Hepatic zonation of toxic metabolite formation: perspectives of matrix-assisted laser desorption mass spectrometry imaging.




Arch Toxicol


Archives of toxicology


Murad W,Abbass T,Seddek AL





2018-11-01 00:00:00














  • Nephrotoxicity of 4-cycloocten-1-carbaldehyde.

    abstract::Natural and synthetic chemicals are often used in the fragrance industry. A toxicological profile of the synthetic fragrance booster, 4-cycloocten-1-carbaldehyde, was generated using a test program including the following methods: acute oral toxicity, acute dermal toxicity, acute skin and eye irritation, skin sensitiz...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Messinger H,Kleber M,Aulmann W

    更新日期:2004-12-01 00:00:00

  • Synthetic cannabinoid CP-55,940 induces apoptosis in a human skeletal muscle model via regulation of CB1 receptors and L-type Ca2+ channels.

    abstract::Rhabdomyolysis has been reported in patients who abuse synthetic cannabinoids. However, no studies have yet assessed whether these cases reflect the direct cytotoxicity of synthetic cannabinoids on skeletal muscle, a possibility that the present study sought to address. Specifically, this study investigated the cytoto...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Tomiyama KI,Funada M

    更新日期:2020-11-10 00:00:00

  • In utero exposure to nicotine and chlorpyrifos alone, and in combination produces persistent sensorimotor deficits and Purkinje neuron loss in the cerebellum of adult offspring rats.

    abstract::This study was carried out to investigate the effect of in utero exposure to the cholinotoxicants, nicotine and chlorpyrifos, alone or in combination on neurobehavioral alterations and neuronal morphology latter in adult age. In the present study, 90 days old (corresponding to a human adult age) male and female offspr...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Abou-Donia MB,Khan WA,Dechkovskaia AM,Goldstein LB,Bullman SL,Abdel-Rahman A

    更新日期:2006-09-01 00:00:00

  • A novel genotoxicity assay of carbon nanotubes using functional macrophage receptor with collagenous structure (MARCO)-expressing chicken B lymphocytes.

    abstract::Although carbon nanotubes (CNTs) are promising nanomaterials, their potential carcinogenicity is a major concern. We previously established a genetic method of analyzing genotoxicity of chemical compounds, where we evaluated their cytotoxic effect on the DT40 lymphoid cell line comparing DNA-repair-deficient isogenic ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Mohiuddin,Keka IS,Evans TJ,Hirota K,Shimizu H,Kono K,Takeda S,Hirano S

    更新日期:2014-01-01 00:00:00

  • Arsenic-containing hydrocarbons: effects on gene expression, epigenetics, and biotransformation in HepG2 cells.

    abstract::Arsenic-containing hydrocarbons (AsHCs), a subgroup of arsenolipids found in fish and algae, elicit substantial toxic effects in various human cell lines and have a considerable impact on cellular energy levels. The underlying mode of action, however, is still unknown. The present study analyzes the effects of two AsH...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Müller SM,Finke H,Ebert F,Kopp JF,Schumacher F,Kleuser B,Francesconi KA,Raber G,Schwerdtle T

    更新日期:2018-05-01 00:00:00

  • Studies on the toxicology of hexachlorobenzene. I. Pharmacokinetics.

    abstract::In female rats dosed orally with 14C-hexachlorobenzene the extent of intestinal absorption of carbon-14 has been found to be dependent on the form of application. When the substance was given as a solution in oil about 80% of the dose administered was absorbed, but when given as an aqueous suspension only 6%. In anima...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Koss G,Koransky W

    更新日期:1975-11-20 00:00:00

  • Urinary trehalase as an early indicator of cadmium-induced renal tubular damage in rabbit.

    abstract::The significance of urinary trehalase as a possible early indicator of renal disorder was examined using Cd-treated rabbits, which received 1 mg/kg Cd thrice weekly for 3 months subcutaneously. The results showed that urinary trehalase increased significantly from 1 week after treatment, earlier than LAP, ALP, protein...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Nishimura N,Oshima H,Nakano M

    更新日期:1986-12-01 00:00:00

  • Standardisation of defined approaches for skin sensitisation testing to support regulatory use and international adoption: position of the International Cooperation on Alternative Test Methods.

