Abstract：
:We analyzed adverse events in a clinical phase I trial to assess dose-dependent metabolic effects of St. John's wort co-administered with rifampicin in 12 healthy volunteers. Within 3-6 days after increasing the St. John's wort dose from 300 to 600 mg TID, five of six female participants developed ambient temperature-dependent allodynia and paresthesia in sun-exposed areas (back of the hands and perioral and nasal area). Aggravation of symptoms resulted in persistence of paresthesia and phototoxic erythrodermia. None of the male participants showed any of these effects. Gender, duration of treatment, dose, and solar exposure seem to be extrinsic and host factors facilitating St. John's wort-induced neuropathy. The risk to develop this adverse effect is almost exclusively present in women.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Hohmann N,Maus A,Carls A,Haefeli WE,Mikus Gdoi
10.1007/s00204-015-1532-7subject
Has Abstractpub_date
2016-04-01 00:00:00pages
1013-5issue
4eissn
0340-5761issn
1432-0738pii
10.1007/s00204-015-1532-7journal_volume
90pub_type
杂志文章abstract：:Polyclonal antibodies raised toward a debrisoquine 4-hydroxylating cytochrome P-450 species purified from rat liver (P-450UT-A) were used to determine which monooxygenase reactions are linked to debrisoquine hydroxylation in human liver. Anti P-450UT-A did not inhibit the oxidation of dimethylnitrosamine, morphine, di...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00296955
更新日期：1987-01-01 00:00:00
abstract：:The US Environmental Protection Agency's ToxCast program has generated toxicity data for thousands of chemicals but does not adequately assess potential neurotoxicity. Networks of neurons grown on microelectrode arrays (MEAs) offer an efficient approach to screen compounds for neuroactivity and distinguish between com...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-019-02636-x
更新日期：2020-02-01 00:00:00
abstract：:The uptake, distribution, and elimination of 3H-toluene in various tissues of rats were studied after inhalation or after gastric intubation. The maximum radioactivity was measured 2--3 h after gastric intubation in tissues, except in white adipose tissue, where the peak radioactivity was reached at 5 h. After inhala...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00293651
更新日期：1977-09-28 00:00:00
abstract：:Oxidative stress is discussed as a possible hepatocarcinogenic mechanism of peroxisome proliferators (PP) in rodents and is suggested to result from the induction of peroxisomal beta-oxidation (PBOX) by PP. The induced PBOX is assumed to produce excessive H2O2 from the degradation of fatty acids, ultimately leading to...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050429
更新日期：1997-01-01 00:00:00
abstract：:Chemical formation of dichlorvos (2, 2-dichlorovinyl dimethyl phosphate) was found to occur in mouse brain after i.p. injection of metrifonate (2, 2, 2-trichloro-1-hydroxyethyl dimethyl phosphonate). A mass fragmentographic technique was used. Different isotopic variants were used both as internal standards and to com...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00351767
更新日期：1978-10-13 00:00:00
abstract：:Primary hepatocytes are a widely used cell model to analyse the expression and regulation of hepatic cytochrome P450 (CYP) isoenzymes. Transforming growth factor-beta1 (TGF-beta1) was previously shown to inhibit constitutive and induced CYP1 expression in human cell lines and primary hepatocytes but not in rat cells. ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050667
更新日期：2000-05-01 00:00:00
abstract：:Certain esterase inhibitors such as O-(2-chloro-2,3,3-trifluorocyclobutyl) O-ethyl S-propyl phosphorothioate (KBR-2822) and phenylmethanesulfonyl fluoride (PMSF) cause exacerbation (promotion) of toxic and traumatic axonopathies. Although these chemicals are capable of inhibiting neuropathy target esterase (NTE), whic...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050473
更新日期：1998-01-01 00:00:00
abstract：:Milacemide (2-n-pentylaminoacetamide) hydrochloride was administered by continuous i.v. infusion for up to 7 days, at 300 and 600 mg/kg per day to male Sprague-Dawley rats. This was intended to provide high and sustained exposure to evaluate the effect of a preterminal 24-h fast on liver lipid content. Liver lipid con...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050067
