Hepatic zonation of toxic metabolite formation: perspectives of matrix-assisted laser desorption mass spectrometry imaging.




Arch Toxicol


Archives of toxicology


Murad W,Abbass T,Seddek AL





2018-11-01 00:00:00














  • The effect of 1-deamino-2-tyr(ethyl) oxytocin upon peri- and postnatal development of the rat: growth retardation of the offspring.

    abstract::The effect of 1-deamino-2-tyr(ethyl) oxytocin (dEtOT) upon peri- and postnatal development of the rat was studied in two experiments when administered between day 15 of pregnancy and the day of parturition. The investigation showed that dEtOT did not affect the pups at birth, that dEtOT caused a dose-related growth re...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Magnusson G,Melin P

    更新日期:1985-09-01 00:00:00

  • Comparative analysis of phase I and II enzyme activities in 5 hepatic cell lines identifies Huh-7 and HCC-T cells with the highest potential to study drug metabolism.

    abstract::Primary human hepatocytes (hHeps) are still gold standard to perform human drug metabolism studies, but their availability is limited by donor organ scarcity. Therefore, hepatoma cell lines are widely used as alternatives, although their phases I and II drug-metabolizing activities are substantially lower compared wit...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Lin J,Schyschka L,Mühl-Benninghaus R,Neumann J,Hao L,Nussler N,Dooley S,Liu L,Stöckle U,Nussler AK,Ehnert S

    更新日期:2012-01-01 00:00:00

  • Ethylmorphine concentrations in human samples in an overdose case.

    abstract::Capillary gas chromatography coupled to mass spectrometry was employed to quantify ethylmorphine in biological fluids and tissues in a death attributed to oral ethylmorphine ingestion. The femoral blood concentration of the drug was 488 ng/ml. Hair analysis revealed the individual's drug abuse pattern, particularly th...

    journal_title:Archives of toxicology

    pub_type: 信件


    authors: Kintz P,Jamey C,Mangin P

    更新日期:1994-01-01 00:00:00

  • 25C-NBF, a new psychoactive substance, has addictive and neurotoxic potential in rodents.

    abstract::The use of new psychoactive substances (NPSs) as a substitute for illegal drugs is increasing rapidly and is a serious threat to public health. 25C-NBF is a newly synthesized phenethylamine-type NPS that acts as a 5-hydroxyindoleacetic acid (5-HT) receptor agonist, but little is known about its pharmacological effects...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Hur KH,Kim SE,Lee BR,Ko YH,Seo JY,Kim SK,Ma SX,Kim YJ,Jeong Y,Pham DT,Trinh QD,Shin EJ,Kim HC,Lee YS,Lee SY,Jang CG

    更新日期:2020-07-01 00:00:00

  • Effect of phenobarbital pretreatment on in vitro enzyme kinetics and in vivo biotransformation of benzene in the rat.

    abstract::Phenobarbital pretreatment (50 mg/kg/day for 3 days orally) of male Wistar rats increased Vmax of benzene in vitro hepatic microsomal biotransformation about 6-fold without changing Km. However, benzene blood levels after oral, intraperitoneal, or subcutaneous benzene administration (3-3.5 mmoles/kg) were not influenc...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Gut I

    更新日期:1976-06-08 00:00:00

  • Increased oxidative stress in subjects exposed to carbon disulfide (CS2)--an occupational coronary risk factor.

    abstract::There is considerable epidemiological evidence that workers exposed to carbon disulfide (CS2) develop premature atherosclerosis leading to increased rates of coronary heart disease (CHD), but mechanisms underlying this association remain obscure. The present study documents that occupational exposure to CS2 modifies t...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Wronska-Nofer T,Chojnowska-Jezierska J,Nofer JR,Halatek T,Wisniewska-Knypl J

    更新日期:2002-04-01 00:00:00

  • A simple transcriptomic signature able to predict drug-induced hepatic steatosis.

    abstract::It is estimated that only a few marketed drugs are able to directly induce liver steatosis. However, many other drugs may exacerbate or precipitate fatty liver in the presence of other risk factors or in patients prone to non-alcoholic fatty liver disease. On the other hand, current in vitro tests for drug-induced ste...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Benet M,Moya M,Donato MT,Lahoz A,Hervás D,Guzmán C,Gómez-Lechón MJ,Castell JV,Jover R

