Abstract：
:The use of nanotechnology is increasing exponentially, whereas the possible adverse health effects of engineered nanoparticles (NPs) are so far less known. Standardized mouse bioassay was used to study sensory and pulmonary irritation, airflow limitation, and inflammation potency of nanosized TiO(2). Single exposure (0.5 h) to in situ generated TiO(2) (primary particle size 20 nm; geometric mean diameters of 91, 113, and 130 nm at mass concentrations of 8, 20, and 30 mg/m(3), respectively; crystal phase anatase + brookite (3:1)) caused airflow limitation in the conducting airways at each studied exposure concentration, which was shown as a reduction in expiratory flow, being at the lowest 73% of baseline. The response was not dose dependent. Repeated exposures (altogether 16 h, 1 h/day, 4 days/week for 4 weeks) to TiO(2) at mass concentration of 30 mg/m(3) caused as intense airflow limitation effect as the single exposures, and the extent of the responses stayed about the same along the exposure days. Sensory irritation was fairly minor. Pulmonary irritation was more pronounced during the latter part of the repeated exposures compared to the single exposures and the beginning of the repeated exposures. Sensory and pulmonary irritation were observed also in the control group, and, therefore, reaction by-products (NO(2) and C(3)H(6)) may have contributed to the irritation effects. TiO(2) NPs accumulated mainly in the pulmonary macrophages, and they did not cause nasal or pulmonary inflammation. In conclusion, the irritation and inflammation potencies of studied TiO(2) seemed to be low.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Leppänen M,Korpi A,Miettinen M,Leskinen J,Torvela T,Rossi EM,Vanhala E,Wolff H,Alenius H,Kosma VM,Joutsensaari J,Jokiniemi J,Pasanen Pdoi
10.1007/s00204-011-0644-ysubject
Has Abstractpub_date
2011-07-01 00:00:00pages
827-39issue
7eissn
0340-5761issn
1432-0738journal_volume
85pub_type
杂志文章abstract：:Perfluorooctanoic acid (PFOA) has been shown to cause hepatotoxicity and other toxicological effects. Though PPARα activation by PFOA in the liver has been well accepted as an important mechanism of PFOA-induced hepatotoxicity, several pieces of evidence have shown that the hepatotoxic effects of PFOA may not be fully...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1675-1
更新日期：2017-01-01 00:00:00
abstract：:Orally administered meso-2,3-dimercaptosuccinic acid (DMSA) is an effective antagonist for acute oral cadmium chloride (1 mmol/kg) intoxication in mice when administered up to 8 h after cadmium ingestion. Administration of sodium N-benzyl-N-dithiocarboxy-D-glucamine (NaB) i.p. along with DMSA p.o. resulted in kidney a...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00316253
更新日期：1988-08-01 00:00:00
abstract：:3-Chloro-1,2-propanediol (3-MCPD) fatty acid esters are formed upon thermal processing of fat-containing foods in the presence of chloride ions. Upon hydrolytic cleavage, these substances could release free 3-MCPD. This compound is toxicologically well characterised and displayed cancerogenic potential in rodent model...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-011-0657-6
更新日期：2011-10-01 00:00:00
abstract：:Etoposide (ETP) and anthracyclines are applied for wide anti-cancer treatments. However, the ETP-induced cardiotoxicity remains to be a major safety issue and the underlying cardiotoxic mechanisms are not well understood. This study is aiming to unravel the cardiotoxicity profile of ETP in comparison to anthracyclines...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2170-7
更新日期：2018-04-01 00:00:00
abstract：:Membrane transporters play an important role in the absorption, distribution, metabolism and excretion of drugs. The cellular accumulation of many drugs is the result of the net function of efflux and influx transporters. Efflux transporters such as P-glycoprotein/ABCB1 have been shown to confer multidrug resistance i...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-019-02417-6
更新日期：2019-04-01 00:00:00
abstract：:Unfolded protein response (UPR) and endoplasmic reticulum (ER)-phagy are essential for cell homeostasis. Quantum dots (QDs), which have been widely used for biomedical applications, can accumulate in the kidney tissues and may cause renal dysfunction. However, the molecular mechanism of QDs-induced nephrotoxicity is s...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2169-0
更新日期：2018-04-01 00:00:00
abstract：:Carcinogenic risk and molecular mechanisms underlying the liver tumor-promoting activity of copper gluconate, an additive of functional foods, were investigated using a rat medium-term liver carcinogenicity bioassay protocol (Ito test) and a 2-week short-term administration experiment. In the medium-term liver bioassa...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-008-0294-x
