Abstract：
:Treatment of tuberculosis (TB) has been a therapeutic challenge because of not only the naturally high resistance level of Mycobacterium tuberculosis to antibiotics but also the newly acquired mutations that confer further resistance. Currently standardized regimens require patients to daily ingest up to four drugs under direct observation of a healthcare worker for a period of 6-9 months. Although they are quite effective in treating drug susceptible TB, these lengthy treatments often lead to patient non-adherence, which catalyzes for the emergence of M. tuberculosis strains that are increasingly resistant to the few available anti-TB drugs. The rapid evolution of M. tuberculosis, from mono-drug-resistant to multiple drug-resistant, extensively drug-resistant and most recently totally drug-resistant strains, is threatening to make TB once again an untreatable disease if new therapeutic options do not soon become available. Here, I discuss the molecular mechanisms by which M. tuberculosis confers its profound resistance to antibiotics. This knowledge may help in developing novel strategies for weakening drug resistance, thus enhancing the potency of available antibiotics against both drug susceptible and resistant M. tuberculosis strains.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Nguyen Ldoi
10.1007/s00204-016-1727-6subject
Has Abstractpub_date
2016-07-01 00:00:00pages
1585-604issue
7eissn
0340-5761issn
1432-0738pii
10.1007/s00204-016-1727-6journal_volume
90pub_type
杂志文章,评审abstract：:Possible induction of chromosomal aberrations and/or sister chromatid exchanges by astemizole was studied in vitro on human lymphocytes. In vivo chromosomal damage was assessed by a micronucleus test on rats and a dominant lethal test on both male and female mice. All these tests yielded negative results for astemizol...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00373399
更新日期：1982-07-01 00:00:00
abstract：:Whether pregnancy-induced immunosuppression when combined with exposure to 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) could exacerbate immunotoxicity has not been previously investigated. The current study evaluated the immune status of C57BL/6 pregnant and virgin mice following exposure to TCDD. To this end, syngene...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-003-0538-8
更新日期：2004-05-01 00:00:00
abstract：:Boric acid and sodium borates are currently classified as being toxic to reproduction under "Category 1B" with the hazard statement of "H360 FD" in the European CLP regulation. This has prompted studies on boron-mediated reprotoxic effects in male workers in boron mining areas and boric acid production plants. By cont...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2238-4
更新日期：2018-08-01 00:00:00
abstract：:Blooms of cyanobacteria have been documented throughout history, all over the world. Mass populations of these organisms typically present hazards to human health and are known for the production of a wide range of highly toxic metabolites-cyanotoxins, of which among the most common and most investigated are the micro...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-016-1921-6
更新日期：2017-02-01 00:00:00
abstract：:The effect of 1-deamino-2-tyr(ethyl) oxytocin (dEtOT) upon peri- and postnatal development of the rat was studied in two experiments when administered between day 15 of pregnancy and the day of parturition. The investigation showed that dEtOT did not affect the pups at birth, that dEtOT caused a dose-related growth re...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00324786
更新日期：1985-09-01 00:00:00
abstract：:Rodents are relatively insensitive to the neurotoxic effects of various organophosphorus compounds. The purpose of this investigation was to determine if differences in inactivation of CBDP could explain the strain differences in the sensitivity to neurotoxicity following administration of TOCP (tri-o-cresyl phosphate...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01973466
更新日期：1990-01-01 00:00:00
abstract：:The kinetic analysis of esterase inhibition by acylating compounds (organophosphorus carbamates and sulfonyl fluorides) is sometimes unable to yield consistent results by fitting simple inhibition kinetic models to experimental data of complex systems. In this work, kinetic data were obtained for phenylmethylsulfonyl ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-012-0817-3
更新日期：2012-05-01 00:00:00
abstract：:Engineered amorphous silica nanoparticles (nanosilica) are widely used in industry yet can induce adverse effects, which might be classified according to the oxidative stress model. However, the underlying mechanisms as well as the potential interactions of the three postulated different tiers of toxicity-i.e. oxidati...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2223-y
更新日期：2018-07-01 00:00:00
abstract：:In the present study the toxicological potential of a tumor-inhibiting dinuclear platinum(II) complex (bis(acetato)diammine-bis-micro-acetato diplatinum(II) dihydrate (BAP)) was evaluated, utilizing in vitro models of nephrotoxicity, myelosuppression and neurotoxicity. Regarding the discrepancies between the hallmark ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0078-0
更新日期：2006-09-01 00:00:00
abstract：:Perfluorooctanoic acid (PFOA) has been shown to cause hepatotoxicity and other toxicological effects. Though PPARα activation by PFOA in the liver has been well accepted as an important mechanism of PFOA-induced hepatotoxicity, several pieces of evidence have shown that the hepatotoxic effects of PFOA may not be fully...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1675-1
更新日期：2017-01-01 00:00:00
abstract：:Trichloroethylene (TCE)-induced liver toxicity and carcinogenesis is believed to be mediated in part by activation of the peroxisome proliferator-activated receptor α (PPARα). However, the contribution of the two TCE metabolites, dichloroacetate (DCA) and trichloroacetate (TCA) to the toxicity of TCE, remains unclear....
