Ethylmorphine concentrations in human samples in an overdose case.

abstract：:3-monochloropropane-1,2-diol (3-MCPD), a rat renal and testicular carcinogen, has been reported to occur in various foods and food ingredients as free or esterified forms. Since reports about toxicity of 3-MCPD esters are limited, we conducted a 13-week rat subchronic toxicity study of 3-MCPD esters (palmitate diester...

journal_title：Archives of toxicology

authors： Onami S,Cho YM,Toyoda T,Mizuta Y,Yoshida M,Nishikawa A,Ogawa K

更新日期：2014-04-01 00:00:00

abstract：:It is estimated that only a few marketed drugs are able to directly induce liver steatosis. However, many other drugs may exacerbate or precipitate fatty liver in the presence of other risk factors or in patients prone to non-alcoholic fatty liver disease. On the other hand, current in vitro tests for drug-induced ste...

journal_title：Archives of toxicology

authors： Benet M,Moya M,Donato MT,Lahoz A,Hervás D,Guzmán C,Gómez-Lechón MJ,Castell JV,Jover R

更新日期：2014-04-01 00:00:00

abstract：:Steatosis, also known as fatty liver disease (FLD), is a disorder in which the lipid metabolism of the liver is disturbed, leading to the abnormal retention of lipids in hepatocytes. FLD can be induced by several drugs, and although it is mostly asymptomatic, it can lead to steatohepatitis, which is associated with li...

journal_title：Archives of toxicology

authors： Rodrigues RM,Branson S,De Boe V,Sachinidis A,Rogiers V,De Kock J,Vanhaecke T

更新日期：2016-03-01 00:00:00

abstract：:The object of this study was to compare the relative sensitivity of markers of exposure and effects in the lung of rats exposed to polymeric diphenyl-methane-4,4'-diisocyanate (pMDI) aerosol. Rats were repeatedly exposed to 12.9 mg pMDI/m(3) (6 h/day, 5 days/week for 14 days; exposure was from days 0--17 followed by a...

journal_title：Archives of toxicology

authors： Pauluhn J

更新日期：2002-02-01 00:00:00

abstract：:Engineered amorphous silica nanoparticles (nanosilica) are widely used in industry yet can induce adverse effects, which might be classified according to the oxidative stress model. However, the underlying mechanisms as well as the potential interactions of the three postulated different tiers of toxicity-i.e. oxidati...

journal_title：Archives of toxicology

authors： Fritsch-Decker S,Marquardt C,Stoeger T,Diabaté S,Weiss C

更新日期：2018-07-01 00:00:00

abstract：:Metabolism of carbaryl by rat liver and skin post-mitochondrial fraction has been measured in the presence and absence of cofactors to promote different metabolic pathways. The metabolic capacity was compared with the metabolism of carbaryl during percutaneous absorption in a static skin diffusion system using a varie...

journal_title：Archives of toxicology

authors： MacPherson SE,Scott RC,Williams FM

更新日期：1991-01-01 00:00:00

abstract：:Amanita phalloides is responsible for more than 90 % of mushroom-related fatalities, and no effective antidote is available. α-Amanitin, the main toxin of A. phalloides, inhibits RNA polymerase II (RNAP II), causing hepatic and kidney failure. In silico studies included docking and molecular dynamics simulation couple...

journal_title：Archives of toxicology

authors： Garcia J,Costa VM,Carvalho AT,Silvestre R,Duarte JA,Dourado DF,Arbo MD,Baltazar T,Dinis-Oliveira RJ,Baptista P,de Lourdes Bastos M,Carvalho F

更新日期：2015-12-01 00:00:00

abstract：:Chronic ethanol consumption is a strong risk factor for the development of liver disease. Multiple mechanisms are involved in ethanol-mediated liver injury; oxidative stress being pointed has an important factor. However, it should be noted that moderate consumption of red wine has been associated with hepatoprotectiv...

journal_title：Archives of toxicology

authors： Silva P,Fernandes E,Carvalho F

更新日期：2015-10-01 00:00:00

abstract：:Previous studies have shown the antidotal efficacy of topical iodine at 15 and 30 min post-exposure to sulfur mustard (SM). Here we demonstrate efficacy at longer intervals (20, 30, 45, and 60 min, respectively, for data) using an improved topical povidone-iodine preparation termed N66, which contains steroidal and no...

journal_title：Archives of toxicology

authors： Wormser U,Sintov A,Brodsky B,Casillas RP,Nyska A

更新日期：2004-03-01 00:00:00

abstract：:Iron (Fe) plays essential roles in biological processes, whereas cadmium (Cd) is a toxic and non-essential metal. Two metal transporters, divalent metal transporter 1 (DMT1) and metal transporter protein 1 (MTP1), are responsible for Fe transport in mammals. Here, we studied the effect of dietary Fe on the expression ...