    abstract::Skin sensitisation is the regulatory endpoint that has been at the centre of concerted efforts to replace animal testing in recent years, as demonstrated by the Organisation for Economic Co-operation and Development (OECD) adoption of five non-animal methods addressing mechanisms under the first three key events of th...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Casati S,Aschberger K,Barroso J,Casey W,Delgado I,Kim TS,Kleinstreuer N,Kojima H,Lee JK,Lowit A,Park HK,Régimbald-Krnel MJ,Strickland J,Whelan M,Yang Y,Zuang V

    更新日期:2018-02-01 00:00:00

  • Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on maternal immune response during pregnancy.

    abstract::Whether pregnancy-induced immunosuppression when combined with exposure to 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) could exacerbate immunotoxicity has not been previously investigated. The current study evaluated the immune status of C57BL/6 pregnant and virgin mice following exposure to TCDD. To this end, syngene...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Camacho IA,Nagarkatti M,Nagarkatti PS

    更新日期:2004-05-01 00:00:00

  • Effect of acrylamide on neurotransmitter metabolism and neuropeptide levels in several brain regions and upon circulating hormones.

    abstract::The effect of acute and subchronic acrylamide treatment on levels of dopamine, serotonin, and their metabolites was determined in several brain regions of the rat. Concentrations of several neuropeptides and circulating hormones were also measured. Both a single and repeated doses of acrylamide resulted in elevated le...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Ali SF,Hong JS,Wilson WE,Uphouse LL,Bondy SC

    更新日期:1983-01-01 00:00:00

  • Resveratrol protects primary cilia integrity of human mesenchymal stem cells from cigarette smoke to improve osteogenic differentiation in vitro.

    abstract::Several studies have explored the negative effects of cigarette smoke on bone healing; however, the complex pathogenesis still remains unclear. One crucial and primary factor determining effective fracture repair is the recruitment and differentiation of mesenchymal stem cells (MSCs) into bone-forming cells. Recently,...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Sreekumar V,Aspera-Werz R,Ehnert S,Strobel J,Tendulkar G,Heid D,Schreiner A,Arnscheidt C,Nussler AK

    更新日期:2018-04-01 00:00:00

  • NF-κB in cancer therapy.

    abstract::The transcription factor nuclear factor kappa B (NF-κB) has attracted increasing attention in the field of cancer research from last few decades. Aberrant activation of this transcription factor is frequently encountered in a variety of solid tumors and hematological malignancies. NF-κB family members and their regula...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,评审


    authors: Li F,Zhang J,Arfuso F,Chinnathambi A,Zayed ME,Alharbi SA,Kumar AP,Ahn KS,Sethi G

    更新日期:2015-05-01 00:00:00

  • Toxic response of graphene nanoplatelets in vivo and in vitro.

    abstract::With the development of nanotechnology, myriad types of novel materials have been discovered at the nanoscale, among which the most interesting material is graphene. However, the toxicity data available on graphene are extremely limited. In this study, we explored toxic response of commercially available graphene nano...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Park EJ,Lee GH,Han BS,Lee BS,Lee S,Cho MH,Kim JH,Kim DW

    更新日期:2015-09-01 00:00:00

  • Determination of urinary thymidine glycol using affinity chromatography, HPLC and post-column reaction detection: a biomarker of oxidative DNA damage upon kidney transplantation.

    abstract::Reactive oxygen species are generated during ischaemia-reperfusion of tissue. Oxidation of thymidine by hydroxyl radicals (HO) leads to the formation of 5,6-dihydroxy-5,6-dihydrothymidine (thymidine glycol). Thymidine glycol is excreted in urine and can be used as biomarker of oxidative DNA damage. Time dependent chan...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Thier R,Brüning T,Kocher K,Blaszkewicz M,Makropoulos V,Sundberg A,Bolt HM

    更新日期:1999-11-01 00:00:00

  • Electroretinographic assessment of early retinopathy in rats.

    abstract::Amoscanate, a substance which damages photoreceptors, was administered orally to Wistar rats in doses of 10, 40, and 125 mg/kg body weight once daily for 3 or 10 days. At both times electroretinographic, ophthalmological, and histopathological examinations of the retina were carried out to compare the sensitivity of c...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Maertins T,Kroetlinger F,Sander E,Pauluhn J,Machemer L

