In vitro studies on the metabolism of aflatoxin B1 and aldrin in testes of genetically different strains of Drosophila melanogaster.

abstract：:Sulfur dioxide (SO2) is a common air pollutant, and inhaled SO2 in airway epithelium easily forms its soluble derivatives in vivo (bisulfite and sulfite), which are toxic to the respiratory system and related to the exacerbation of asthma. To investigate the effects of SO2 derivatives on the expressions of asthma rela...

journal_title：Archives of toxicology

authors： Li R,Meng Z

更新日期：2007-12-01 00:00:00

abstract：:Rats were coexposed to lead (Pb) and Copper (Cu) through drinking water and intraperitoneally, respectively, for a period of 21 days. Neurochemical studies in these rats showed significant reduction in the activity of adenosine triphosphatase, cytochrome-c-oxidase, diaphorase and in the levels of biogenic amines in th...

journal_title：Archives of toxicology

authors： Malhotra KM,Shukla GS,Chandra SV

更新日期：1982-03-01 00:00:00

abstract：:Using the rat liver foci bioassay a dose-response relationship was evaluated for the promoting activity of the ubiquitous and persistent environmental pollutants polychlorinated biphenyls (PCBs) and chloroform. Initiation of liver foci was performed by oral administration of a single dose of 8 mg/kg body wt of diethyl...

journal_title：Archives of toxicology

authors： Deml E,Oesterle D

更新日期：1987-01-01 00:00:00

abstract：:Genistein and daidzein are the main isoflavones in soy. Their potential beneficial or adverse effects in males like the prevention of prostate cancer or the impact on reproductive functions are controversially discussed. Major determinants of their bioactivity are the absorption and biotransformation of isoflavones. I...

journal_title：Archives of toxicology

authors： Soukup ST,Müller DR,Kurrat A,Diel P,Kulling SE

更新日期：2017-04-01 00:00:00

abstract：:The routinely used analytical method for detecting the abuse of anabolic steroids only allows the detection of molecules with known analytical properties. In our supplementary approach to structure-independent detection, substances are identified by their biological activity. In the present study, urines excreted afte...

journal_title：Archives of toxicology

authors： Wolf S,Diel P,Parr MK,Rataj F,Schänzer W,Vollmer G,Zierau O

更新日期：2011-04-01 00:00:00

abstract：:Insulin analogues are widely used in clinical practice. Modifications on the insulin molecular structure can affect the affinity and activation towards two closely related receptor tyrosine kinases: the insulin receptor (INSR) and the insulin-like growth factor 1 receptor (IGF1R). A switch towards higher IGF1R affinit...

journal_title：Archives of toxicology

authors： ter Braak B,Siezen CL,Kannegieter N,Koedoot E,van de Water B,van der Laan JW

更新日期：2014-04-01 00:00:00

abstract：:A study was conducted to determine the levels of cis-diamminedichloroplatinum (II) (cisplatin) in plasma proteins and hemoglobin of cancer patients after cisplatin chemotherapy. Thirty-seven cancer patients with different type of cancers (lung, esophageal, urinary tract, and testicular cancer, melanoma, osteosarcoma e...

journal_title：Archives of toxicology

authors： Mustonen R,Hietanen P,Leppälä S,Takala M,Hemminki K

更新日期：1989-01-01 00:00:00

abstract：:Sertoli cells play a critical role in spermatogenesis, and in adults, they are terminally differentiated with loss of proliferative activity. This study revealed Sertoli cell proliferation in 17-week-old Sprague-Dawley rats whose dams had been intragastrically administered 250 ng of 3,3',4,4',5-pentachlorobiphenyl/kg ...

journal_title：Archives of toxicology

authors： Wakui S,Muto T,Suzuki Y,Takahashi H,Hano H

更新日期：2012-01-01 00:00:00

abstract：:Possible induction of chromosomal aberrations and/or sister chromatid exchanges by astemizole was studied in vitro on human lymphocytes. In vivo chromosomal damage was assessed by a micronucleus test on rats and a dominant lethal test on both male and female mice. All these tests yielded negative results for astemizol...

journal_title：Archives of toxicology

authors： Vanparys P,Fabry L,Léonard A,Marsboom R

更新日期：1982-07-01 00:00:00

abstract：:Neutrophils infiltrate tissues during inflammation, and when activated, they release β-glucuronidase. Since inflammation is associated with carcinogenesis, we investigated how extracellular β-glucuronidase changed the in vitro cellular response to the chemical carcinogen benzo(a)pyrene (B[a]P). For this we exposed hum...

