Toluene concentrations in various tissues of rats after inhalation and oral administration.

abstract：:The aim of our study was to determine the period of maximum sensitivity for the induction of characteristic malformations with thalidomide (TH) in Himalayan rabbits. TH was administered orally in different doses (50, 100, 150 and 200 mg/kg) four times at 24-h intervals starting at 192 h of gestation. The malformations...

journal_title：Archives of toxicology

authors： Sterz H,Nothdurft H,Lexa P,Ockenfels H

更新日期：1987-07-01 00:00:00

abstract：:3-monochloropropane-1,2-diol (3-MCPD), a rat renal and testicular carcinogen, has been reported to occur in various foods and food ingredients as free or esterified forms. Since reports about toxicity of 3-MCPD esters are limited, we conducted a 13-week rat subchronic toxicity study of 3-MCPD esters (palmitate diester...

journal_title：Archives of toxicology

authors： Onami S,Cho YM,Toyoda T,Mizuta Y,Yoshida M,Nishikawa A,Ogawa K

更新日期：2014-04-01 00:00:00

abstract：:Nucleotide excision repair (NER) is a versatile pathway that removes helix-distorting DNA lesions from the genomes of organisms across the evolutionary scale, from bacteria to humans. The serial steps in NER involve recognition of lesions, adducts or structures that disrupt the DNA double helix, removal of a short oli...

journal_title：Archives of toxicology

authors： Spivak G

更新日期：2016-11-01 00:00:00

abstract：:Cadmium (Cd), a highly toxic heavy metal, is distributed widely in the general environment of today. The characteristic clinical manifestations of chronic Cd intoxication include renal proximal tubular dysfunction, general osteomalacia with severe pains, and anemia. We have recently reported that the serum level of er...

journal_title：Archives of toxicology

authors： Horiguchi H,Sato M,Konno N,Fukushima M

更新日期：1996-01-01 00:00:00

abstract：:Drug-induced liver injuries have been a major focus of current research in drug development, and are also one of the major reasons for the failure and withdrawal of drugs in development. Drug-induced liver injuries have been systematically recorded in many public databases, which have become valuable resources in this...

journal_title：Archives of toxicology

authors： Luo G,Shen Y,Yang L,Lu A,Xiang Z

更新日期：2017-09-01 00:00:00

abstract：:The aim of this study was to assess the neurotoxicity of diazinon oxon (DZO), a major in vivo metabolite of the phosphorothionate insecticide diazinon (DZ), on differentiating mouse N2a neuroblastoma cells. When used at concentrations of 1, 5 and 10 microM, DZO did not cause cell death but it impaired the outgrowth of...

journal_title：Archives of toxicology

authors： Sidiropoulou E,Sachana M,Flaskos J,Harris W,Hargreaves AJ,Woldehiwet Z

更新日期：2009-04-01 00:00:00

abstract：:Interactions between chemicals in a mixture and interactions of mixture components with the skin can significantly alter the rate and extent of percutaneous absorption, as well as the cutaneous disposition of a topically applied chemical. The predictive ability of dermal absorption models, and consequently the dermal ...

journal_title：Archives of toxicology

authors： Riviere JE,Qiao G,Baynes RE,Brooks JD,Mumtaz M

更新日期：2001-08-01 00:00:00

abstract：:Sunitinib (SNT) is a multi-targeted receptor tyrosine kinase inhibitor that has been approved by the FDA for cancer therapy. However, its cardiotoxicity has limited the clinical applicability with no effective therapeutic approach available. As a broadband kinase inhibitor, the function of several kinases that are ess...

journal_title：Archives of toxicology

authors： Li C,Zou R,Zhang H,Wang Y,Qiu B,Qiu S,Wang W,Xu Y

更新日期：2019-06-01 00:00:00

abstract：:Fulminant hepatitis is a serious inflammatory condition of the liver characterized by massive necrosis of liver parenchyma following excessive immune cell infiltration into the liver, and possibly causing sudden hepatic failure and medical emergency. However, the underlying mechanisms are not fully understood. Here, w...

journal_title：Archives of toxicology

authors： Noh JR,Kim JH,Na SY,Lee IB,Seo YJ,Choi JH,Seo Y,Lee TG,Choi HS,Kim YH,Lee CH

更新日期：2020-02-01 00:00:00

abstract：:The rodenticide tetramethylenedisulfotetramine (TETS) is a potent convulsant (lethal dose in humans 7-10 mg) that is listed as a possible threat agent by the United States Department of Homeland Security. TETS has previously been studied in vivo for toxicity and in vitro in binding assays, with the latter demonstratin...

