Effect of DMPS and various adsorbents on the arsenic excretion in guinea-pigs after injection with As2O3.


:The present experiments were performed to test the possibility of interrupting the enterohepatic circulation of arsenic (As). Therefore the efficacy of adsorbents to bind As and/or As-DMPS adducts in vitro and their effect on the excretion of As into the feces and urine in vivo were investigated after injection of As2O3 and DMPS in guinea-pigs. The adsorbents bentonite, activated charcoal or colestyramine, respectively, were tested. Only slight binding of 73As (< 5% of the 73As dose) was observed to all adsorbents in vitro. After addition of DMPS, a good binding was found for 73As to colestyramine (50%) or activated charcoal (60%), respectively. However, the 73As-DMPS adduct was removed from the activated charcoal during washing. In the first in vivo experiment, male guinea-pigs (n = 4/group) received As2O3 [0.02 mmol As(III)/kg s.c. labelled with a tracer dose of 73As(III) (0.14 kBq/g)], 30 min later DMPS (0.1 mmol/kg i.p.) and by gastric tube (10 ml/kg body wt) either saline, bentonite (1 g/kg), activated charcoal (1 g/kg) or colestyramine (0.2 g/kg), respectively. Urine and feces were collected for 24 h. No increase in 73As excretion into the feces was observed after administration of DMPS and all adsorbents, compared to control animals. In the second in vivo experiment male guinea-pigs (n = 4/group) received the same As2O3 (+ 73As)- and DMPS dose. In addition, with a gastric tube (10 ml/kg) saline, colestyramine (0.2 g/kg), DMPS (0.1 mmol/kg), or the combination of DMPS (0.1 mmol/kg) + colestyramine (0.2 g/kg) were administered according to the scheme given in the following table. The amount of feces excreted did not differ between groups. Excretion of 73As within the feces during the first 12 h after As injection is shown in the following table (mean +/- SEM). The same amount of 73As (34% of the 73As dose) was excreted into the urine from animals in groups 4 and 5 during this time. Obviously, the combined oral administration of DMPS + colestyramine markedly enhanced fecal excretion of As mobilized by DMPS i.p. It is suggested that interruption of enterohepatic circulation of As may be a valuable adjunct in the treatment of As poisoning.


Arch Toxicol


Archives of toxicology


Reichl FX,Hunder G,Liebl B,Fichtl B,Forth W




Has Abstract


1995-01-01 00:00:00












  • Sexual dimorphism of cadmium-induced toxicity in rats: involvement of sex hormones.

    abstract::The toxic effect of cadmium varies with sex in experimental animals. Previous studies have demonstrated that pretreatment of male Fischer 344 (F344) rats with the female sex hormone progesterone markedly enhances the susceptibility to cadmium, suggesting a role for progesterone in the sexual dimorphism of cadmium toxi...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Shimada H,Hashiguchi T,Yasutake A,Waalkes MP,Imamura Y

    更新日期:2012-09-01 00:00:00

  • Effects of n-hexane and its metabolites on cloned voltage-operated neuronal potassium channels.

    abstract::In order to study the mechanisms of acute n-hexane intoxication, the effects of n-hexane and its metabolites 2-hexanol, methyl-n-butyl ketone, 2,5-hexanediol and 2,5-hexanedione on the cloned voltage-operated potassium channels Kv1.1, Kv1.4, Kv2.1 and Kv3.4 were investigated with electrophysiological techniques in the...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Madeja M,Binding N,Musshoff U,Witting U,Speckmann EJ

    更新日期:1997-01-01 00:00:00

  • The explosive trinitrotoluene (TNT) induces gene expression of carbonyl reductase in the blue mussel (Mytilus spp.): a new promising biomarker for sea dumped war relicts?

    abstract::Millions of tons of all kind of munitions, including mines, bombs and torpedoes have been dumped after World War II in the marine environment and do now pose a new threat to the seas worldwide. Beside the acute risk of unwanted detonation, there is a chronic risk of contamination, because the metal vessels corrode and...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Strehse JS,Brenner M,Kisiela M,Maser E

