Effect of DMPS and various adsorbents on the arsenic excretion in guinea-pigs after injection with As2O3.


:The present experiments were performed to test the possibility of interrupting the enterohepatic circulation of arsenic (As). Therefore the efficacy of adsorbents to bind As and/or As-DMPS adducts in vitro and their effect on the excretion of As into the feces and urine in vivo were investigated after injection of As2O3 and DMPS in guinea-pigs. The adsorbents bentonite, activated charcoal or colestyramine, respectively, were tested. Only slight binding of 73As (< 5% of the 73As dose) was observed to all adsorbents in vitro. After addition of DMPS, a good binding was found for 73As to colestyramine (50%) or activated charcoal (60%), respectively. However, the 73As-DMPS adduct was removed from the activated charcoal during washing. In the first in vivo experiment, male guinea-pigs (n = 4/group) received As2O3 [0.02 mmol As(III)/kg s.c. labelled with a tracer dose of 73As(III) (0.14 kBq/g)], 30 min later DMPS (0.1 mmol/kg i.p.) and by gastric tube (10 ml/kg body wt) either saline, bentonite (1 g/kg), activated charcoal (1 g/kg) or colestyramine (0.2 g/kg), respectively. Urine and feces were collected for 24 h. No increase in 73As excretion into the feces was observed after administration of DMPS and all adsorbents, compared to control animals. In the second in vivo experiment male guinea-pigs (n = 4/group) received the same As2O3 (+ 73As)- and DMPS dose. In addition, with a gastric tube (10 ml/kg) saline, colestyramine (0.2 g/kg), DMPS (0.1 mmol/kg), or the combination of DMPS (0.1 mmol/kg) + colestyramine (0.2 g/kg) were administered according to the scheme given in the following table. The amount of feces excreted did not differ between groups. Excretion of 73As within the feces during the first 12 h after As injection is shown in the following table (mean +/- SEM). The same amount of 73As (34% of the 73As dose) was excreted into the urine from animals in groups 4 and 5 during this time. Obviously, the combined oral administration of DMPS + colestyramine markedly enhanced fecal excretion of As mobilized by DMPS i.p. It is suggested that interruption of enterohepatic circulation of As may be a valuable adjunct in the treatment of As poisoning.


Arch Toxicol


Archives of toxicology


Reichl FX,Hunder G,Liebl B,Fichtl B,Forth W




Has Abstract


1995-01-01 00:00:00












  • Urinary trehalase as an early indicator of cadmium-induced renal tubular damage in rabbit.

    abstract::The significance of urinary trehalase as a possible early indicator of renal disorder was examined using Cd-treated rabbits, which received 1 mg/kg Cd thrice weekly for 3 months subcutaneously. The results showed that urinary trehalase increased significantly from 1 week after treatment, earlier than LAP, ALP, protein...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Nishimura N,Oshima H,Nakano M

    更新日期:1986-12-01 00:00:00

  • A frequent misinterpretation in current research on liver fibrosis: the vessel in the center of CCl4-induced pseudolobules is a portal vein.

    abstract::Carbon tetrachloride-induced liver injury is a thoroughly studied model for regeneration and fibrosis in rodents. Nevertheless, its pattern of liver fibrosis is frequently misinterpreted as portal type. To clarify this, we show that collagen type IV+ "streets" and α-SMA+ cells accumulate pericentrally and extend to ne...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Hammad S,Braeuning A,Meyer C,Mohamed FEZA,Hengstler JG,Dooley S

    更新日期:2017-11-01 00:00:00

  • Activation of nuclear receptor CAR by an environmental pollutant perfluorooctanoic acid.

    abstract::Perfluorocarboxylic acids (PFCAs) including perfluorooctanoic acid (PFOA) are environmental pollutants showing high accumulation, thermochemical stability and hepatocarcinogenicity. Peroxisome proliferator-activated receptor α is suggested to mediate their toxicities, but the precise mechanism remains unclear. Previou...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Abe T,Takahashi M,Kano M,Amaike Y,Ishii C,Maeda K,Kudoh Y,Morishita T,Hosaka T,Sasaki T,Kodama S,Matsuzawa A,Kojima H,Yoshinari K

    更新日期:2017-06-01 00:00:00

  • Long-term cadmium exposure induces anemia in rats through hypoinduction of erythropoietin in the kidneys.

    abstract::Cadmium (Cd), a highly toxic heavy metal, is distributed widely in the general environment of today. The characteristic clinical manifestations of chronic Cd intoxication include renal proximal tubular dysfunction, general osteomalacia with severe pains, and anemia. We have recently reported that the serum level of er...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Horiguchi H,Sato M,Konno N,Fukushima M

    更新日期:1996-01-01 00:00:00

  • Urinary metallothionein as a new index of renal dysfunction in "Itai-Itai" disease patients and other Japanese women environmentally exposed to cadmium.

