当前位置： SCI文献检索 > ARCHIVES OF TOXICOLOGY期刊下所有文献 > Quantification of tetrabromo benzoic acid and tetrabromo phthalic acid in rats exposed to the flame retardant Uniplex FPR-45.

Quantification of tetrabromo benzoic acid and tetrabromo phthalic acid in rats exposed to the flame retardant Uniplex FPR-45.

Abstract：

:The first withdrawal of certain polybrominated diphenyl ethers flame retardants from the US market occurred in 2004. Since then, use of brominated non-PBDE compounds such as bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate (BEH-TEBP) and 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB) in commercial formulations has increased. Assessing human exposure to these chemicals requires identifying metabolites that can potentially serve as their biomarkers of exposure. We administered by gavage a dose of 500 mg/Kg bw of Uniplex FRP-45 (>95 % BEH-TEBP) to nine adult female Sprague-Dawley rats. Using authentic standards and mass spectrometry, we positively identified and quantified 2,3,4,5-tetrabromo benzoic acid (TBBA) and 2,3,4,5-tetrabromo phthalic acid (TBPA) in 24-h urine samples collected 1 day after dosing the rats and in serum at necropsy, 2 days post-exposure. Interestingly, TBBA and TBPA concentrations correlated well (R (2) = 0.92). The levels of TBBA, a known metabolite of EH-TBB, were much higher than the levels of TBPA both in urine and serum. Because Uniplex FRP-45 was technical grade and EH-TBB was present in the formulation, TBBA likely resulted from the metabolism of EH-TBB. Taken together, our data suggest that TBBA and TBPA may serve as biomarkers of exposure to non-PBDE brominated flame retardant mixtures. Additional research can provide useful information to better understand the composition and in vivo toxicokinetics of these commercial mixtures.

journal_name

Arch Toxicol

journal_title

Archives of toxicology

authors

Silva MJ,Hilton D,Furr J,Gray LE,Preau JL,Calafat AM,Ye X

doi

10.1007/s00204-015-1489-6

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

551-7

issue

3

eissn

0340-5761

issn

1432-0738

pii

10.1007/s00204-015-1489-6

journal_volume

90

pub_type

杂志文章

相关文献

ARCHIVES OF TOXICOLOGY文献大全
  • Lack of direct immunosuppressive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on human peripheral blood lymphocyte subsets in vitro.

    abstract：:A wide variety of immunosuppressive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in experimental animals has been documented. In contrast, the impact of dioxin on the human immune system remains controversial, although adverse health effects have been reported in humans after occupational or accidental exposu...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s002040050072

    authors： Lang DS,Becker S,Clark GC,Devlin RB,Koren HS

    更新日期：1994-01-01 00:00:00

  • Peripheral neuropathy following intraneural injection of mercury compounds.

    abstract：:Between 0.25-25 micrograms of an aqueous solution of either mercuric chloride or methyl mercuric acetate was injected directly into the sciatic nerve of 28 adult Wistar rats. The resultant pathological changes in the nerve were examined by teasing individual fibres and by light and electron microscopy. In most respect...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF00310442

    authors： Mitchell J,Gallagher PJ

    更新日期：1980-12-01 00:00:00

  • Activation of the Nrf2-ARE pathway by the Alternaria alternata mycotoxins altertoxin I and II.

    abstract：:The mycotoxins altertoxin I and II (ATX I and II) are secondary metabolites produced by Alternaria alternata fungi and may occur as food and feed contaminants, especially after long storage periods. Although the toxic potential of altertoxins has been previously investigated, little is known about the pathways that pl...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-016-1726-7

    authors： Jarolim K,Del Favero G,Pahlke G,Dostal V,Zimmermann K,Heiss E,Ellmer D,Stark TD,Hofmann T,Marko D

    更新日期：2017-01-01 00:00:00

  • Mutagenicity tests with astemizole in vitro and in vivo.

