Transcription-coupled repair: an update.

abstract：:Boric acid and sodium borates are currently classified as being toxic to reproduction under "Category 1B" with the hazard statement of "H360 FD" in the European CLP regulation. This has prompted studies on boron-mediated reprotoxic effects in male workers in boron mining areas and boric acid production plants. By cont...

journal_title：Archives of toxicology

authors： Duydu Y,Başaran N,Üstündağ A,Aydın S,Yalçın CÖ,Anlar HG,Bacanlı M,Aydos K,Atabekoğlu CS,Golka K,Ickstadt K,Schwerdtle T,Werner M,Meyer S,Bolt HM

更新日期：2018-08-01 00:00:00

abstract：:Chlorpyrifos (CPF) is a widely used organophosphorus pesticide. Earlier work from our laboratory and others has demonstrated that the sensitivity to CPF exposure changes markedly during maturation. A number of studies suggest that in addition to inhibiting acetylcholinesterase (AChE), CPF oxon may also interact direct...

journal_title：Archives of toxicology

authors： Zhang H,Liu J,Pope CN

更新日期：2002-01-01 00:00:00

abstract：:Manufactured nanomaterials (MNMs) selected from a library of over 120 different MNMs with varied compositions, sizes, and surface coatings were tested by four different laboratories for toxicity by high-throughput/-content (HT/C) techniques. The selected particles comprise 14 MNMs composed of CeO2, Ag, TiO2, ZnO and S...

journal_title：Archives of toxicology

authors： Hansjosten I,Rapp J,Reiner L,Vatter R,Fritsch-Decker S,Peravali R,Palosaari T,Joossens E,Gerloff K,Macko P,Whelan M,Gilliland D,Ojea-Jimenez I,Monopoli MP,Rocks L,Garry D,Dawson K,Röttgermann PJF,Murschhauser A,Rädl

更新日期：2018-02-01 00:00:00

abstract：:Standard treatment of poisoning by organophosphates (OP) includes the administration of an antimuscarinic agent, e.g. atropine, and of an acetylcholinesterase (AChE) reactivator (oxime). The presently available oximes, obidoxime and pralidoxime (2-PAM), are considered to be insufficient for highly toxic OPs, e.g. sari...

journal_title：Archives of toxicology

authors： Worek F,Reiter G,Eyer P,Szinicz L

更新日期：2002-09-01 00:00:00

abstract：:Neurotoxic properties of acrylamide and seven related compounds in rats were studied with regard to the effects on rotarod performance, morphology of nerves and neurotubulin. Compounds used in the present study were acrylamide, N-hydroxymethylacrylamide, N-isopropylacrylamide, methacrylamide, N-methylacrylamide, croto...

journal_title：Archives of toxicology

authors： Tanii H,Hashimoto K

更新日期：1983-11-01 00:00:00

abstract：:The nephrotoxicity of 4-amino-3-S-glutathionylphenol (PAP-GSH), a known metabolite of 4-amino-phenol (PAP), was determined in male Fischer 344 rats. Administration of a single dose of 40 or 60 mumol kg-1 caused a marked elevation in blood urea nitrogen and an increase in the urinary excretion of glucose, protein and g...

journal_title：Archives of toxicology

authors： Fowler LM,Foster JR,Lock EA

更新日期：1994-01-01 00:00:00

abstract：:Certain esterase inhibitors such as O-(2-chloro-2,3,3-trifluorocyclobutyl) O-ethyl S-propyl phosphorothioate (KBR-2822) and phenylmethanesulfonyl fluoride (PMSF) cause exacerbation (promotion) of toxic and traumatic axonopathies. Although these chemicals are capable of inhibiting neuropathy target esterase (NTE), whic...

journal_title：Archives of toxicology

authors： Jokanovic M,Moretto A,Lotti M

更新日期：1998-01-01 00:00:00

abstract：:The cadmilm-induced (Cd) damage of mammalian testes is thought to be correlated with an inhibition of carbonic anhydrase (CAH) by Cd. Since Cd causes dose-dependent changes in blood flow of the testes, an inhibition of CAH in the testes could be simulated by a decrease of CAH-rich erythrocytes. Therefore, CAH activiti...

journal_title：Archives of toxicology

authors： Alsen C,Köpcke C,Ohnesorge FK,Schneider J

更新日期：1976-12-23 00:00:00

abstract：:The hepatotoxicity of acetaminophen (APAP) overdose depends on metabolic activation to a toxic reactive metabolite via hepatic mixed function oxidase. In vitro studies have indicated that APAP may also be cooxidized by prostaglandin H synthetase. The present experiments were designed to assess the possible contributio...

journal_title：Archives of toxicology

authors： Ben-Zvi Z,Weissman-Teitellman B,Katz S,Danon A

更新日期：1990-01-01 00:00:00

abstract：:Renal papillary necrosis (RPN) was induced in Fischer 344 (F344) rats (n = 4) using 2-bromoethanamine hydrobromide (BEA) dosed at 150 mg/kg, and in multimammate desert mice (Mastomys natalensis) at 150 and 250 mg/kg (n = 4 per group). Control rats and Mastomys were dosed with 0.9% saline (n = 4 per group). Urine was c...