    abstract::The significance of elevated excretion of metallothionein in urine of women living in cadmium-polluted areas of Japan was studied with respect to renal dysfunction. The relationships between the concentrations of metallothionein in urine and those of other non-specific urinary indices of renal dysfunction, i.e., total...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Tohyama C,Shaikh ZA,Nogawa K,Kobayashi E,Honda R

    更新日期:1982-07-01 00:00:00

  • Inhibition of ferrochelatase and accumulation of porphyrins in mouse hepatocyte cultures exposed to porphyrinogenic chemicals.

    abstract::The ability of 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC), 3,5-diethoxycarbonyl-4-ethyl-1,4-dihydro-2,6-dimethylpyridine (EDDC) and griseofulvin to induce porphyria in primary cultures of mouse hepatocytes has been examined. Exposure of cultured mouse hepatocytes to DDC, EDDC or griseofulvin resulted in a marked ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Brady AM,Lock EA

    更新日期:1992-01-01 00:00:00

  • Acute and subacute oral administration of mycotoxin deoxynivalenol exacerbates the pro-inflammatory and pro-pruritic responses in a mouse model of allergic dermatitis.

    abstract::Deoxynivalenol (DON) contamination in food is a public health concern; however, the effect of DON exposure on immune disorders including allergies remains unclear. The aim of this study is to elucidate the effect of oral exposure to DON on pro-inflammatory and pro-pruritic responses in a mouse model of allergic dermat...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Aihara R,Ookawara T,Morimoto A,Iwashita N,Takagi Y,Miyasaka A,Kushiro M,Miyake S,Fukuyama T

    更新日期:2020-12-01 00:00:00

  • Fatal sotalol poisoning.

    abstract::Sotalol [4-(2-isopropylamino-1-hydroxyethyl)-methane-sulfonanilide hydrochloride] is a beta-adrenergic blocking agent. Despite the widespread use of these drugs, poisonings are not frequent. In this report the authors describe the first recorded case of fatal sotalol overdosage to their knowledge. The results of toxic...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Montagna M,Groppi A

    更新日期:1980-01-01 00:00:00

  • Arsenic-containing hydrocarbons: effects on gene expression, epigenetics, and biotransformation in HepG2 cells.

    abstract::Arsenic-containing hydrocarbons (AsHCs), a subgroup of arsenolipids found in fish and algae, elicit substantial toxic effects in various human cell lines and have a considerable impact on cellular energy levels. The underlying mode of action, however, is still unknown. The present study analyzes the effects of two AsH...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Müller SM,Finke H,Ebert F,Kopp JF,Schumacher F,Kleuser B,Francesconi KA,Raber G,Schwerdtle T

    更新日期:2018-05-01 00:00:00

  • Tamoxifen induces hepatocellular carcinoma in rat liver: a 1-year study with two antiestrogens.

    abstract::The effects of equimolar doses of the triphenylethylene antiestrogens tamoxifen and toremifene on female Sprague-Dawley rat liver were studied in a 52-week toxicity study which included a 13-week recovery period. Liver tumors were found in four out of five rats at the highest dose level of tamoxifen (45 mg/kg per day)...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Hirsimäki P,Hirsimäki Y,Nieminen L,Payne BJ

    更新日期:1993-01-01 00:00:00

  • Meso-2,3-dimercaptosuccinic acid and sodium N-benzyl-N-dithiocarboxy-D-glucamine as antagonists for cadmium intoxication.

    abstract::Orally administered meso-2,3-dimercaptosuccinic acid (DMSA) is an effective antagonist for acute oral cadmium chloride (1 mmol/kg) intoxication in mice when administered up to 8 h after cadmium ingestion. Administration of sodium N-benzyl-N-dithiocarboxy-D-glucamine (NaB) i.p. along with DMSA p.o. resulted in kidney a...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Jones MM,Basinger MA,Topping RJ,Gale GR,Jones SG,Holscher MA

    更新日期:1988-08-01 00:00:00

  • Cadmium chloride inhibits lactate gluconeogenesis in isolated human renal proximal tubules: a cellular metabolomic approach with 13C-NMR.

    abstract::As part of a study on cadmium nephrotoxicity, we studied the effect of cadmium chloride (CdCl2) in isolated human renal proximal tubules metabolizing the physiological substrate lactate. Dose-effect experiments showed that 10-500 μM CdCl2 reduced lactate removal, glucose production and the cellular levels of ATP, coen...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Faiz H,Conjard-Duplany A,Boghossian M,Martin G,Baverel G,Ferrier B

    更新日期:2011-09-01 00:00:00

  • Insulin-like growth factor-1 protects preimplantation embryos from anti-developmental actions of menadione.