    abstract：:Possible induction of chromosomal aberrations and/or sister chromatid exchanges by astemizole was studied in vitro on human lymphocytes. In vivo chromosomal damage was assessed by a micronucleus test on rats and a dominant lethal test on both male and female mice. All these tests yielded negative results for astemizol...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF00373399

    authors： Vanparys P,Fabry L,Léonard A,Marsboom R

    更新日期：1982-07-01 00:00:00

  • Induction of CYP2A5 by pyrazole and its derivatives in mouse primary hepatocytes.

    abstract：:Mouse liver CYP2A5 is induced by several structurally unrelated compounds. In intact mouse liver, pyrazole (PYR) and 4-hydroxypyrazole (4-OH) induce selectively the expression of CYP2A5 while expression of other CYPs is decreased. In this study we exposed mouse primary hepatocytes to PYR, 4-OH, 4-methylpyrazole (4Me; ...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s002040050511

    authors： Kojo A,Viitala P,Pasanen M,Pelkonen O,Raunio H,Juvonen R

    更新日期：1998-05-01 00:00:00

  • The role of SerpinB2 in human bronchial epithelial cells responses to particulate matter exposure.

    abstract：:Exposure to particulate matter (PM) has been related to the onset of adverse health effects including lung cancer, but the underlying molecular mechanisms are still under investigation. Epithelial-to-mesenchymal transition (EMT) is regarded as a crucial step in cancer progression. In a previous study, we reported EMT-...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-018-2259-z

    authors： Longhin E,Camatini M,Bersaas A,Mantecca P,Mollerup S

    更新日期：2018-09-01 00:00:00

  • Inhibition of mitochondrial respiration in vivo is an early event in acetaminophen-induced hepatotoxicity.

    abstract：:Morphological changes in mitochondria are observed early in the course of acetaminophen (AA)-induced hepatotoxicity, and mitochondrial dysfunction has been observed both in vivo and in vitro following exposure to AA. This study examined the early effects of AA exposure in vivo on mitochondrial respiration and evaluate...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s002040050043

    authors： Donnelly PJ,Walker RM,Racz WJ

    更新日期：1994-01-01 00:00:00

  • Electroretinographic assessment of early retinopathy in rats.

    abstract：:Amoscanate, a substance which damages photoreceptors, was administered orally to Wistar rats in doses of 10, 40, and 125 mg/kg body weight once daily for 3 or 10 days. At both times electroretinographic, ophthalmological, and histopathological examinations of the retina were carried out to compare the sensitivity of c...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF01973682

    authors： Maertins T,Kroetlinger F,Sander E,Pauluhn J,Machemer L

    更新日期：1993-01-01 00:00:00

  • Neurofilament degradation in the nervous system of rats intoxicated with acrylamide, related compounds or 2,5-hexanedione.

    abstract：:Degradation of neurofilament (NF) proteins by Ca2+-activated neutral protease (CANP) was studied in the nervous system of rats treated with neurotoxic or non-neurotoxic compounds. In the tibial nerve, the degradation of NF 68K was depressed by five neurotoxic compounds: acrylamide, N-hydroxymetylacrylamide, N-isopropy...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF00316261

    authors： Tanii H,Hayashi M,Hashimoto K

    更新日期：1988-08-01 00:00:00

  • Cytotoxicity of novel fluorinated alternatives to long-chain perfluoroalkyl substances to human liver cell line and their binding capacity to human liver fatty acid binding protein.

    abstract：:Although shorter chain homologues and other types of fluorinated chemicals are currently used as alternatives to long-chain perfluoroalkyl substances (PFASs), their safety information remains unclear and urgently needed. Here, the cytotoxicity of several fluorinated alternatives (i.e., 6:2 fluorotelomer carboxylic aci...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-017-2055-1

    authors： Sheng N,Cui R,Wang J,Guo Y,Wang J,Dai J

    更新日期：2018-01-01 00:00:00

  • Genetic control of responsiveness of rat liver supernatant aldehyde dehydrogenase to phenobarbital and 3-methylcholanthrene.