journal_title：Archives of toxicology

authors： Holmes E,Bonner FW,Nicholson JK

更新日期：1995-01-01 00:00:00

abstract：:Concerning molecular and cellular mechanisms of aluminum toxicity, recent studies support the hypothesis that interactions of aluminum ions with elements of signal transduction pathways are apparently primary events in cells. In the case of the phosphoinositide-associated signalling pathway of neuroblastoma cells, gua...

journal_title：Archives of toxicology

authors： Haug A,Shi B,Vitorello V

更新日期：1994-01-01 00:00:00

abstract：:The cytotoxicity of trivalent and pentavalent inorganic arsenic salts was determined in mouse fibroblasts in vitro. Concentrations of As (III) in the microM range led to a reduction of proliferation and viability with a concomitant increase in LDH release and stimulation of lactic acid production. Similar effects were...

journal_title：Archives of toxicology

authors： Fischer AB,Buchet JP,Lauwerys RR

更新日期：1985-08-01 00:00:00

abstract：:Phenethyl isothiocyanate is a chemopreventive phytochemical present in cruciferous vegetables where it exists as the glucosinolate gluconasturtiin. It is a mechanism-based inhibitor of both rat and human cytochrome P450 enzymes. The principal objective of the present study was to ascertain whether phenethyl isocyanate...

journal_title：Archives of toxicology

authors： Konsue N,Ioannides C

更新日期：2010-10-01 00:00:00

abstract：:Carbromal is metabolized extensively in humans. The major metabolites known to date are bromoethylbutyramide, ethylbutyrylurea and inorganic bromide. After ingestion of a therapeutic dose of 1.0 g carbromal (4.2 mmoles) by four healthy volunteers highest concentrations in serum were found to be for carbromal 30 mumole...

journal_title：Archives of toxicology

authors： Vohland HW,Schirop T,Barckow D,Kreutz G,Streichert B

更新日期：1978-06-16 00:00:00

abstract：:Sexual differentiation in the brain takes place from late gestation to the early postnatal days. This is dependent on the conversion of circulating testosterone into estradiol by the enzyme aromatase. The glyphosate was shown to alter aromatase activity and decrease serum testosterone concentrations. Thus, the aim of ...

journal_title：Archives of toxicology

authors： Romano MA,Romano RM,Santos LD,Wisniewski P,Campos DA,de Souza PB,Viau P,Bernardi MM,Nunes MT,de Oliveira CA

更新日期：2012-04-01 00:00:00

abstract：:Airway smooth muscle (ASM) cell phenotypic switching played an important role in airway remodeling in asthma. In vitro platelet-derived growth factor (PDGF) induced ASM cell phenotypic switching from a mature to pro-remodeling phenotype, but the mechanism remained incompletely understood. This study was to explore the...

journal_title：Archives of toxicology

authors： Ning Y,Huang H,Dong Y,Sun Q,Zhang W,Xu W,Li Q

更新日期：2013-05-01 00:00:00

abstract：:The metabolic fate of 2-ethylhexyl diphenyl phosphate (EHDPP) was studied in male rats. Orally administered 14C-EHDPP was rapidly absorbed and about 80% of the radioactivity was excreted in the urine and feces in the first 24 h. By 7 days, 48% and 52% of the radioactivity was recovered in urine and feces, respectively...

journal_title：Archives of toxicology

authors： Nishimaki-Mogami T,Minegishi K,Tanaka A,Sato M

更新日期：1988-01-01 00:00:00

abstract：:Chronic ciprofibrate administration resulted in distinct differences in hepatic responses between the two species examined. In the rat, hepatomegaly was observed with the coordinate induction of carnitine acetyltransferase, peroxisomal beta-oxidation and cytochrome P450IVA1 activities. The latter induction of cytochro...

journal_title：Archives of toxicology

authors： Makowska JM,Bonner FW,Gibson GG

更新日期：1991-01-01 00:00:00

abstract：:The uptake, distribution, and elimination of 3H-toluene in various tissues of rats were studied after inhalation or after gastric intubation. The maximum radioactivity was measured 2--3 h after gastric intubation in tissues, except in white adipose tissue, where the peak radioactivity was reached at 5 h. After inhala...

journal_title：Archives of toxicology

authors： Pyykkö K,Tähti H,Vapaatalo H

更新日期：1977-09-28 00:00:00

abstract：:The inhibitory effect and mechanism of action of nicotinamide to paraquat toxicity were studied in male Sprague-Dawley rats. Proteins of submitochondrial particles (SMP), especially of mol. wt. 25-30 kDa, in rat lungs were destroyed by paraquat radicals, and aggregated protein bands approximately 100 kDa were observed...

