Abstract：
:Although polybrominated naphthalenes (PBNs) are contaminants of the commercial fire retardant fireMaster BP-6, the individual PBN isomers have not been identified. In order to study PBNs possessing an analogous level of bromination to those found in fireMaster BP-6, three synthetic PBN mixtures, averaging 5.0, 5.3, and 5.6 bromines per naphthalene were synthetized and partially characterized. The PBN mixtures were administered to immature male Wistar rats and found to be potent inducers of cytochrome P-450-dependent monooxygenases. At the lowest dose tested, 30 mumol X kg-1, each PBN mixture caused maximal induction of benzo[a]pyrene hydroxylase activity. On the basis of enzyme activities, ligand-binding spectra and sodium dodecyl sulfate-polyacrylamide gel electrophoresis, the PBN mixtures were determined to be 3-methylcholanthrene-type inducers of cytochrome P-450 (P-448), resembling qualitatively the most toxic polyhalogenated biphenyls, dibenzofurans, and dioxins in this respect. Liver weights were significantly increased and thymus weights diminished by PBN treatment. Light microscopy revealed proliferation of the smooth endoplasmic reticulum in periportal hepatocytes as a consistent change; some rats also had mild fatty changes in centrilobular hepatocytes. Thymuses displayed mild to marked depletion of cortical lymphocytes. The PBN mixtures were much more potent than fireMaster BP-6 in causing these effects; raising the possibility that PBNs are among the minor components of fireMaster BP-6 that contribute significantly to the toxicity of this environmental contaminant.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Robertson LW,Thompson K,Parkinson Adoi
10.1007/BF00346051subject
Has Abstractpub_date
1984-07-01 00:00:00pages
127-31issue
2eissn
0340-5761issn
1432-0738journal_volume
55pub_type
杂志文章abstract：:We analyzed adverse events in a clinical phase I trial to assess dose-dependent metabolic effects of St. John's wort co-administered with rifampicin in 12 healthy volunteers. Within 3-6 days after increasing the St. John's wort dose from 300 to 600 mg TID, five of six female participants developed ambient temperature-...
journal_title：Archives of toxicology
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更新日期：2004-11-01 00:00:00
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doi：10.1007/BF00695874
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journal_title：Archives of toxicology
pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1007/BF01969264
更新日期：1993-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
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更新日期：1991-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01969922
更新日期：1993-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00204-004-0637-1
更新日期：2005-07-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-002-0350-x
更新日期：2002-08-01 00:00:00
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journal_title：Archives of toxicology
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doi：10.1007/BF00316124
更新日期：1984-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-10-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
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更新日期：1997-01-01 00:00:00
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更新日期：2020-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01977402
更新日期：1993-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
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更新日期：2013-04-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
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更新日期：1994-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
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更新日期：2010-02-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040000154
更新日期：2000-11-01 00:00:00
abstract：:In the present study, spiking was used as a strategy to evaluate the mutagenicity of individual compounds in a mixture. Mutagenicity of individual polycyclic aromatic hydrocarbons (PAH) was evaluated in an organic extract of diesel exhaust particles (DEP). The particles were extracted with dichloromethane (DCM). After...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050555
更新日期：1998-10-01 00:00:00
abstract：:Intermittent inhalation of 300 ppm of xylene vapour 6 h daily for 2 weeks caused a marked accumulation of the solvent in the perirenal fat. Simultaneous ethanol ingestion reduced the solvent load significantly although the perirenal xylene concentration increased in both test groups between the first and second week o...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00354091
更新日期：1978-12-28 00:00:00
