Abstract：
:The objective of this study was to evaluate the role of apoptosis in the development of the newborn cochlear structures and hearing loss caused by prenatal cis-diaminedichloroplatinum (cisplatin) exposure. Pregnant albino guinea pigs were intraperitoneally injected with 1.5 mg/kg body weight cisplatin once a day for seven consecutive days at gestational day (GD) 51 to GD 57. At postnatal day (PND) 14, pups were examined in the distortion product otoacoustic emission (DPOAE) task. The temporal bones were then removed and immunohistochemically stained for caspase 3, using the terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling (TUNEL) method. Cisplatin used during pregnancy could induce hearing loss in newborn and cochlear hair cell apoptosis. In conclusion, apoptosis may play an important role in the development of hearing impairment, caused by perinatal cisplatin exposure.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Hao S,Jiang X,Yan A,Yang Bdoi
10.1007/s00204-010-0543-7subject
Has Abstractpub_date
2011-01-01 00:00:00pages
19-25issue
1eissn
0340-5761issn
1432-0738journal_volume
85pub_type
杂志文章abstract：:Pentachlorophenol (PCP) and Dichlorodiphenyltrichloroethane (DDT) are environmental contaminants found in human blood. Previous studies have shown that PCP and DDT inhibit the lytic function of highly purified human natural killer (NK) lymphocytes and decrease the expression of several surface proteins on NK cells. In...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1829-1
更新日期：2017-04-01 00:00:00
abstract：:Groups of rats were exposed simultaneously to manganese chloride (3 mg Mn2+/ml water) through drinking water and lead acetate intraperitoneally at dosages of 5.0, 8.0 and 12.0 mgPb2+/kg daily for a period of 14 days. The magnitude of changes in the behavioral pattern, contents of biogenic amines and accumulation of le...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00352071
更新日期：1981-11-01 00:00:00
abstract：:Previously we reported that exposure of mouse and human mast cells to aryl hydrocarbon receptor (AhR) ligands resulted in reactive oxygen species (ROS)- and calcium (Ca2+)-dependent activation of mast cells in vitro and in vivo. However, the mechanisms through which the AhR-ligand axis mediates stress response, Ca2+ s...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1861-1
更新日期：2017-04-01 00:00:00
abstract：:Several structurally different metal chelating agents were screened for their relative efficacy in counteracting acute manganese intoxication in mice. Polyaminocarboxylic acids with nitrogen and oxygen as metal binding sites were more effective than certain sulfhydryl chelating agents and common drugs in preventing mo...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00569233
更新日期：1982-05-01 00:00:00
abstract：:The International Agency for Research on Cancer considers the carcinogenicity of welding fume of priority for re-evaluation. Genotoxic effects in experimental animals are still inconclusive. Here, we investigated the association of personal exposure to metals in respirable welding fumes during a working shift with oxi...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-014-1319-2
更新日期：2015-08-01 00:00:00
abstract：:Inhibition mechanism(s) of protein kinase B/Akt1 and its consequences on related cell signaling were investigated in human neuroblastoma SH-SY5Y cells exposed to 4-hydroxy-trans-2-nonenal (4-HNE), one of the most reactive aldehyde by-products of lipid peroxidation. In silico data indicate that 4-HNE interacts with kin...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-014-1260-4
更新日期：2015-02-01 00:00:00
abstract：:Sertoli cells play a critical role in spermatogenesis, and in adults, they are terminally differentiated with loss of proliferative activity. This study revealed Sertoli cell proliferation in 17-week-old Sprague-Dawley rats whose dams had been intragastrically administered 250 ng of 3,3',4,4',5-pentachlorobiphenyl/kg ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-011-0736-8
更新日期：2012-01-01 00:00:00
abstract：:MDMA-induced impairments of memory performance have been reported in different human and animal studies. However, the correlation between spatial memory impairment, brain mitochondrial function, and concentrations of MDMA and its metabolites has not yet been investigated despite it being needed for comparison with hum...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02673-x
