Treatments of a phthalocyanine-based green ink for tattoo removal purposes: generation of toxic fragments and potentially harmful morphologies.

abstract：:Vitamin E acetate (VEA) has come under significant scrutiny due to its association with e-cigarette, or vaping, product use-associated lung injury (EVALI). In 1965, Sir Austin Bradford Hill proposed a set of criteria used to critically assess an association for causality. In this article, we apply the Bradford Hill ca...

journal_title：Archives of toxicology

authors： Feldman R,Meiman J,Stanton M,Gummin DD

更新日期：2020-06-01 00:00:00

abstract：:A new class of potent anticancer drugs, alkylphosphocholines has been recognized lately. Miltefosine (Hexadecylphosphochlorine, HPC) has been found to express select antineoplastic effect on human breast cancer skin metastases with simultaneous preservation of bone marrow proliferative activity and low clastogenicity....

journal_title：Archives of toxicology

authors： Martinova Y,Topashka-Ancheva M,Konstantinov S,Petkova S,Karaivanova M,Berger M

更新日期：2006-01-01 00:00:00

abstract：:Bromethylbutyramide (Carbromide), a quantitatively important metabolite of carbromal, diminished the contractility of electrically driven and the frequency of spontaneously beating guinea-pig atria. The negative inotropic action of bromethylbutyramide occurred at concentrations which are reached in human carbromal poi...

journal_title：Archives of toxicology

authors： Strubelt O

更新日期：1978-04-27 00:00:00

abstract：:The oxidizing capacity of phagocytic cells is suspected to play a major role in the generation of immunogenic drug metabolites, in particular those that cause extrahepatic immunopathological lesions. In the case of the antirheumatic drug gold(I) disodium thiomalate (Na2Au(I)TM), oxidation of the Au(I) ion to Au(III) a...

journal_title：Archives of toxicology

authors： Goebel C,Kubicka-Muranyi M,Tonn T,Gonzalez J,Gleichmann E

更新日期：1995-01-01 00:00:00

abstract：:Aspergillus versicolor and A. flavus are primary colonizers in damp dwellings, and they produce sterigmatocystin (ST) and aflatoxin B1 (AFB(1)), respectively. These hepatotoxic and carcinogenic mycotoxins and their precursors and derivates possess a furofuran ring, which has proven responsible for their toxicity. The ...

journal_title：Archives of toxicology

authors： Jakšić D,Puel O,Canlet C,Kopjar N,Kosalec I,Klarić MŠ

更新日期：2012-10-01 00:00:00

abstract：:The immunotoxic potential of many classes of environmental contaminants has been well established in laboratory studies, with much attention being focussed on aryl hydrocarbon (Ah)-receptor binding polychlorinated biphenyl (PCB), polychlorinated dibenzo-p-dioxin (PCDD), and polychlorinated dibenzofuran (PCDF) congener...

journal_title：Archives of toxicology

authors： Ross PS,Van Loveren H,de Swart RL,van der Vliet H,de Klerk A,Timmerman HH,van Binnendijk R,Brouwer A,Vos JG,Osterhaus AD

更新日期：1996-01-01 00:00:00

abstract：:Rats were coexposed to lead (Pb) and Copper (Cu) through drinking water and intraperitoneally, respectively, for a period of 21 days. Neurochemical studies in these rats showed significant reduction in the activity of adenosine triphosphatase, cytochrome-c-oxidase, diaphorase and in the levels of biogenic amines in th...

journal_title：Archives of toxicology

authors： Malhotra KM,Shukla GS,Chandra SV

更新日期：1982-03-01 00:00:00

abstract：:5-Hydroxymethylfurfural (HMF) and furfuryl alcohol (FFA) are moderately potent rodent carcinogens that are present in thermally processed foodstuffs. The carcinogenic effects were hypothesized to originate from sulfotransferase (SULT)-mediated bioactivation yielding DNA-reactive and mutagenic sulfate esters, a confirm...

journal_title：Archives of toxicology

authors： Sachse B,Meinl W,Sommer Y,Glatt H,Seidel A,Monien BH

更新日期：2016-01-01 00:00:00

abstract：:Aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor, has been studied extensively in carcinogenesis through the genomic pathway. In recent years, AHR has also been reported to exert positive or negative effects on epithelial-mesenchymal transition (EMT), the crucial step in tumor malignant progres...

journal_title：Archives of toxicology

authors： Li CH,Liu CW,Tsai CH,Peng YJ,Yang YH,Liao PL,Lee CC,Cheng YW,Kang JJ

更新日期：2017-05-01 00:00:00

abstract：:Tributyltin (TBT) has been shown to disrupt the ability of natural killer (NK) cells to destroy tumor targets in vitro even at exposures of 25 nM for 24 h, but cell viability was not significantly impacted. Thus, evaluation of intracellular molecular events that regulate cell viability in TBT exposed NK cells are of i...