更新日期：2008-08-01 00:00:00
abstract：:In a previous study, we showed that bisphenol A (BPA) had oestrogen-like effects in bird embryos, causing malformations of the oviducts in Japanese quail (Coturnix japonica) and feminisation of the left testis in chicken (Gallus domesticus). In this study, uptake and distribution of BPA and tetrabromobisphenol A (TBBP...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040100277
更新日期：2001-12-01 00:00:00
abstract：:Dose-dependent excretion of p,p'DDE in rats was investigated. p,p'DDE itself was the major excreta in rats. But some o,p'isomer of DDE was detected in feces by GC-MS analysis. The excretion of p,p'DDE after a single administration was modified by its dose level. The time pattern of p,p'DDE excretion agrees well with t...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00332361
更新日期：1982-01-01 00:00:00
abstract：:Groups of adult male Sprague-Dawley rats were treated i.p. with 0, 0.3 and 0.5 mmole bromobenzene (BB)/kg per day in corn oil, 5 days a week for 4 weeks. Thereafter, one half of each of these groups was treated i.p. with a single acute toxic dose of 2.5 mmole BB/kg. Urines were then collected for 24 h and the animals ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF02098037
更新日期：1991-01-01 00:00:00
abstract：:Perfluoroalkyl acids are widely used in numerous industrial and commercial applications due to their unique physical and chemical characteristics. Although perfluorooctanoic acid (PFOA) is associated with hepatomegaly through peroxisome proliferator-activated receptor α (PPARα) activation, liver fat accumulation and c...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-014-1322-7
更新日期：2015-09-01 00:00:00
abstract：:Steatosis, also known as fatty liver disease (FLD), is a disorder in which the lipid metabolism of the liver is disturbed, leading to the abnormal retention of lipids in hepatocytes. FLD can be induced by several drugs, and although it is mostly asymptomatic, it can lead to steatohepatitis, which is associated with li...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-015-1483-z
更新日期：2016-03-01 00:00:00
abstract：:Hydrogen sulfide (H2S), the third gasotransmitter, has been shown to act as a neuroprotective factor in numerous pathological processes; however, its underlying mechanism(s) of action remain unclear. It is widely accepted that activation of moderate autophagy and the Nrf2/ARE signaling pathway play important roles in ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2208-x
更新日期：2018-06-01 00:00:00
abstract：:The effect of duration of employment at a North American cadmium smelter on urinary metallothionein (MT), total protein, beta 2-microglobulin (beta 2-MG), glucose, cadmium, copper and zinc of 53 men was studied. The levels of all urinary parameters increased with the duration of employment. Smoking history did not aff...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00295090
更新日期：1987-02-01 00:00:00
abstract：:Platinum coordination complexes (PtCx) are potent against several types of cancer but are often nephrotoxic. With a view to developing a PtCx nephrotoxicity model, the toxicity of cisplatin (cDDP), transplatin (tDDP) and carboplatin (CBDCA) was studied in primary cultures of rabbit proximal tubule (RPT) cells and in t...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01973705
更新日期：1993-01-01 00:00:00
abstract：:Chemical formation of dichlorvos (2, 2-dichlorovinyl dimethyl phosphate) was found to occur in mouse brain after i.p. injection of metrifonate (2, 2, 2-trichloro-1-hydroxyethyl dimethyl phosphonate). A mass fragmentographic technique was used. Different isotopic variants were used both as internal standards and to com...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00351767
更新日期：1978-10-13 00:00:00
abstract：:The effect of pretreatment with cadmium (Cd) complexes on the distribution and accumulation of Cd in the liver and kidneys was examined for the Cd complexes that are reabsorbed site-selectively at the renal proximal tubules of rats. Cd was administered simultaneously with excess cysteine or as metallothionein (MT) and...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00297117
更新日期：1986-04-01 00:00:00
abstract：:Occupational and environmental asbestos exposure is the main determinant of malignant pleural mesothelioma (MPM), however, the mechanisms by which its fibres contribute to cell toxicity and transformation are not completely clear. Aberrant DNA methylation is a common event in cancer but epigenetic modifications involv...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2179-y
更新日期：2018-05-01 00:00:00