更新日期：1994-01-01 00:00:00
abstract：:Changes in the urinary excretion of hippuric acid (HIA) and phenaceturic acid (PUA) as well as their metabolic precursors, i.e. benzoic (BA) and phenylacetic acid (PAA), in rats housed in glass metabolic cages for 4 days were monitored using gas-liquid chromatography. The amount of HIA excreted was 128 +/- 63 mumol/kg...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00324554
更新日期：1987-01-01 00:00:00
abstract：:In the recent years, the toxicity of certain divalent cations has been associated with the alteration of intracellular Ca2+ homeostasis. Among other mechanisms, these cations may affect the functionality of certain Ca2+-binding proteins and/or Ca2+ pumps. The plasma membrane calcium pump (PMCA) maintains Ca2+ homeosta...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-017-2031-9
更新日期：2018-01-01 00:00:00
abstract：:Nanoparticles (NP) have a tendency to agglomerate after dispersion in physiological media, which can be prevented by the addition of serum. This may however result in modification of the toxic potential of particles due to the formation of protein corona. Our study aimed to analyze the role of serum that is added to i...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1673-3
更新日期：2017-01-01 00:00:00
abstract：:The effect of dental composite components triethyleneglycoldimethacrylate (TEGDMA) and hydroxyethylmethacrylate (HEMA) as well as mercuric chloride (HgCl(2)) and methylmercury chloride (MeHgCl) on gluconeogenesis was investigated in isolated rat kidney tubules. From starved rats kidney tubules were prepared and isolat...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050677
更新日期：1999-09-01 00:00:00
abstract：:Inhibition mechanism(s) of protein kinase B/Akt1 and its consequences on related cell signaling were investigated in human neuroblastoma SH-SY5Y cells exposed to 4-hydroxy-trans-2-nonenal (4-HNE), one of the most reactive aldehyde by-products of lipid peroxidation. In silico data indicate that 4-HNE interacts with kin...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-014-1260-4
更新日期：2015-02-01 00:00:00
abstract：:The effect of isosorbide diuresis on gentamicin excretion and tissue accumulation as well as gentamicin-induced histopathologic changes in renal tissue were examine in rats. Gentamicin (30, 60, 120, 160 mg/kg) was administered s.c. for 10 consecutive days with or without isosorbide pretreatment. Osmotic diuresis with ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF02419001
更新日期：1980-09-01 00:00:00
abstract：:Neurotoxic properties of acrylamide and seven related compounds in rats were studied with regard to the effects on rotarod performance, morphology of nerves and neurotubulin. Compounds used in the present study were acrylamide, N-hydroxymethylacrylamide, N-isopropylacrylamide, methacrylamide, N-methylacrylamide, croto...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01239204
更新日期：1983-11-01 00:00:00
abstract：:A wide variety of immunosuppressive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in experimental animals has been documented. In contrast, the impact of dioxin on the human immune system remains controversial, although adverse health effects have been reported in humans after occupational or accidental exposu...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050072
更新日期：1994-01-01 00:00:00
abstract：:Cisplatin and its derivatives are widely used chemotherapeutic drugs for cancer treatment. However, they have debilitating side effects in normal tissues and induce ototoxicity, neurotoxicity, and nephrotoxicity. In kidneys, cisplatin preferentially accumulates in renal tubular cells causing tubular cell injury and de...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-015-1633-3
更新日期：2015-12-01 00:00:00
abstract：:The cardiovascular effects were investigated after acute and subacute treatment with chlorodibromomethane (CDBM; 0.4 to 3.2 mmol/kg p.o.), trichloromethane (TCM; 0.31 and 1.25 mmol/kg p.o.) and mixtures of CDBM and TCM (acute, 0.8 mmol CDBM/kg + 1.25 mmol TCM/kg p.o.; subacute, 0.4 mmol CDBM/kg + 0.31 mmol TCM/kg p.o....
