Hepatic zonation of toxic metabolite formation: perspectives of matrix-assisted laser desorption mass spectrometry imaging.

abstract：:The regional distribution of dopamine, norepinephrine and homovanillic acid was assessed in adult male rabbits exposed to styrene vapours. The turnover of dopamine and norepinephrine was also measured in several brain regions by the decay in endogenous catecholamines after inhibition of tyrosine hydroxylase by alpha-m...

journal_title：Archives of toxicology

authors： Mutti A,Falzoi M,Romanelli A,Franchini I

更新日期：1984-09-01 00:00:00

abstract：:Phenobarbital pretreatment (50 mg/kg/day for 3 days orally) of male Wistar rats increased Vmax of benzene in vitro hepatic microsomal biotransformation about 6-fold without changing Km. However, benzene blood levels after oral, intraperitoneal, or subcutaneous benzene administration (3-3.5 mmoles/kg) were not influenc...

journal_title：Archives of toxicology

authors： Gut I

更新日期：1976-06-08 00:00:00

abstract：:Heat shock proteins (HSPs) are a group of proteins that are rapidly induced in response to physiological stress, including hyperthermia and exposure to toxicants. Thus they may provide a useful index of toxicity in in vitro systems for screening for toxicity. We have recently developed a rat nasal explant system for i...

journal_title：Archives of toxicology

authors： Simpson SA,Alexander DJ,Reed CJ

更新日期：2004-06-01 00:00:00

abstract：:Unfolded protein response (UPR) and endoplasmic reticulum (ER)-phagy are essential for cell homeostasis. Quantum dots (QDs), which have been widely used for biomedical applications, can accumulate in the kidney tissues and may cause renal dysfunction. However, the molecular mechanism of QDs-induced nephrotoxicity is s...

journal_title：Archives of toxicology

authors： Jiang S,Lin Y,Yao H,Yang C,Zhang L,Luo B,Lei Z,Cao L,Lin N,Liu X,Lin Z,He C

更新日期：2018-04-01 00:00:00

abstract：:Nanoparticles (NP) have a tendency to agglomerate after dispersion in physiological media, which can be prevented by the addition of serum. This may however result in modification of the toxic potential of particles due to the formation of protein corona. Our study aimed to analyze the role of serum that is added to i...

journal_title：Archives of toxicology

authors： Vranic S,Gosens I,Jacobsen NR,Jensen KA,Bokkers B,Kermanizadeh A,Stone V,Baeza-Squiban A,Cassee FR,Tran L,Boland S

更新日期：2017-01-01 00:00:00

abstract：:This is with reference to the note of the Editor-in-Chief of the Archives of Toxicology. ...

journal_title：Archives of toxicology

authors： Khan F,Niaz K,Ismail Hassan F,Abdollahi M

更新日期：2018-07-01 00:00:00

abstract：:Early hepatocyte death occurs in most liver injury cases and triggers liver inflammation, which in combination with other risk factors leads to the development of liver disease. However, the pathogenesis of early phase hepatocyte death remains poorly understood. Here, C57BL/6J mice were treated with the hepatotoxic dr...

journal_title：Archives of toxicology

authors： Song B,Aoki S,Liu C,Ito K

更新日期：2019-06-01 00:00:00

abstract：:Sulfites whether ingested or produced through the sulfur-containing amino acids metabolism of the animal are very active molecules and can cause cellular toxicity. Sulfite oxidase (SOX), a heme- and molybdenum containing mitochondrial enzyme, prevents mammalian cells from adverse effects of sulfite toxicity by metabol...

journal_title：Archives of toxicology

authors： Oztürk OH,Küçükatay V,Yönden Z,Ağar A,Bağci H,Delibaş N

更新日期：2006-10-01 00:00:00

abstract：:Due to its unique physical structure and chemical properties, graphene family nanomaterials (GFNs) and derived commodities have been widely used in commercial products, particularly biomedical applications, which has significantly increased the risk of human exposure. There exists significant evidence that GFNs are ac...

journal_title：Archives of toxicology

authors： Xiaoli F,Qiyue C,Weihong G,Yaqing Z,Chen H,Junrong W,Longquan S

更新日期：2020-06-01 00:00:00

abstract：:This study was performed to assess the relation between occupational exposure to N,N-dimethylformamide after an 8 h work shift in the acrylic fibre industry and its three biological markers N-methylformamide (NMFtotal), N-acetyl-S-(N-methylcarbamoyl)cysteine (AMCC), and N-methylcarbamoyl adduct at haemoglobin (MCVal)....