    更新日期:2020-12-01 00:00:00

  • Interactions of trichloroethylene with DNA in vitro and with RNA and DNA of various mouse tissues in vivo.

    abstract::The covalent binding of 14C-1,1,2-trichloroethylene (14C-TRI) metabolites to calf thymus DNA in vitro and to RNA and DNA of mouse brain, lung, liver, kidney, spleen, pancreas, and testis after repeated i.p. injections has been studied. Hydrolysates of DNA reacted with 14C-TRI in vitro and hydrolysates of RNA and DNA f...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Bergman K

    更新日期:1983-11-01 00:00:00

  • The protective role of NAD(P)H:quinone oxidoreductase 1 on acetaminophen-induced liver injury is associated with prevention of adenosine triphosphate depletion and improvement of mitochondrial dysfunction.

    abstract:UNLABELLED:An overdose of acetaminophen (APAP) causes hepatotoxicity due to its metabolite, N-acetyl-p-benzoquinone imine. NAD(P)H:quinone oxidoreductase 1 (NQO1) is an important enzyme for detoxification, because it catabolizes endogenous/exogenous quinone to hydroquinone. Although various studies have suggested the ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Hwang JH,Kim YH,Noh JR,Gang GT,Kim KS,Chung HK,Tadi S,Yim YH,Shong M,Lee CH

    更新日期:2015-11-01 00:00:00

  • Effect of osmotic diuresis on gentamicin-induced nephrotoxicity in rats.

    abstract::The effect of isosorbide diuresis on gentamicin excretion and tissue accumulation as well as gentamicin-induced histopathologic changes in renal tissue were examine in rats. Gentamicin (30, 60, 120, 160 mg/kg) was administered s.c. for 10 consecutive days with or without isosorbide pretreatment. Osmotic diuresis with ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Newman RA,Weinstock LB,Gump DW,Hacker MP,Yates JW

    更新日期:1980-09-01 00:00:00

  • Toxic effects of A2E in human ARPE-19 cells were prevented by resveratrol: a potential nutritional bioactive for age-related macular degeneration treatment.

    abstract::Age-related macular degeneration (AMD) is a late-onset retinal disease and the leading cause of central vision loss in the elderly. Degeneration of retinal pigment epithelial cells (RPE) is a crucial contributing factor responsible for the onset and progression of AMD. The toxic fluorophore N-retinyl-N-retinylidene et...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Alaimo A,Di Santo MC,Domínguez Rubio AP,Chaufan G,García Liñares G,Pérez OE

    更新日期:2020-02-01 00:00:00

  • Neurotoxic effects in zebrafish embryos by valproic acid and nine of its analogues: the fish-mouse connection?

    abstract::Since teratogenicity testing in mammals is a particular challenge from an animal welfare perspective, there is a great need for the development of alternative test systems. In this context, the zebrafish (Danio rerio) embryo has received increasing attention as a non-protected embryonic vertebrate in vivo model. The p...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Brotzmann K,Wolterbeek A,Kroese D,Braunbeck T

    更新日期:2020-10-27 00:00:00

  • Regulation of uterine AHR battery gene expression by 17β-Estradiol is predominantly mediated by estrogen receptor α.

    abstract::The aryl hydrocarbon receptor (AHR) is known to mediate the cellular response to numerous xenobiotics including dioxin. Surprisingly AHR knockout mice provide evidence for the involvement of the AHR signalling cascade in estrogen regulated physiological functions of the female reproductive system. Several studies alre...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Rataj F,Möller FJ,Jähne M,Zierau O,Diel P,Vollmer G,Kretzschmar G

    更新日期:2012-10-01 00:00:00

  • Induction of Dectin-1 and asthma-associated signal transduction pathways in RAW 264.7 cells by a triple-helical (1, 3)-β-D glucan, curdlan.