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-013-1053-1
更新日期：2013-11-01 00:00:00
abstract：:The results from a survey of the expert information that is publicly accessible on the use of the dog as test species during the regulatory evaluation of agricultural chemicals and pesticides are reported. Methods that are being used or considered in order to reduce the number of dogs used for this purpose are describ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-005-0678-0
更新日期：2005-11-01 00:00:00
abstract：:Natural and synthetic chemicals are often used in the fragrance industry. A toxicological profile of the synthetic fragrance booster, 4-cycloocten-1-carbaldehyde, was generated using a test program including the following methods: acute oral toxicity, acute dermal toxicity, acute skin and eye irritation, skin sensitiz...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-004-0596-6
更新日期：2004-12-01 00:00:00
abstract：:The toxicokinetics of the four stereoisomers of the nerve agent C(+/-)P(+/-)-soman was analysed in cerebrospinal fluid (CSF) and blood in anaesthetized, spontaneously breathing pigs during a 90-min period after injection of soman. The pigs were challenged with different intravenous (i.v.) doses of C(+/-)P(+/-)-soman c...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050529
更新日期：1998-07-01 00:00:00
abstract：:The development of non-animal methodology to evaluate the potential for a chemical to cause systemic toxicity is one of the grand challenges of modern science. The European research programme SEURAT is active in this field and will conclude its first phase, SEURAT-1, in December 2015. Drawing on the experience gained ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-014-1421-5
更新日期：2015-01-01 00:00:00
abstract：:Exposure to alkylanilines found in tobacco smoke and indoor air is associated with risk of bladder cancer. Genetic factors significantly influence the metabolism of arylamine carcinogens and the toxicological outcomes that result from exposure. We utilized nucleotide excision repair (NER)-deficient immortalized human ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02901-4
更新日期：2021-01-01 00:00:00
abstract：:4, 4'-Methylenedianiline (MDA) is used extensively as a curing agent in the production of elastomers and is classified as reasonably anticipated to be a human carcinogen based on sufficient evidence in animal experiments. Human N-acetyltransferase 1 (NAT1) and 2 (NAT2) catalyze the N-acetylation of aromatic amines and...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-019-02516-4
更新日期：2019-08-01 00:00:00
abstract：:Lead (Pb) exposure of consumers and the environment has been reduced over the past decades. Despite all measures taken, immission of Pb onto agricultural soils still occurs, with fertilizer application, lead shot from hunting activities, and Pb from air deposition representing major sources. Little is known about the ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02762-x
更新日期：2020-07-01 00:00:00
abstract：:Aspergillus versicolor and A. flavus are primary colonizers in damp dwellings, and they produce sterigmatocystin (ST) and aflatoxin B1 (AFB(1)), respectively. These hepatotoxic and carcinogenic mycotoxins and their precursors and derivates possess a furofuran ring, which has proven responsible for their toxicity. The ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-012-0871-x
更新日期：2012-10-01 00:00:00
abstract：:In the recent years, the toxicity of certain divalent cations has been associated with the alteration of intracellular Ca2+ homeostasis. Among other mechanisms, these cations may affect the functionality of certain Ca2+-binding proteins and/or Ca2+ pumps. The plasma membrane calcium pump (PMCA) maintains Ca2+ homeosta...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-017-2031-9
更新日期：2018-01-01 00:00:00