    更新日期:1993-01-01 00:00:00

  • 3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo.

    abstract::Liver disease is an escalating global health issue. While liver transplantation is an effective mode of therapy, patient mortality has increased due to the shortage of donor organs. Developing renewable sources of human liver tissue is therefore attractive. Pluripotent stem cell-derived liver tissue represents a poten...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Rashidi H,Luu NT,Alwahsh SM,Ginai M,Alhaque S,Dong H,Tomaz RA,Vernay B,Vigneswara V,Hallett JM,Chandrashekran A,Dhawan A,Vallier L,Bradley M,Callanan A,Forbes SJ,Newsome PN,Hay DC

    更新日期:2018-10-01 00:00:00

  • Oxime-type acetylcholinesterase reactivators in pregnancy: an overview.

    abstract::Oxime-type acetylcholinesterase reactivators (oxime-AChER) are used as an adjunct in the treatment for organophosphorus anticholinesterase poisoning. Because of the widespread usage and exposure of organophosphorus compounds (OPCs), its poisoning and fatalities is obvious in pregnant women, embryos and fetuses. OPCs i...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,评审


    authors: Nurulain SM,Kornelia T,Naqvi SN,Sharma C,Ojha S,Adem A

    更新日期:2014-03-01 00:00:00

  • Hair analysis for drugs of abuse. IV. Determination of total morphine and confirmation of 6-acetylmorphine in monkey and human hair by GC/MS.

    abstract::The reliable analytical method for total morphine in hair was established by GC/MS-SIM. The calibration curve for morphine in hair showed linear over 0.5-100 ng/mg hair. Though the limit of detection was 0.1 ng/mg hair with an S/N > 3 of the base ion(m/z 429) for morphine, the limit of confirmation by detection of thr...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Nakahara Y,Takahashi K,Shimamine M,Saitoh A

    更新日期:1992-01-01 00:00:00

  • Sweat gland toxicity induced by bis (tributyltin) oxide: an ultrastructural and X-ray microanalysis study.

    abstract::Acute toxicity of bis (tributyltin) oxide in the sweat glands in the rat footpad was investigated by electron microscopy and an energy-dispersive X-ray microanalyzer. Male Wistar rats received an intramuscular injection of 0.5 ml/kg bis (tributyltin) oxide. After 6-8 h, swelling of mitochondria appeared in the secreto...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Yamamoto O,Doi Y,Kudo H,Yoshizuka M,Fujimoto S

    更新日期:2000-12-01 00:00:00

  • Effects of acetone administration on cytochrome P-450-dependent monooxygenases in hamster liver, kidney, and lung.

    abstract::The effects of acetone on liver, kidney, and lung monooxygenases were studied using hamsters administered 8% acetone in drinking water. Binding of aniline to liver microsomes induced a type II difference spectrum, and the spectral binding was enhanced in hamsters pretreated with acetone. Administration of acetone caus...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Ueng TH,Tsai JN,Ju JM,Ueng YF,Iwasaki M,Guengerich FP

    更新日期:1991-01-01 00:00:00

  • Structure-toxicity relationship of ethylene glycol ethers.

    abstract::The ultimate purpose of the present study was to evaluate correlations between acute in vivo and in vitro toxicity and log P (P is n-octanol-water partition coefficient). The in vitro toxicity to cloned cells (neuroblastoma N18TG-2 and glioma C6) in culture (ED50) and the in vivo toxicity to mice (LD50) of ethylene gl...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Tanii H,Saito S,Hashimoto K

    更新日期:1992-01-01 00:00:00

  • Hashish smoking and T-lymphocytes.

    abstract::To investigate the effect of long term hashish use on T-lymphocytes we have measured the incorporation of 14C-thymidine by peripheral blood lymphocytes, unstimulated and stimulated by phytohemagglutinin, as well as the proportion and number of E-rosettes in 12 healthy male chronic users of the drug before and after a ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Kaklamani E,Trichopoulos D,Koutselinis A,Drouga M,Karalis D

    更新日期:1978-04-27 00:00:00

  • Driving gradual endogenous c-myc overexpression by flow-sorting: intracellular signaling and tumor cell phenotype correlate with oncogene expression.