    abstract::Menadione is a naphthoquinone used as a vitamin K source in animal feed that can generate reactive oxygen species (ROS) and cause apoptosis. Here, we examined whether menadione reduces development of preimplantation bovine embryos in a ROS-dependent process and tested the hypothesis that actions of menadione would be ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Moss JI,Pontes E,Hansen PJ

    更新日期:2009-11-01 00:00:00

  • Role of striatal acetylcholine and free ammmonia in the central stimulatory effects of pp'DDT in rats. Protective effects of barbiturates.

    abstract::pp'DDT (600 mg/kg, orally) produced an increase in the level of free ammonia and a decrease of acetylcholine in the corpus striatum of rats. These effects were maximal 5 h after the administration of pp'DDT. The animals showed tremors after 2 h, mild or moderate convulsions after 3.5 h and severe convulsions 5 h after...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Matin MA,Jaffery FN,Kar PP

    更新日期:1980-05-01 00:00:00

  • Detection of early signals of hepatotoxicity by gene expression profiling studies with cultures of metabolically competent human hepatocytes.

    abstract::Xenobiotic induced liver injury is a leading cause for drug withdrawal and toxicogenomics may help to identify molecular causes. Here we report studies with cultures of human hepatocytes to detect early responses of liver toxicity upon treatment with the hepatotoxin Aroclor 1254. We studied transcript abundance of 302...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Thum T,Borlak J

    更新日期:2008-02-01 00:00:00

  • Comparative induction of cytochrome P450IVA1 and peroxisome proliferation by ciprofibrate in the rat and marmoset.

    abstract::Chronic ciprofibrate administration resulted in distinct differences in hepatic responses between the two species examined. In the rat, hepatomegaly was observed with the coordinate induction of carnitine acetyltransferase, peroxisomal beta-oxidation and cytochrome P450IVA1 activities. The latter induction of cytochro...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Makowska JM,Bonner FW,Gibson GG

    更新日期:1991-01-01 00:00:00

  • Effect of acute and chronic cadmium treatment on hepatic drug metabolism in male rats.

    abstract::The effect of acute and chronic cadmium administration on hepatic drug metabolism was investigated in the male rat. 3 days after the acute administration of cadmium by either the intraperitoneal (0.84 mg Cd/kg) or the oral (greater than 80 mg Cd/kg) route, there was a significant potentiation in duration of hexobarbit...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Schnell RC,Yuhas EM,Pence DH,Means JR,Roberts SA,Yau ET,Miya TS,Mennear JH

    更新日期:1978-08-09 00:00:00

  • Electron microscopy and X-ray microanalyses of uterine epithelium from lead-injected mice in an experimental delay of implantation.

    abstract::Mice in experimental delay of implantation were injected intravenously with 75 micrograms.g-1 body weight of lead chloride, corresponding to a dose of lead of about 56 micrograms.g-1 body weight. Delay of implantation was obtained by ovariectomy 3 days after mating followed by a depot dose of progesterone every fifth ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Nilsson BO,Ljung L,Wide M

    更新日期:1991-01-01 00:00:00

  • Inhibition, reactivation and aging kinetics of cyclohexylmethylphosphonofluoridate-inhibited human cholinesterases.

    abstract::Cyclohexylmethylphosphonofluoridate (cyclosarin) is a highly toxic organophosphate, which was shown to be rather resistant to conventional oxime therapy. To give more insight into the inhibition, reactivation and aging kinetics, human acetyl-(AChE) and butyrylcholinesterase (BChE) were inhibited by cyclosarin (k2 of 7...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Worek F,Eyer P,Szinicz L

    更新日期:1998-09-01 00:00:00

  • Study on the mechanism of photosensitive dermatitis caused by ketoprofen in the guinea pig.

    abstract::To investigate the mechanism on photosensitive dermatitis caused by ketoprofen (KP) in humans, the following experiments were performed by topical application on guinea pigs. The phototoxicity study involving treatment with 10% solution of KP, its enantiomers (R-KP and S-KP), loxoprofen, and flurbiprofen revealed no p...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Nakazawa T,Shimo T,Chikamatsu N,Igarashi T,Nagata O,Yamamoto M

    更新日期:2006-07-01 00:00:00

  • Bioactivation of food genotoxicants 5-hydroxymethylfurfural and furfuryl alcohol by sulfotransferases from human, mouse and rat: a comparative study.

    abstract::5-Hydroxymethylfurfural (HMF) and furfuryl alcohol (FFA) are moderately potent rodent carcinogens that are present in thermally processed foodstuffs. The carcinogenic effects were hypothesized to originate from sulfotransferase (SULT)-mediated bioactivation yielding DNA-reactive and mutagenic sulfate esters, a confirm...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Sachse B,Meinl W,Sommer Y,Glatt H,Seidel A,Monien BH