abstract：:The use of nanotechnology is increasing exponentially, whereas the possible adverse health effects of engineered nanoparticles (NPs) are so far less known. Standardized mouse bioassay was used to study sensory and pulmonary irritation, airflow limitation, and inflammation potency of nanosized TiO(2). Single exposure (...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-011-0644-y
更新日期：2011-07-01 00:00:00
abstract：:The neurological effects of four synthetic pyrethroids resmethrin, permethrin, cypermethrin, and deltamethrin have been investigated in the rat to establish whether there is a correlation between the clinical-functional status of the animal and peripheral nerve damage as measured biochemically. Neuromuscular dysfuncti...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00294995
更新日期：1983-08-01 00:00:00
abstract：:The highly directional maternal-to-fetal transfer of essential fatty acids (EFAs) across the placenta plays a critical role in guiding proper fetal development. Exposure to xenobiotics that may alter the fetal supply of EFAs/lipids could lead to fetal toxicity. Since the placenta is the first fetal arising organ that ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-005-0047-z
更新日期：2006-05-01 00:00:00
abstract：:This study was conducted to determine the functional role of phospholipase D (PLD) involved in testicular Leydig cell damage caused by di (2-ethylhexyl) phthalate (DEHP) in Sprague-Dawley rats. DEHP (500 mg/kg/day) was administered orally to prepubertal rats for 1, 7, 14, 21 or 28 days. After 7 days of exposure, DEHP ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-010-0618-5
更新日期：2011-08-01 00:00:00
abstract：:The current test systems employed by pharmaceutical industry are poorly predictive for drug-induced liver injury (DILI). The 'MIP-DILI' project addresses this situation by the development of innovative preclinical test systems which are both mechanism-based and of physiological, pharmacological and pathological releva...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-016-1845-1
更新日期：2016-12-01 00:00:00
abstract：:A number of studies have evaluated the possibility that stress-induced changes in blood-brain barrier permeability enhanced the central effects of the carbamate acetylcholinesterase inhibitor, pyridostigmine. We previously found relatively little evidence of stress-induced changes in the acute toxicity of pyridostigmi...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0144-7
更新日期：2007-04-01 00:00:00
abstract：:The effect of lindane and heptachlor on haem metabolism was studied with the aim to elucidate the mechanism of their porphyrinogenic action. The effects of these compounds on delta-aminolaevulinate synthase (ALA-S) and ferrochelatase were evaluated and the mechanism of increase of ALA-S activity was especially studied...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050566
更新日期：1998-11-01 00:00:00
abstract：:The metabolic fate of 2-ethylhexyl diphenyl phosphate (EHDPP) was studied in male rats. Orally administered 14C-EHDPP was rapidly absorbed and about 80% of the radioactivity was excreted in the urine and feces in the first 24 h. By 7 days, 48% and 52% of the radioactivity was recovered in urine and feces, respectively...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00364847
更新日期：1988-01-01 00:00:00
abstract：:The International Agency for Research on Cancer considers the carcinogenicity of welding fume of priority for re-evaluation. Genotoxic effects in experimental animals are still inconclusive. Here, we investigated the association of personal exposure to metals in respirable welding fumes during a working shift with oxi...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-014-1319-2
更新日期：2015-08-01 00:00:00
abstract：:Using male ICR mice, the LC50 and acute and subacute inhalation toxicity of dichlorosilane (SiH2Cl2, DCS) and the fate of DCS released into the air were investigated. DCS resolved and minute particles including silicon and chloride were observed, when DCS was released into the air. Most particles were under 1 micron i...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050263
更新日期：1996-01-01 00:00:00