    abstract：:The responsiveness of the hepatic supernatant NAD+-dependent aldehyde dehydrogenase with a high Km value (high Km-AldDH) to phenobarbital (PB) and 3-methylcholanthrene (3-MC) treatment was studied in male rats of three strains; Wistar, Long-Evans, and Sprague-Dawley. A remarkable strain difference in the response of t...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF00333620

    authors： Nakanishi S,Shiohara E,Tsukada M,Yamazaki H,Nishiguchi K,Saladin R

    更新日期：1979-12-01 00:00:00

  • In vitro activation of dibromoacetonitrile to cyanide: role of xanthine oxidase.

    abstract：:Dibromoacetonitrile (DBAN) is a disinfection byproduct of chlorination of drinking water. Epidemiological studies indicate that it might present a potential hazard to human health. The present work provides evidence for DBAN activation to cyanide (CN(-)) by the hypoxanthine (HX)/xanthine oxidase (XO)/iron (Fe) system ...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-002-0418-7

    authors： Mohamadin AM,Abdel-Naim AB

    更新日期：2003-02-01 00:00:00

  • Myeloid hyperplasia in growing rats after chronic treatment with delta 9-THC at behavioral doses.

    abstract：:Delta 9-THC at the dose of 1 mg/kg/die was administered subcutaneously in growing rats, from the second to the 30th day of life. A statistically significant myeloid hyperplasia was demonstrated, which persisted up to 4 months after the end of the treatment, together with significant blood granulocytosis. ...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF00353318

    authors： Giusti GV,Carnevale A

    更新日期：1975-10-20 00:00:00

  • Omnisphero: a high-content image analysis (HCA) approach for phenotypic developmental neurotoxicity (DNT) screenings of organoid neurosphere cultures in vitro.

    abstract：:Current developmental neurotoxicity (DNT) testing in animals faces major limitations, such as high cost and time demands as well as uncertainties in their methodology, evaluation and regulation. Therefore, the use of human-based 3D in vitro systems in combination with high-content image analysis (HCA) might contribute...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-016-1852-2

    authors： Schmuck MR,Temme T,Dach K,de Boer D,Barenys M,Bendt F,Mosig A,Fritsche E

    更新日期：2017-04-01 00:00:00

  • Kinetic characteristics of norcocaine N-hydroxylation in mouse and human liver microsomes: involvement of CYP enzymes.

    abstract：:The first step in the oxidative metabolism of cocaine is N-demethylation to norcocaine, which is further N-hydroxylated to more toxic N-hydroxynorcocaine. In this study we examined the kinetics of norcocaine N-hydroxylation mediated by cytochrome P450 (CYP) in mouse and human liver microsomes. N-hydroxynorcocaine was ...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s002040000154

    authors： Pellinen P,Kulmala L,Konttila J,Auriola S,Pasanen M,Juvonen R

    更新日期：2000-11-01 00:00:00

  • miR-138-1* regulates aflatoxin B1-induced malignant transformation of BEAS-2B cells by targeting PDK1.

    abstract：:Environmental carcinogens-induced lung cancer and potential mechanisms have attracted widespread attention. Currently, microRNAs (miRNAs) have been recognized as key players in development of cancer, among which guide strand of miRNA has been well documented rather than its passenger strand (miRNA*). Our previous stud...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-015-1551-4

    authors： Wang Y,Zhang Z,Wang H,Zhang Y,Ji M,Xu H,Wang C,Sun Z,Gao W,Wang SL

    更新日期：2016-05-01 00:00:00

  • Comparative studies on the nephrotoxicity of 2-bromoethanamine hydrobromide in the Fischer 344 rat and the multimammate desert mouse (Mastomys natalensis).

    abstract：:Renal papillary necrosis (RPN) was induced in Fischer 344 (F344) rats (n = 4) using 2-bromoethanamine hydrobromide (BEA) dosed at 150 mg/kg, and in multimammate desert mice (Mastomys natalensis) at 150 and 250 mg/kg (n = 4 per group). Control rats and Mastomys were dosed with 0.9% saline (n = 4 per group). Urine was c...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF02733668

    authors： Holmes E,Bonner FW,Nicholson JK

    更新日期：1995-01-01 00:00:00

  • The closed chamber technique--uptake, endogenous production, excretion, steady-state kinetics and rates of metabolism of gases and vapors.