journal_title：Archives of toxicology

authors： Kim DW,Kim KY,Choi BS,Youn P,Ryu DY,Klaassen CD,Park JD

更新日期：2007-05-01 00:00:00

abstract：:Membrane transporters play an important role in the absorption, distribution, metabolism and excretion of drugs. The cellular accumulation of many drugs is the result of the net function of efflux and influx transporters. Efflux transporters such as P-glycoprotein/ABCB1 have been shown to confer multidrug resistance i...

journal_title：Archives of toxicology

authors： Windt T,Tóth S,Patik I,Sessler J,Kucsma N,Szepesi Á,Zdrazil B,Özvegy-Laczka C,Szakács G

更新日期：2019-04-01 00:00:00

abstract：:Exposure to toxic metals is a well-known problem in industrialized countries. Metals interfere with a number of physiological processes, including central nervous system (CNS), haematopoietic, hepatic and renal functions. In the evaluation of the toxicity of a particular metal it is crucial to consider many parameters...

journal_title：Archives of toxicology

authors： Sinicropi MS,Amantea D,Caruso A,Saturnino C

更新日期：2010-07-01 00:00:00

abstract：:Some nucleoside analogues are used to treat herpes simplex and other viral infections. They are known to impair spermatogenesis, but published data are scarce. We studied the effects of four nucleosides on SerW3 cells, a rat Sertoli cell line. Cells were cultured for 3 days in DMEM supplemented with four different con...

journal_title：Archives of toxicology

authors： Qiu R,Horvath A,Stahlmann R

更新日期：2016-08-01 00:00:00

abstract：:The first step in the oxidative metabolism of cocaine is N-demethylation to norcocaine, which is further N-hydroxylated to more toxic N-hydroxynorcocaine. In this study we examined the kinetics of norcocaine N-hydroxylation mediated by cytochrome P450 (CYP) in mouse and human liver microsomes. N-hydroxynorcocaine was ...

journal_title：Archives of toxicology

authors： Pellinen P,Kulmala L,Konttila J,Auriola S,Pasanen M,Juvonen R

更新日期：2000-11-01 00:00:00

abstract：:Previous studies indicate that benzanthrone, an anthraquinone dye intermediate, caused significant depletion of ascorbic acid (AsA). In this investigation the effect of benzanthrone on the status of different forms of AsA and other bio-antioxidants such as glutathione (GSH) was studied. Oral administration of benzanth...

journal_title：Archives of toxicology

authors： Dwivedi N,Das M,Khanna SK

更新日期：2001-06-01 00:00:00

abstract：:Effects of the oxime HI-6, unrelated to reactivation of acetylcholinesterase (AChE), on field potentials in the dentate gyrus of the rat hippocampus following AChE inhibition, were investigated both in vitro and in vivo. In hippocampal slices, AChE inhibition decreased the perforant path evoked population spike amplit...

journal_title：Archives of toxicology

authors： Melchers BP,van der Laaken AL,Busker RW,Bruijnzeel PL,Van Helden HP

更新日期：1994-01-01 00:00:00

abstract：:The effect of culture medium on glutathione (GSH) dependent detoxification defence system of primary cultured hepatocyte from either male or female rats was studied. Intracellular reduced (GSH) and oxidized glutathione (GSSG), and six GSH-related enzyme activities, including GSH peroxidase (GSH Px), GSH reductase (GSH...

journal_title：Archives of toxicology

authors： Lii CK,Wang ST,Chen HW,Sheen LY

更新日期：1996-01-01 00:00:00

abstract：:The efficacy of oxime (HI-6, toxogonin or PAM Cl) therapy against GF (cyclohexyl methylphosphonofluoridate) poisoning was assessed in mice. It was found that the combinations of atropine and either toxogonin or HI-6 were effective therapies against GF poisoning. PAM therapy was ineffective. HI-6 was the only oxime whi...

journal_title：Archives of toxicology

authors： Clement JG

更新日期：1992-01-01 00:00:00

abstract：:The comet assay is a versatile, reliable, cost-efficient, and fast technique for detecting DNA damage and repair in any tissue. It is useable in almost any cell type and applicable to both eukaryotic and prokaryotic organisms. Instead of highlighting one of the numerous specific aspects of the comet assay, the present...

journal_title：Archives of toxicology

authors： Glei M,Schneider T,Schlörmann W

更新日期：2016-10-01 00:00:00

abstract：:Fulminant hepatitis is a serious inflammatory condition of the liver characterized by massive necrosis of liver parenchyma following excessive immune cell infiltration into the liver, and possibly causing sudden hepatic failure and medical emergency. However, the underlying mechanisms are not fully understood. Here, w...