    abstract::People living in damp buildings are typically exposed to spore and mycelial fragments of the fungi that grow on damp building materials. There is experimental evidence that this exposure to triple-helical (1, 3)-β-D glucan and low molecular weight toxins may be associated with non-atopic asthma observed in damp and mo...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Rand TG,Robbins C,Rajaraman D,Sun M,Miller JD

    更新日期:2013-10-01 00:00:00

  • Hydroxyethylvaline adduct formation in haemoglobin as a biological monitor of cigarette smoke intake.

    abstract::The ethylene oxide adduct formed on the N-terminal valine in haemoglobin was investigated as a biological monitor of tobacco smoke intake. The modified method developed for the determination of the hydroxyethylvaline adduct (HOEtVal) involved reaction of globin with pentafluorophenyl isothiocyanate, extraction of the ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Bailey E,Brooks AG,Dollery CT,Farmer PB,Passingham BJ,Sleightholm MA,Yates DW

    更新日期:1988-01-01 00:00:00

  • Comparative study of quercetin and its two glycoside derivatives quercitrin and rutin against methylmercury (MeHg)-induced ROS production in rat brain slices.

    abstract::The hypothesis that methylmercury (MeHg) potently induces formation of reactive oxygen species (ROS) in the brain is supported by observations on the neuroprotective effects of various classes of antioxidants. Flavonoids have been reported to possess divalent metal chelating properties, antioxidant activities and to r...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Wagner C,Vargas AP,Roos DH,Morel AF,Farina M,Nogueira CW,Aschner M,Rocha JB

    更新日期:2010-02-01 00:00:00

  • Influence of arsenate and arsenite on signal transduction pathways: an update.

    abstract::Arsenic has been a recognized contaminant and toxicant, as well as a medicinal compound throughout human history. Populations throughout the world are exposed to arsenic and these exposures have been associated with a number of human cancers. Not much is known about the role of arsenic as a human carcinogen and more r...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,评审


    authors: Druwe IL,Vaillancourt RR

    更新日期:2010-08-01 00:00:00

  • The role of SerpinB2 in human bronchial epithelial cells responses to particulate matter exposure.

    abstract::Exposure to particulate matter (PM) has been related to the onset of adverse health effects including lung cancer, but the underlying molecular mechanisms are still under investigation. Epithelial-to-mesenchymal transition (EMT) is regarded as a crucial step in cancer progression. In a previous study, we reported EMT-...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Longhin E,Camatini M,Bersaas A,Mantecca P,Mollerup S

    更新日期:2018-09-01 00:00:00

  • CCR5 knockout mice with C57BL6 background are resistant to acetaminophen-mediated hepatotoxicity due to decreased macrophages migration into the liver.

    abstract::Overdose of acetaminophen (APAP) causes necrosis of centrilobular cells of the liver. Accumulating evidence suggests that innate immune system may contribute to APAP-induced hepatotoxicity. Interaction between RANTES and its receptor C-C chemokine receptor (CCR) 5 is related to recruitment of macrophages to sites of i...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Choi DY,Ban JO,Kim SC,Hong JT

    更新日期:2015-02-01 00:00:00

  • A physiologically based pharmacokinetic model for the oxime TMB-4: simulation of rodent and human data.

    abstract::Multiple oximes have been synthesized and evaluated for use as countermeasures against chemical warfare nerve agents. The current U.S. military and civilian oxime countermeasure, 2-[(hydroxyimino)methyl]-1-methylpyridin-1-ium chloride (2-PAM), is under consideration for replacement with a more effective acetylcholines...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Sterner TR,Ruark CD,Covington TR,Yu KO,Gearhart JM

    更新日期:2013-04-01 00:00:00

  • A survey of metabolic databases emphasizing the MetaCyc family.