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050459
更新日期：1997-01-01 00:00:00
abstract：:3-Chloro-1,2-propanediol (3-MCPD) fatty acid esters are formed upon thermal processing of fat-containing foods in the presence of chloride ions. Upon hydrolytic cleavage, these substances could release free 3-MCPD. This compound is toxicologically well characterised and displayed cancerogenic potential in rodent model...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-011-0657-6
更新日期：2011-10-01 00:00:00
abstract：:The influence of pivalic acid (PIV), a compound often used to make pro-drugs, and of the structurally related trichloroacetic acid (TCA), on several hepatic and renal enzymes was investigated in Sprague-Dawley rats, following a 4-day treatment period. The PIV and TCA treatments resulted in a similar and selective indu...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050253
更新日期：1996-01-01 00:00:00
abstract：:To examine the demethylation reaction of methylmercury (MeHg) in rat liver, slices prepared from MeHg-treated rats were incubated in L-15 medium under 95% O2/5% CO2 atmosphere. During the incubation, the amount of inorganic Hg in the slices markedly increased in a time-dependent manner, although the concentration of t...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040100256
更新日期：2001-09-01 00:00:00
abstract：:Between 0.25-25 micrograms of an aqueous solution of either mercuric chloride or methyl mercuric acetate was injected directly into the sciatic nerve of 28 adult Wistar rats. The resultant pathological changes in the nerve were examined by teasing individual fibres and by light and electron microscopy. In most respect...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00310442
更新日期：1980-12-01 00:00:00
abstract：:Skin sensitisation is the regulatory endpoint that has been at the centre of concerted efforts to replace animal testing in recent years, as demonstrated by the Organisation for Economic Co-operation and Development (OECD) adoption of five non-animal methods addressing mechanisms under the first three key events of th...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-017-2097-4
更新日期：2018-02-01 00:00:00
abstract：:A histochemical technique for detection of the in vivo induced cellular aldehydes based on the direct Schiff's reaction is reported in this paper. CCl4-intoxicated rat liver was used as an experimental model. Fresh and non-pretreated rat liver cryostat sections fixed in 10% formol calcium solution and washed in distil...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00334622
更新日期：1988-04-01 00:00:00
abstract：:Adverse outcome pathways (AOPs) have been recently introduced as tools to map the mechanisms underlying toxic events relevant for chemical risk assessment. AOPs particularly depict the linkage between a molecular initiating event and an adverse outcome through a number of intermediate key events. An AOP has been previ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02691-9
更新日期：2020-04-01 00:00:00
abstract：:Rhabdomyolysis has been reported in patients who abuse synthetic cannabinoids. However, no studies have yet assessed whether these cases reflect the direct cytotoxicity of synthetic cannabinoids on skeletal muscle, a possibility that the present study sought to address. Specifically, this study investigated the cytoto...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02944-7
更新日期：2020-11-10 00:00:00
abstract：:The kinetics of vitamin E was followed in serum, liver and kidney of 10- and 55-day-old rats after the administration of a single i.m. dose of 100 mg alpha-tocopherol acetate/100 g body wt. The basal levels without vitamin E administration were significantly higher in serum and liver of 10- than 55-day-old rats. The e...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050444
更新日期：1997-01-01 00:00:00
abstract：:Mouse liver tumors that harbor activating mutations in Ctnnb1, encoding β-catenin, express high levels of various cytochromes P450 (CYP), including CYP2E1 and CYP1A2. Acetaminophen (AAP) is metabolized in hepatocytes by these CYPs to the reactive intermediate N-acetyl-p-benzoquinone-imine, which is toxic to hepatocyte...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-013-1030-8
更新日期：2013-08-01 00:00:00
abstract：:Ziram is a carbamate pesticide, which is widely used throughout the world as a fungicide in agriculture and as an accelerating agent in latex production. In the present study, we investigated the effect of ziram at 0.031-4 μM in vitro on human natural killer (NK) and lymphokine-activated killer (LAK) and murine cytoto...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-011-0771-5
更新日期：2012-03-01 00:00:00
abstract：:The uncertainties that surround the methods used for risk assessment of exposure to carcinogens have been highlighted by a recent document advocating an approach based on the T25 dose (the dose giving a 25% incidence of cancer in an appropriately designed animal experiment). This method relies on derivation of the T25...
journal_title：Archives of toxicology
pub_type：
doi：10.1007/s002040100271
更新日期：2001-11-01 00:00:00