journal_title：Archives of toxicology

authors： Shi Q,Haenen GR,Maas L,Arlt VM,Spina D,Vasquez YR,Moonen E,Veith C,Van Schooten FJ,Godschalk RWL

更新日期：2016-09-01 00:00:00

abstract：:The organophosphorus (OP) pesticide malathion is a neurotoxic compound whose acute toxicity is primarily caused by the inhibition of acetylcholinesterase (AChE), leading to cholinergic syndrome-related symptoms. Some lines of evidence indicate that long-term exposure to low levels of OP may produce neuropsychiatric an...

journal_title：Archives of toxicology

authors： dos Santos AA,Naime AA,de Oliveira J,Colle D,dos Santos DB,Hort MA,Moreira EL,Suñol C,de Bem AF,Farina M

更新日期：2016-03-01 00:00:00

abstract：:Emerging mycotoxins produced by Alternaria spp. were previously reported to exert cytotoxic, genotoxic, but also estrogenic effects in human cells. The involved mechanisms are very complex and not fully elucidated yet. Thus, we followed an in silico target fishing approach to extend knowledge on the possible biologica...

journal_title：Archives of toxicology

authors： Aichinger G,Dellafiora L,Pantazi F,Del Favero G,Galaverna G,Dall'Asta C,Marko D

更新日期：2020-06-01 00:00:00

abstract：:The trichothecene mycotoxin deoxynivalenol (DON) is produced in wheat, barley and corn following infestation by the fungus Fusarium in the field and during storage. Colloquially known as "vomitoxin" because of its emetic effects in pigs, DON has been associated with human gastroenteritis. Since DON is commonly detecte...

journal_title：Archives of toxicology

authors： Pestka JJ

更新日期：2010-09-01 00:00:00

abstract：:Adverse outcome pathways (AOPs) have been recently introduced as tools to map the mechanisms underlying toxic events relevant for chemical risk assessment. AOPs particularly depict the linkage between a molecular initiating event and an adverse outcome through a number of intermediate key events. An AOP has been previ...

journal_title：Archives of toxicology

authors： Gijbels E,Vilas-Boas V,Annaert P,Vanhaecke T,Devisscher L,Vinken M

更新日期：2020-04-01 00:00:00

abstract：:The toxicity of 60 micrograms/kg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) given IP in corn oil/5% acetone was examined in male Sprague-Dawley rats adapted to 25 degrees C or 4 degrees C ambient temperature. Cold exposure significantly reduced mean time to death and tended to increase mortality. Body weight at the ti...

journal_title：Archives of toxicology

authors： Rozman K,Greim H

更新日期：1986-12-01 00:00:00

abstract：:We previously reported a novel toxic peptide identified from the anthozoan Protopalythoa variabilis transcriptome which is homologous to a novel structural type of sodium channel toxin isolated from a parental species (Palythoa caribaeorum). The peptide was named, according to its homologous, as Pp V-shape α-helical p...

journal_title：Archives of toxicology

authors： Liao Q,Li S,Siu SWI,Morlighem JRL,Wong CTT,Wang X,Rádis-Baptista G,Lee SM

更新日期：2019-01-01 00:00:00

abstract：:The aim of our study was to determine the period of maximum sensitivity for the induction of characteristic malformations with thalidomide (TH) in Himalayan rabbits. TH was administered orally in different doses (50, 100, 150 and 200 mg/kg) four times at 24-h intervals starting at 192 h of gestation. The malformations...

journal_title：Archives of toxicology

authors： Sterz H,Nothdurft H,Lexa P,Ockenfels H

更新日期：1987-07-01 00:00:00

abstract：:A number of industrial chemicals and therapeutic agents cause liver tumors in rats and mice by activating the nuclear receptor peroxisome proliferator-activated receptor α (PPARα). The molecular and cellular events by which PPARα activators induce rodent hepatocarcinogenesis have been extensively studied elucidating a...

journal_title：Archives of toxicology

authors： Corton JC,Peters JM,Klaunig JE

更新日期：2018-01-01 00:00:00

abstract：:A number of studies have evaluated the possibility that stress-induced changes in blood-brain barrier permeability enhanced the central effects of the carbamate acetylcholinesterase inhibitor, pyridostigmine. We previously found relatively little evidence of stress-induced changes in the acute toxicity of pyridostigmi...

journal_title：Archives of toxicology

authors： Baireddy P,Mirajkar N,Nallapaneni A,Singleton N,Pope CN

更新日期：2007-04-01 00:00:00

abstract：:The lacrimatory agent CS was examined for genotoxic properties. In vitro, Salmonella typhimurium was exposed to CS at concentrations up to 1.5 mg per plate and reverse mutations were assayed. In vivo: male Drosophilae were fed with CS and sex-linked recessive lethal mutations in sperm cells were assayed using the Basc...

