Abstract：
:Dorsal root ganglia from control and methylmercury (MeHg)-treated rats were incubated in vitro with 35S-methionine ant the proteins synthesized were analyzed by two-dimensional electrophoresis. The double labelling method, in which proteins of control dorsal root ganglia labelled in vitro with 3H-leucine were added to each of the two samples as an internal standard, was used to minimize unavoidable errors arising from the resolving procedure itself. The results obtained showed that the effect of MeHg on the synthesis of proteins in dorsal root ganglia was not uniform for individual protein species in the latent period of MeHg intoxication. Among 200 protein species investigated, 157 showed inhibition of synthesis close to that of the total proteins in the tissue (68% of the control). Among the remaining protein species, 20 showed real stimulation of synthesis, whereas 7 were moderately inhibited and 16 were inhibited more strongly than the total proteins in the tissue. These results suggest that the effect of MeHg on the synthetic rates for protein species in dorsal root ganglia differs with the species, and that unusual elevation or reduction of the synthesis of some protein species caused by MeHg may lead to impairment of normal nerve functions.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Kasama H,Itoh K,Omata S,Sugano Hdoi
10.1007/BF00316373subject
Has Abstractpub_date
1989-01-01 00:00:00pages
226-30issue
3eissn
0340-5761issn
1432-0738journal_volume
63pub_type
杂志文章abstract：:The involvement of oxidative stress has been suggested as a mechanism for neurotoxicity caused by methylmercury (MeHg), but the mechanism for MeHg selective toxicity in the central nervous system is still unclear. In this research, to clarify the mechanism of selective neurotoxicity caused by MeHg, the oxygen consumpt...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-007-0209-2
更新日期：2007-11-01 00:00:00
abstract：:The effect of lindane and heptachlor on haem metabolism was studied with the aim to elucidate the mechanism of their porphyrinogenic action. The effects of these compounds on delta-aminolaevulinate synthase (ALA-S) and ferrochelatase were evaluated and the mechanism of increase of ALA-S activity was especially studied...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050566
更新日期：1998-11-01 00:00:00
abstract：:Alternative methods to detect non-genotoxic carcinogens are urgently needed, as this class of carcinogens goes undetected in the current testing strategy for carcinogenicity under REACH. A complicating factor is that non-genotoxic carcinogens act through several distinctive modes of action, which makes prediction of t...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-014-1368-6
更新日期：2015-12-01 00:00:00
abstract：:Perfluorooctanoic acid (PFOA) has been shown to cause hepatotoxicity and other toxicological effects. Though PPARα activation by PFOA in the liver has been well accepted as an important mechanism of PFOA-induced hepatotoxicity, several pieces of evidence have shown that the hepatotoxic effects of PFOA may not be fully...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1675-1
更新日期：2017-01-01 00:00:00
abstract：:Cyclic AMP (c-AMP), added on its own to rat hepatocyte cultures, caused a marked accumulation of coproporphyrin III. The results obtained by comparing the effect of c-AMP to that of exogenous 5-aminolevulinate (ALA), and from adding c-AMP and ALA together, indicated that the coproporphyrinogen III metabolism was block...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-004-0637-1
更新日期：2005-07-01 00:00:00
abstract：:The use of silver nanoparticles is one of the fastest growing product categories in the nanotechnology industry, with a focus on antimicrobial activity. However, thus far, toxicity data for silver nanoparticles are limited. In this study, we investigated the cytotoxic effects of silver nanoparticles (Ag NPs) and the p...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-011-0714-1
更新日期：2011-12-01 00:00:00
abstract：:The current management of rodent pest populations is based on second-generation anticoagulant rodenticides (SGAR). These molecules, of which difethialone is part, are much more efficient than the first generation. Nevertheless, this efficiency comes with a major drawback, SGARs are tissue persistent that increases the...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02662-0
更新日期：2020-03-01 00:00:00
abstract：:The development of metabolically competent in vitro models is of utmost importance for predicting adverse drug reactions, thereby preventing attrition-related economical and clinical burdens. Using the antiretroviral drug nevirapine (NVP) as a model, this work aimed to validate rat hepatocyte 3D spheroid cultures as c...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1792-x