journal_title：Archives of toxicology

authors： Pressly B,Nguyen HM,Wulff H

更新日期：2018-02-01 00:00:00

abstract：:We have used the minipig as a prospective animal model for human risk characterization to study primary biochemical alterations upon oral contaminant intake. The effects of three orally administered soils containing polycyclic aromatic hydrocarbons (PAH) on the expression pattern of the cytochrome P450 enzyme CYP1A1 i...

journal_title：Archives of toxicology

authors： Roos PH,Tschirbs S,Welge P,Hack A,Theegarten D,Mogilevski G,Wilhelm M

更新日期：2002-06-01 00:00:00

abstract：:Rat embryos (9.5-day-old) were cultured for 48 h in the presence of nifedipine (NIF), nimodipine (NIM), nitrendipine (NIT), gallopamil HCl (GAL), verapamil HCl (VER) and diltiazem HCl (DIL). The effects on growth and morphogenetic differentiation in vitro were monitored. Dose-response relationships were evaluated, inc...

journal_title：Archives of toxicology

authors： Stein G,Srivastava MK,Merker HJ,Neubert D

更新日期：1990-01-01 00:00:00

abstract：:The effect of dental composite components triethyleneglycoldimethacrylate (TEGDMA) and hydroxyethylmethacrylate (HEMA) as well as mercuric chloride (HgCl(2)) and methylmercury chloride (MeHgCl) on gluconeogenesis was investigated in isolated rat kidney tubules. From starved rats kidney tubules were prepared and isolat...

journal_title：Archives of toxicology

authors： Reichl FX,Durner J,Mückter H,Elsenhans B,Forth W,Kunzelmann KH,Hickel R,Spahl W,Hume WR,Moes GW

更新日期：1999-09-01 00:00:00

abstract：:The cholestatic effect of the newly developed oestradiol sulphamate (J995) was compared with that of the natural oestrogen oestradiol (E) and of the cholestatic standard oestrogen ethinyloestradiol (EE). Female ovariectomized rats were orally treated for 7 days with oestrogen doses molar equivalent to 0.01, 0.1, 1, an...

journal_title：Archives of toxicology

authors： Barth A,Elger W,Schneider B,Schwarz S

更新日期：1997-01-01 00:00:00

abstract：:Tea (Camellia sinensis, Theaceace), a popular beverage consumed world-wide, has been studied for its preventive effects against cancer as well as cardiovascular, neurodegenerative, and other diseases. Most of the proposed beneficial effects have been attributed to the polyphenolic compounds in tea, but the nature of t...

journal_title：Archives of toxicology

authors： Yang CS,Lambert JD,Sang S

更新日期：2009-01-01 00:00:00

abstract：:Cats were given vincristine sulfate (50 micrograms/kg i.v. every 4 days) and studied after 7-29 injections when neurological deficits became evident. The conduction velocity spectrum of individual afferent nerves from soleus muscles was shifted toward slower velocities. Relatively few functional muscle spindles or oth...

journal_title：Archives of toxicology

authors： Goldstein BD,Lowndes HE,Cho E

更新日期：1981-11-01 00:00:00

abstract：:Oxime-type acetylcholinesterase reactivators (oxime-AChER) are used as an adjunct in the treatment for organophosphorus anticholinesterase poisoning. Because of the widespread usage and exposure of organophosphorus compounds (OPCs), its poisoning and fatalities is obvious in pregnant women, embryos and fetuses. OPCs i...

journal_title：Archives of toxicology

authors： Nurulain SM,Kornelia T,Naqvi SN,Sharma C,Ojha S,Adem A

更新日期：2014-03-01 00:00:00

abstract：:We analyzed adverse events in a clinical phase I trial to assess dose-dependent metabolic effects of St. John's wort co-administered with rifampicin in 12 healthy volunteers. Within 3-6 days after increasing the St. John's wort dose from 300 to 600 mg TID, five of six female participants developed ambient temperature-...

journal_title：Archives of toxicology

authors： Hohmann N,Maus A,Carls A,Haefeli WE,Mikus G

更新日期：2016-04-01 00:00:00

abstract：:To investigate the mechanism on photosensitive dermatitis caused by ketoprofen (KP) in humans, the following experiments were performed by topical application on guinea pigs. The phototoxicity study involving treatment with 10% solution of KP, its enantiomers (R-KP and S-KP), loxoprofen, and flurbiprofen revealed no p...

journal_title：Archives of toxicology

authors： Nakazawa T,Shimo T,Chikamatsu N,Igarashi T,Nagata O,Yamamoto M

更新日期：2006-07-01 00:00:00

abstract：:The use of silver nanoparticles is one of the fastest growing product categories in the nanotechnology industry, with a focus on antimicrobial activity. However, thus far, toxicity data for silver nanoparticles are limited. In this study, we investigated the cytotoxic effects of silver nanoparticles (Ag NPs) and the p...