更新日期：2020-03-01 00:00:00
abstract：:The peroxisome proliferator class of non-genotoxic rodent hepatocarcinogens cause hepatocyte DNA synthesis, peroxisome proliferation and liver tumours when administered to rats and mice, but fail to induce S-phase or peroxisome proliferation in hepatocytes from other species including guinea-pigs, dogs, and primates i...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050483
更新日期：1998-02-01 00:00:00
abstract：:Aspergillus versicolor and A. flavus are primary colonizers in damp dwellings, and they produce sterigmatocystin (ST) and aflatoxin B1 (AFB(1)), respectively. These hepatotoxic and carcinogenic mycotoxins and their precursors and derivates possess a furofuran ring, which has proven responsible for their toxicity. The ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-012-0871-x
更新日期：2012-10-01 00:00:00
abstract：:In vivo screening methods for detection of thyroid function modulators are now under development in many research laboratories. We assessed the applicability of the Hershberger assay protocol to screen for thyroid function modulators. In experiment 1, castrated male BrlHan WIST@Jcl (GALAS) rats were administered a pot...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-005-0677-1
更新日期：2005-11-01 00:00:00
abstract：:Bromethylbutyramide (Carbromide), a quantitatively important metabolite of carbromal, diminished the contractility of electrically driven and the frequency of spontaneously beating guinea-pig atria. The negative inotropic action of bromethylbutyramide occurred at concentrations which are reached in human carbromal poi...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01891970
更新日期：1978-04-27 00:00:00
abstract：:The tissue distribution, metabolism and excretion of 14C-2,2',4,4',5-pentachlorodiphenyl ether (PCDE) were studied in the rat. Radioactivity was distributed in all tissues examined, with the highest concentrations being found in the fat followed by the skin, liver, kidney and muscle. Most of the radioactivity found in...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00332484
更新日期：1988-01-01 00:00:00
abstract：:In the present study, spiking was used as a strategy to evaluate the mutagenicity of individual compounds in a mixture. Mutagenicity of individual polycyclic aromatic hydrocarbons (PAH) was evaluated in an organic extract of diesel exhaust particles (DEP). The particles were extracted with dichloromethane (DCM). After...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050555
更新日期：1998-10-01 00:00:00
abstract：:The present experiments were performed to test the possibility of interrupting the enterohepatic circulation of arsenic (As). Therefore the efficacy of adsorbents to bind As and/or As-DMPS adducts in vitro and their effect on the excretion of As into the feces and urine in vivo were investigated after injection of As2...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050237
更新日期：1995-01-01 00:00:00
abstract：:The effects of dicamba, a widely used broad-leaf herbicide, on rat liver mitochondrial bioenergetic activities were examined. The results obtained for state 4 respiration indicate not only an uncoupling effect, the result of an increase on the permeability of inner mitochondria membrane to protons, but also a strong i...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-003-0456-9
更新日期：2003-07-01 00:00:00
abstract：:The effect of isosorbide diuresis on gentamicin excretion and tissue accumulation as well as gentamicin-induced histopathologic changes in renal tissue were examine in rats. Gentamicin (30, 60, 120, 160 mg/kg) was administered s.c. for 10 consecutive days with or without isosorbide pretreatment. Osmotic diuresis with ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF02419001
更新日期：1980-09-01 00:00:00
abstract：:A new class of potent anticancer drugs, alkylphosphocholines has been recognized lately. Miltefosine (Hexadecylphosphochlorine, HPC) has been found to express select antineoplastic effect on human breast cancer skin metastases with simultaneous preservation of bone marrow proliferative activity and low clastogenicity....
