Abstract：
:The effect of ethanol on metabolism of 20 nitriles was studied in vivo and in vitro in mice. The hepatic microsomal metabolizing activity for nitriles was at a maximum 13 h after ethanol dosing (4.0 g/kg). Using microsomes from mice pretreated with ethanol under the above conditions, enhancement of the in vitro metabolism of nitriles was 1.00-1.83 compared with the glucose-treated control. When mice were orally given nitriles 13 h after dosing with either ethanol (4.0 g/kg) or glucose (7.0 g/kg), the hepatic metabolizing activity of nitriles for the ethanol-treated group was always higher than that for the glucose group, although no change in the content of hepatic microsomal P-450 was observed between the two groups. However, ethanol added to the incubation mixture inhibited the in vitro metabolism of most nitriles. The results in the present study suggest that ethanol can enhance the acute toxicity of nitriles.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Tanii H,Hashimoto Kdoi
10.1007/BF00340977subject
Has Abstractpub_date
1986-02-01 00:00:00pages
171-6issue
3eissn
0340-5761issn
1432-0738journal_volume
58pub_type
杂志文章abstract：:The effect of pretreatment with SKF-525A, which inhibits hepatic cytochrome P450 enzymes, on metabolism and hepatotoxicity was examined in mice orally administered tributyltin chloride (TBTC) or dibutyltin dichloride (DBTC) at a dose of 180 mumol/kg. Analysis of butyltin compounds showed that the main metabolites in l...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050421
更新日期：1997-01-01 00:00:00
abstract：:Several aromatic amines (AAs) are known to be carcinogens for humans. AAs are considered to be substantially absorbed through the skin. However, the database for dermal absorption of AAs in general is limited and no specific studies on dermal absorption of beta-naphthylamine (BNA) and o-toluidine (OT) have been publis...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0095-z
更新日期：2006-10-01 00:00:00
abstract：:Renal papillary necrosis (RPN) was induced in Fischer 344 (F344) rats (n = 4) using 2-bromoethanamine hydrobromide (BEA) dosed at 150 mg/kg, and in multimammate desert mice (Mastomys natalensis) at 150 and 250 mg/kg (n = 4 per group). Control rats and Mastomys were dosed with 0.9% saline (n = 4 per group). Urine was c...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF02733668
更新日期：1995-01-01 00:00:00
abstract：:New strategies are needed to address the data gap between the bioactivity of chemicals in the environment versus existing hazard information. We address whether a high-throughput screening (HTS) system using a vertebrate organism (embryonic zebrafish) can characterize chemical-elicited behavioral responses at an early...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-015-1554-1
更新日期：2016-06-01 00:00:00
abstract：:Rat embryos (9.5-day-old) were cultured for 48 h in the presence of nifedipine (NIF), nimodipine (NIM), nitrendipine (NIT), gallopamil HCl (GAL), verapamil HCl (VER) and diltiazem HCl (DIL). The effects on growth and morphogenetic differentiation in vitro were monitored. Dose-response relationships were evaluated, inc...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01974690
更新日期：1990-01-01 00:00:00
abstract：:4-Nonylphenol (para-nonylphenol, 4-NP), metabolites including linear and branched isoforms of nonylphenol (n-NP and t-NP, respectively), has been considered an endocrine disrupting substance resulting in reproductive dysfunction and increasing reactive oxygen species production in testis, liver, kidney, and brain. How...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-009-0447-6
更新日期：2009-10-01 00:00:00
abstract：:Previously we reported that exposure of mouse and human mast cells to aryl hydrocarbon receptor (AhR) ligands resulted in reactive oxygen species (ROS)- and calcium (Ca2+)-dependent activation of mast cells in vitro and in vivo. However, the mechanisms through which the AhR-ligand axis mediates stress response, Ca2+ s...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1861-1
更新日期：2017-04-01 00:00:00
abstract：:The peroxisome proliferator class of non-genotoxic rodent hepatocarcinogens cause hepatocyte DNA synthesis, peroxisome proliferation and liver tumours when administered to rats and mice, but fail to induce S-phase or peroxisome proliferation in hepatocytes from other species including guinea-pigs, dogs, and primates i...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050483