    abstract::Insulin-exposed rat mammary cancer cells were flow sorted based on a c-myc reporter plasmid encoding a destabilized green fluorescent protein. Sorted cells exhibited gradual increases in c-myc levels. Cells overexpressing c-myc by only 10% exhibited phenotypic changes attributable to c-myc overexpression, such as cell...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Knudsen KJ,Nelander Holm GM,Krabbe JS,Listov-Saabye N,Kiehr B,Dufva M,Svendsen JE,Oleksiewicz MB

    更新日期:2009-12-01 00:00:00

  • Human CYP2E1 mediates the formation of glycidamide from acrylamide.

    abstract::Regarding the cancer risk assessment of acrylamide (AA) it is of basic interest to know, as to what amount of the absorbed AA is metabolized to glycidamide (GA) in humans, compared to what has been observed in laboratory animals. GA is suspected of being the ultimate carcinogenic metabolite of AA. From experiments wit...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Settels E,Bernauer U,Palavinskas R,Klaffke HS,Gundert-Remy U,Appel KE

    更新日期:2008-10-01 00:00:00

  • Absorption and metabolism of the food contaminant 3-chloro-1,2-propanediol (3-MCPD) and its fatty acid esters by human intestinal Caco-2 cells.

    abstract::3-Chloro-1,2-propanediol (3-MCPD) fatty acid esters are formed upon thermal processing of fat-containing foods in the presence of chloride ions. Upon hydrolytic cleavage, these substances could release free 3-MCPD. This compound is toxicologically well characterised and displayed cancerogenic potential in rodent model...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Buhrke T,Weisshaar R,Lampen A

    更新日期:2011-10-01 00:00:00

  • Acute and subacute inhalation toxicity of dichlorosilane in male ICR mice.

    abstract::Using male ICR mice, the LC50 and acute and subacute inhalation toxicity of dichlorosilane (SiH2Cl2, DCS) and the fate of DCS released into the air were investigated. DCS resolved and minute particles including silicon and chloride were observed, when DCS was released into the air. Most particles were under 1 micron i...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Nakashima H,Omae K,Takebayashi T,Ishizuka C,Sakurai H,Yamazaki K,Nakaza M,Shibata T,Kudo M,Koshi S

    更新日期:1996-01-01 00:00:00

  • Use of M-mode and Doppler echocardiography to investigate the cardiotoxicity of minoxidil in beagle dogs.

    abstract::Doppler and M-mode echocardiography (EC) were used to investigate the effects of minoxidil on the cardiac function of the dog and potentially to clarify the pathogenesis of cardiac lesions, in particular the necrotic lesion in the left ventricle and the haemorrhagic lesion in the right atrium. Groups of three dogs wer...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Hanton G,Gautier M,Bonnet P

    更新日期:2004-01-01 00:00:00

  • Exploring sex differences in human health risk assessment for PFNA and PFDA using a PBPK model.

    abstract::Perfluorononanoic acid (PFNA) and perfluorodecanoic acid (PFDA), which are classified as perfluoroalkyl and polyfluoroalkyl substances (PFASs), have been widely used in industrial applications as a surface protectant. PFASs have been detected in wildlife and in humans around the globe. The purposes of this study are t...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Kim SJ,Choi EJ,Choi GW,Lee YB,Cho HY

    更新日期:2019-02-01 00:00:00

  • The isoflavone irilone contributes to the estrogenic potential of dietary supplements containing red clover.

    abstract::A recent intervention study demonstrated the occurrence of irilone as second most abundant isoflavone next to daidzein in human plasma after consumption of a red clover-based dietary supplement (RCDS) containing predominately formononetin ≫ biochanin A > irilone (12 % of these isoflavones). To elucidate the relevance ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Lutter S,Schmalbach K,Esch HL,Lehmann L

    更新日期:2014-02-01 00:00:00

  • Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells.

    abstract::Etoposide (ETP) and anthracyclines are applied for wide anti-cancer treatments. However, the ETP-induced cardiotoxicity remains to be a major safety issue and the underlying cardiotoxic mechanisms are not well understood. This study is aiming to unravel the cardiotoxicity profile of ETP in comparison to anthracyclines...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Nemade H,Chaudhari U,Acharya A,Hescheler J,Hengstler JG,Papadopoulos S,Sachinidis A

    更新日期:2018-04-01 00:00:00