journal_title：Archives of toxicology

authors： Aluoch AO,Odman-Ghazi SO,Whalen MM

更新日期：2007-04-01 00:00:00

abstract：:A pharmacokinetic profile of [14C] leptophos was determined in laying hens following a single oral dose of 400 mg/kg (0.58 muCi). Most of the radioactivity was excreted into the urine and feces. After 15 days, the total radioactivity recovered in the combined urinary-fecal excretion was 73.5% of the administered dose....

journal_title：Archives of toxicology

authors： Abou-Donia MB

更新日期：1976-10-28 00:00:00

abstract：:Previous histomorphometric studies led us to hypothesize that suppression of hepatocellular regeneration and the repair of the hepatolobular architecture was involved besides bioactivation phenomenon in the progressive and irreversible phase of toxicity resulting from CD + CCl4 interaction. We have recently observed s...

journal_title：Archives of toxicology

authors： Kodavanti PR,Joshi UM,Young RA,Bell AN,Mehendale HM

更新日期：1989-01-01 00:00:00

abstract：:Prudhoe Bay crude oil (PBCO) and its aliphatic, aromatic and heterocyclic fractions were tested on the developing chick embryo for (i) embryotoxicity (ii) their ability to induce hepatic and renal cytochrome P450 levels as well as hepatic, renal and pulmonary aryl hydrocarbon hydroxylase activities. On the basis of it...

journal_title：Archives of toxicology

authors： Walters P,Khan S,O'Brien PJ,Payne JF,Rahimtula AD

更新日期：1987-08-01 00:00:00

abstract：:Knowledge about established breast carcinogens can support improved and modernized toxicological testing methods by identifying key mechanistic events. Ionizing radiation (IR) increases the risk of breast cancer, especially for women and for exposure at younger ages, and evidence overall supports a linear dose-respons...

journal_title：Archives of toxicology

authors： Helm JS,Rudel RA

更新日期：2020-05-01 00:00:00

abstract：:DW-116, 1-(5-fluoro-2-pyridyl)-6-fluoro-7-(4-methyl-l-piperazinyl)-1, 4-dihydro-4-oxoquinolone-3-carboxylic acid hydrochloride, is a newly developed fluoroquinolone antibacterial. The potential of DW-116 to induce developmental toxicity was, investigated in Sprague-Dawley rats. DW-116 was administered by gavage to pre...

journal_title：Archives of toxicology

authors： Kim JC,Yun HI,Shin HC,Han SS,Chung MK

更新日期：2000-04-01 00:00:00

abstract：:We investigated the hepatotoxicity induced by AQ using a glutathione (GSH)-depleted mice model. Although sole administration of either AQ or L-buthionine-S,R-sulfoxinine (BSO), a well-known GSH synthesis inhibitor, produced no significant hepatotoxicity, combined administration of AQ with BSO induced hepatotoxicity ch...

journal_title：Archives of toxicology

authors： Shimizu S,Atsumi R,Itokawa K,Iwasaki M,Aoki T,Ono C,Izumi T,Sudo K,Okazaki O

更新日期：2009-07-01 00:00:00

abstract：:Previous studies in our laboratory identified retinoid-induced defects that are mediated by RAR-RXR heterodimerization using interaction of synthetic ligands selective for the retinoid receptors RAR and RXR in mice (Elmazar et al. 1997, Toxicol Appl Pharmacol 146:21-28; Elmazar et al. 2001, Toxicol Appl Pharmacol 170:...

journal_title：Archives of toxicology

authors： Elmazar MM,Nau H

更新日期：2004-11-01 00:00:00

abstract：:The present experiments were performed to test the possibility of interrupting the enterohepatic circulation of arsenic (As). Therefore the efficacy of adsorbents to bind As and/or As-DMPS adducts in vitro and their effect on the excretion of As into the feces and urine in vivo were investigated after injection of As2...

journal_title：Archives of toxicology

authors： Reichl FX,Hunder G,Liebl B,Fichtl B,Forth W

更新日期：1995-01-01 00:00:00

abstract：:The influence of pivalic acid (PIV), a compound often used to make pro-drugs, and of the structurally related trichloroacetic acid (TCA), on several hepatic and renal enzymes was investigated in Sprague-Dawley rats, following a 4-day treatment period. The PIV and TCA treatments resulted in a similar and selective indu...

journal_title：Archives of toxicology

authors： Zanelli U,Puccini P,Acerbi D,Ventura P,Gervasi PG

更新日期：1996-01-01 00:00:00

abstract：:Two Ceria nanomaterials (NM-211 and NM-212) were tested for inhalation toxicity and organ burdens in order to design a chronic and carcinogenicity inhalation study (OECD TG No. 453). Rats inhaled aerosol concentrations of 0.5, 5, and 25 mg/m(3) by whole-body exposure for 6 h/day on 5 consecutive days for 1 or 4 weeks ...

