Abstract:
:Rats were exposed to single periods of inhalation of fumes generated by arc welding. Two processes were compared: either manual metal arc (MMA) using flux-coated mild steel (MS) electrodes or metal inert-gas (MIG) welding with stainless steel (SS). Widespread but small deposits of fume particles were cleared effectively from alveoli and airways. Peribronchial and subpleural aggregates of particle-laden macrophages remained. More massive and persistent lung-burdens were established by intratracheal administration of suspensions of fume-particles (10 mg and 50 mg, single doses). Initial pneumonitis was attributed to irritant gases or soluble toxic components of particles. MIG-SS particle deposits were more persistent and lesions more severe, inhibition of phagocytosis or clearance and damage to epithelial cells being associated with possible toxic effects in macrophages. Both types of particle caused alveolar epithelial thickening, with proliferation of granular pneumocytes and exudation of lamellar material. Foam cells appeared in alveoli. Long-term effects (80-300 days) involved formation of nodular aggregates of particle-laden macrophages. Giant cells were formed. Nodules containing MIG-SS material were irregular and surrounded by collapsed and thickened epithelium. Soluble chromium or nickel constituents are cited as probable active agents producing effects resembling those of cytotoxic non-fibrogenic dusts, e.g., soluble silicas . MMA-MS particles produced low-grade fibrotic ( collagenised ) changes.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Hicks R,Lam HF,Al-Shamma KJ,Hewitt PJdoi
10.1007/BF00316578subject
Has Abstractpub_date
1984-03-01 00:00:00pages
1-10issue
1eissn
0340-5761issn
1432-0738journal_volume
55pub_type
杂志文章abstract::Second order rate constants for the initial reaction of 12 mammalian oxyhemoglobins (Hb) with equimolar phenylhydrazine (PHZ), a compound inducing Heinz body hemolytic anemia, were determined by recording continuous changes in absorbance with time at 577 nm. The rate constants were varied in a range from 43 m-1.s-1 wi...
journal_title:Archives of toxicology
pub_type: 杂志文章
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pub_type: 信件
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Archives of toxicology
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abstract:: ...
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pub_type: 评论,信件
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journal_title:Archives of toxicology
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journal_title:Archives of toxicology
pub_type: 杂志文章
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journal_title:Archives of toxicology
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更新日期:1997-01-01 00:00:00
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journal_title:Archives of toxicology
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journal_title:Archives of toxicology
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journal_title:Archives of toxicology
pub_type: 杂志文章,评审
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