更新日期：1998-02-01 00:00:00
abstract：:Manufactured nanomaterials (MNMs) selected from a library of over 120 different MNMs with varied compositions, sizes, and surface coatings were tested by four different laboratories for toxicity by high-throughput/-content (HT/C) techniques. The selected particles comprise 14 MNMs composed of CeO2, Ag, TiO2, ZnO and S...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-017-2106-7
更新日期：2018-02-01 00:00:00
abstract：:Dorsal root ganglia from control and methylmercury (MeHg)-treated rats were incubated in vitro with 35S-methionine ant the proteins synthesized were analyzed by two-dimensional electrophoresis. The double labelling method, in which proteins of control dorsal root ganglia labelled in vitro with 3H-leucine were added to...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00316373
更新日期：1989-01-01 00:00:00
abstract：:We recently presented a modified local lymph node test which made it possible to quickly and reliably differentiate between irritative and allergic skin reactions with extremely simple parameters. The Integrated Model for the Differentiation of Skin Reactions (IMDS) test combines measurement of cell proliferation in d...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050001
更新日期：2000-01-01 00:00:00
abstract：:The comet assay is a versatile, reliable, cost-efficient, and fast technique for detecting DNA damage and repair in any tissue. It is useable in almost any cell type and applicable to both eukaryotic and prokaryotic organisms. Instead of highlighting one of the numerous specific aspects of the comet assay, the present...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-016-1767-y
更新日期：2016-10-01 00:00:00
abstract：:Mice in experimental delay of implantation were injected intravenously with 75 micrograms.g-1 body weight of lead chloride, corresponding to a dose of lead of about 56 micrograms.g-1 body weight. Delay of implantation was obtained by ovariectomy 3 days after mating followed by a depot dose of progesterone every fifth ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF02307315
更新日期：1991-01-01 00:00:00
abstract：:The circadian rhythms of HMG-CoA reductase and cholesterol-7 alpha-hydroxylase (low values, during light, rising in the evening with maximum at 12.00 p.m.) are investigated in rats under diverse conditions. Intragastral administration of cholestyramine (bile acid-absorbing resin) leads to an increased rhythm of both e...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00340534
更新日期：1976-12-17 00:00:00
abstract：:Groups of rats were exposed simultaneously to manganese chloride (3 mg Mn2+/ml water) through drinking water and lead acetate intraperitoneally at dosages of 5.0, 8.0 and 12.0 mgPb2+/kg daily for a period of 14 days. The magnitude of changes in the behavioral pattern, contents of biogenic amines and accumulation of le...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00352071
更新日期：1981-11-01 00:00:00
abstract：:Whether pregnancy-induced immunosuppression when combined with exposure to 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) could exacerbate immunotoxicity has not been previously investigated. The current study evaluated the immune status of C57BL/6 pregnant and virgin mice following exposure to TCDD. To this end, syngene...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-003-0538-8
更新日期：2004-05-01 00:00:00
abstract：:Experimental manganese lymphadenopathy was produced by guinea pigs by intratracheal inoculation of manganese dioxide (50 mg/300 g body weight) and histopathologic changes in the tracheobronchial lymph nodes were studied up to 180 days. There was slow extracellular transport of manganese dust into the nodes, which did ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00351975
更新日期：1976-10-28 00:00:00
abstract：:This study was performed to assess the relation between occupational exposure to N,N-dimethylformamide after an 8 h work shift in the acrylic fibre industry and its three biological markers N-methylformamide (NMFtotal), N-acetyl-S-(N-methylcarbamoyl)cysteine (AMCC), and N-methylcarbamoyl adduct at haemoglobin (MCVal)....
