Abstract:
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journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Murad W,Abbass T,Seddek ALdoi
10.1007/s00204-018-2310-0subject
pub_date
2018-11-01 00:00:00pages
3435-3437issue
11eissn
0340-5761issn
1432-0738pii
10.1007/s00204-018-2310-0journal_volume
92pub_type
评论,信件abstract::Chronic exposure to inorganic arsenic (As) [As(III) + As(V)], which affects millions of people, increases the incidence of some kinds of cancer and other non-carcinogenic pathologies. Although the oral pathway is the main form of exposure, in vivo studies have not been conducted to verify the intestinal toxicity of th...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-019-02510-w
更新日期:2019-08-01 00:00:00
abstract::In recent years test systems have been described that may be applied routinely to discriminate between contact allergens and irritants in vitro. Using human monocyte-derived dendritic cells (MoDC), this study was designed to refine the settings of a potential routine screening protocol for contact allergens and to inv...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-004-0606-8
更新日期:2005-01-01 00:00:00
abstract::The activity of 18 vitamin D analogs on soft tissue calcification and growth impairment in neonatal rats and their effect on bone calcium mobilization, intestinal calcium absorption and binding to intestinal 1,25-dihydroxyvitamin D3 receptors in adult rats were compared. Depending on the chemical modification of the v...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00303129
更新日期:1989-01-01 00:00:00
abstract::The effect of culture medium on glutathione (GSH) dependent detoxification defence system of primary cultured hepatocyte from either male or female rats was studied. Intracellular reduced (GSH) and oxidized glutathione (GSSG), and six GSH-related enzyme activities, including GSH peroxidase (GSH Px), GSH reductase (GSH...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050345
更新日期:1996-01-01 00:00:00
abstract::Conventional in vitro toxicity studies have focused on identifying IC50 and the underlying mechanisms, but how toxicants influence biophysical and biomechanical changes in human cells, especially during developmental stages, remain understudied. Here, using an atomic force microscope, we characterized changes in bioph...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-019-02549-9
更新日期:2019-10-01 00:00:00
abstract::HCB was detected in all preparations of human placenta, maternal blood, milk, and cord blood. It was confirmed that HCB transferred from mother to fetus through the placenta. A significant linear correlation exists between the HCB concentration in placenta and that in cord blood. Therefore, the placental concentration...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00333426
更新日期:1985-01-01 00:00:00
abstract::MDMA-induced impairments of memory performance have been reported in different human and animal studies. However, the correlation between spatial memory impairment, brain mitochondrial function, and concentrations of MDMA and its metabolites has not yet been investigated despite it being needed for comparison with hum...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-020-02673-x
更新日期:2020-03-01 00:00:00
abstract::Prudhoe Bay crude oil (PBCO) and its aliphatic, aromatic and heterocyclic fractions were tested on the developing chick embryo for (i) embryotoxicity (ii) their ability to induce hepatic and renal cytochrome P450 levels as well as hepatic, renal and pulmonary aryl hydrocarbon hydroxylase activities. On the basis of it...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00302389
更新日期:1987-08-01 00:00:00
abstract::The metabolism of 74As-arsenate (As V, 0.4 mg As/kg body weight, IV) in marmoset monkeys (two males and two females) was studied. Unlike all other animal species studied so far, the marmoset was found to be unable to metabolize the arsenate to dimethylarsinic acid. Most of the absorbed arsenate was reduced to arsenite...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00343121
更新日期:1985-06-01 00:00:00
abstract::Phytoestrogens have been described as weak estrogens, selective estrogen receptor mediators (SERMs) or to exhibit antiestrogenic properties. However, information about their activity in combination with xenoestrogens and 17beta-estradiol in vivo, is limited. Therefore, the combinatory activity of the phytoestrogen gen...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-006-0102-4
更新日期:2006-12-01 00:00:00
abstract::The increasing number of man-made chemicals in the environment that may pose a carcinogenic risk emphasizes the need to develop reliable time- and cost-effective approaches for carcinogen detection. To address this issue, we have investigated the utility of human hepatocytes for the in vitro identification of genotoxi...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-019-02569-5
更新日期:2019-11-01 00:00:00
abstract::The toxicity of 60 micrograms/kg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) given IP in corn oil/5% acetone was examined in male Sprague-Dawley rats adapted to 25 degrees C or 4 degrees C ambient temperature. Cold exposure significantly reduced mean time to death and tended to increase mortality. Body weight at the ti...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00290540
更新日期:1986-12-01 00:00:00
abstract::There is considerable epidemiological evidence that workers exposed to carbon disulfide (CS2) develop premature atherosclerosis leading to increased rates of coronary heart disease (CHD), but mechanisms underlying this association remain obscure. The present study documents that occupational exposure to CS2 modifies t...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-001-0311-9
更新日期:2002-04-01 00:00:00
abstract::The toxicokinetics of the four stereoisomers of the nerve agent C(+/-)P(+/-)-soman was analysed in cerebrospinal fluid (CSF) and blood in anaesthetized, spontaneously breathing pigs during a 90-min period after injection of soman. The pigs were challenged with different intravenous (i.v.) doses of C(+/-)P(+/-)-soman c...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050529
更新日期:1998-07-01 00:00:00
abstract::The asexual freshwater planarian Dugesia japonica has emerged as a medium-throughput alternative animal model for neurotoxicology. We have previously shown that D. japonica are sensitive to organophosphorus pesticides (OPs) and characterized the in vitro inhibition profile of planarian cholinesterase (DjChE) activity ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-2130-7