    abstract：:The "closed chamber technique" (CCT) is presented. It allows investigation of pharmacokinetics of volatile substances in vivo in animals and in man and in vitro using tissue fractions. During the exposure period only the atmospheric concentrations of the substance are measured. The concentration-time data obtained are...

    journal_title：Archives of toxicology

    pub_type： 杂志文章,评审

    doi：10.1007/BF02307263

    authors： Filser JG

    更新日期：1992-01-01 00:00:00

  • Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury.

    abstract：:Adverse outcome pathways (AOPs) have been recently introduced as tools to map the mechanisms underlying toxic events relevant for chemical risk assessment. AOPs particularly depict the linkage between a molecular initiating event and an adverse outcome through a number of intermediate key events. An AOP has been previ...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-020-02691-9

    authors： Gijbels E,Vilas-Boas V,Annaert P,Vanhaecke T,Devisscher L,Vinken M

    更新日期：2020-04-01 00:00:00

  • Inducing coproporphyria in rat hepatocyte cultures using cyclic AMP and cyclic AMP-releasing agents.

    abstract：:Cyclic AMP (c-AMP), added on its own to rat hepatocyte cultures, caused a marked accumulation of coproporphyrin III. The results obtained by comparing the effect of c-AMP to that of exogenous 5-aminolevulinate (ALA), and from adding c-AMP and ALA together, indicated that the coproporphyrinogen III metabolism was block...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-004-0637-1

    authors： De Matteis F,Harvey C

    更新日期：2005-07-01 00:00:00

  • Effects of fluoroquinolones and magnesium deficiency in murine limb bud cultures.

    abstract：:Quinolone-induced arthropathy is probably caused by a lack of functionally available magnesium in immature joint cartilage. We used an in vitro assay to study the effects of fluoroquinolones on cartilage formation in mouse limb buds from 12-day-old mouse embryos in regular and in magnesium-deficient medium. Omission o...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s002040050521

    authors： Förster C,Rücker M,Shakibaei M,Baumann-Wilschke I,Vormann J,Stahlmann R

    更新日期：1998-06-01 00:00:00

  • A 13-week repeated dose study of three 3-monochloropropane-1,2-diol fatty acid esters in F344 rats.

    abstract：:3-monochloropropane-1,2-diol (3-MCPD), a rat renal and testicular carcinogen, has been reported to occur in various foods and food ingredients as free or esterified forms. Since reports about toxicity of 3-MCPD esters are limited, we conducted a 13-week rat subchronic toxicity study of 3-MCPD esters (palmitate diester...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-013-1190-6

    authors： Onami S,Cho YM,Toyoda T,Mizuta Y,Yoshida M,Nishikawa A,Ogawa K

    更新日期：2014-04-01 00:00:00

  • Regulation of uterine AHR battery gene expression by 17β-Estradiol is predominantly mediated by estrogen receptor α.

    abstract：:The aryl hydrocarbon receptor (AHR) is known to mediate the cellular response to numerous xenobiotics including dioxin. Surprisingly AHR knockout mice provide evidence for the involvement of the AHR signalling cascade in estrogen regulated physiological functions of the female reproductive system. Several studies alre...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-012-0870-y

    authors： Rataj F,Möller FJ,Jähne M,Zierau O,Diel P,Vollmer G,Kretzschmar G

    更新日期：2012-10-01 00:00:00

  • Mixture component effects on the in vitro dermal absorption of pentachlorophenol.