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2219-7
更新日期：2018-07-01 00:00:00
abstract：:The acute toxicity of cyanide is determined by its peak levels reached in the body. Compared to the ingestion of free cyanide, lower peak levels may be expected after consumption of foods containing cyanogenic glycosides with the same equivalent dose of cyanide. This is due to possible delayed and/or incomplete releas...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-015-1479-8
更新日期：2016-03-01 00:00:00
abstract：:Quinolone-induced arthropathy is probably caused by a lack of functionally available magnesium in immature joint cartilage. We used an in vitro assay to study the effects of fluoroquinolones on cartilage formation in mouse limb buds from 12-day-old mouse embryos in regular and in magnesium-deficient medium. Omission o...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050521
更新日期：1998-06-01 00:00:00
abstract：:We analyzed adverse events in a clinical phase I trial to assess dose-dependent metabolic effects of St. John's wort co-administered with rifampicin in 12 healthy volunteers. Within 3-6 days after increasing the St. John's wort dose from 300 to 600 mg TID, five of six female participants developed ambient temperature-...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-015-1532-7
更新日期：2016-04-01 00:00:00
abstract：:The α,β-unsaturated carbonyl group is recognized as alert for mutagenicity, attributed to (1) its direct reaction with DNA, counteractable by glutathione (GSH), and (2) oxidative stress caused indirectly by GSH depletion. Accordingly, the α,β,γ,δ-unsaturated lactone patulin (PAT), a mycotoxin detected in fruits and pr...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-014-1443-z
更新日期：2016-02-01 00:00:00
abstract：:The elevations of blood urea nitrogen and serum creatinine caused by cis-platinum in rats can be prevented by a combination of procedures centered around the administration of sodium N-methyl-N-dithiocarboxyglucamine (NaG), before and very soon after the cis-platinum is administered in hypertonic (4.5%) saline. Elevat...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00316327
更新日期：1986-10-01 00:00:00
abstract：:There is considerable epidemiological evidence that workers exposed to carbon disulfide (CS2) develop premature atherosclerosis leading to increased rates of coronary heart disease (CHD), but mechanisms underlying this association remain obscure. The present study documents that occupational exposure to CS2 modifies t...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-001-0311-9
更新日期：2002-04-01 00:00:00
abstract：:Chondrotoxicity is a rare toxicological finding which is observed in dogs after administration of quinolone antibacterials. To study this effect chondrocytes from articular cartilage of dogs were isolated, and incubated with quinolone derivatives. The effects on cell viability, mitochondrial dehydrogenase, and proteog...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01977402
更新日期：1993-01-01 00:00:00
abstract：:Spin trapping in vivo was first achieved in the author's laboratory and is shown to be a feasible method for demonstrating that highly reactive free radical intermediates are generated in the tissues of intact animals as a result of the exposure to certain toxic compounds and to ionizing radiation. The method is based...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/BF00296966
更新日期：1987-01-01 00:00:00
abstract：:The development and application of high throughput in vitro assays is an important development for risk assessment in the twenty-first century. However, there are still significant challenges to incorporate in vitro assays into routine toxicity testing practices. In this paper, a robust learning approach was developed...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2260-6
更新日期：2018-09-01 00:00:00
abstract：:In a two-step study on exposure control method for occupational handling of permethrin was developed. Air sampling on a filter can be used in case of exposure to permethrin in powder form. The detection limit is 0.001 mg/m3. If biological sampling is used, the acid metabolite moiety in the urine must be monitored. How...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00569234
更新日期：1982-05-01 00:00:00
abstract：:Although carbon nanotubes (CNTs) are promising nanomaterials, their potential carcinogenicity is a major concern. We previously established a genetic method of analyzing genotoxicity of chemical compounds, where we evaluated their cytotoxic effect on the DT40 lymphoid cell line comparing DNA-repair-deficient isogenic ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-013-1084-7
更新日期：2014-01-01 00:00:00
abstract：:UDP-glucuronosyltransferases (UGTs) are involved in phase II conjugation reactions of xenobiotics and differences in their isoform activities result in interindividual kinetic differences of UGT probe substrates. Here, extensive literature searches were performed to identify probe substrates (14) for various UGT isofo...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02765-8
更新日期：2020-08-01 00:00:00
