Abstract：
:Cadmium (Cd), a highly toxic heavy metal, is distributed widely in the general environment of today. The characteristic clinical manifestations of chronic Cd intoxication include renal proximal tubular dysfunction, general osteomalacia with severe pains, and anemia. We have recently reported that the serum level of erythropoietin (EPO) remained low despite the severe anemia in patients with Itai-itai disease, the most severe form of chronic Cd intoxication. In order to prove that the anemia observed in chronic Cd intoxication arises from low production of EPO in the kidneys following the renal injury, we administered Cd to rats for a long period and performed the analysis of EPO mRNA inducibility in the kidneys. The rats administered Cd for 6 and 9 months showed anemia with low levels of plasma EPO as well as biochemical and histological renal tubular damage, and also hypoinduction of EPO mRNA in the kidneys. The results indicate that chronic Cd intoxication causes anemia by disturbing the EPO-production capacity of renal cells.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Horiguchi H,Sato M,Konno N,Fukushima Mdoi
10.1007/s002040050352subject
Has Abstractpub_date
1996-01-01 00:00:00pages
11-9issue
1-2eissn
0340-5761issn
1432-0738journal_volume
71pub_type
杂志文章abstract：:Iron (Fe) plays essential roles in biological processes, whereas cadmium (Cd) is a toxic and non-essential metal. Two metal transporters, divalent metal transporter 1 (DMT1) and metal transporter protein 1 (MTP1), are responsible for Fe transport in mammals. Here, we studied the effect of dietary Fe on the expression ...
journal_title：Archives of toxicology
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abstract：:Amygdalin (D-mandelonitrile-beta-D-gentiobioside) is a cyanogenic glycoside claimed to show anti-cancer activity, sold under the incorrect name "Laetrile". For a sensible discussion of its alleged activity and its established toxicity it is necessary that its fate in the organism is known. The pharmacokinetics of amyg...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00347879
更新日期：1982-03-01 00:00:00
abstract：:Chronic arsenite exposure induces immunosuppression, but the precise mechanisms remain elusive. Our previous studies demonstrated that arsenite exposure for 24 h induces G0/G1 arrest in mouse B lymphoma A20 cells and the arrest is caused through induction of cyclin-dependent kinase inhibitor p16(INK4a) followed by acc...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-015-1500-2
更新日期：2016-04-01 00:00:00
abstract：:Drug-induced liver injuries have been a major focus of current research in drug development, and are also one of the major reasons for the failure and withdrawal of drugs in development. Drug-induced liver injuries have been systematically recorded in many public databases, which have become valuable resources in this...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-017-2024-8
更新日期：2017-09-01 00:00:00
abstract：:The possibility that the exposure of the embryo to certain chemical substances can lead to behavioral disturbances is known from human epidemiological studies, e.g., in chronic poisoning with mercury and ethanol. Therefore, efforts are made to develop toxicological techniques with which new behavioral teratogens can b...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/BF00310480
更新日期：1981-09-01 00:00:00
abstract：:A study was conducted to determine the levels of cis-diamminedichloroplatinum (II) (cisplatin) in plasma proteins and hemoglobin of cancer patients after cisplatin chemotherapy. Thirty-seven cancer patients with different type of cancers (lung, esophageal, urinary tract, and testicular cancer, melanoma, osteosarcoma e...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00303124
更新日期：1989-01-01 00:00:00
abstract：:The regional distribution of dopamine, norepinephrine and homovanillic acid was assessed in adult male rabbits exposed to styrene vapours. The turnover of dopamine and norepinephrine was also measured in several brain regions by the decay in endogenous catecholamines after inhibition of tyrosine hydroxylase by alpha-m...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00316123
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abstract：:Boric acid and sodium borates are currently classified as being toxic to reproduction under "Category 1B" with the hazard statement of "H360 FD" in the European CLP regulation. This has prompted studies on boron-mediated reprotoxic effects in male workers in boron mining areas and boric acid production plants. By cont...
journal_title：Archives of toxicology
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doi：10.1007/s00204-018-2238-4
更新日期：2018-08-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00293860
更新日期：1977-06-18 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00290553
更新日期：1986-12-01 00:00:00
abstract：:The toxicity of amphetamines is conditioned by a complex array of mechanisms, involving the increase of neurotransmission (e.g. leading to hyperthermia) and enzymatic and non-enzymatic oxidation of amphetamines and biogenic amines. Considering that all these processes may increase the generation of hydrogen peroxide (...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040100264
更新日期：2001-10-01 00:00:00
abstract：:The in ovo carcinogenicity assessing (IOCA) assay was used to examine the morphological changes in fetal turkey livers caused by the DNA-reactive carcinogen diethylnitrosamine (DEN). Fertilized turkey eggs were allocated into 3 groups: nondosed control (NDC), vehicle (water) control (VC) and DEN-dosed. At day 0, the f...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-010-0603-z
更新日期：2011-06-01 00:00:00
abstract：:Previous studies indicate that benzanthrone, an anthraquinone dye intermediate, caused significant depletion of ascorbic acid (AsA). In this investigation the effect of benzanthrone on the status of different forms of AsA and other bio-antioxidants such as glutathione (GSH) was studied. Oral administration of benzanth...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040100222
更新日期：2001-06-01 00:00:00
abstract：:Many in the welding industry suffer from bronchitis, lung function changes, metal fume fever, and diseases related to respiratory damage. These phenomena are associated with welding fumes; however, the mechanism behind these findings remains to be elucidated. In this study, the lungs of cynomolgus monkeys were exposed...