journal_title：Archives of toxicology

authors： Wild D,Eckhardt K,Harnasch D,King MT

更新日期：1983-10-01 00:00:00

abstract：:Intravenous administration of lead acetate to rabbits for 10 weeks at 2 week intervals resulted in significantly elevated blood lead levels, slight anemia with marked microspherocytosis and moderate basophilic stippling, and marked depression of red cell delta-aminolevulinic acid (ALA) dehydratase activity. However th...

journal_title：Archives of toxicology

authors： Fujii H

更新日期：1979-10-01 00:00:00

abstract：:A series of experiments was set up to elucidate the effects of pollution on marine and estuarine fish health, since the European flounder (Platichthys flesus) has shown a relatively high prevalence of (pre)neoplastic liver lesions and lymphocystis virus disease in Dutch coastal and estuarine waters. The hypothesis of ...

journal_title：Archives of toxicology

authors： Grinwis GC,van den Brandhof EJ,Engelsma MY,Kuiper RV,Vaal MA,Vethaak AD,Wester PW,Vos JG

更新日期：2001-04-01 00:00:00

abstract：: ...

journal_title：Archives of toxicology

authors： Murad W,Abbass T,Seddek AL

更新日期：2018-11-01 00:00:00

abstract：:The uncertainties that surround the methods used for risk assessment of exposure to carcinogens have been highlighted by a recent document advocating an approach based on the T25 dose (the dose giving a 25% incidence of cancer in an appropriately designed animal experiment). This method relies on derivation of the T25...

journal_title：Archives of toxicology

authors： Roberts RA,Crump KS,Lutz WK,Wiegand HJ,Williams GM,Harrison PT,Purchase IF

更新日期：2001-11-01 00:00:00

abstract：:Pregnane X receptor (PXR) is a nuclear receptor that plays a key regulatory role in xenobiotic metabolism in a ligand-dependent manner. Recently, ethanol was reported to be either an inducer or inhibitor of Cytochrome P450 (CYP) 3A expression. According to our recent microarray data, chronic ethanol upregulates the ex...

journal_title：Archives of toxicology

authors： Je YT,Sim WC,Kim DG,Jung BH,Shin HS,Lee BH

更新日期：2015-04-01 00:00:00

abstract：:Morphological changes in mitochondria are observed early in the course of acetaminophen (AA)-induced hepatotoxicity, and mitochondrial dysfunction has been observed both in vivo and in vitro following exposure to AA. This study examined the early effects of AA exposure in vivo on mitochondrial respiration and evaluate...

journal_title：Archives of toxicology

authors： Donnelly PJ,Walker RM,Racz WJ

更新日期：1994-01-01 00:00:00

abstract：:Some nucleoside analogues are used to treat herpes simplex and other viral infections. They are known to impair spermatogenesis, but published data are scarce. We studied the effects of four nucleosides on SerW3 cells, a rat Sertoli cell line. Cells were cultured for 3 days in DMEM supplemented with four different con...

journal_title：Archives of toxicology

authors： Qiu R,Horvath A,Stahlmann R

更新日期：2016-08-01 00:00:00

abstract：:Effects of the oxime HI-6, unrelated to reactivation of acetylcholinesterase (AChE), on field potentials in the dentate gyrus of the rat hippocampus following AChE inhibition, were investigated both in vitro and in vivo. In hippocampal slices, AChE inhibition decreased the perforant path evoked population spike amplit...

journal_title：Archives of toxicology

authors： Melchers BP,van der Laaken AL,Busker RW,Bruijnzeel PL,Van Helden HP

更新日期：1994-01-01 00:00:00

abstract：:In vitro assays are often used for the hazard characterisation of compounds, but their application for quantitative risk assessment purposes is limited. This is because in vitro assays cannot provide a complete in vivo dose-response curve from which a point of departure (PoD) for risk assessment can be derived, like t...

journal_title：Archives of toxicology

authors： Strikwold M,Spenkelink B,Woutersen RA,Rietjens IM,Punt A

更新日期：2013-09-01 00:00:00

abstract：:As part of a study on cadmium nephrotoxicity, we studied the effect of cadmium chloride (CdCl2) in isolated human renal proximal tubules metabolizing the physiological substrate lactate. Dose-effect experiments showed that 10-500 μM CdCl2 reduced lactate removal, glucose production and the cellular levels of ATP, coen...

journal_title：Archives of toxicology

authors： Faiz H,Conjard-Duplany A,Boghossian M,Martin G,Baverel G,Ferrier B

更新日期：2011-09-01 00:00:00