Abstract:
:Chronic ethanol consumption is a strong risk factor for the development of liver disease. Multiple mechanisms are involved in ethanol-mediated liver injury; oxidative stress being pointed has an important factor. However, it should be noted that moderate consumption of red wine has been associated with hepatoprotective effects, mainly due to the antioxidant effect of resveratrol, one of its polyphenolic compounds. In this paper, the potential molecular mechanisms through which the protective effects of resveratrol counteract the oxidative effect of ethanol and the way as this dual effect impacts liver oxidative stress are reviewed. Mechanistic evaluation of modulation of oxidative signaling pathways by ethanol and resveratrol may explain the pathogenesis of various liver diseases and ultimately to disclose possible pharmacological therapies.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Silva P,Fernandes E,Carvalho Fdoi
10.1007/s00204-015-1538-1subject
Has Abstractpub_date
2015-10-01 00:00:00pages
1681-93issue
10eissn
0340-5761issn
1432-0738pii
10.1007/s00204-015-1538-1journal_volume
89pub_type
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