Effect of SKF-525A on liver metabolism and hepatotoxicity of tri- and dibutyltin compounds in mice.

abstract：:Mice in experimental delay of implantation were injected intravenously with 75 micrograms.g-1 body weight of lead chloride, corresponding to a dose of lead of about 56 micrograms.g-1 body weight. Delay of implantation was obtained by ovariectomy 3 days after mating followed by a depot dose of progesterone every fifth ...

journal_title：Archives of toxicology

authors： Nilsson BO,Ljung L,Wide M

更新日期：1991-01-01 00:00:00

abstract：:O,O,S-Trimethyl phosphorothioate (OOS-TMP) is known to induce unique symptoms, which are characterized by hypophagia, progressive weight loss, and hypothermia. To determine whether there is the possibility of a causal relationship between these toxic symptoms and a direct action of OOS-TMP on the central nervous syste...

journal_title：Archives of toxicology

authors： Ohtaka K,Hamade N,Yamazaki Y,Suzuki M,Koizumi A

更新日期：1995-01-01 00:00:00

abstract：:The toxic effect of cadmium varies with sex in experimental animals. Previous studies have demonstrated that pretreatment of male Fischer 344 (F344) rats with the female sex hormone progesterone markedly enhances the susceptibility to cadmium, suggesting a role for progesterone in the sexual dimorphism of cadmium toxi...

journal_title：Archives of toxicology

authors： Shimada H,Hashiguchi T,Yasutake A,Waalkes MP,Imamura Y

更新日期：2012-09-01 00:00:00

abstract：:The tetrahydroxylated biphenyl-ketone 2,2',4,4'-tetrahydroxybenzophenone (BP2), one of twelve benzophenone-derived UV-filters, is used in cosmetic products and in packaging materials to protect these products from light induced damage. Recently published studies showed that BP2 exerts estrogenic activity; thus, it is ...

journal_title：Archives of toxicology

authors： Schlecht C,Klammer H,Wuttke W,Jarry H

更新日期：2006-10-01 00:00:00

abstract：:The aim of our study was to determine the period of maximum sensitivity for the induction of characteristic malformations with thalidomide (TH) in Himalayan rabbits. TH was administered orally in different doses (50, 100, 150 and 200 mg/kg) four times at 24-h intervals starting at 192 h of gestation. The malformations...

journal_title：Archives of toxicology

authors： Sterz H,Nothdurft H,Lexa P,Ockenfels H

更新日期：1987-07-01 00:00:00

abstract：:The influence of haemoperfusion on some immunological parameters was investigated in a pilot study involving two groups of three patients each. In columns containing cellulose-coated activated charcoal or polystyrene resin a temporary reduction of the total white cell number, particularly involving the segmented and b...

journal_title：Archives of toxicology

authors： Rommes JH,Sangster B,Gmelig Meyling FH,Daha MR,van Heijst AN

更新日期：1983-02-01 00:00:00

abstract：:The toxicity of 60 micrograms/kg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) given IP in corn oil/5% acetone was examined in male Sprague-Dawley rats adapted to 25 degrees C or 4 degrees C ambient temperature. Cold exposure significantly reduced mean time to death and tended to increase mortality. Body weight at the ti...

journal_title：Archives of toxicology

authors： Rozman K,Greim H

更新日期：1986-12-01 00:00:00

abstract：:Assay conditions in determining total cytochrome P-450 in four laboratories were compared. Although the determination was derived from the original Omura and Sato method in each laboratory, the four standard protocols differed slightly, resulting in considerable differences in the results. Since the cytochrome P-450 c...

journal_title：Archives of toxicology

authors： Rutten AA,Falke HE,Catsburg JF,Topp R,Blaauboer BJ,van Holsteijn I,Doorn L,van Leeuwen FX

更新日期：1987-01-01 00:00:00

abstract：:Whether pregnancy-induced immunosuppression when combined with exposure to 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) could exacerbate immunotoxicity has not been previously investigated. The current study evaluated the immune status of C57BL/6 pregnant and virgin mice following exposure to TCDD. To this end, syngene...

journal_title：Archives of toxicology

authors： Camacho IA,Nagarkatti M,Nagarkatti PS

更新日期：2004-05-01 00:00:00

abstract：:Since tattoos became overwhelmingly fashionable worldwide, the demand for removal has proportionally increased, Nd:YAG Q-switch laser being the most commonly used tool for the purpose. In this framework we investigated the composition and products of laser treatment of green tattoo ink, the Green Concentrate from Eter...

journal_title：Archives of toxicology

authors： Bauer EM,Scibetta EV,Cecchetti D,Piccirillo S,Antonaroli S,Sennato S,Cerasa M,Tagliatesta P,Carbone M