    abstract：:Interactions between chemicals in a mixture and interactions of mixture components with the skin can significantly alter the rate and extent of percutaneous absorption, as well as the cutaneous disposition of a topically applied chemical. The predictive ability of dermal absorption models, and consequently the dermal ...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s002040100242

    authors： Riviere JE,Qiao G,Baynes RE,Brooks JD,Mumtaz M

    更新日期：2001-08-01 00:00:00

  • Inhibition of ferrochelatase and accumulation of porphyrins in mouse hepatocyte cultures exposed to porphyrinogenic chemicals.

    abstract：:The ability of 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC), 3,5-diethoxycarbonyl-4-ethyl-1,4-dihydro-2,6-dimethylpyridine (EDDC) and griseofulvin to induce porphyria in primary cultures of mouse hepatocytes has been examined. Exposure of cultured mouse hepatocytes to DDC, EDDC or griseofulvin resulted in a marked ...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF01974011

    authors： Brady AM,Lock EA

    更新日期：1992-01-01 00:00:00

  • Effects of cadmium on carbonic anhydrase activity and hemoglobin content of rat testes.

    abstract：:The cadmilm-induced (Cd) damage of mammalian testes is thought to be correlated with an inhibition of carbonic anhydrase (CAH) by Cd. Since Cd causes dose-dependent changes in blood flow of the testes, an inhibition of CAH in the testes could be simulated by a decrease of CAH-rich erythrocytes. Therefore, CAH activiti...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF00353353

    authors： Alsen C,Köpcke C,Ohnesorge FK,Schneider J

    更新日期：1976-12-23 00:00:00

  • Activation of nuclear receptor CAR by an environmental pollutant perfluorooctanoic acid.

    abstract：:Perfluorocarboxylic acids (PFCAs) including perfluorooctanoic acid (PFOA) are environmental pollutants showing high accumulation, thermochemical stability and hepatocarcinogenicity. Peroxisome proliferator-activated receptor α is suggested to mediate their toxicities, but the precise mechanism remains unclear. Previou...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-016-1888-3

    authors： Abe T,Takahashi M,Kano M,Amaike Y,Ishii C,Maeda K,Kudoh Y,Morishita T,Hosaka T,Sasaki T,Kodama S,Matsuzawa A,Kojima H,Yoshinari K

    更新日期：2017-06-01 00:00:00

  • Comparison of the effects of tamoxifen and toremifene on rat hepatocarcinogenesis.

    abstract：:The hepatoproliferative and cytochrome P450 enzyme inducing effects of two antiestrogens, tamoxifen and toremifene, were compared in female Sprague-Dawley rats using immunohistochemical staining methods. Equimolar doses of the antiestrogens (tamoxifen 45 mg/kg and toremifene 48 mg/kg) were given by oral administration...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s002040000116

    authors： Kärki A,Mäntylä E,Hirsimäki Y,Karlsson S,Toikkanen S,Hirsimäki P

    更新日期：2000-07-01 00:00:00

  • Toxic effects of A2E in human ARPE-19 cells were prevented by resveratrol: a potential nutritional bioactive for age-related macular degeneration treatment.

    abstract：:Age-related macular degeneration (AMD) is a late-onset retinal disease and the leading cause of central vision loss in the elderly. Degeneration of retinal pigment epithelial cells (RPE) is a crucial contributing factor responsible for the onset and progression of AMD. The toxic fluorophore N-retinyl-N-retinylidene et...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-019-02637-w

    authors： Alaimo A,Di Santo MC,Domínguez Rubio AP,Chaufan G,García Liñares G,Pérez OE

    更新日期：2020-02-01 00:00:00

  • Melanin and neuromelanin binding of drugs and chemicals: toxicological implications.

    abstract：:Melanin is a polyanionic pigment that colors, e.g., the hair, skin and eyes. The pigment neuromelanin is closely related to melanin and is mainly produced in specific neurons of the substantia nigra. Certain drugs and chemicals bind to melanin/neuromelanin and are retained in pigment cells for long periods. This speci...

    journal_title：Archives of toxicology

    pub_type： 杂志文章,评审

    doi：10.1007/s00204-016-1757-0

    authors： Karlsson O,Lindquist NG

    更新日期：2016-08-01 00:00:00