Effects of arsenic exposure on D-serine metabolism in the hippocampus of offspring mice at different developmental stages.

abstract：:The mycotoxin ochratoxin A (OTA) and its metabolite ochratoxin alpha (OT-alpha) were investigated, to examine their potency to induce sister chromatid exchanges (SCE) in cultured porcine urinary bladder epithelial cells (PUBEC) (primary culture). Serum-free cultured PUBEC were incubated for 5 h with either OTA or OT-a...

journal_title：Archives of toxicology

authors： Föllmann W,Hillebrand IE,Creppy EE,Bolt HM

更新日期：1995-01-01 00:00:00

abstract：:Membrane transporters play an important role in the absorption, distribution, metabolism and excretion of drugs. The cellular accumulation of many drugs is the result of the net function of efflux and influx transporters. Efflux transporters such as P-glycoprotein/ABCB1 have been shown to confer multidrug resistance i...

journal_title：Archives of toxicology

authors： Windt T,Tóth S,Patik I,Sessler J,Kucsma N,Szepesi Á,Zdrazil B,Özvegy-Laczka C,Szakács G

更新日期：2019-04-01 00:00:00

abstract：:The cholestatic effect of the newly developed oestradiol sulphamate (J995) was compared with that of the natural oestrogen oestradiol (E) and of the cholestatic standard oestrogen ethinyloestradiol (EE). Female ovariectomized rats were orally treated for 7 days with oestrogen doses molar equivalent to 0.01, 0.1, 1, an...

journal_title：Archives of toxicology

authors： Barth A,Elger W,Schneider B,Schwarz S

更新日期：1997-01-01 00:00:00

abstract：:A paradigm shift is occurring in toxicology following the report of the National Research Council of the USA National Academies entitled "Toxicity testing in the 21st Century: a vision and strategy". This new vision encourages the use of in vitro and in silico models for toxicity testing. In the goal to identify new r...

journal_title：Archives of toxicology

authors： Calderazzo S,Tavel D,Zurich MG,Kopp-Schneider A

更新日期：2019-09-01 00:00:00

abstract：:UDP-glucuronosyltransferases (UGTs) are involved in phase II conjugation reactions of xenobiotics and differences in their isoform activities result in interindividual kinetic differences of UGT probe substrates. Here, extensive literature searches were performed to identify probe substrates (14) for various UGT isofo...

journal_title：Archives of toxicology

authors： Kasteel EEJ,Darney K,Kramer NI,Dorne JLCM,Lautz LS

更新日期：2020-08-01 00:00:00

abstract：:The increasing number of man-made chemicals in the environment that may pose a carcinogenic risk emphasizes the need to develop reliable time- and cost-effective approaches for carcinogen detection. To address this issue, we have investigated the utility of human hepatocytes for the in vitro identification of genotoxi...

journal_title：Archives of toxicology

authors： Tryndyak V,Borowa-Mazgaj B,Beland FA,Pogribny IP

更新日期：2019-11-01 00:00:00

abstract：:Two Ceria nanomaterials (NM-211 and NM-212) were tested for inhalation toxicity and organ burdens in order to design a chronic and carcinogenicity inhalation study (OECD TG No. 453). Rats inhaled aerosol concentrations of 0.5, 5, and 25 mg/m(3) by whole-body exposure for 6 h/day on 5 consecutive days for 1 or 4 weeks ...

journal_title：Archives of toxicology

authors： Keller J,Wohlleben W,Ma-Hock L,Strauss V,Gröters S,Küttler K,Wiench K,Herden C,Oberdörster G,van Ravenzwaay B,Landsiedel R

更新日期：2014-11-01 00:00:00

abstract：:The effects of small repeated oral doses of mono-2-cresyl diphenyl phosphate (MOCP, 2.5 mg/kg/day) on hen brain and spinal cord neurotoxic esterase (NTE) were measured. The enzyme levels were depressed to about 40% and 55% of normal respectively and maintained at that level for 8 weeks. No clinical and only doubtful h...

journal_title：Archives of toxicology

authors： Lotti M,Johnson MK

更新日期：1980-10-01 00:00:00

abstract：:The pregnancy outcomes of 109 women who were intoxicated during pregnancy due to excessive amounts of drugs and other agents were studied. Seventy per cent of the women attempted suicide, and the intoxication in 78% of all cases was caused by drugs. The stillbirth rate (4%) was higher than that in previous and subsequ...

journal_title：Archives of toxicology

authors： Czeizel A,Szentesi I,Szekeres I,Molnár G,Glauber A,Bucski P

更新日期：1988-08-01 00:00:00

abstract：:Boric acid and sodium borates are currently classified as being toxic to reproduction under "Category 1B" with the hazard statement of "H360 FD" in the European CLP regulation. This has prompted studies on boron-mediated reprotoxic effects in male workers in boron mining areas and boric acid production plants. By cont...