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-005-0010-z
更新日期：2006-01-01 00:00:00
abstract：:Perfluorocarboxylic acids (PFCAs) including perfluorooctanoic acid (PFOA) are environmental pollutants showing high accumulation, thermochemical stability and hepatocarcinogenicity. Peroxisome proliferator-activated receptor α is suggested to mediate their toxicities, but the precise mechanism remains unclear. Previou...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1888-3
更新日期：2017-06-01 00:00:00
abstract：:Quercetin (QC), a polyphenolic compound widely distributed in fruits and vegetables has recently gained interest due to its cisplatin (CP) sensitizing properties in cancer cells. It is currently unknown, whether quercetin also increases the susceptibility of the kidneys to cisplatin toxicity. We studied the effects of...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050539
更新日期：1998-07-01 00:00:00
abstract：:Many carcinogens and mutagens are electrophilic in nature and will react with nucleophilic sites in protein and nucleic acid. Determination of the extent of formation of these adducts of genotoxic agents with protein provides a practical method of monitoring human exposure and of determining the possible risk associat...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00296978
更新日期：1987-01-01 00:00:00
abstract：:DNA binding in vivo: [6,7-3H]beta-trenbolone (beta-TBOH) was administered p.o. and i.p. to rats. After 8 or 16 h, DNA was isolated from the livers and purified to constant specific radioactivity. Enzymatic digestion to deoxyribonucleotides and separation by HPLC revealed about 90% of the DNA radioactivity eluting in t...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00570127
更新日期：1988-01-01 00:00:00
abstract：:Particle-induced carcinogenicity is not well understood, but might involve inflammation. The proinflammatory cytokine tumor necrosis factor (TNF) is considered to be an important mediator in inflammation. We investigated its role in particle-induced inflammation and DNA damage in mice with and without TNF signaling. T...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-004-0613-9
更新日期：2005-03-01 00:00:00
abstract：:Interactions between chemicals in a mixture and interactions of mixture components with the skin can significantly alter the rate and extent of percutaneous absorption, as well as the cutaneous disposition of a topically applied chemical. The predictive ability of dermal absorption models, and consequently the dermal ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040100242
更新日期：2001-08-01 00:00:00
abstract：:The aim of this study was to investigate the electrophilic tissue burden (ETB) formation, assessed as covalent binding of the ultimate carcinogen benzo( a)pyrene diolepoxide (BaPDE) with cellular proteins, in liver, lung and heart, as well as with haemoglobin (Hb) following repeated exposure to binary mixtures of benz...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-003-0518-z
更新日期：2004-02-01 00:00:00
abstract：:A method is outlined to estimate from hemodialysis or hemoperfusion data, respectively, the rate constants, the distribution volume in the beta-phase, and other pharmacokinetic parameters of toxic substances. All calculations are based on the assumption that the usual linear open two-compartment system is also the app...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01459998
更新日期：1983-05-01 00:00:00
abstract：:A method is described for the determination of lorazepam plasma levels involving extraction from the sample and analysis of the intact lorazepam by electron capture gas-liquid chromatography. Using mass spectrometry it is demonstrated, that lorazepam shows a thermal rearrangement under gas chromatographic conditions. ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00293571
更新日期：1976-06-08 00:00:00
abstract：:Drug-induced liver injuries have been a major focus of current research in drug development, and are also one of the major reasons for the failure and withdrawal of drugs in development. Drug-induced liver injuries have been systematically recorded in many public databases, which have become valuable resources in this...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-017-2024-8
更新日期：2017-09-01 00:00:00
abstract：:The pregnancy outcomes of 109 women who were intoxicated during pregnancy due to excessive amounts of drugs and other agents were studied. Seventy per cent of the women attempted suicide, and the intoxication in 78% of all cases was caused by drugs. The stillbirth rate (4%) was higher than that in previous and subsequ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00316249
更新日期：1988-08-01 00:00:00
abstract：:Acetaminophen (APAP) is a widely-used analgesic and a known hepatotoxic agent. Vascular endothelial growth factor (VEGF) is a growth factor with multiple functional roles. VEGF plays an important role in angiogenesis and hepatic regeneration. The aim of this study was to determine the expression of VEGF isoforms and i...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-007-0201-x
更新日期：2007-10-01 00:00:00