    abstract::Thanks to the confluence of genome sequencing and bioinformatics, the number of metabolic databases has expanded from a handful in the mid-1990s to several thousand today. These databases lie within distinct families that have common ancestry and common attributes. The main families are the MetaCyc, KEGG, Reactome, Mo...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,评审


    authors: Karp PD,Caspi R

    更新日期:2011-09-01 00:00:00

  • Suppression of erythropoietin gene expression by cadmium depends on inhibition of HIF-1, not stimulation of GATA-2.

    abstract::Long-term exposure of rats to cadmium (Cd) resulted in a marked suppression of erythropoietin (Epo) mRNA expression in the kidneys and the development of severe anemia. A recent report revealed that Cd inhibited hypoxia-inducible factor 1 (HIF-1) binding activity and Epo mRNA expression and protein production. However...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Obara N,Imagawa S,Nakano Y,Suzuki N,Yamamoto M,Nagasawa T

    更新日期:2003-05-01 00:00:00

  • Culprit or correlate? An application of the Bradford Hill criteria to Vitamin E acetate.

    abstract::Vitamin E acetate (VEA) has come under significant scrutiny due to its association with e-cigarette, or vaping, product use-associated lung injury (EVALI). In 1965, Sir Austin Bradford Hill proposed a set of criteria used to critically assess an association for causality. In this article, we apply the Bradford Hill ca...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,评审


    authors: Feldman R,Meiman J,Stanton M,Gummin DD

    更新日期:2020-06-01 00:00:00

  • A novel genotoxicity assay of carbon nanotubes using functional macrophage receptor with collagenous structure (MARCO)-expressing chicken B lymphocytes.

    abstract::Although carbon nanotubes (CNTs) are promising nanomaterials, their potential carcinogenicity is a major concern. We previously established a genetic method of analyzing genotoxicity of chemical compounds, where we evaluated their cytotoxic effect on the DT40 lymphoid cell line comparing DNA-repair-deficient isogenic ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Mohiuddin,Keka IS,Evans TJ,Hirota K,Shimizu H,Kono K,Takeda S,Hirano S

    更新日期:2014-01-01 00:00:00

  • Effects of bisphenol A on breast cancer and its risk factors.

    abstract::The incidence of breast cancer in Korea has been increasing for the last two decades (1983-2005), and now, breast cancer is ranked the leading cause of cancer in Korean women. Along with other endocrine disrupting chemicals (EDCs), bisphenol A (BPA) has been suspected as a potential risk factor for breast cancer. We s...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Yang M,Ryu JH,Jeon R,Kang D,Yoo KY

    更新日期:2009-03-01 00:00:00

  • Reactivating potency of obidoxime, pralidoxime, HI 6 and HLö 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds.

    abstract::The treatment of poisoning by highly toxic organophosphorus compounds (nerve agents) is unsatisfactory. Until now, the efficacy of new potential antidotes has primarily been evaluated in animals. However, the extrapolation of these results to humans is hampered by species differences. Since oximes are believed to act ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Worek F,Widmann R,Knopff O,Szinicz L

    更新日期:1998-03-01 00:00:00

  • Hepatocyte SHP deficiency protects mice from acetaminophen-evoked liver injury in a JNK-signaling regulation and GADD45β-dependent manner.

    abstract::Acetaminophen (APAP) overdose is a leading cause of drug-induced acute liver failure. Prolonged c-Jun N-terminal kinase (JNK) activation plays a central role in APAP-induced liver injury; however, growth arrest and DNA damage-inducible 45 beta (GADD45β) is known to inhibit JNK phosphorylation. The orphan nuclear recep...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Kim YH,Noh JR,Hwang JH,Kim KS,Choi DH,Kim JH,Moon SJ,Choi JH,Hérault Y,Lee TG,Choi HS,Lee CH

    更新日期:2018-08-01 00:00:00

  • Hydrogen peroxide production in mouse tissues after acute d-amphetamine administration. Influence of monoamine oxidase inhibition.