更新日期:2018-03-01 00:00:00
abstract::The acute toxicity of cyanide is determined by its peak levels reached in the body. Compared to the ingestion of free cyanide, lower peak levels may be expected after consumption of foods containing cyanogenic glycosides with the same equivalent dose of cyanide. This is due to possible delayed and/or incomplete releas...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-015-1479-8
更新日期:2016-03-01 00:00:00
abstract::Aluminum phosphide (AlP), one of the most commonly used pesticides worldwide, has been the leading cause of self-poisoning mortalities among many Asian countries. The heart is the main organ affected in AlP poisoning. Melatonin has been previously shown to be beneficial in reversing toxic changes in the heart. The pre...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-1998-6
更新日期:2017-09-01 00:00:00
abstract::Using isolated rat hepatocytes the biochemical effects of hydrazine have been investigated using both conventional assay techniques and high resolution proton NMR. High resolution proton NMR revealed that hydrazine caused a significant increase in alanine and lactate levels in the incubation buffer, whereas levels of ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01981506
更新日期:1992-01-01 00:00:00
abstract::The excretion and biotransformation of [14C] 1,1-dichloroethylene (vinylidene chloride, VDC) after administration of a single oral dose has been investigated in female rats. Seventy-two hours after a dose of 0.5, 5.0, and 50.0 mg/kg, 1.26, 9.70, 16.47%, respectively, are exhaled as unchanged VDC, and 13.64, 11.35, 6.1...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00353707
更新日期:1979-07-11 00:00:00
abstract::Rats were coexposed to lead (Pb) and Copper (Cu) through drinking water and intraperitoneally, respectively, for a period of 21 days. Neurochemical studies in these rats showed significant reduction in the activity of adenosine triphosphatase, cytochrome-c-oxidase, diaphorase and in the levels of biogenic amines in th...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00347881
更新日期:1982-03-01 00:00:00
abstract::Drugs may cause serotonin toxicity by a number of different mechanisms including inhibition of serotonin uptake and metabolism, increased serotonin synthesis and release, activation of serotonin receptors, and inhibition of cytochrome P450 oxidases. Some drug interactions involving opioids can increase intrasynaptic l...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-018-2244-6
更新日期:2018-08-01 00:00:00
abstract::The elevations of blood urea nitrogen and serum creatinine caused by cis-platinum in rats can be prevented by a combination of procedures centered around the administration of sodium N-methyl-N-dithiocarboxyglucamine (NaG), before and very soon after the cis-platinum is administered in hypertonic (4.5%) saline. Elevat...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00316327
更新日期:1986-10-01 00:00:00
abstract::Acrylamide (AA) is a widely studied industrial chemical that is neurotoxic, mutagenic to somatic and germ cells, and carcinogenic in rodents. The recent discovery of AA at ppm levels in a wide variety of commonly consumed foods has energized research efforts worldwide to define toxicity and prevention. Metabolism and ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-006-0109-x
更新日期:2006-12-01 00:00:00
abstract::Amanita phalloides is responsible for more than 90 % of mushroom-related fatalities, and no effective antidote is available. α-Amanitin, the main toxin of A. phalloides, inhibits RNA polymerase II (RNAP II), causing hepatic and kidney failure. In silico studies included docking and molecular dynamics simulation couple...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-015-1582-x
更新日期:2015-12-01 00:00:00
abstract::The associations of four single nucleotide polymorphisms (p.Arg194Trp, p.Arg280His, p.Pro206Pro, and p.Arg399Gln) in X-ray repair cross-complementing group 1 with urinary arsenic metabolites and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were investigated in a Vietnamese population (n = 100). Individuals with genotype AA in...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-015-1490-0
更新日期:2016-04-01 00:00:00
abstract::The covalent binding of 14C-1,1,2-trichloroethylene (14C-TRI) metabolites to calf thymus DNA in vitro and to RNA and DNA of mouse brain, lung, liver, kidney, spleen, pancreas, and testis after repeated i.p. injections has been studied. Hydrolysates of DNA reacted with 14C-TRI in vitro and hydrolysates of RNA and DNA f...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01239202
更新日期:1983-11-01 00:00:00
abstract::Nucleotide excision repair (NER) is a versatile pathway that removes helix-distorting DNA lesions from the genomes of organisms across the evolutionary scale, from bacteria to humans. The serial steps in NER involve recognition of lesions, adducts or structures that disrupt the DNA double helix, removal of a short oli...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-016-1820-x
更新日期:2016-11-01 00:00:00
abstract::Many in the welding industry suffer from bronchitis, lung function changes, metal fume fever, and diseases related to respiratory damage. These phenomena are associated with welding fumes; however, the mechanism behind these findings remains to be elucidated. In this study, the lungs of cynomolgus monkeys were exposed...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-009-0486-z
更新日期:2010-03-01 00:00:00
abstract::Evading apoptosis and chemo-resistance are considered as very important factors which help tumour progression and metastasis. Hence, to overcome chemo-resistance, there is an urgent requirement for emergence of more effective treatment options. Myricetin, a naturally occurring flavonoid, is present in various plant-de...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-020-02938-5
更新日期:2021-01-01 00:00:00
abstract::Although polybrominated naphthalenes (PBNs) are contaminants of the commercial fire retardant fireMaster BP-6, the individual PBN isomers have not been identified. In order to study PBNs possessing an analogous level of bromination to those found in fireMaster BP-6, three synthetic PBN mixtures, averaging 5.0, 5.3, an...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00346051
更新日期:1984-07-01 00:00:00