Dose concentration and spatial memory and brain mitochondrial function association after 3,4-methylenedioxymethamphetamine (MDMA) administration in rats.


:MDMA-induced impairments of memory performance have been reported in different human and animal studies. However, the correlation between spatial memory impairment, brain mitochondrial function, and concentrations of MDMA and its metabolites has not yet been investigated despite it being needed for comparison with human studies. Therefore, the aim of this study was to investigate the dose concentration and spatial memory as well as brain mitochondrial function association after MDMA administration in rats. We assessed the effects of MDMA [0.5, 2.5, 5, 10 and 15 mg/kg; intraperitoneally (I.P)] on spatial memory of male Wistar rats in the Morris water maze test (MWM) and brain mitochondrial function (i.e., reactive oxygen species, mitochondrial membrane potential, swelling and outer membrane damage, cytochrome c release, and ADP/ATP ratio). Concentrations of MDMA and its metabolite, MDA, were determined in plasma, cerebrospinal fluid (CSF) and brain which was obtained immediately after probe test of MWM (i.e., 4 h after last training trial). The results of this study indicate nonlinear kinetics of MDMA after I.P adminstration. Also, an insignificant correlation was observed between MDMA doses and the MDA/MDMA ratio in plasma, CSF, and brain. Moreover, the results showed that MDMA, but not MDA, accumulated in brain tissue by increasing the administered doses. Beside, MDMA-induced impairments of spatial memory and brain mitochondrial function were significantly correlated with the concentrations of both MDMA and MDA in plasma, CSF, and brain. Therefore, it can be suggested that MDMA and its metabolite, MDA, affect spatial memory and brain mitochondrial function.


Arch Toxicol


Archives of toxicology


Taghizadeh G,Mehdizadeh H,Lavasani H,Hosseinzadeh Ardakani Y,Foroumadi A,Halvaei Khankahdani Z,Moshtagh A,Pourahmad J,Sharifzadeh M,Rouini MR




Has Abstract


2020-03-01 00:00:00














  • Use of M-mode and Doppler echocardiography to investigate the cardiotoxicity of minoxidil in beagle dogs.

    abstract::Doppler and M-mode echocardiography (EC) were used to investigate the effects of minoxidil on the cardiac function of the dog and potentially to clarify the pathogenesis of cardiac lesions, in particular the necrotic lesion in the left ventricle and the haemorrhagic lesion in the right atrium. Groups of three dogs wer...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Hanton G,Gautier M,Bonnet P

    更新日期:2004-01-01 00:00:00

  • Resveratrol protects primary cilia integrity of human mesenchymal stem cells from cigarette smoke to improve osteogenic differentiation in vitro.

    abstract::Several studies have explored the negative effects of cigarette smoke on bone healing; however, the complex pathogenesis still remains unclear. One crucial and primary factor determining effective fracture repair is the recruitment and differentiation of mesenchymal stem cells (MSCs) into bone-forming cells. Recently,...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Sreekumar V,Aspera-Werz R,Ehnert S,Strobel J,Tendulkar G,Heid D,Schreiner A,Arnscheidt C,Nussler AK

    更新日期:2018-04-01 00:00:00

  • In vitro toxicological evaluation of a dinuclear platinum(II) complex with acetate ligands.

    abstract::In the present study the toxicological potential of a tumor-inhibiting dinuclear platinum(II) complex (bis(acetato)diammine-bis-micro-acetato diplatinum(II) dihydrate (BAP)) was evaluated, utilizing in vitro models of nephrotoxicity, myelosuppression and neurotoxicity. Regarding the discrepancies between the hallmark ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Momekov G,Ferdinandov D,Bakalova A,Zaharieva M,Konstantinov S,Karaivanova M

    更新日期:2006-09-01 00:00:00

  • Sensory irritation mechanisms investigated from model compounds: trifluoroethanol, hexafluoroisopropanol and methyl hexafluoroisopropyl ether.

    abstract::Quantitative structure-activity relationships (QSAR) have suggested the importance of hydrogen bonding in relation to activation of the sensory irritant receptor by nonreactive volatile organic chemicals. To investigate this possibility further, three model compounds with different hydrogen bond acidity, trifluoroetha...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Nielsen GD,Abraham MH,Hansen LF,Hammer M,Cooksey CJ,Andonian-Haftvan J,Alarie Y

    更新日期:1996-01-01 00:00:00

  • Comparative study of activities in reactive oxygen species production/defense system in mitochondria of rat brain and liver, and their susceptibility to methylmercury toxicity.