journal_title：Archives of toxicology
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doi：10.1007/s00204-009-0486-z
更新日期：2010-03-01 00:00:00
abstract：:Contents of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and of 16 further congeners--polychlorinated dibenzodioxins and dibenzofuranes (PCDD/PCDF)--were determined in lipids of adipose tissue and of livers of 3 stillborns and of 17 infants (0.43-44 weeks old) who died from sudden infant death syndrome. International to...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050402
更新日期：1997-01-01 00:00:00
abstract：:Selenium (Se) is an essential dietary component for animals including humans and is regarded as a protective agent against cancer. Although the mode of anticancer action of Se is not fully understood yet, several mechanisms, such as antioxidant protection by selenoenzymes, specific inhibition of tumor cell growth by S...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-010-0595-8
更新日期：2010-12-01 00:00:00
abstract：:The transcription factor nuclear factor kappa B (NF-κB) has attracted increasing attention in the field of cancer research from last few decades. Aberrant activation of this transcription factor is frequently encountered in a variety of solid tumors and hematological malignancies. NF-κB family members and their regula...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-015-1470-4
更新日期：2015-05-01 00:00:00
abstract：:Carcinogenic risk and molecular mechanisms underlying the liver tumor-promoting activity of copper gluconate, an additive of functional foods, were investigated using a rat medium-term liver carcinogenicity bioassay protocol (Ito test) and a 2-week short-term administration experiment. In the medium-term liver bioassa...
journal_title：Archives of toxicology
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doi：10.1007/s00204-008-0294-x
更新日期：2008-08-01 00:00:00
abstract：:Labilization of lysosomal enzymes is often associated with the general process of inflammation. The present study investigated the effect of the pneumotoxin cadmium on the release and activity of two lung lysosomal enzymes. Incubation of rat lung lysosomes with cadmium resulted in the release of beta-glucuronidase but...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050181
更新日期：1995-01-01 00:00:00
abstract：:Human precision-cut liver slices (hPCLS) are a valuable ex vivo model that can be used in acute toxicity studies. However, a rapid decline in metabolic enzyme activity limits their use in studies that require a prolonged xenobiotic exposure. The aim of the study was to extend the viability and function of hPCLS to 5 d...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1865-x
更新日期：2017-05-01 00:00:00
abstract：:The highly directional maternal-to-fetal transfer of essential fatty acids (EFAs) across the placenta plays a critical role in guiding proper fetal development. Exposure to xenobiotics that may alter the fetal supply of EFAs/lipids could lead to fetal toxicity. Since the placenta is the first fetal arising organ that ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-005-0047-z
更新日期：2006-05-01 00:00:00
abstract：:In vitro assays are often used for the hazard characterisation of compounds, but their application for quantitative risk assessment purposes is limited. This is because in vitro assays cannot provide a complete in vivo dose-response curve from which a point of departure (PoD) for risk assessment can be derived, like t...
journal_title：Archives of toxicology
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更新日期：2013-09-01 00:00:00
abstract：:The incidence of breast cancer in Korea has been increasing for the last two decades (1983-2005), and now, breast cancer is ranked the leading cause of cancer in Korean women. Along with other endocrine disrupting chemicals (EDCs), bisphenol A (BPA) has been suspected as a potential risk factor for breast cancer. We s...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-008-0364-0
更新日期：2009-03-01 00:00:00
abstract：:The present study was carried out to elucidate the mechanisms behind an increase in the incidence of malignant or multiple mammary tumors as a result of oral administration of rolipram in a 104-week carcinogenicity study. The organs and tissues of Sprague-Dawley (SD) rats of both sexes, which had been subjected to a 1...
journal_title：Archives of toxicology
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更新日期：2006-02-01 00:00:00
abstract：:A dual-label time-resolved fluoroimmunoassay (TRFIA) for simultaneous quantification of aflatoxin B1 (AFB1) and ochratoxin A (OTA) is described. For this, microtitration wells were coated with AFB1-horse radish peroxidase (HRP) and OTA-bovine serum albumin. The standards and samples were loaded on the coated plates, a...
journal_title：Archives of toxicology
pub_type： 杂志文章
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更新日期：2009-06-01 00:00:00
abstract：:The present study was performed to investigate the potential toxic effects of prenatal exposure to 4-tert-octylphenol (OP) on liver, kidney, spleen, and hematologic parameters of male and female rats in adult life. The rats were treated with OP subcutaneously in utero at doses of control (vehicle, corn oil), 100 or 25...
journal_title：Archives of toxicology
pub_type： 杂志文章
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更新日期：2009-04-01 00:00:00
abstract：:As Drosophila melanogaster occupies an important position within the test battery for mutagens and carcinogens, it is of interest to study the xenobiotics metabolism of this insect. Likewise, the genetic control of these important enzyme systems falls within this interest. Our attempt was to get new strains, which sho...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00316345
更新日期：1984-11-01 00:00:00
abstract：:Our previous study suggested the possibilities that dicyclanil (DC), a nongenotoxic carcinogen, produces oxidative stress in the liver of the two-stage hepatocarcinogenesis model of mice and the stress induced probably causes secondary oxidative DNA damage. However, clear evidences demonstrating the relationship betwe...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0086-0
更新日期：2006-10-01 00:00:00
abstract：:The effect of acute and subchronic acrylamide treatment on levels of dopamine, serotonin, and their metabolites was determined in several brain regions of the rat. Concentrations of several neuropeptides and circulating hormones were also measured. Both a single and repeated doses of acrylamide resulted in elevated le...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00317980
更新日期：1983-01-01 00:00:00
abstract：:In order to clarify the possible mechanism of hepatocarcinogenesis induced by piperonyl butoxide, we attempted to identify the transcription factor activated by piperonyl butoxide in the male ICR mouse liver. Administration of 0.6% piperonyl butoxide for 24 h elevated the level of liver nuclear proteins that bind to a...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-008-0283-0
更新日期：2008-10-01 00:00:00