更新日期：2020-07-01 00:00:00

abstract：:A rapid gas-chromatographic method for the qualitative and quantitative measurement of various drugs in human plasma and other body fluids has been developed. The extraction procedure is done within 5 min, and gas-chromatographic measurement carried out on 2 diverse columns with detection by flame ionisation detectors...

journal_title：Archives of toxicology

authors： Pentz R,Schütt A

更新日期：1978-01-25 00:00:00

abstract：:Groups of adult male Sprague-Dawley rats were treated i.p. with 0, 0.3 and 0.5 mmole bromobenzene (BB)/kg per day in corn oil, 5 days a week for 4 weeks. Thereafter, one half of each of these groups was treated i.p. with a single acute toxic dose of 2.5 mmole BB/kg. Urines were then collected for 24 h and the animals ...

journal_title：Archives of toxicology

authors： Chakrabarti S

更新日期：1991-01-01 00:00:00

abstract：:Between 0.25-25 micrograms of an aqueous solution of either mercuric chloride or methyl mercuric acetate was injected directly into the sciatic nerve of 28 adult Wistar rats. The resultant pathological changes in the nerve were examined by teasing individual fibres and by light and electron microscopy. In most respect...

journal_title：Archives of toxicology

authors： Mitchell J,Gallagher PJ

更新日期：1980-12-01 00:00:00

abstract：:In anaesthetized and artificially ventilated rabbits an intravenous infusion of paraoxon (0.8 mg/kg) was given over 30 min. The effects on cardiac output, blood flow to various vascular beds, and on the mass discharge of the postganglionic sympathetic efferents to the spleen and kidney were monitored. Immediately foll...

journal_title：Archives of toxicology

authors： Kullmann R,Reinsberg J,Amirmanssouri M

更新日期：1982-09-01 00:00:00

abstract：:To investigate the effect of long term hashish use on T-lymphocytes we have measured the incorporation of 14C-thymidine by peripheral blood lymphocytes, unstimulated and stimulated by phytohemagglutinin, as well as the proportion and number of E-rosettes in 12 healthy male chronic users of the drug before and after a ...

journal_title：Archives of toxicology

authors： Kaklamani E,Trichopoulos D,Koutselinis A,Drouga M,Karalis D

更新日期：1978-04-27 00:00:00

abstract：:Chronic arsenite exposure induces immunosuppression, but the precise mechanisms remain elusive. Our previous studies demonstrated that arsenite exposure for 24 h induces G0/G1 arrest in mouse B lymphoma A20 cells and the arrest is caused through induction of cyclin-dependent kinase inhibitor p16(INK4a) followed by acc...

journal_title：Archives of toxicology

authors： Okamura K,Nohara K

更新日期：2016-04-01 00:00:00

abstract：:This study examined the effect of tamoxifen, an anti-breast cancer drug, on Ca2+ handling in bladder female transitional cancer cells. Changes in cytosolic free Ca2+ levels were recorded by using the Ca2+-sensitive dye fura-2. In a dose-dependent manner, tamoxifen induced intracellular free Ca2+ concentrations ([Ca2+]...

journal_title：Archives of toxicology

authors： Chang HT,Huang JK,Wang JL,Cheng JS,Lee KC,Lo YK,Lin MC,Tang KY,Jan CR

更新日期：2001-05-01 00:00:00

abstract：:The mycotoxin ochratoxin A (OTA) and its metabolite ochratoxin alpha (OT-alpha) were investigated, to examine their potency to induce sister chromatid exchanges (SCE) in cultured porcine urinary bladder epithelial cells (PUBEC) (primary culture). Serum-free cultured PUBEC were incubated for 5 h with either OTA or OT-a...

journal_title：Archives of toxicology

authors： Föllmann W,Hillebrand IE,Creppy EE,Bolt HM

更新日期：1995-01-01 00:00:00

abstract：:Carcinogenic risk and molecular mechanisms underlying the liver tumor-promoting activity of copper gluconate, an additive of functional foods, were investigated using a rat medium-term liver carcinogenicity bioassay protocol (Ito test) and a 2-week short-term administration experiment. In the medium-term liver bioassa...

journal_title：Archives of toxicology

authors： Abe M,Usuda K,Hayashi S,Ogawa I,Furukawa S,Igarashi M,Nakae D

更新日期：2008-08-01 00:00:00

abstract：:Liver microsomes were prepared from Wistar rat by the Ca2+ aggregation method. Under various conditions, ethyl mercury chloride (EtHgCl) or methyl mercury chloride (MeHgCl) was incubated with the microsomal preparations. After the incubation, the amounts of inorganic Hg and hydroxyl radical (.OH) in the preparations w...