    更新日期:2016-01-01 00:00:00

  • Difference in rates of the reaction of various mammalian oxyhemoglobins with phenylhydrazine.

    abstract::Second order rate constants for the initial reaction of 12 mammalian oxyhemoglobins (Hb) with equimolar phenylhydrazine (PHZ), a compound inducing Heinz body hemolytic anemia, were determined by recording continuous changes in absorbance with time at 577 nm. The rate constants were varied in a range from 43 m-1.s-1 wi...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Kinuta M,Matteson JL,Itano HA

    更新日期:1995-01-01 00:00:00

  • Effect of lindane and heptachlor on delta-aminolaevulinate synthase and its regulation.

    abstract::The effect of lindane and heptachlor on haem metabolism was studied with the aim to elucidate the mechanism of their porphyrinogenic action. The effects of these compounds on delta-aminolaevulinate synthase (ALA-S) and ferrochelatase were evaluated and the mechanism of increase of ALA-S activity was especially studied...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Taira MC,San Martín de Viale LC

    更新日期:1998-11-01 00:00:00

  • Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum.

    abstract::Trichloroethylene (TCE)-induced liver toxicity and carcinogenesis is believed to be mediated in part by activation of the peroxisome proliferator-activated receptor α (PPARα). However, the contribution of the two TCE metabolites, dichloroacetate (DCA) and trichloroacetate (TCA) to the toxicity of TCE, remains unclear....

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Fang ZZ,Krausz KW,Tanaka N,Li F,Qu A,Idle JR,Gonzalez FJ

    更新日期:2013-11-01 00:00:00

  • DNA damage response in cisplatin-induced nephrotoxicity.

    abstract::Cisplatin and its derivatives are widely used chemotherapeutic drugs for cancer treatment. However, they have debilitating side effects in normal tissues and induce ototoxicity, neurotoxicity, and nephrotoxicity. In kidneys, cisplatin preferentially accumulates in renal tubular cells causing tubular cell injury and de...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,评审


    authors: Zhu S,Pabla N,Tang C,He L,Dong Z

    更新日期:2015-12-01 00:00:00

  • Mitochondrial dysregulation and protection in cisplatin nephrotoxicity.

    abstract::Nephrotoxicity is a major side effect of cisplatin in chemotherapy. Pathologically, cisplatin nephrotoxicity is characterized by cell injury and death in renal tubules. The research in the past decade has gained significant understanding of the cellular and molecular mechanisms of tubular cell death, revealing a centr...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,评审


    authors: Yang Y,Liu H,Liu F,Dong Z

    更新日期:2014-06-01 00:00:00

  • Effects of bisphenol A on breast cancer and its risk factors.

    abstract::The incidence of breast cancer in Korea has been increasing for the last two decades (1983-2005), and now, breast cancer is ranked the leading cause of cancer in Korean women. Along with other endocrine disrupting chemicals (EDCs), bisphenol A (BPA) has been suspected as a potential risk factor for breast cancer. We s...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Yang M,Ryu JH,Jeon R,Kang D,Yoo KY

    更新日期:2009-03-01 00:00:00

  • Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on liver phosphoenolpyruvate carboxykinase (PEPCK) activity, glucose homeostasis and plasma amino acid concentrations in the most TCDD-susceptible and the most TCDD-resistant rat strains.

    abstract::Reduced gluconeogenesis due to decreased activity of key gluconeogenic enzymes in liver, together with feed refusal, has been suggested to play an important role in 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD)-induced lethality in rats. This study was carried out to further analyse the toxicological significance of red...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Viluksela M,Unkila M,Pohjanvirta R,Tuomisto JT,Stahl BU,Rozman KK,Tuomisto J

    更新日期:1999-08-01 00:00:00

  • Biochemical and toxicological effects of short-term, intermittent xylene inhalation exposure and combined ethanol intake.

    abstract::Intermittent inhalation of 300 ppm of xylene vapour 6 h daily for 2 weeks caused a marked accumulation of the solvent in the perirenal fat. Simultaneous ethanol ingestion reduced the solvent load significantly although the perirenal xylene concentration increased in both test groups between the first and second week o...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Savolainen H,Vainio H,Helojoki M,Elovaara E

    更新日期:1978-12-28 00:00:00

  • In vitro toxicological evaluation of a dinuclear platinum(II) complex with acetate ligands.

    abstract::In the present study the toxicological potential of a tumor-inhibiting dinuclear platinum(II) complex (bis(acetato)diammine-bis-micro-acetato diplatinum(II) dihydrate (BAP)) was evaluated, utilizing in vitro models of nephrotoxicity, myelosuppression and neurotoxicity. Regarding the discrepancies between the hallmark ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Momekov G,Ferdinandov D,Bakalova A,Zaharieva M,Konstantinov S,Karaivanova M

    更新日期:2006-09-01 00:00:00