A rapid gas-chromatographic method for the determination of drugs in clinical toxicology.

abstract：:Rats were exposed to single periods of inhalation of fumes generated by arc welding. Two processes were compared: either manual metal arc (MMA) using flux-coated mild steel (MS) electrodes or metal inert-gas (MIG) welding with stainless steel (SS). Widespread but small deposits of fume particles were cleared effective...

journal_title：Archives of toxicology

authors： Hicks R,Lam HF,Al-Shamma KJ,Hewitt PJ

更新日期：1984-03-01 00:00:00

abstract：:HCB was detected in all preparations of human placenta, maternal blood, milk, and cord blood. It was confirmed that HCB transferred from mother to fetus through the placenta. A significant linear correlation exists between the HCB concentration in placenta and that in cord blood. Therefore, the placental concentration...

journal_title：Archives of toxicology

authors： Ando M,Hirano S,Itoh Y

更新日期：1985-01-01 00:00:00

abstract：:In case of mycotoxin contaminations, food and feedstuff are usually contaminated by more than one toxin. However toxicological data concerning the effects of mycotoxin combinations are sparse. The intestinal epithelium is the first barrier against food contaminants and this constantly renewing organ is particularly se...

journal_title：Archives of toxicology

authors： Alassane-Kpembi I,Puel O,Oswald IP

更新日期：2015-08-01 00:00:00

abstract：:The activity of 18 vitamin D analogs on soft tissue calcification and growth impairment in neonatal rats and their effect on bone calcium mobilization, intestinal calcium absorption and binding to intestinal 1,25-dihydroxyvitamin D3 receptors in adult rats were compared. Depending on the chemical modification of the v...

journal_title：Archives of toxicology

authors： Kistler A,Galli B,Horst R,Truitt GA,Uskoković MR

更新日期：1989-01-01 00:00:00

abstract：:Natural and synthetic chemicals are often used in the fragrance industry. A toxicological profile of the synthetic fragrance booster, 4-cycloocten-1-carbaldehyde, was generated using a test program including the following methods: acute oral toxicity, acute dermal toxicity, acute skin and eye irritation, skin sensitiz...

journal_title：Archives of toxicology

authors： Messinger H,Kleber M,Aulmann W

更新日期：2004-12-01 00:00:00

abstract：:Current developmental neurotoxicity (DNT) testing in animals faces major limitations, such as high cost and time demands as well as uncertainties in their methodology, evaluation and regulation. Therefore, the use of human-based 3D in vitro systems in combination with high-content image analysis (HCA) might contribute...

journal_title：Archives of toxicology

authors： Schmuck MR,Temme T,Dach K,de Boer D,Barenys M,Bendt F,Mosig A,Fritsche E

更新日期：2017-04-01 00:00:00

abstract：:Inhabitants of a private home suffered from symptoms possibly due to dichloroacetylene intoxication. Subsequent anamnesis revealed that abundant amounts of trichloroethylene had been used to remove a wax coating from a concrete-lined stone floor. This prompted us to examine whether dichloroacetylene could have been fo...

journal_title：Archives of toxicology

authors： Greim H,Wolff T,Höfler M,Lahaniatis E

更新日期：1984-12-01 00:00:00

abstract：:Regarding the cancer risk assessment of acrylamide (AA) it is of basic interest to know, as to what amount of the absorbed AA is metabolized to glycidamide (GA) in humans, compared to what has been observed in laboratory animals. GA is suspected of being the ultimate carcinogenic metabolite of AA. From experiments wit...

journal_title：Archives of toxicology

authors： Settels E,Bernauer U,Palavinskas R,Klaffke HS,Gundert-Remy U,Appel KE

更新日期：2008-10-01 00:00:00

abstract：:O,O,S-Trimethyl phosphorothioate (OOS-TMP) is known to induce unique symptoms, which are characterized by hypophagia, progressive weight loss, and hypothermia. To determine whether there is the possibility of a causal relationship between these toxic symptoms and a direct action of OOS-TMP on the central nervous syste...

journal_title：Archives of toxicology

authors： Ohtaka K,Hamade N,Yamazaki Y,Suzuki M,Koizumi A

更新日期：1995-01-01 00:00:00

abstract：:The cytotoxicity of trivalent and pentavalent inorganic arsenic salts was determined in mouse fibroblasts in vitro. Concentrations of As (III) in the microM range led to a reduction of proliferation and viability with a concomitant increase in LDH release and stimulation of lactic acid production. Similar effects were...

journal_title：Archives of toxicology

authors： Fischer AB,Buchet JP,Lauwerys RR

更新日期：1985-08-01 00:00:00

abstract：:Microsomal and soluble epoxide hydrolase (mEH and sEH) fulfill apparently distinct roles: Whereas mEH detoxifies xenobiotics, sEH hydrolyzes fatty acid (FA) signaling molecules and is thus implicated in a variety of physiological functions. These epoxy FAs comprise epoxyeicosatrienoic acids (EETs) and epoxy-octadeceno...