更新日期：2017-03-01 00:00:00
abstract：:Several aromatic amines (AAs) are known to be carcinogens for humans. AAs are considered to be substantially absorbed through the skin. However, the database for dermal absorption of AAs in general is limited and no specific studies on dermal absorption of beta-naphthylamine (BNA) and o-toluidine (OT) have been publis...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0095-z
更新日期：2006-10-01 00:00:00
abstract：:Liver disease is an escalating global health issue. While liver transplantation is an effective mode of therapy, patient mortality has increased due to the shortage of donor organs. Developing renewable sources of human liver tissue is therefore attractive. Pluripotent stem cell-derived liver tissue represents a poten...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2280-2
更新日期：2018-10-01 00:00:00
abstract：:Ethylenediaminetetraacetic acid (EDTA) is widely used in food and other industries to sequester metal ions and to prevent their disadvantageous effects. The objective of the current study was to evaluate the protective effect of Panax ginseng extract standardized with ginsenoside Rg3 (ginsenoside Rg3 content was 3.6% ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-007-0237-y
更新日期：2008-03-01 00:00:00
abstract：:Lead (Pb) exposure of consumers and the environment has been reduced over the past decades. Despite all measures taken, immission of Pb onto agricultural soils still occurs, with fertilizer application, lead shot from hunting activities, and Pb from air deposition representing major sources. Little is known about the ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02762-x
更新日期：2020-07-01 00:00:00
abstract：:The kinetic analysis of esterase inhibition by acylating compounds (organophosphorus carbamates and sulfonyl fluorides) is sometimes unable to yield consistent results by fitting simple inhibition kinetic models to experimental data of complex systems. In this work, kinetic data were obtained for phenylmethylsulfonyl ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-012-0817-3
更新日期：2012-05-01 00:00:00
abstract：:Pyrrolizidine alkaloids (PAs) are widely occurring phytotoxins which can induce severe liver damage in humans and other mammalian species by mechanisms that are not fully understood. Therefore, we investigated the development of PA hepatotoxicity in vivo, using an acutely toxic dose of the PA senecionine in mice, in c...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-019-02582-8
更新日期：2020-01-01 00:00:00
abstract：:The antidepressants, imipramine and mianserin, have been reported to cause liver damage. We investigated a role of cytochrome P450 (CYP)-mediated formation of a reactive metabolite in antidepressant-induced acute cell injury using hepatocytes isolated from male and female Wistar rats, and male Dark Agouti rats, which ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050599
更新日期：1999-04-01 00:00:00
abstract：:A compound was isolated from the urine of workers exposed to carbon disulfide during the production of rayon. The compound was identified as 2-thiothiazolidine-4-carboxylic acid (TTCA) by GC/MS and NMR. A HPLC method for the quantitative determination of TTCA was elaborated and applied to urine samples. The method all...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00297130
更新日期：1981-03-01 00:00:00
abstract：:Recent work concerned with the mechanism underlying the development of organophosphorous compound-induced delayed neurotoxicity (OPIDN) is reviewed. Topics covered include the prophylaxis of OPIDN by phenylmethylsulfonyl fluoride and other agents, neurotoxic esterase (NTE) as measured using either labelled di-isopropy...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/BF00316365
更新日期：1989-01-01 00:00:00
abstract：:Etridiazole, 5-ethoxy-3-trichloromethyl-1,2,4-thiadiazole, was orally administered to rats and human volunteers. Two metabolites of etridiazole were synthesized: 5-ethoxy-1,2,4-thiadiazole-3-carboxylic acid (ET-CA) and N-acetyl-S-(5-ethoxy-1,2,4-thiadiazol-3-yl-methyl)-L-cysteine (ET-MA). Selective and sensitive analy...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF02098027
更新日期：1991-01-01 00:00:00
abstract：:The mycotoxin deoxynivalenol (DON) has a high global prevalence in grain-based products. Biomarkers of exposure are detectable in most humans and farm animals. Considering the acute emetic and chronic anorexigenic toxicity of DON, maximum levels for food and feed have been implemented by food authorities. The tolerabl...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-019-02470-1