abstract：:Xenobiotic induced liver injury is a leading cause for drug withdrawal and toxicogenomics may help to identify molecular causes. Here we report studies with cultures of human hepatocytes to detect early responses of liver toxicity upon treatment with the hepatotoxin Aroclor 1254. We studied transcript abundance of 302...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-007-0234-1
更新日期：2008-02-01 00:00:00
abstract：:Organophosphorus (OP) pesticides and nerve agents still pose a threat to the population. Treatment of OP poisoning is an ongoing challenge and burden for medical services. Standard drug treatment consists of atropine and an oxime as reactivator of OP-inhibited acetylcholinesterase and is virtually unchanged since more...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-020-02797-0
更新日期：2020-07-01 00:00:00
abstract：:Chronic exposure to carbon disulfide (CS2) can induce polyneuropathy in occupational worker and experimental animals, but underlying mechanism for CS2 neurotoxicity is currently unknown. In the present study, male Wistar rats were randomly divided into two experimental groups and one control group. The rats in two exp...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-008-0399-2
更新日期：2009-06-01 00:00:00
abstract：:Pathological changes induced by cadmium aerosol had features common to the changes evoked by oxidants. Female rats were exposed to fumes of lead, antimony, zinc and cadmium (15-100 nmoles/m3). One hour after termination of exposure, superoxide dismutase (SOD) activity in erythrocytes of the exposed rats lowered by 15-...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00347869
更新日期：1982-03-01 00:00:00
abstract：:Manufactured nanomaterials (MNMs) selected from a library of over 120 different MNMs with varied compositions, sizes, and surface coatings were tested by four different laboratories for toxicity by high-throughput/-content (HT/C) techniques. The selected particles comprise 14 MNMs composed of CeO2, Ag, TiO2, ZnO and S...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-017-2106-7
更新日期：2018-02-01 00:00:00
abstract：:The effect of ethanol on metabolism of 20 nitriles was studied in vivo and in vitro in mice. The hepatic microsomal metabolizing activity for nitriles was at a maximum 13 h after ethanol dosing (4.0 g/kg). Using microsomes from mice pretreated with ethanol under the above conditions, enhancement of the in vitro metabo...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00340977
更新日期：1986-02-01 00:00:00
abstract：:A new class of potent anticancer drugs, alkylphosphocholines has been recognized lately. Miltefosine (Hexadecylphosphochlorine, HPC) has been found to express select antineoplastic effect on human breast cancer skin metastases with simultaneous preservation of bone marrow proliferative activity and low clastogenicity....
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-005-0010-z
更新日期：2006-01-01 00:00:00
abstract：:A single dose of 10 mg methylmercury chloride per kg body weight was given to 30 days old rats and to adult rats (180-200g)(. This resulted in brain levels of 1.4-2.2 micrograms Hg/g wet weight. In the young rats electron microscopic morphometry showed swelling of the granule cells. The extent of changes was more pron...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00332352
更新日期：1981-04-01 00:00:00
abstract：:This is with reference to the note of the Editor-in-Chief of the Archives of Toxicology. ...
journal_title：Archives of toxicology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00204-018-2221-0
更新日期：2018-07-01 00:00:00
abstract：:The in vitro DNA strand breaking activity of metallothionein (MT) containing Cd2+ and Zn2+ in a molar ratio of 5:2 is described. Studies with radical scavengers and electron paramagnetic resonance spectroscopy indicate that the DNA damage might be caused by a radical species formed by the native protein (i.e., MT) cha...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01973498
更新日期：1991-01-01 00:00:00
abstract：:The significance of urinary trehalase as a possible early indicator of renal disorder was examined using Cd-treated rabbits, which received 1 mg/kg Cd thrice weekly for 3 months subcutaneously. The results showed that urinary trehalase increased significantly from 1 week after treatment, earlier than LAP, ALP, protein...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00290547
更新日期：1986-12-01 00:00:00
abstract：:Phenethyl isothiocyanate is a chemopreventive phytochemical present in cruciferous vegetables where it exists as the glucosinolate gluconasturtiin. It is a mechanism-based inhibitor of both rat and human cytochrome P450 enzymes. The principal objective of the present study was to ascertain whether phenethyl isocyanate...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-010-0522-z
更新日期：2010-10-01 00:00:00