    abstract::The involvement of oxidative stress has been suggested as a mechanism for neurotoxicity caused by methylmercury (MeHg), but the mechanism for MeHg selective toxicity in the central nervous system is still unclear. In this research, to clarify the mechanism of selective neurotoxicity caused by MeHg, the oxygen consumpt...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Mori N,Yasutake A,Hirayama K

    更新日期:2007-11-01 00:00:00

  • Infer the in vivo point of departure with ToxCast in vitro assay data using a robust learning approach.

    abstract::The development and application of high throughput in vitro assays is an important development for risk assessment in the twenty-first century. However, there are still significant challenges to incorporate in vitro assays into routine toxicity testing practices. In this paper, a robust learning approach was developed...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Wang D

    更新日期:2018-09-01 00:00:00

  • Imipramine- and mianserin-induced acute cell injury in primary cultured rat hepatocytes: implication of different cytochrome P450 enzymes.

    abstract::The antidepressants, imipramine and mianserin, have been reported to cause liver damage. We investigated a role of cytochrome P450 (CYP)-mediated formation of a reactive metabolite in antidepressant-induced acute cell injury using hepatocytes isolated from male and female Wistar rats, and male Dark Agouti rats, which ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Masubuchi Y,Konishi M,Horie T

    更新日期:1999-04-01 00:00:00

  • Hair analysis for drugs of abuse. IV. Determination of total morphine and confirmation of 6-acetylmorphine in monkey and human hair by GC/MS.

    abstract::The reliable analytical method for total morphine in hair was established by GC/MS-SIM. The calibration curve for morphine in hair showed linear over 0.5-100 ng/mg hair. Though the limit of detection was 0.1 ng/mg hair with an S/N > 3 of the base ion(m/z 429) for morphine, the limit of confirmation by detection of thr...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Nakahara Y,Takahashi K,Shimamine M,Saitoh A

    更新日期:1992-01-01 00:00:00

  • Non-N-methyl-D-aspartate (NMDA) receptor antagonist 1,2,3, 4-tetrahydro-6-nitro-2,3-dioxo-benzo(f)quinoxaline-7-sulphonamide (NBQX) decreases functional disorders in cytotoxic brain oedema.

    abstract::N-methyl-D-aspartate (NMDA) and non-NMDA receptors were found to be involved in development of functional disorders caused by hexachlorophene. In order to specify the role of glutamate receptors we studied the protective effects of the selective antagonist of the kainate/(+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Häntzschel A,Andreas K

    更新日期:2000-01-01 00:00:00

  • Molecular mechanism of 1,1-dichloroethylene toxicity: excreted metabolites reveal different pathways of reactive intermediates.

    abstract::The excretion and biotransformation of [14C] 1,1-dichloroethylene (vinylidene chloride, VDC) after administration of a single oral dose has been investigated in female rats. Seventy-two hours after a dose of 0.5, 5.0, and 50.0 mg/kg, 1.26, 9.70, 16.47%, respectively, are exhaled as unchanged VDC, and 13.64, 11.35, 6.1...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Reichert D,Werner HW,Metzler M,Henschler D

    更新日期:1979-07-11 00:00:00

  • Differential effects of methylmercury on the synthesis of protein species in dorsal root ganglia of the rat.

    abstract::Dorsal root ganglia from control and methylmercury (MeHg)-treated rats were incubated in vitro with 35S-methionine ant the proteins synthesized were analyzed by two-dimensional electrophoresis. The double labelling method, in which proteins of control dorsal root ganglia labelled in vitro with 3H-leucine were added to...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Kasama H,Itoh K,Omata S,Sugano H

    更新日期:1989-01-01 00:00:00

  • Effect of DMPS and various adsorbents on the arsenic excretion in guinea-pigs after injection with As2O3.

    abstract::The present experiments were performed to test the possibility of interrupting the enterohepatic circulation of arsenic (As). Therefore the efficacy of adsorbents to bind As and/or As-DMPS adducts in vitro and their effect on the excretion of As into the feces and urine in vivo were investigated after injection of As2...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Reichl FX,Hunder G,Liebl B,Fichtl B,Forth W

    更新日期:1995-01-01 00:00:00

  • Inhibition, reactivation and aging kinetics of cyclohexylmethylphosphonofluoridate-inhibited human cholinesterases.

    abstract::Cyclohexylmethylphosphonofluoridate (cyclosarin) is a highly toxic organophosphate, which was shown to be rather resistant to conventional oxime therapy. To give more insight into the inhibition, reactivation and aging kinetics, human acetyl-(AChE) and butyrylcholinesterase (BChE) were inhibited by cyclosarin (k2 of 7...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Worek F,Eyer P,Szinicz L