journal_title：Archives of toxicology

authors： Marowsky A,Meyer I,Erismann-Ebner K,Pellegrini G,Mule N,Arand M

更新日期：2017-11-01 00:00:00

abstract：:Acrylamide (AA) is a widely studied industrial chemical that is neurotoxic, mutagenic to somatic and germ cells, and carcinogenic in rodents. The recent discovery of AA at ppm levels in a wide variety of commonly consumed foods has energized research efforts worldwide to define toxicity and prevention. Metabolism and ...

journal_title：Archives of toxicology

authors： Kurebayashi H,Ohno Y

更新日期：2006-12-01 00:00:00

abstract：:The nephrotoxic action of aristolochic acid (AA) was investigated in female Wistar rats given single doses of 10, 50 or 100 mg/kg by gastric tube. Renal lesions developed within 3 days, the effect being dose-dependent. Histologically, there was evidence of necrosis of the epithelium of the renal tubules, and functiona...

journal_title：Archives of toxicology

authors： Mengs U,Stotzem CD

更新日期：1993-01-01 00:00:00

abstract：:The International Agency for Research on Cancer considers the carcinogenicity of welding fume of priority for re-evaluation. Genotoxic effects in experimental animals are still inconclusive. Here, we investigated the association of personal exposure to metals in respirable welding fumes during a working shift with oxi...

journal_title：Archives of toxicology

authors： Pesch B,Lotz A,Koch HM,Marczynski B,Casjens S,Käfferlein HU,Welge P,Lehnert M,Heinze E,Van Gelder R,Hahn JU,Behrens T,Raulf M,Hartwig A,Weiss T,Brüning T

更新日期：2015-08-01 00:00:00

abstract：:Bisphenol A (BPA) is a chemical in widespread use that is under scientific discussion due to its endocrine activity. Controversies exist about how to interpret reportedly high blood concentrations measured in uncontrolled situations. Physiologically based pharmaco-/toxicokinetic modelling resulted in 10-100-fold lower...

journal_title：Archives of toxicology

authors： Partosch F,Mielke H,Gundert-Remy U

更新日期：2013-07-01 00:00:00

abstract：:MDMA-induced impairments of memory performance have been reported in different human and animal studies. However, the correlation between spatial memory impairment, brain mitochondrial function, and concentrations of MDMA and its metabolites has not yet been investigated despite it being needed for comparison with hum...

journal_title：Archives of toxicology

authors： Taghizadeh G,Mehdizadeh H,Lavasani H,Hosseinzadeh Ardakani Y,Foroumadi A,Halvaei Khankahdani Z,Moshtagh A,Pourahmad J,Sharifzadeh M,Rouini MR

更新日期：2020-03-01 00:00:00

abstract：:Cadmium (Cd), an occupational and environmental pollutant, induces nephrotoxicity by primarily damaging renal proximal tubular cells. In this study, we hypothesized that pyroptosis, a caspase-1-dependent inflammatory programmed cell death mechanism, mediates Cd-induced nephrotoxicity. Human proximal tubular epithelial...

journal_title：Archives of toxicology

authors： Chou X,Ding F,Zhang X,Ding X,Gao H,Wu Q

更新日期：2019-04-01 00:00:00

abstract：:The ethylene oxide adduct formed on the N-terminal valine in haemoglobin was investigated as a biological monitor of tobacco smoke intake. The modified method developed for the determination of the hydroxyethylvaline adduct (HOEtVal) involved reaction of globin with pentafluorophenyl isothiocyanate, extraction of the ...

journal_title：Archives of toxicology

authors： Bailey E,Brooks AG,Dollery CT,Farmer PB,Passingham BJ,Sleightholm MA,Yates DW

更新日期：1988-01-01 00:00:00

abstract：:Amoscanate, a substance which damages photoreceptors, was administered orally to Wistar rats in doses of 10, 40, and 125 mg/kg body weight once daily for 3 or 10 days. At both times electroretinographic, ophthalmological, and histopathological examinations of the retina were carried out to compare the sensitivity of c...

journal_title：Archives of toxicology

authors： Maertins T,Kroetlinger F,Sander E,Pauluhn J,Machemer L

更新日期：1993-01-01 00:00:00

abstract：:Possible induction of chromosomal aberrations and/or sister chromatid exchanges by astemizole was studied in vitro on human lymphocytes. In vivo chromosomal damage was assessed by a micronucleus test on rats and a dominant lethal test on both male and female mice. All these tests yielded negative results for astemizol...