journal_title：Archives of toxicology

authors： Keller J,Wohlleben W,Ma-Hock L,Strauss V,Gröters S,Küttler K,Wiench K,Herden C,Oberdörster G,van Ravenzwaay B,Landsiedel R

更新日期：2014-11-01 00:00:00

abstract：:The reduction of 20 microM hexavalent chromium [chromium(VI)] by L-ascorbic acid (AsA) (0.06-2 mM) and/or glutathione (GSH) (2-15 mM) in buffer solutions, cell-free bronchoalveolar lavage fluids or soluble fractions of rat lungs was investigated at physiological pH (37 degrees C). The reduction in AsA solution was pse...

journal_title：Archives of toxicology

authors： Suzuki Y,Fukuda K

更新日期：1990-01-01 00:00:00

abstract：:The ultimate purpose of the present study was to evaluate correlations between acute in vivo and in vitro toxicity and log P (P is n-octanol-water partition coefficient). The in vitro toxicity to cloned cells (neuroblastoma N18TG-2 and glioma C6) in culture (ED50) and the in vivo toxicity to mice (LD50) of ethylene gl...

journal_title：Archives of toxicology

authors： Tanii H,Saito S,Hashimoto K

更新日期：1992-01-01 00:00:00

abstract：:Gene expression analysis has been established as a tool for the characterization of genotoxic mechanisms of chemical mutagens. It has been suggested that expression analysis is capable of distinguishing compounds that cause DNA damage from those that interfere with mitotic spindle function. Formaldehyde (FA) is known ...

journal_title：Archives of toxicology

authors： Kuehner S,Holzmann K,Speit G

更新日期：2013-11-01 00:00:00

abstract：:The "closed chamber technique" (CCT) is presented. It allows investigation of pharmacokinetics of volatile substances in vivo in animals and in man and in vitro using tissue fractions. During the exposure period only the atmospheric concentrations of the substance are measured. The concentration-time data obtained are...

journal_title：Archives of toxicology

authors： Filser JG

更新日期：1992-01-01 00:00:00

abstract：:The highly directional maternal-to-fetal transfer of essential fatty acids (EFAs) across the placenta plays a critical role in guiding proper fetal development. Exposure to xenobiotics that may alter the fetal supply of EFAs/lipids could lead to fetal toxicity. Since the placenta is the first fetal arising organ that ...

journal_title：Archives of toxicology

authors： Xu Y,Knipp GT,Cook TJ

更新日期：2006-05-01 00:00:00

abstract：:Amoscanate, a substance which damages photoreceptors, was administered orally to Wistar rats in doses of 10, 40, and 125 mg/kg body weight once daily for 3 or 10 days. At both times electroretinographic, ophthalmological, and histopathological examinations of the retina were carried out to compare the sensitivity of c...

journal_title：Archives of toxicology

authors： Maertins T,Kroetlinger F,Sander E,Pauluhn J,Machemer L

更新日期：1993-01-01 00:00:00

abstract：:To explain the mechanism of renal injury caused by liver ischemia-reperfusion, we investigated biochemical and morphological changes in the liver and kidney in rats. After reperfusion following 60 min of liver ischemia, numerous changes were found. The level of serum transaminases and lipid peroxide formation in the l...

journal_title：Archives of toxicology

authors： Kudo Y,Egashira T,Takayama F,Yamanaka Y,Shimada T

更新日期：1993-01-01 00:00:00

abstract：:The evaluation of developmental and reproductive toxicity of food contact materials (FCMs) is an important task for food safety. Since traditional experiments are both time-consuming and labor-intensive, only a small number of FCMs have sufficient toxicological data for evaluating their effects on human health. While ...

journal_title：Archives of toxicology

authors： Tung CW,Cheng HJ,Wang CC,Wang SS,Lin P

更新日期：2020-02-01 00:00:00

abstract：:Sotalol [4-(2-isopropylamino-1-hydroxyethyl)-methane-sulfonanilide hydrochloride] is a beta-adrenergic blocking agent. Despite the widespread use of these drugs, poisonings are not frequent. In this report the authors describe the first recorded case of fatal sotalol overdosage to their knowledge. The results of toxic...

journal_title：Archives of toxicology

authors： Montagna M,Groppi A

更新日期：1980-01-01 00:00:00

abstract：:It is estimated that only a few marketed drugs are able to directly induce liver steatosis. However, many other drugs may exacerbate or precipitate fatty liver in the presence of other risk factors or in patients prone to non-alcoholic fatty liver disease. On the other hand, current in vitro tests for drug-induced ste...

journal_title：Archives of toxicology

authors： Benet M,Moya M,Donato MT,Lahoz A,Hervás D,Guzmán C,Gómez-Lechón MJ,Castell JV,Jover R

更新日期：2014-04-01 00:00:00