更新日期：2019-07-01 00:00:00
abstract：:Membrane transporters play an important role in the absorption, distribution, metabolism and excretion of drugs. The cellular accumulation of many drugs is the result of the net function of efflux and influx transporters. Efflux transporters such as P-glycoprotein/ABCB1 have been shown to confer multidrug resistance i...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-019-02417-6
更新日期：2019-04-01 00:00:00
abstract：:The disposition, elimination, and metabolism of 50 mg/kg (1.36 muCi/animal) of tri-o-cresyl [phenyl-U-14C] phosphate after ten daily oral doses was investigated in adult male Fischer 344 rats. Groups of three treated animals were killed at intervals of 24, 48, 72, and 96 h after the last administrations. Generally, th...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01971837
更新日期：1990-01-01 00:00:00
abstract：:Thanks to the confluence of genome sequencing and bioinformatics, the number of metabolic databases has expanded from a handful in the mid-1990s to several thousand today. These databases lie within distinct families that have common ancestry and common attributes. The main families are the MetaCyc, KEGG, Reactome, Mo...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-011-0705-2
更新日期：2011-09-01 00:00:00
abstract：:Exposure to toxic metals is a well-known problem in industrialized countries. Metals interfere with a number of physiological processes, including central nervous system (CNS), haematopoietic, hepatic and renal functions. In the evaluation of the toxicity of a particular metal it is crucial to consider many parameters...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-010-0544-6
更新日期：2010-07-01 00:00:00
abstract：:Sarin, a potent organophosphate cholinesterase inhibitor, induces an array of toxic effects including convulsions. Many antidotal treatments contain anticonvulsants to block seizure activity and the ensuing brain damage. Magnesium sulfate (MGS) is used to suppress eclamptic seizures in pregnant women with hypertension...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-012-0916-1
更新日期：2013-02-01 00:00:00
abstract：:Perfluorononanoic acid (PFNA) and perfluorodecanoic acid (PFDA), which are classified as perfluoroalkyl and polyfluoroalkyl substances (PFASs), have been widely used in industrial applications as a surface protectant. PFASs have been detected in wildlife and in humans around the globe. The purposes of this study are t...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2365-y
更新日期：2019-02-01 00:00:00
abstract：:The EU-EuroMix project adopted the strategy of the European Food Safety Authority (EFSA) for cumulative risk assessment, which limits the number of chemicals to consider in a mixture to those that induce a specific toxicological phenotype. These so-called cumulative assessment groups (CAGs) are refined at several leve...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2320-y
更新日期：2018-12-01 00:00:00
abstract：:Neutrophils infiltrate tissues during inflammation, and when activated, they release β-glucuronidase. Since inflammation is associated with carcinogenesis, we investigated how extracellular β-glucuronidase changed the in vitro cellular response to the chemical carcinogen benzo(a)pyrene (B[a]P). For this we exposed hum...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-015-1593-7
更新日期：2016-09-01 00:00:00
abstract：:The objective of this study was to evaluate the role of apoptosis in the development of the newborn cochlear structures and hearing loss caused by prenatal cis-diaminedichloroplatinum (cisplatin) exposure. Pregnant albino guinea pigs were intraperitoneally injected with 1.5 mg/kg body weight cisplatin once a day for s...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-010-0543-7
更新日期：2011-01-01 00:00:00
abstract：:Phenethyl isothiocyanate is a chemopreventive phytochemical present in cruciferous vegetables where it exists as the glucosinolate gluconasturtiin. It is a mechanism-based inhibitor of both rat and human cytochrome P450 enzymes. The principal objective of the present study was to ascertain whether phenethyl isocyanate...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-010-0522-z
更新日期：2010-10-01 00:00:00
abstract：:Several structurally different metal chelating agents were screened for their relative efficacy in counteracting acute manganese intoxication in mice. Polyaminocarboxylic acids with nitrogen and oxygen as metal binding sites were more effective than certain sulfhydryl chelating agents and common drugs in preventing mo...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00569233
更新日期：1982-05-01 00:00:00