journal_title：Archives of toxicology

authors： Seitz M,Kilo S,Eckert E,Müller J,Drexler H,Göen T

更新日期：2018-07-01 00:00:00

abstract：:Dorsal root ganglia from control and methylmercury (MeHg)-treated rats were incubated in vitro with 35S-methionine ant the proteins synthesized were analyzed by two-dimensional electrophoresis. The double labelling method, in which proteins of control dorsal root ganglia labelled in vitro with 3H-leucine were added to...

journal_title：Archives of toxicology

authors： Kasama H,Itoh K,Omata S,Sugano H

更新日期：1989-01-01 00:00:00

abstract：:For ethical and regulatory reasons, in vitro tests for scoring potential toxicities of cosmetics are essential. A test strategy for investigating potential skin sensitization using two human keratinocytic and two human dendritic cell lines has been developed (Mehling et al. Arch Toxicol 86:1273–1295, 2012). Since proh...

journal_title：Archives of toxicology

authors： Fabian E,Vogel D,Blatz V,Ramirez T,Kolle S,Eltze T,van Ravenzwaay B,Oesch F,Landsiedel R

更新日期：2013-09-01 00:00:00

abstract：:The antidepressants, imipramine and mianserin, have been reported to cause liver damage. We investigated a role of cytochrome P450 (CYP)-mediated formation of a reactive metabolite in antidepressant-induced acute cell injury using hepatocytes isolated from male and female Wistar rats, and male Dark Agouti rats, which ...

journal_title：Archives of toxicology

authors： Masubuchi Y,Konishi M,Horie T

更新日期：1999-04-01 00:00:00

abstract：:UDP-glucuronosyltransferases (UGTs) are involved in phase II conjugation reactions of xenobiotics and differences in their isoform activities result in interindividual kinetic differences of UGT probe substrates. Here, extensive literature searches were performed to identify probe substrates (14) for various UGT isofo...

journal_title：Archives of toxicology

authors： Kasteel EEJ,Darney K,Kramer NI,Dorne JLCM,Lautz LS

更新日期：2020-08-01 00:00:00

abstract：:The influence of haemoperfusion on some immunological parameters was investigated in a pilot study involving two groups of three patients each. In columns containing cellulose-coated activated charcoal or polystyrene resin a temporary reduction of the total white cell number, particularly involving the segmented and b...

journal_title：Archives of toxicology

authors： Rommes JH,Sangster B,Gmelig Meyling FH,Daha MR,van Heijst AN

更新日期：1983-02-01 00:00:00

abstract：:Cytokeratins (CK) constitute a family of cytoskeletal intermediate filament proteins that are typically expressed in epithelial cells. An abnormal structure and function are effects that are clearly related to liver diseases as non-alcoholic steatohepatitis, cirrhosis and hepatocellular carcinoma. We have previously o...

journal_title：Archives of toxicology

authors： Gonsebatt ME,Del Razo LM,Cerbon MA,Zúñiga O,Sanchez-Peña LC,Ramírez P

更新日期：2007-09-01 00:00:00

abstract：:Epoxide hydrolases (EH) are ubiquitously expressed in all living organisms and in almost all organs and tissues. They are mainly subdivided into microsomal and soluble EH and catalyze the hydration of epoxides, three-membered-cyclic ethers, to their corresponding dihydrodiols. Owning to the high chemical reactivity of...

journal_title：Archives of toxicology

authors： El-Sherbeni AA,El-Kadi AO

更新日期：2014-11-01 00:00:00

abstract：:Diet is directly related with physiological alterations occurring at a cell and subcellular level. However, the role of diet manipulation on mitochondrial physiology is still largely unexplored. Aiming at correlating diet with alterations of mitochondrial membrane composition and bioenergetics, Wistar-Han male rats we...

journal_title：Archives of toxicology

authors： Monteiro JP,Pereira CV,Silva AM,Maciel E,Baldeiras I,Peixoto F,Domingues MR,Jurado AS,Oliveira PJ

更新日期：2013-12-01 00:00:00

abstract：:Mercury exists in the environment in various forms, all of which pose a risk to human health. Despite guidelines regulating the industrial release of mercury into the environment, humans continue to be exposed regularly to various forms of this metal via inhalation or ingestion. Following exposure, mercuric ions are t...

journal_title：Archives of toxicology

authors： Bridges CC,Zalups RK

更新日期：2017-01-01 00:00:00

abstract：:Inhalation exposure to toluene diisocyanate (TDI) can result in a variety of airway diseases. Concern has been expressed that a putative carcinogenic potential of TDI exists as a result of the formation of toluenediamine (TDA) by hydrolysis of the isocyanate in the body. Results from long-term bioassays (TDI inhalatio...

