Abstract：
:Chronic ethanol consumption is a strong risk factor for the development of liver disease. Multiple mechanisms are involved in ethanol-mediated liver injury; oxidative stress being pointed has an important factor. However, it should be noted that moderate consumption of red wine has been associated with hepatoprotective effects, mainly due to the antioxidant effect of resveratrol, one of its polyphenolic compounds. In this paper, the potential molecular mechanisms through which the protective effects of resveratrol counteract the oxidative effect of ethanol and the way as this dual effect impacts liver oxidative stress are reviewed. Mechanistic evaluation of modulation of oxidative signaling pathways by ethanol and resveratrol may explain the pathogenesis of various liver diseases and ultimately to disclose possible pharmacological therapies.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Silva P,Fernandes E,Carvalho Fdoi
10.1007/s00204-015-1538-1subject
Has Abstractpub_date
2015-10-01 00:00:00pages
1681-93issue
10eissn
0340-5761issn
1432-0738pii
10.1007/s00204-015-1538-1journal_volume
89pub_type
杂志文章,评审abstract：:Cocaine is an intrinsic hepatotoxin in laboratory animals, and there is growing evidence that high doses of cocaine can precipitate hepatic necrosis in humans. The rodent model of cocaine hepatotoxicity is commensurate with the concept that a multistep mainly cytochrome P-450 dependent N-oxidative pathway is responsib...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/BF02284256
更新日期：1991-01-01 00:00:00
abstract：:Perfluoroalkyl acids are widely used in numerous industrial and commercial applications due to their unique physical and chemical characteristics. Although perfluorooctanoic acid (PFOA) is associated with hepatomegaly through peroxisome proliferator-activated receptor α (PPARα) activation, liver fat accumulation and c...
journal_title：Archives of toxicology
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更新日期：2015-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00204-019-02616-1
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00293807
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-007-0278-2
更新日期：2008-09-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2011-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
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更新日期：2012-05-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-004-0586-8
更新日期：2004-11-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00333421
更新日期：1985-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0095-z
更新日期：2006-10-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01973715
更新日期：1991-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0138-5
更新日期：2007-03-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
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更新日期：2008-11-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
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journal_title：Archives of toxicology
pub_type： 杂志文章
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更新日期：2014-04-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01270911
更新日期：1980-07-01 00:00:00
abstract：:The uncertainties that surround the methods used for risk assessment of exposure to carcinogens have been highlighted by a recent document advocating an approach based on the T25 dose (the dose giving a 25% incidence of cancer in an appropriately designed animal experiment). This method relies on derivation of the T25...
journal_title：Archives of toxicology
pub_type：
doi：10.1007/s002040100271
更新日期：2001-11-01 00:00:00
abstract：:Quantitative structure-activity relationships (QSAR) have suggested the importance of hydrogen bonding in relation to activation of the sensory irritant receptor by nonreactive volatile organic chemicals. To investigate this possibility further, three model compounds with different hydrogen bond acidity, trifluoroetha...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050281
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abstract：:Prudhoe Bay crude oil (PBCO) and its aliphatic, aromatic and heterocyclic fractions were tested on the developing chick embryo for (i) embryotoxicity (ii) their ability to induce hepatic and renal cytochrome P450 levels as well as hepatic, renal and pulmonary aryl hydrocarbon hydroxylase activities. On the basis of it...
journal_title：Archives of toxicology
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01973722
更新日期：1991-01-01 00:00:00
abstract：:Nine bispyridinium oximes containing two pyridinium rings linked by dimethylether were synthesised. Each compound had on one of the pyridinium rings a hydroxyiminomethyl group in position 2 or 4, while the other ring was unsubstituted or had a methyl or a hydroxyiminomethyl group in position 2 or 4. The reactivating p...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00296900
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journal_title：Archives of toxicology
pub_type： 杂志文章,评审
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更新日期：2010-12-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00332484
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0125-x
更新日期：2006-10-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-004-0606-8
更新日期：2005-01-01 00:00:00