journal_title：Archives of toxicology

authors： Vanparys P,Fabry L,Léonard A,Marsboom R

更新日期：1982-07-01 00:00:00

abstract：:The uptake, distribution, and elimination of 3H-toluene in various tissues of rats were studied after inhalation or after gastric intubation. The maximum radioactivity was measured 2--3 h after gastric intubation in tissues, except in white adipose tissue, where the peak radioactivity was reached at 5 h. After inhala...

journal_title：Archives of toxicology

authors： Pyykkö K,Tähti H,Vapaatalo H

更新日期：1977-09-28 00:00:00

abstract：:The development of non-animal methodology to evaluate the potential for a chemical to cause systemic toxicity is one of the grand challenges of modern science. The European research programme SEURAT is active in this field and will conclude its first phase, SEURAT-1, in December 2015. Drawing on the experience gained ...

journal_title：Archives of toxicology

authors： Daston G,Knight DJ,Schwarz M,Gocht T,Thomas RS,Mahony C,Whelan M

更新日期：2015-01-01 00:00:00

abstract：:The regional distribution of dopamine, norepinephrine and homovanillic acid was assessed in adult male rabbits exposed to styrene vapours. The turnover of dopamine and norepinephrine was also measured in several brain regions by the decay in endogenous catecholamines after inhibition of tyrosine hydroxylase by alpha-m...

journal_title：Archives of toxicology

authors： Mutti A,Falzoi M,Romanelli A,Franchini I

更新日期：1984-09-01 00:00:00

abstract：:Interactions between chemicals in a mixture and interactions of mixture components with the skin can significantly alter the rate and extent of percutaneous absorption, as well as the cutaneous disposition of a topically applied chemical. The predictive ability of dermal absorption models, and consequently the dermal ...

journal_title：Archives of toxicology

authors： Riviere JE,Qiao G,Baynes RE,Brooks JD,Mumtaz M

更新日期：2001-08-01 00:00:00

abstract：:The role of the functional substituents on the pyridinium ring of bisquaternary pyridinium compounds, mostly oximes, in exerting reversible and irreversible inhibition of binding of [3H]-N-methyl-4-piperidyl benzilate [( 3H]-4NMPB) to rat brain stem muscarinic receptors was studied. The drugs tested, i.e. HGG-42, HGG-...

journal_title：Archives of toxicology

authors： Kloog Y,Galron R,Balderman D,Sokolovsky M

更新日期：1985-10-01 00:00:00

abstract：:Di-n-butylin dichloride (DBTCl), which is commonly used as heat and light stabilizer for polyvinyl chloride (PVC) plastics, is a teratogen in vivo. In the present study, the toxic effects were investigated of DBTCl on cultured rat embryos during three different stages of organogenesis. Rat embryos explanted on gestati...

journal_title：Archives of toxicology

authors： Ema M,Iwase T,Iwase Y,Ohyama N,Ogawa Y

更新日期：1996-01-01 00:00:00

abstract：:Groups of adult male Sprague-Dawley rats were treated i.p. with 0, 0.3 and 0.5 mmole bromobenzene (BB)/kg per day in corn oil, 5 days a week for 4 weeks. Thereafter, one half of each of these groups was treated i.p. with a single acute toxic dose of 2.5 mmole BB/kg. Urines were then collected for 24 h and the animals ...

journal_title：Archives of toxicology

authors： Chakrabarti S

更新日期：1991-01-01 00:00:00

abstract：:DNA damage induced by methylmethane sulfonate, cyclophosphamide, doxorubicin and procarbazine in male germ cells was assessed in rabbits by the demonstration of unscheduled DNA synthesis (UDS), in meiotic and postmeiotic phases of maturation. Immediately after treatment by the intravenous route tritiated thymidine was...

journal_title：Archives of toxicology

authors： Zbinden G

更新日期：1980-11-01 00:00:00

abstract：:The US Environmental Protection Agency's ToxCast program has generated toxicity data for thousands of chemicals but does not adequately assess potential neurotoxicity. Networks of neurons grown on microelectrode arrays (MEAs) offer an efficient approach to screen compounds for neuroactivity and distinguish between com...

journal_title：Archives of toxicology

authors： Kosnik MB,Strickland JD,Marvel SW,Wallis DJ,Wallace K,Richard AM,Reif DM,Shafer TJ

更新日期：2020-02-01 00:00:00

abstract：:The effect of 1-deamino-2-tyr(ethyl) oxytocin (dEtOT) upon peri- and postnatal development of the rat was studied in two experiments when administered between day 15 of pregnancy and the day of parturition. The investigation showed that dEtOT did not affect the pups at birth, that dEtOT caused a dose-related growth re...

journal_title：Archives of toxicology

authors： Magnusson G,Melin P

更新日期：1985-09-01 00:00:00