    abstract::The toxicity of amphetamines is conditioned by a complex array of mechanisms, involving the increase of neurotransmission (e.g. leading to hyperthermia) and enzymatic and non-enzymatic oxidation of amphetamines and biogenic amines. Considering that all these processes may increase the generation of hydrogen peroxide (...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Carvalho F,Duarte JA,Neuparth MJ,Carmo H,Fernandes E,Remião F,Bastos ML

    更新日期:2001-10-01 00:00:00

  • Metabolism-dependent hepatotoxicity of amodiaquine in glutathione-depleted mice.

    abstract::We investigated the hepatotoxicity induced by AQ using a glutathione (GSH)-depleted mice model. Although sole administration of either AQ or L-buthionine-S,R-sulfoxinine (BSO), a well-known GSH synthesis inhibitor, produced no significant hepatotoxicity, combined administration of AQ with BSO induced hepatotoxicity ch...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Shimizu S,Atsumi R,Itokawa K,Iwasaki M,Aoki T,Ono C,Izumi T,Sudo K,Okazaki O

    更新日期:2009-07-01 00:00:00

  • Regional alterations of brain catecholamines by styrene exposure in rabbits.

    abstract::The regional distribution of dopamine, norepinephrine and homovanillic acid was assessed in adult male rabbits exposed to styrene vapours. The turnover of dopamine and norepinephrine was also measured in several brain regions by the decay in endogenous catecholamines after inhibition of tyrosine hydroxylase by alpha-m...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Mutti A,Falzoi M,Romanelli A,Franchini I

    更新日期:1984-09-01 00:00:00

  • Tumor necrosis factor is not required for particle-induced genotoxicity and pulmonary inflammation.

    abstract::Particle-induced carcinogenicity is not well understood, but might involve inflammation. The proinflammatory cytokine tumor necrosis factor (TNF) is considered to be an important mediator in inflammation. We investigated its role in particle-induced inflammation and DNA damage in mice with and without TNF signaling. T...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Saber AT,Bornholdt J,Dybdahl M,Sharma AK,Loft S,Vogel U,Wallin H

    更新日期:2005-03-01 00:00:00

  • Age-related effects of chlorpyrifos on muscarinic receptor-mediated signaling in rat cortex.

    abstract::Chlorpyrifos (CPF) is a widely used organophosphorus pesticide. Earlier work from our laboratory and others has demonstrated that the sensitivity to CPF exposure changes markedly during maturation. A number of studies suggest that in addition to inhibiting acetylcholinesterase (AChE), CPF oxon may also interact direct...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Zhang H,Liu J,Pope CN

    更新日期:2002-01-01 00:00:00

  • Omnisphero: a high-content image analysis (HCA) approach for phenotypic developmental neurotoxicity (DNT) screenings of organoid neurosphere cultures in vitro.

    abstract::Current developmental neurotoxicity (DNT) testing in animals faces major limitations, such as high cost and time demands as well as uncertainties in their methodology, evaluation and regulation. Therefore, the use of human-based 3D in vitro systems in combination with high-content image analysis (HCA) might contribute...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Schmuck MR,Temme T,Dach K,de Boer D,Barenys M,Bendt F,Mosig A,Fritsche E

    更新日期:2017-04-01 00:00:00

  • The pyrrolizidine alkaloid senecionine induces CYP-dependent destruction of sinusoidal endothelial cells and cholestasis in mice.

    abstract::Pyrrolizidine alkaloids (PAs) are widely occurring phytotoxins which can induce severe liver damage in humans and other mammalian species by mechanisms that are not fully understood. Therefore, we investigated the development of PA hepatotoxicity in vivo, using an acutely toxic dose of the PA senecionine in mice, in c...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Hessel-Pras S,Braeuning A,Guenther G,Adawy A,Enge AM,Ebmeyer J,Henderson CJ,Hengstler JG,Lampen A,Reif R

    更新日期:2020-01-01 00:00:00