journal_title：Archives of toxicology

authors： Lee YS,Kim DW,Lee YH,Oh JH,Yoon S,Choi MS,Lee SK,Kim JW,Lee K,Song CW

更新日期：2011-12-01 00:00:00

abstract：:The aim of this study was to investigate the genotoxic potential of DNA adducts and to compare DNA adduct levels and patterns in petroleum vacuum distillates, coal tar distillate, bitumen fume condensates, and related substances that have a wide range of boiling temperatures. An in vitro assay was used for DNA adduct ...

journal_title：Archives of toxicology

authors： Akkineni LK,Zeisig M,Baranczewski P,Ekström LG,Möller L

更新日期：2001-01-01 00:00:00

abstract：:Carcinogenic risk and molecular mechanisms underlying the liver tumor-promoting activity of copper gluconate, an additive of functional foods, were investigated using a rat medium-term liver carcinogenicity bioassay protocol (Ito test) and a 2-week short-term administration experiment. In the medium-term liver bioassa...

journal_title：Archives of toxicology

authors： Abe M,Usuda K,Hayashi S,Ogawa I,Furukawa S,Igarashi M,Nakae D

更新日期：2008-08-01 00:00:00

abstract：:Dinitrochlorobenzene (DNCB) absorption through mouse and rat dorsal skin, pig ear skin and human abdominal skin in vitro was determined, and local metabolism to the glutathione conjugate was related to glutathione transferase activities and glutathione status in the skin. Absorption studies were conducted using skin m...

journal_title：Archives of toxicology

authors： Jewell C,Heylings J,Clowes HM,Williams FM

更新日期：2000-09-01 00:00:00

abstract：:Aciclovir (synonym: acyclovir) causes abnormal thymus development in rats. After treatment on day 10 of gestation a weight reduction of the organ is obvious in 21-day-old fetuses which persists postnatally. Adult male rats exposed in utero to one or three injections of 100 mg aciclovir/kg body wt given to the dam on d...

journal_title：Archives of toxicology

authors： Stahlmann R,Korte M,Van Loveren H,Vos JG,Thiel R,Neubert D

更新日期：1992-01-01 00:00:00

abstract：:This review provides a compendium of the results of genotoxicity and carcinogenicity assays performed on marketed antihistamines. Of the 70 drugs examined, 29 (41.4%) have at least one genotoxicity and/or carcinogenicity test result: 12 tested positive in at least one genotoxicity assay, six in at least one carcinogen...

journal_title：Archives of toxicology

authors： Brambilla G,Mattioli F,Robbiano L,Martelli A

更新日期：2011-10-01 00:00:00

abstract：:Cocaine is an intrinsic hepatotoxin in laboratory animals, and there is growing evidence that high doses of cocaine can precipitate hepatic necrosis in humans. The rodent model of cocaine hepatotoxicity is commensurate with the concept that a multistep mainly cytochrome P-450 dependent N-oxidative pathway is responsib...

journal_title：Archives of toxicology

authors： Boelsterli UA,Göldlin C

更新日期：1991-01-01 00:00:00

abstract：:Chronic ethanol consumption is a strong risk factor for the development of liver disease. Multiple mechanisms are involved in ethanol-mediated liver injury; oxidative stress being pointed has an important factor. However, it should be noted that moderate consumption of red wine has been associated with hepatoprotectiv...

journal_title：Archives of toxicology

authors： Silva P,Fernandes E,Carvalho F

更新日期：2015-10-01 00:00:00

abstract：:Betulinic acid (BA), a compound isolated from the bark of white birch (Betula pubescens), was reported to induce apoptosis in many types of cancer through mitochondrial dysfunction with low side effects in normal cells. Because of these features, BA is regarded as a potential anti-cancer agent. However, the effect of ...

journal_title：Archives of toxicology

authors： Gao M,Lau PM,Kong SK

更新日期：2014-03-01 00:00:00

abstract：:UDP-glucuronosyltransferases (UGTs) are involved in phase II conjugation reactions of xenobiotics and differences in their isoform activities result in interindividual kinetic differences of UGT probe substrates. Here, extensive literature searches were performed to identify probe substrates (14) for various UGT isofo...

journal_title：Archives of toxicology

authors： Kasteel EEJ,Darney K,Kramer NI,Dorne JLCM,Lautz LS

更新日期：2020-08-01 00:00:00

abstract：:O,O,S-Trimethyl phosphorothioate (OOS-TMP) is known to induce unique symptoms, which are characterized by hypophagia, progressive weight loss, and hypothermia. To determine whether there is the possibility of a causal relationship between these toxic symptoms and a direct action of OOS-TMP on the central nervous syste...

journal_title：Archives of toxicology

authors： Ohtaka K,Hamade N,Yamazaki Y,Suzuki M,Koizumi A

更新日期：1995-01-01 00:00:00