    更新日期:1998-09-01 00:00:00

  • Early morphological changes in rat cerebellum caused by a single dose of methylmercury.

    abstract::A single dose of 10 mg methylmercury chloride per kg body weight was given to 30 days old rats and to adult rats (180-200g)(. This resulted in brain levels of 1.4-2.2 micrograms Hg/g wet weight. In the young rats electron microscopic morphometry showed swelling of the granule cells. The extent of changes was more pron...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Syversen TL,Totland G,Flood PR

    更新日期:1981-04-01 00:00:00

  • Penetration of beta-naphthylamine and o-toluidine through human skin in vitro.

    abstract::Several aromatic amines (AAs) are known to be carcinogens for humans. AAs are considered to be substantially absorbed through the skin. However, the database for dermal absorption of AAs in general is limited and no specific studies on dermal absorption of beta-naphthylamine (BNA) and o-toluidine (OT) have been publis...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Lüersen L,Wellner T,Koch HM,Angerer J,Drexler H,Korinth G

    更新日期:2006-10-01 00:00:00

  • Pneumoconiotic effects of welding-fume particles from mild and stainless steel deposited in the lung of the rat.

    abstract::Rats were exposed to single periods of inhalation of fumes generated by arc welding. Two processes were compared: either manual metal arc (MMA) using flux-coated mild steel (MS) electrodes or metal inert-gas (MIG) welding with stainless steel (SS). Widespread but small deposits of fume particles were cleared effective...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Hicks R,Lam HF,Al-Shamma KJ,Hewitt PJ

    更新日期:1984-03-01 00:00:00

  • Electrophilic tissue burden in male Sprague-Dawley rats following repeated exposure to binary mixtures of polycyclic aromatic hydrocarbons.

    abstract::The aim of this study was to investigate the electrophilic tissue burden (ETB) formation, assessed as covalent binding of the ultimate carcinogen benzo( a)pyrene diolepoxide (BaPDE) with cellular proteins, in liver, lung and heart, as well as with haemoglobin (Hb) following repeated exposure to binary mixtures of benz...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Tzekova A,Leroux S,Viau C

    更新日期:2004-02-01 00:00:00

  • Arsenic-containing hydrocarbons: effects on gene expression, epigenetics, and biotransformation in HepG2 cells.

    abstract::Arsenic-containing hydrocarbons (AsHCs), a subgroup of arsenolipids found in fish and algae, elicit substantial toxic effects in various human cell lines and have a considerable impact on cellular energy levels. The underlying mode of action, however, is still unknown. The present study analyzes the effects of two AsH...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Müller SM,Finke H,Ebert F,Kopp JF,Schumacher F,Kleuser B,Francesconi KA,Raber G,Schwerdtle T

    更新日期:2018-05-01 00:00:00

  • A role of red cell pyrimidine 5'-nucleotidase in experimental lead poisoning.

    abstract::Intravenous administration of lead acetate to rabbits for 10 weeks at 2 week intervals resulted in significantly elevated blood lead levels, slight anemia with marked microspherocytosis and moderate basophilic stippling, and marked depression of red cell delta-aminolevulinic acid (ALA) dehydratase activity. However th...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Fujii H

    更新日期:1979-10-01 00:00:00

  • Toluene concentrations in various tissues of rats after inhalation and oral administration.

    abstract::The uptake, distribution, and elimination of 3H-toluene in various tissues of rats were studied after inhalation or after gastric intubation. The maximum radioactivity was measured 2--3 h after gastric intubation in tissues, except in white adipose tissue, where the peak radioactivity was reached at 5 h. After inhala...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Pyykkö K,Tähti H,Vapaatalo H

    更新日期:1977-09-28 00:00:00

  • Survivors of soman poisoning: recovery of the soman LD50 to control value in the presence of extensive acetylcholinesterase inhibition.

    abstract::Initially, mice were pretreated with atropine (17.4 mg/kg; IP) and the oxime reactivator HI-6 (50 mg/kg; IP) 5 min prior to an injection of soman (287 micrograms/kg, SC); approximately 2.1 x LD50 dose). More than 95% of the mice survived this dose of soman with atropine and HI-6 pretreatment. In these survivors of som...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Clement JG

    更新日期:1989-01-01 00:00:00

  • Gene expression and cytosine DNA methylation alterations in induced pluripotent stem-cell-derived human hepatocytes treated with low doses of chemical carcinogens.