    更新日期:2014-04-01 00:00:00

  • Learning, memory and the expression of cholinergic components in mice are modulated by the pesticide chlorpyrifos depending upon age at exposure and apolipoprotein E (APOE) genotype.

    abstract::Polymorphisms of the apolipoprotein E (APOE) gene differentially affect neurobiological functions and cognitive performance and confer different vulnerabilities to subclinical exposures to chlorpyrifos (CPF), a pesticide used worldwide. The data reported on this topic suggest a complex interaction between cholinergic ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Basaure P,Guardia-Escote L,Cabré M,Peris-Sampedro F,Sánchez-Santed F,Domingo JL,Colomina MT

    更新日期:2019-03-01 00:00:00

  • Occupational exposure to cadmium: effect on metallothionein and other biological indices of exposure and renal function.

    abstract::The effect of duration of employment at a North American cadmium smelter on urinary metallothionein (MT), total protein, beta 2-microglobulin (beta 2-MG), glucose, cadmium, copper and zinc of 53 men was studied. The levels of all urinary parameters increased with the duration of employment. Smoking history did not aff...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Shaikh ZA,Tohyama C,Nolan CV

    更新日期:1987-02-01 00:00:00

  • [Cardiotoxicity of bromethylbutyramide (carbromide) (author's transl)].

    abstract::Bromethylbutyramide (Carbromide), a quantitatively important metabolite of carbromal, diminished the contractility of electrically driven and the frequency of spontaneously beating guinea-pig atria. The negative inotropic action of bromethylbutyramide occurred at concentrations which are reached in human carbromal poi...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Strubelt O

    更新日期:1978-04-27 00:00:00

  • Anticancer potential of myricetin bulk and nano forms in vitro in lymphocytes from myeloma patients.

    abstract::Evading apoptosis and chemo-resistance are considered as very important factors which help tumour progression and metastasis. Hence, to overcome chemo-resistance, there is an urgent requirement for emergence of more effective treatment options. Myricetin, a naturally occurring flavonoid, is present in various plant-de...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Akhtar S,Najafzadeh M,Isreb M,Newton L,Gopalan RC,Anderson D

    更新日期:2021-01-01 00:00:00

  • Possible role of the acetone-inducible cytochrome P-450IIE1 in the metabolism and hepatotoxicity of thiobenzamide.

    abstract::The effect of acetone pretreatment (5% in drinking water for 10 days on rat liver metabolism and toxicity of thiobenzamide (TB) was investigated. Hepatic microsomes from acetone-pretreated rats showed a significant increase of TB-S-oxidation rate which, on the basis of selective thermal inactivation of FAD-containing ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Chieli E,Saviozzi M,Puccini P,Longo V,Gervasi PG

    更新日期:1990-01-01 00:00:00

  • Nuclear aberrations in hair follicle cells of patients receiving cyclophosphamide. A possible in vivo assay for human exposure to genotoxic agents.

    abstract::The toxic effect of cyclophosphamide on the proliferative cell population of hair follicles plucked from the human scalp was examined by the in vivo nuclear aberration assay. Patients participating in an independent clinical trial received oral low dose cyclophosphamide, intravenous high dose cyclophosphamide or oral ...

    journal_title:Archives of toxicology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Goldberg MT,Tackaberry LE,Hardy MH,Noseworthy JH

    更新日期:1990-01-01 00:00:00

  • A study of adverse effects on the progeny after intoxication during pregnancy.

    abstract::The pregnancy outcomes of 109 women who were intoxicated during pregnancy due to excessive amounts of drugs and other agents were studied. Seventy per cent of the women attempted suicide, and the intoxication in 78% of all cases was caused by drugs. The stillbirth rate (4%) was higher than that in previous and subsequ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Czeizel A,Szentesi I,Szekeres I,Molnár G,Glauber A,Bucski P

    更新日期:1988-08-01 00:00:00

  • Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

    abstract::This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, zonated lobules, the liver consists of approximately 80 % hepatocytes and 20 % non-parenchymal cells, the latter being involved in a seco...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,评审


    authors: Godoy P,Hewitt NJ,Albrecht U,Andersen ME,Ansari N,Bhattacharya S,Bode JG,Bolleyn J,Borner C,Böttger J,Braeuning A,Budinsky RA,Burkhardt B,Cameron NR,Camussi G,Cho CS,Choi YJ,Craig Rowlands J,Dahmen U,Damm G,Dirsch