journal_title：Archives of toxicology

authors： Fukushima T,Gao T,Tawara T,Hojo N,Isobe A,Yamane Y

更新日期：1997-01-01 00:00:00

abstract：:Due to its unique physical structure and chemical properties, graphene family nanomaterials (GFNs) and derived commodities have been widely used in commercial products, particularly biomedical applications, which has significantly increased the risk of human exposure. There exists significant evidence that GFNs are ac...

journal_title：Archives of toxicology

authors： Xiaoli F,Qiyue C,Weihong G,Yaqing Z,Chen H,Junrong W,Longquan S

更新日期：2020-06-01 00:00:00

abstract：:Perfluorononanoic acid (PFNA) and perfluorodecanoic acid (PFDA), which are classified as perfluoroalkyl and polyfluoroalkyl substances (PFASs), have been widely used in industrial applications as a surface protectant. PFASs have been detected in wildlife and in humans around the globe. The purposes of this study are t...

journal_title：Archives of toxicology

authors： Kim SJ,Choi EJ,Choi GW,Lee YB,Cho HY

更新日期：2019-02-01 00:00:00

abstract：:Deoxynivalenol (DON) contamination in food is a public health concern; however, the effect of DON exposure on immune disorders including allergies remains unclear. The aim of this study is to elucidate the effect of oral exposure to DON on pro-inflammatory and pro-pruritic responses in a mouse model of allergic dermat...

journal_title：Archives of toxicology

authors： Aihara R,Ookawara T,Morimoto A,Iwashita N,Takagi Y,Miyasaka A,Kushiro M,Miyake S,Fukuyama T

更新日期：2020-12-01 00:00:00

abstract：:For ethical and regulatory reasons, in vitro tests for scoring potential toxicities of cosmetics are essential. A test strategy for investigating potential skin sensitization using two human keratinocytic and two human dendritic cell lines has been developed (Mehling et al. Arch Toxicol 86:1273–1295, 2012). Since proh...

journal_title：Archives of toxicology

authors： Fabian E,Vogel D,Blatz V,Ramirez T,Kolle S,Eltze T,van Ravenzwaay B,Oesch F,Landsiedel R

更新日期：2013-09-01 00:00:00

abstract：:Polyclonal antibodies raised toward a debrisoquine 4-hydroxylating cytochrome P-450 species purified from rat liver (P-450UT-A) were used to determine which monooxygenase reactions are linked to debrisoquine hydroxylation in human liver. Anti P-450UT-A did not inhibit the oxidation of dimethylnitrosamine, morphine, di...

journal_title：Archives of toxicology

authors： Wolff T,Distlerath LM,Worthington MT,Guengerich FP

更新日期：1987-01-01 00:00:00

abstract：:Platinum coordination complexes (PtCx) are potent against several types of cancer but are often nephrotoxic. With a view to developing a PtCx nephrotoxicity model, the toxicity of cisplatin (cDDP), transplatin (tDDP) and carboplatin (CBDCA) was studied in primary cultures of rabbit proximal tubule (RPT) cells and in t...

journal_title：Archives of toxicology

authors： Courjault F,Leroy D,Coquery L,Toutain H

更新日期：1993-01-01 00:00:00

abstract：:Rats were administered a sublethal dose of thallium (12.35 mg/kg as aqueous thallous sulfate, Tl2SO4, equivalent to 10 mg Tl+/kg per os) on day 0. Urine and feces were collected separately every day for 8 days and analyzed by atomic absorption spectroscopy. Based on information in the literature, five antidotal treatm...

journal_title：Archives of toxicology

authors： Lehmann PA,Favari L

更新日期：1985-04-01 00:00:00

abstract：:This review summarises the current state of knowledge regarding the physiology and control of production of thyroid hormones, the effects of chemicals in perturbing their synthesis and release that result in thyroid cancer. It does not consider the potential neurodevelopmental consequences of low thyroid hormones. The...

journal_title：Archives of toxicology

authors： Foster JR,Tinwell H,Melching-Kollmuss S

更新日期：2021-01-05 00:00:00

abstract：:MDMA-induced impairments of memory performance have been reported in different human and animal studies. However, the correlation between spatial memory impairment, brain mitochondrial function, and concentrations of MDMA and its metabolites has not yet been investigated despite it being needed for comparison with hum...

journal_title：Archives of toxicology

authors： Taghizadeh G,Mehdizadeh H,Lavasani H,Hosseinzadeh Ardakani Y,Foroumadi A,Halvaei Khankahdani Z,Moshtagh A,Pourahmad J,Sharifzadeh M,Rouini MR

更新日期：2020-03-01 00:00:00

abstract：:The genotoxicity of the sensory irritant 2-chlorobenzylidene malonitrile (CS) to V79 Chinese hamster cells was investigated using the induction of gene mutations, micronuclei and DNA repair synthesis as biological endpoints. CS efficiently induced micronuclei and mutants resistant to 6-thioguanine in these cells, but ...

journal_title：Archives of toxicology

authors： Ziegler-Skylakakis K,Summer KH,Andrae U

更新日期：1989-01-01 00:00:00