journal_title：Archives of toxicology

authors： Kennedy AL,Wilson TR,Stock MF,Alarie Y,Brown WE

更新日期：1994-01-01 00:00:00

abstract：:To investigate the mechanism on photosensitive dermatitis caused by ketoprofen (KP) in humans, the following experiments were performed by topical application on guinea pigs. The phototoxicity study involving treatment with 10% solution of KP, its enantiomers (R-KP and S-KP), loxoprofen, and flurbiprofen revealed no p...

journal_title：Archives of toxicology

authors： Nakazawa T,Shimo T,Chikamatsu N,Igarashi T,Nagata O,Yamamoto M

更新日期：2006-07-01 00:00:00

abstract：:The increasing number of man-made chemicals in the environment that may pose a carcinogenic risk emphasizes the need to develop reliable time- and cost-effective approaches for carcinogen detection. To address this issue, we have investigated the utility of human hepatocytes for the in vitro identification of genotoxi...

journal_title：Archives of toxicology

authors： Tryndyak V,Borowa-Mazgaj B,Beland FA,Pogribny IP

更新日期：2019-11-01 00:00:00

abstract：:High-dosage alcohol intoxication (i.e., binge drinking in humans) is an increasingly prevalent problem. Despite the well-known long-term consequences, the acute effects of high-dosage alcohol intoxication on cognitive control processes have not been investigated with respect to neurophysiological changes in humans. We...

journal_title：Archives of toxicology

authors： Stock AK,Blaszkewicz M,Beste C

更新日期：2014-02-01 00:00:00

abstract：:Many carcinogens and mutagens are electrophilic in nature and will react with nucleophilic sites in protein and nucleic acid. Determination of the extent of formation of these adducts of genotoxic agents with protein provides a practical method of monitoring human exposure and of determining the possible risk associat...

journal_title：Archives of toxicology

authors： Bailey E,Farmer PB,Shuker DE

更新日期：1987-01-01 00:00:00

abstract：:The routinely used analytical method for detecting the abuse of anabolic steroids only allows the detection of molecules with known analytical properties. In our supplementary approach to structure-independent detection, substances are identified by their biological activity. In the present study, urines excreted afte...

journal_title：Archives of toxicology

authors： Wolf S,Diel P,Parr MK,Rataj F,Schänzer W,Vollmer G,Zierau O

更新日期：2011-04-01 00:00:00

abstract：:People living in damp buildings are typically exposed to spore and mycelial fragments of the fungi that grow on damp building materials. There is experimental evidence that this exposure to triple-helical (1, 3)-β-D glucan and low molecular weight toxins may be associated with non-atopic asthma observed in damp and mo...

journal_title：Archives of toxicology

authors： Rand TG,Robbins C,Rajaraman D,Sun M,Miller JD

更新日期：2013-10-01 00:00:00

abstract：:The responsiveness of the hepatic supernatant NAD+-dependent aldehyde dehydrogenase with a high Km value (high Km-AldDH) to phenobarbital (PB) and 3-methylcholanthrene (3-MC) treatment was studied in male rats of three strains; Wistar, Long-Evans, and Sprague-Dawley. A remarkable strain difference in the response of t...

journal_title：Archives of toxicology

authors： Nakanishi S,Shiohara E,Tsukada M,Yamazaki H,Nishiguchi K,Saladin R

更新日期：1979-12-01 00:00:00

abstract：:The effects of a single dose of ethanol on the metabolism and toxicity of chloroform administered to rats per os (p.o.), intraperitoneally (i.p.), or by inhalation (inh) at different doses were investigated. Rats that had been given either ethanol (2 g/kg) or vehicle (water) alone at 4 p.m. on the previous day were ch...

journal_title：Archives of toxicology

authors： Wang PY,Kaneko T,Tsukada H,Sato A

更新日期：1994-01-01 00:00:00

abstract：:In mutagenicity testing of pharmaceuticals it is advisable, whenever possible, to use in vivo mammalian systems where the pharmacokinetic properties of a drug would be more or less similar to those in man. However, although there are a number of different genetic endpoints which are important in mutagen testing, suffi...

journal_title：Archives of toxicology

authors： Matter BE,Tsuchimoto T

更新日期：1980-11-01 00:00:00

abstract：:To reveal the molecular mechanism of deficit in learning and memory induced by chronic fluorosis, the expression of muscarinic acetylcholine receptors (mAChRs) and oxidative stress were investigated. Sixty Sprague-Dawley (SD) rats were divided randomly into two groups (30 cases in each), i.e., the control group (<0.5 ...

journal_title：Archives of toxicology

authors： Dong YT,Wang Y,Wei N,Zhang QF,Guan ZZ

更新日期：2015-11-01 00:00:00