    更新日期:2013-08-01 00:00:00

  • Pulmonary clearance and inflammatory potency of intratracheally instilled or acutely inhaled nickel sulfate in rats.

    abstract::Rats were exposed to nickel sulfate (NiSO4) either by intratracheal (IT) instillation or by acute aerosol inhalation, and pulmonary clearance of Ni and pulmonary inflammatory responses were studied. The half-time of Ni in the lung (initial lung burden = 50 micrograms Ni/rat) was about 32 h in both the IT instillation ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Hirano S,Shimada T,Osugi J,Kodama N,Suzuki KT

    更新日期:1994-01-01 00:00:00

  • Experimental and computational insights on the recognition mechanism between the estrogen receptor α with bisphenol compounds.

    abstract::Certain bisphenols (BPs) have been regarded as endocrine-disrupting chemicals due to their structural similarities to bisphenol A (BPA), a well-known weak estrogenic chemical. However, very limited data are currently available on the relationship between estrogenic activity and the structure of BP analogs. Therefore, ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Cao H,Wang F,Liang Y,Wang H,Zhang A,Song M

    更新日期:2017-12-01 00:00:00

  • Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man.

    abstract::The current test systems employed by pharmaceutical industry are poorly predictive for drug-induced liver injury (DILI). The 'MIP-DILI' project addresses this situation by the development of innovative preclinical test systems which are both mechanism-based and of physiological, pharmacological and pathological releva...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,评审


    authors: Dragovic S,Vermeulen NP,Gerets HH,Hewitt PG,Ingelman-Sundberg M,Park BK,Juhila S,Snoeys J,Weaver RJ

    更新日期:2016-12-01 00:00:00

  • NF-κB in cancer therapy.

    abstract::The transcription factor nuclear factor kappa B (NF-κB) has attracted increasing attention in the field of cancer research from last few decades. Aberrant activation of this transcription factor is frequently encountered in a variety of solid tumors and hematological malignancies. NF-κB family members and their regula...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,评审


    authors: Li F,Zhang J,Arfuso F,Chinnathambi A,Zayed ME,Alharbi SA,Kumar AP,Ahn KS,Sethi G

    更新日期:2015-05-01 00:00:00

  • Testosterone hydroxylase in evaluating induction and suppression of murine CYP isoenzymes by fenarimol.

    abstract::This study aimed to investigate the effect of single and repeated administration of fenarimol on murine liver, kidney and lung microsomal CYP-catalyzed drug metabolism. The modulation of the regio- and stereo-selective hydroxylation of testosterone by fenarimol was considered in evaluating cocarcinogenic properties. I...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Paolini M,Pozzetti L,Mesirca R,Sapone A,Cantelli-Forti G

    更新日期:1996-01-01 00:00:00

  • Distribution of bisphenol A and tetrabromobisphenol A in quail eggs, embryos and laying birds and studies on reproduction variables in adults following in ovo exposure.

    abstract::In a previous study, we showed that bisphenol A (BPA) had oestrogen-like effects in bird embryos, causing malformations of the oviducts in Japanese quail (Coturnix japonica) and feminisation of the left testis in chicken (Gallus domesticus). In this study, uptake and distribution of BPA and tetrabromobisphenol A (TBBP...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Halldin K,Berg C,Bergman A,Brandt I,Brunström B

    更新日期:2001-12-01 00:00:00

  • Cytotoxic effects of 3,4-methylenedioxy-N-alkylamphetamines, MDMA and its analogues, on isolated rat hepatocytes.

    abstract::The amphetamine-derived designer drugs have been illegally used worldwide as recreational drugs, some of which are known to be hepatotoxic in humans. To compare their cytotoxic effects, 3,4-methylenedioxy-N-methamphetamine (MDMA) and its related analogues, N-methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine (MBDB), 3,4...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Nakagawa Y,Suzuki T,Tayama S,Ishii H,Ogata A

