Abstract:
:Polyclonal antibodies raised toward a debrisoquine 4-hydroxylating cytochrome P-450 species purified from rat liver (P-450UT-A) were used to determine which monooxygenase reactions are linked to debrisoquine hydroxylation in human liver. Anti P-450UT-A did not inhibit the oxidation of dimethylnitrosamine, morphine, diazepam, vinylidene chloride, trichloroethylene, benzo(a)pyrene and its 7.8-dihydrodiol, but was inhibitory for the hydroxylation of debrisoquine, (+/-)-bufuralol, lasiocarpine and monocrotaline. A model interpreting the substrate specificity of the human liver enzyme is presented.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Wolff T,Distlerath LM,Worthington MT,Guengerich FPdoi
10.1007/BF00296955subject
Has Abstractpub_date
1987-01-01 00:00:00pages
89-90issue
1-3eissn
0340-5761issn
1432-0738journal_volume
60pub_type
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