    abstract::The increasing number of man-made chemicals in the environment that may pose a carcinogenic risk emphasizes the need to develop reliable time- and cost-effective approaches for carcinogen detection. To address this issue, we have investigated the utility of human hepatocytes for the in vitro identification of genotoxi...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Tryndyak V,Borowa-Mazgaj B,Beland FA,Pogribny IP

    更新日期:2019-11-01 00:00:00

  • Selenium: a double-edged sword for defense and offence in cancer.

    abstract::Selenium (Se) is an essential dietary component for animals including humans and is regarded as a protective agent against cancer. Although the mode of anticancer action of Se is not fully understood yet, several mechanisms, such as antioxidant protection by selenoenzymes, specific inhibition of tumor cell growth by S...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,评审


    authors: Brozmanová J,Mániková D,Vlčková V,Chovanec M

    更新日期:2010-12-01 00:00:00

  • Biochemical and toxicological effects of short-term, intermittent xylene inhalation exposure and combined ethanol intake.

    abstract::Intermittent inhalation of 300 ppm of xylene vapour 6 h daily for 2 weeks caused a marked accumulation of the solvent in the perirenal fat. Simultaneous ethanol ingestion reduced the solvent load significantly although the perirenal xylene concentration increased in both test groups between the first and second week o...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Savolainen H,Vainio H,Helojoki M,Elovaara E

    更新日期:1978-12-28 00:00:00

  • Expression of Neuropathy Target Esterase in mouse embryonic stem cells during differentiation.

    abstract::Neuropathy Target Esterase (NTE) was initially identified as the primary target esterase of some organophosphorus compounds that cause delayed neuropathy. Some studies in vivo suggest that this protein may also perform a function in embryonic development and therefore also in cell differentiation. The aim of this work...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Pamies D,Reig JA,Vilanova E,Sogorb MA

    更新日期:2010-06-01 00:00:00

  • The effect of 1-deamino-2-tyr(ethyl) oxytocin upon peri- and postnatal development of the rat: growth retardation of the offspring.

    abstract::The effect of 1-deamino-2-tyr(ethyl) oxytocin (dEtOT) upon peri- and postnatal development of the rat was studied in two experiments when administered between day 15 of pregnancy and the day of parturition. The investigation showed that dEtOT did not affect the pups at birth, that dEtOT caused a dose-related growth re...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Magnusson G,Melin P

    更新日期:1985-09-01 00:00:00

  • Fate of carbaryl in rat skin.

    abstract::Metabolism of carbaryl by rat liver and skin post-mitochondrial fraction has been measured in the presence and absence of cofactors to promote different metabolic pathways. The metabolic capacity was compared with the metabolism of carbaryl during percutaneous absorption in a static skin diffusion system using a varie...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: MacPherson SE,Scott RC,Williams FM

    更新日期:1991-01-01 00:00:00

  • Effects of a single haloperidol application to neonatal and early postnatal rats on the neurotransmitter content in the corpus striatum.

    abstract::We investigated the influence of the dopamine antagonist haloperidol on the neurotransmitter content in the developing rat brain. Dopamine (DA), serotonin (5-HT) and the corresponding metabolites dopac, HVA and HIAA were determined in the corpus striatum of the rat between day 1 and day 21 pn by HPLC with electro-chem...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Schwabe R,Thiel R,Chahoud I,Neubert D

    更新日期:1992-01-01 00:00:00

  • The mycotoxin patulin reacts with DNA bases with and without previous conjugation to GSH: implication for related α,β-unsaturated carbonyl compounds?

    abstract::The α,β-unsaturated carbonyl group is recognized as alert for mutagenicity, attributed to (1) its direct reaction with DNA, counteractable by glutathione (GSH), and (2) oxidative stress caused indirectly by GSH depletion. Accordingly, the α,β,γ,δ-unsaturated lactone patulin (PAT), a mycotoxin detected in fruits and pr...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Pfenning C,Esch HL,Fliege R,Lehmann L

    更新日期:2016-02-01 00:00:00

  • Effect of dental materials on gluconeogenesis in rat kidney tubules.

    abstract::The effect of dental composite components triethyleneglycoldimethacrylate (TEGDMA) and hydroxyethylmethacrylate (HEMA) as well as mercuric chloride (HgCl(2)) and methylmercury chloride (MeHgCl) on gluconeogenesis was investigated in isolated rat kidney tubules. From starved rats kidney tubules were prepared and isolat...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Reichl FX,Durner J,Mückter H,Elsenhans B,Forth W,Kunzelmann KH,Hickel R,Spahl W,Hume WR,Moes GW

    更新日期:1999-09-01 00:00:00