    更新日期:2009-01-01 00:00:00

  • In vitro studies on the metabolism of aflatoxin B1 and aldrin in testes of genetically different strains of Drosophila melanogaster.

    abstract::As Drosophila melanogaster occupies an important position within the test battery for mutagens and carcinogens, it is of interest to study the xenobiotics metabolism of this insect. Likewise, the genetic control of these important enzyme systems falls within this interest. Our attempt was to get new strains, which sho...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Foerster RE,Würgler FE

    更新日期:1984-11-01 00:00:00

  • Percutaneous absorption and metabolism of dinitrochlorobenzene in vitro.

    abstract::Dinitrochlorobenzene (DNCB) absorption through mouse and rat dorsal skin, pig ear skin and human abdominal skin in vitro was determined, and local metabolism to the glutathione conjugate was related to glutathione transferase activities and glutathione status in the skin. Absorption studies were conducted using skin m...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Jewell C,Heylings J,Clowes HM,Williams FM

    更新日期:2000-09-01 00:00:00

  • Gene expression profiling in the lung tissue of cynomolgus monkeys in response to repeated exposure to welding fumes.

    abstract::Many in the welding industry suffer from bronchitis, lung function changes, metal fume fever, and diseases related to respiratory damage. These phenomena are associated with welding fumes; however, the mechanism behind these findings remains to be elucidated. In this study, the lungs of cynomolgus monkeys were exposed...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Heo JD,Oh JH,Lee K,Kim CY,Song CW,Yoon S,Han JS,Yu IJ

    更新日期:2010-03-01 00:00:00

  • Experience with fixed-bred charcoal haemoperfusion in the treatment of severe drug intoxication.

    abstract::Fifteen patients who were severely poisoned with either hypnotic drugs or salicylate were treated by charcoal haemoperfusion. The device contained 100g of activated charcoal immobilised by fixation to a polyester film. Two patients showed no response and eventually died. The remainder showed marked lightening of coma ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Hampel G,Crome P,Widdop B,Goulding R

    更新日期:1980-07-01 00:00:00

  • Detection of early signals of hepatotoxicity by gene expression profiling studies with cultures of metabolically competent human hepatocytes.

    abstract::Xenobiotic induced liver injury is a leading cause for drug withdrawal and toxicogenomics may help to identify molecular causes. Here we report studies with cultures of human hepatocytes to detect early responses of liver toxicity upon treatment with the hepatotoxin Aroclor 1254. We studied transcript abundance of 302...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Thum T,Borlak J

    更新日期:2008-02-01 00:00:00

  • Species-specific pharmacokinetics of styrene in rat and mouse.

    abstract::The pharmacokinetics of styrene were investigated in male Sprague-Dawley rats and male B6C3F1 mice using the closed chamber technique. Animals were exposed to styrene vapors of initial concentrations ranging from 550 to 5000 ppm, or received intraperitoneal (i.p.) doses of styrene from 20 to 340 mg/kg or oral (p.o.) d...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Filser JG,Schwegler U,Csanády GA,Greim H,Kreuzer PE,Kessler W

    更新日期:1993-01-01 00:00:00

  • Acute and subacute inhalation toxicity of dichlorosilane in male ICR mice.

    abstract::Using male ICR mice, the LC50 and acute and subacute inhalation toxicity of dichlorosilane (SiH2Cl2, DCS) and the fate of DCS released into the air were investigated. DCS resolved and minute particles including silicon and chloride were observed, when DCS was released into the air. Most particles were under 1 micron i...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Nakashima H,Omae K,Takebayashi T,Ishizuka C,Sakurai H,Yamazaki K,Nakaza M,Shibata T,Kudo M,Koshi S

    更新日期:1996-01-01 00:00:00

  • Effect of transforming growth factor-beta1 on cytochrome P450 expression: inhibition of CYP1 mRNA and protein expression in primary rat hepatocytes.

    abstract::Primary hepatocytes are a widely used cell model to analyse the expression and regulation of hepatic cytochrome P450 (CYP) isoenzymes. Transforming growth factor-beta1 (TGF-beta1) was previously shown to inhibit constitutive and induced CYP1 expression in human cell lines and primary hepatocytes but not in rat cells. ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Müller GF,Döhr O,El-Bahay C,Kahl R,Abel J

    更新日期:2000-05-01 00:00:00