journal_title：Archives of toxicology

authors： Suda I,Hirayama K

更新日期：1992-01-01 00:00:00

abstract：:The "closed chamber technique" (CCT) is presented. It allows investigation of pharmacokinetics of volatile substances in vivo in animals and in man and in vitro using tissue fractions. During the exposure period only the atmospheric concentrations of the substance are measured. The concentration-time data obtained are...

journal_title：Archives of toxicology

authors： Filser JG

更新日期：1992-01-01 00:00:00

abstract：:Experimental manganese lymphadenopathy was produced by guinea pigs by intratracheal inoculation of manganese dioxide (50 mg/300 g body weight) and histopathologic changes in the tracheobronchial lymph nodes were studied up to 180 days. There was slow extracellular transport of manganese dust into the nodes, which did ...

journal_title：Archives of toxicology

authors： Shanker R,Dogra RK,Sahu AP,Zaidi SH

更新日期：1976-10-28 00:00:00

abstract：:Sotalol [4-(2-isopropylamino-1-hydroxyethyl)-methane-sulfonanilide hydrochloride] is a beta-adrenergic blocking agent. Despite the widespread use of these drugs, poisonings are not frequent. In this report the authors describe the first recorded case of fatal sotalol overdosage to their knowledge. The results of toxic...

journal_title：Archives of toxicology

authors： Montagna M,Groppi A

更新日期：1980-01-01 00:00:00

abstract：:The mycotoxin deoxynivalenol (DON) has a high global prevalence in grain-based products. Biomarkers of exposure are detectable in most humans and farm animals. Considering the acute emetic and chronic anorexigenic toxicity of DON, maximum levels for food and feed have been implemented by food authorities. The tolerabl...

journal_title：Archives of toxicology

authors： Faeste CK,Pierre F,Ivanova L,Sayyari A,Massotte D

更新日期：2019-07-01 00:00:00

abstract：:Sexual differentiation in the brain takes place from late gestation to the early postnatal days. This is dependent on the conversion of circulating testosterone into estradiol by the enzyme aromatase. The glyphosate was shown to alter aromatase activity and decrease serum testosterone concentrations. Thus, the aim of ...

journal_title：Archives of toxicology

authors： Romano MA,Romano RM,Santos LD,Wisniewski P,Campos DA,de Souza PB,Viau P,Bernardi MM,Nunes MT,de Oliveira CA

更新日期：2012-04-01 00:00:00

abstract：:This is with reference to the note of the Editor-in-Chief of the Archives of Toxicology. ...

journal_title：Archives of toxicology

authors： Khan F,Niaz K,Ismail Hassan F,Abdollahi M

更新日期：2018-07-01 00:00:00

abstract：:Previous studies indicate that benzanthrone, an anthraquinone dye intermediate, caused significant depletion of ascorbic acid (AsA). In this investigation the effect of benzanthrone on the status of different forms of AsA and other bio-antioxidants such as glutathione (GSH) was studied. Oral administration of benzanth...

journal_title：Archives of toxicology

authors： Dwivedi N,Das M,Khanna SK

更新日期：2001-06-01 00:00:00

abstract：:The effects of acetone on liver, kidney, and lung monooxygenases were studied using hamsters administered 8% acetone in drinking water. Binding of aniline to liver microsomes induced a type II difference spectrum, and the spectral binding was enhanced in hamsters pretreated with acetone. Administration of acetone caus...

journal_title：Archives of toxicology

authors： Ueng TH,Tsai JN,Ju JM,Ueng YF,Iwasaki M,Guengerich FP

更新日期：1991-01-01 00:00:00

abstract：:Insulin-exposed rat mammary cancer cells were flow sorted based on a c-myc reporter plasmid encoding a destabilized green fluorescent protein. Sorted cells exhibited gradual increases in c-myc levels. Cells overexpressing c-myc by only 10% exhibited phenotypic changes attributable to c-myc overexpression, such as cell...

journal_title：Archives of toxicology

authors： Knudsen KJ,Nelander Holm GM,Krabbe JS,Listov-Saabye N,Kiehr B,Dufva M,Svendsen JE,Oleksiewicz MB

更新日期：2009-12-01 00:00:00

abstract：:The effect of acute and chronic cadmium administration on hepatic drug metabolism was investigated in the male rat. 3 days after the acute administration of cadmium by either the intraperitoneal (0.84 mg Cd/kg) or the oral (greater than 80 mg Cd/kg) route, there was a significant potentiation in duration of hexobarbit...

journal_title：Archives of toxicology

authors： Schnell RC,Yuhas EM,Pence DH,Means JR,Roberts SA,Yau ET,Miya TS,Mennear JH

更新日期：1978-08-09 00:00:00