journal_title：Archives of toxicology

authors： Noh JR,Kim JH,Na SY,Lee IB,Seo YJ,Choi JH,Seo Y,Lee TG,Choi HS,Kim YH,Lee CH

更新日期：2020-02-01 00:00:00

abstract：:The current management of rodent pest populations is based on second-generation anticoagulant rodenticides (SGAR). These molecules, of which difethialone is part, are much more efficient than the first generation. Nevertheless, this efficiency comes with a major drawback, SGARs are tissue persistent that increases the...

journal_title：Archives of toxicology

authors： Lefebvre S,Fourel I,Chatron N,Caruel H,Benoit E,Lattard V

更新日期：2020-03-01 00:00:00

abstract：:Phytoestrogens have been described as weak estrogens, selective estrogen receptor mediators (SERMs) or to exhibit antiestrogenic properties. However, information about their activity in combination with xenoestrogens and 17beta-estradiol in vivo, is limited. Therefore, the combinatory activity of the phytoestrogen gen...

journal_title：Archives of toxicology

authors： Schmidt S,Degen GH,Seibel J,Hertrampf T,Vollmer G,Diel P

更新日期：2006-12-01 00:00:00

abstract：:Zearalenone, a cereal mycotoxin with mycoestrogen activity and effect on fertility, is known to trigger apoptosis of a variety of nucleated cell types including hematopoietic progenitor cells. In analogy to apoptosis of nucleated cells, eryptosis, the suicidal death of erythrocytes, leads to cell shrinkage and cell me...

journal_title：Archives of toxicology

authors： Jilani K,Lang F

更新日期：2013-10-01 00:00:00

abstract：:Occupational and environmental asbestos exposure is the main determinant of malignant pleural mesothelioma (MPM), however, the mechanisms by which its fibres contribute to cell toxicity and transformation are not completely clear. Aberrant DNA methylation is a common event in cancer but epigenetic modifications involv...

journal_title：Archives of toxicology

authors： Casalone E,Allione A,Viberti C,Pardini B,Guarrera S,Betti M,Dianzani I,Aldieri E,Matullo G

更新日期：2018-05-01 00:00:00

abstract：:Clark 1 (diphenylarsine chloride) and Clark 2 (diphenylarsine cyanide) were used as chemical weapon agents (CWA), and the soil contamination by these CWA and their degraded products, diphenyl and phenyl arsenicals, has been one of the most serious environmental issues. In a series of comparisons in toxicity between tr...

journal_title：Archives of toxicology

authors： Hirano S,Kobayashi Y,Hayakawa T,Cui X,Yamamoto M,Kanno S,Shraim A

更新日期：2005-01-01 00:00:00

abstract：:In the original publication of the article. ...

journal_title：Archives of toxicology

authors： Wang X,Tanaka N,Hu X,Kimura T,Lu Y,Jia F,Sato Y,Nakayama J,Moriya K,Koike K,Aoyama T

更新日期：2019-06-01 00:00:00

abstract：:Delta 9-THC at the dose of 1 mg/kg/die was administered subcutaneously in growing rats, from the second to the 30th day of life. A statistically significant myeloid hyperplasia was demonstrated, which persisted up to 4 months after the end of the treatment, together with significant blood granulocytosis. ...

journal_title：Archives of toxicology

authors： Giusti GV,Carnevale A

更新日期：1975-10-20 00:00:00

abstract：:Several studies have explored the negative effects of cigarette smoke on bone healing; however, the complex pathogenesis still remains unclear. One crucial and primary factor determining effective fracture repair is the recruitment and differentiation of mesenchymal stem cells (MSCs) into bone-forming cells. Recently,...

journal_title：Archives of toxicology

authors： Sreekumar V,Aspera-Werz R,Ehnert S,Strobel J,Tendulkar G,Heid D,Schreiner A,Arnscheidt C,Nussler AK

更新日期：2018-04-01 00:00:00

abstract：:The oxidizing capacity of phagocytic cells is suspected to play a major role in the generation of immunogenic drug metabolites, in particular those that cause extrahepatic immunopathological lesions. In the case of the antirheumatic drug gold(I) disodium thiomalate (Na2Au(I)TM), oxidation of the Au(I) ion to Au(III) a...

journal_title：Archives of toxicology

authors： Goebel C,Kubicka-Muranyi M,Tonn T,Gonzalez J,Gleichmann E

更新日期：1995-01-01 00:00:00

abstract：:Inhabitants of a private home suffered from symptoms possibly due to dichloroacetylene intoxication. Subsequent anamnesis revealed that abundant amounts of trichloroethylene had been used to remove a wax coating from a concrete-lined stone floor. This prompted us to examine whether dichloroacetylene could have been fo...

journal_title：Archives of toxicology

authors： Greim H,Wolff T,Höfler M,Lahaniatis E

更新日期：1984-12-01 00:00:00