein (i.e., MT) cha...

journal_title：Archives of toxicology

authors： Müller T,Schuckelt R,Jaenicke L

更新日期：1991-01-01 00:00:00

abstract：:The influence of pivalic acid (PIV), a compound often used to make pro-drugs, and of the structurally related trichloroacetic acid (TCA), on several hepatic and renal enzymes was investigated in Sprague-Dawley rats, following a 4-day treatment period. The PIV and TCA treatments resulted in a similar and selective indu...

journal_title：Archives of toxicology

authors： Zanelli U,Puccini P,Acerbi D,Ventura P,Gervasi PG

更新日期：1996-01-01 00:00:00

abstract：:Oxidative stress is discussed as a possible hepatocarcinogenic mechanism of peroxisome proliferators (PP) in rodents and is suggested to result from the induction of peroxisomal beta-oxidation (PBOX) by PP. The induced PBOX is assumed to produce excessive H2O2 from the degradation of fatty acids, ultimately leading to...

journal_title：Archives of toxicology

authors： Huber WW,Grasl-Kraupp B,Stekel H,Gschwentner C,Lang H,Schulte-Hermann R

更新日期：1997-01-01 00:00:00

abstract：:In this review, we introduce a new concept, precision toxicology: the mode of action of chemical- or drug-induced toxicity can be sensitively and specifically investigated by isolating a small group of cells or even a single cell with typical phenotype of interest followed by a single cell sequencing-based analysis. P...

journal_title：Archives of toxicology

authors： Zhang B,Huang K,Zhu L,Luo Y,Xu W

更新日期：2017-07-01 00:00:00

abstract：:The effect of pretreatment with cadmium (Cd) complexes on the distribution and accumulation of Cd in the liver and kidneys was examined for the Cd complexes that are reabsorbed site-selectively at the renal proximal tubules of rats. Cd was administered simultaneously with excess cysteine or as metallothionein (MT) and...

journal_title：Archives of toxicology

authors： Suzuki KT,Takahara T,Watanabe H,Nishikawa M,Yamamura M,Murakami M

更新日期：1986-04-01 00:00:00

abstract：:The toxicokinetics of the four stereoisomers of the nerve agent C(+/-)P(+/-)-soman was analysed in cerebrospinal fluid (CSF) and blood in anaesthetized, spontaneously breathing pigs during a 90-min period after injection of soman. The pigs were challenged with different intravenous (i.v.) doses of C(+/-)P(+/-)-soman c...

journal_title：Archives of toxicology

authors： Göransson-Nyberg A,Fredriksson SA,Karlsson B,Lundström M,Cassel G

更新日期：1998-07-01 00:00:00

abstract：:Tributyltin (TBT) has been shown to disrupt the ability of natural killer (NK) cells to destroy tumor targets in vitro even at exposures of 25 nM for 24 h, but cell viability was not significantly impacted. Thus, evaluation of intracellular molecular events that regulate cell viability in TBT exposed NK cells are of i...

journal_title：Archives of toxicology

authors： Aluoch AO,Odman-Ghazi SO,Whalen MM

更新日期：2007-04-01 00:00:00

abstract：:N-methylformamide (NMF) produced dose-dependent zone 3 haemorrhagic necrosis in mice; the threshold dose was 100-200 mg/kg. In rats a dose of 1000 mg/kg caused hepatic damage in some animals and slight elevations of plasma transaminases. A species difference in susceptibility to NMF-induced hepatotoxicity is clearly i...

journal_title：Archives of toxicology

authors： Tulip K,Timbrell JA

更新日期：1988-01-01 00:00:00

abstract：:Mercury exists in the environment in various forms, all of which pose a risk to human health. Despite guidelines regulating the industrial release of mercury into the environment, humans continue to be exposed regularly to various forms of this metal via inhalation or ingestion. Following exposure, mercuric ions are t...

journal_title：Archives of toxicology

authors： Bridges CC,Zalups RK

更新日期：2017-01-01 00:00:00

abstract：:Initially, mice were pretreated with atropine (17.4 mg/kg; IP) and the oxime reactivator HI-6 (50 mg/kg; IP) 5 min prior to an injection of soman (287 micrograms/kg, SC); approximately 2.1 x LD50 dose). More than 95% of the mice survived this dose of soman with atropine and HI-6 pretreatment. In these survivors of som...

journal_title：Archives of toxicology

authors： Clement JG

更新日期：1989-01-01 00:00:00

abstract：:The aim of this study was to investigate the electrophilic tissue burden (ETB) formation, assessed as covalent binding of the ultimate carcinogen benzo( a)pyrene diolepoxide (BaPDE) with cellular proteins, in liver, lung and heart, as well as with haemoglobin (Hb) following repeated exposure to binary mixtures of benz...

journal_title：Archives of toxicology

authors： Tzekova A,Leroux S,Viau C

更新日期：2004-02-01 00:00:00

abstract：:As previously demonstrated, chronic administration of phenobarbital (0.05% in the drinking water) and of nafenopin (0.1% in the diet) increases the incidence and the kinetics of appearance of liver cancers. If bile acids play a key role in liver carcinogenesis, it might thus be expected that treatments like phenobarbi...

journal_title：Archives of toxicology

authors： Delzenne NM,Taper HS,Roberfroid M

更新日期：1994-01-01 00:00:00

abstract：:Carbromal is metabolized extensively in humans. The major metabolites known to date are bromoethylbutyramide, ethylbutyrylurea and inorganic bromide. After ingestion of a therapeutic dose of 1.0 g carbromal (4.2 mmoles) by four healthy volunteers highest concentrations in serum were found to be for carbromal 30 mumole...

journal_title：Archives of toxicology

authors： Vohland HW,Schirop T,Barckow D,Kreutz G,Streichert B

更新日期：1978-06-16 00:00:00

abstract：:Using male ICR mice, the LC50 and acute and subacute inhalation toxicity of dichlorosilane (SiH2Cl2, DCS) and the fate of DCS released into the air were investigated. DCS resolved and minute particles including silicon and chloride were observed, when DCS was released into the air. Most particles were under 1 micron i...

journal_title：Archives of toxicology

authors： Nakashima H,Omae K,Takebayashi T,Ishizuka C,Sakurai H,Yamazaki K,Nakaza M,Shibata T,Kudo M,Koshi S

更新日期：1996-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a family of endogenous, small, noncoding RNA molecules that involved in a wide range of biological processes including differentiation, proliferation, and apoptosis. A polymorphism G>C (rs2910164) is located in the stem region opposite to the mature miR-146a sequence. In our study, we investigat...

journal_title：Archives of toxicology

authors： Ma L,Zhu L,Gu D,Chu H,Tong N,Chen J,Zhang Z,Wang M

更新日期：2013-05-01 00:00:00

abstract：:The metabolic fate of 2-ethylhexyl diphenyl phosphate (EHDPP) was studied in male rats. Orally administered 14C-EHDPP was rapidly absorbed and about 80% of the radioactivity was excreted in the urine and feces in the first 24 h. By 7 days, 48% and 52% of the radioactivity was recovered in urine and feces, respectively...

journal_title：Archives of toxicology

authors： Nishimaki-Mogami T,Minegishi K,Tanaka A,Sato M

更新日期：1988-01-01 00:00:00