journal_title：Archives of toxicology

authors： Duydu Y,Başaran N,Üstündağ A,Aydın S,Yalçın CÖ,Anlar HG,Bacanlı M,Aydos K,Atabekoğlu CS,Golka K,Ickstadt K,Schwerdtle T,Werner M,Meyer S,Bolt HM

更新日期：2018-08-01 00:00:00

abstract：:Unsaturated compounds are known to cause false-positive reactions in the local lymph node assay (LLNA) but not in the guinea pig maximization test. We have tested a panel of substances (succinic acid, undecylenic acid, 1-octyn-3-ol, fumaric acid, maleic acid, linoleic acid, oleic acid, alpha-linolenic acid, squalene, ...

journal_title：Archives of toxicology

authors： Frohwein TA,Sonnenburg A,Zuberbier T,Stahlmann R,Schreiner M

更新日期：2016-04-01 00:00:00

abstract：:The significance of elevated excretion of metallothionein in urine of women living in cadmium-polluted areas of Japan was studied with respect to renal dysfunction. The relationships between the concentrations of metallothionein in urine and those of other non-specific urinary indices of renal dysfunction, i.e., total...

journal_title：Archives of toxicology

authors： Tohyama C,Shaikh ZA,Nogawa K,Kobayashi E,Honda R

更新日期：1982-07-01 00:00:00

abstract：:The reliable analytical method for total morphine in hair was established by GC/MS-SIM. The calibration curve for morphine in hair showed linear over 0.5-100 ng/mg hair. Though the limit of detection was 0.1 ng/mg hair with an S/N > 3 of the base ion(m/z 429) for morphine, the limit of confirmation by detection of thr...

journal_title：Archives of toxicology

authors： Nakahara Y,Takahashi K,Shimamine M,Saitoh A

更新日期：1992-01-01 00:00:00

abstract：:Since tattoos became overwhelmingly fashionable worldwide, the demand for removal has proportionally increased, Nd:YAG Q-switch laser being the most commonly used tool for the purpose. In this framework we investigated the composition and products of laser treatment of green tattoo ink, the Green Concentrate from Eter...

journal_title：Archives of toxicology

authors： Bauer EM,Scibetta EV,Cecchetti D,Piccirillo S,Antonaroli S,Sennato S,Cerasa M,Tagliatesta P,Carbone M

更新日期：2020-07-01 00:00:00

abstract：:The cytotoxicity of trivalent and pentavalent inorganic arsenic salts was determined in mouse fibroblasts in vitro. Concentrations of As (III) in the microM range led to a reduction of proliferation and viability with a concomitant increase in LDH release and stimulation of lactic acid production. Similar effects were...

journal_title：Archives of toxicology

authors： Fischer AB,Buchet JP,Lauwerys RR

更新日期：1985-08-01 00:00:00

abstract：:Many in the welding industry suffer from bronchitis, lung function changes, metal fume fever, and diseases related to respiratory damage. These phenomena are associated with welding fumes; however, the mechanism behind these findings remains to be elucidated. In this study, the lungs of cynomolgus monkeys were exposed...

journal_title：Archives of toxicology

authors： Heo JD,Oh JH,Lee K,Kim CY,Song CW,Yoon S,Han JS,Yu IJ

更新日期：2010-03-01 00:00:00

abstract：:The effects of acetaldehyde (ACD) on dopamine (DA) and DA-derived salsolinol (SAL) levels were investigated in the striatum of freely moving rats. Dialysate levels of DA and SAL were determined using in vivo reverse microdialysis coupled with high-performance liquid chromatography with an electrochemical detector. Per...

journal_title：Archives of toxicology

authors： Wang W,Ameno K,Jamal M,Kumihashi M,Uekita I,Ameno S,Ijiri I

更新日期：2007-02-01 00:00:00

abstract：:Possible induction of chromosomal aberrations and/or sister chromatid exchanges by astemizole was studied in vitro on human lymphocytes. In vivo chromosomal damage was assessed by a micronucleus test on rats and a dominant lethal test on both male and female mice. All these tests yielded negative results for astemizol...

journal_title：Archives of toxicology

authors： Vanparys P,Fabry L,Léonard A,Marsboom R

更新日期：1982-07-01 00:00:00

abstract：:Recent work concerned with the mechanism underlying the development of organophosphorous compound-induced delayed neurotoxicity (OPIDN) is reviewed. Topics covered include the prophylaxis of OPIDN by phenylmethylsulfonyl fluoride and other agents, neurotoxic esterase (NTE) as measured using either labelled di-isopropy...

journal_title：Archives of toxicology

authors： Carrington CD

更新日期：1989-01-01 00:00:00

abstract：:Emerging mycotoxins produced by Alternaria spp. were previously reported to exert cytotoxic, genotoxic, but also estrogenic effects in human cells. The involved mechanisms are very complex and not fully elucidated yet. Thus, we followed an in silico target fishing approach to extend knowledge on the possible biologica...

journal_title：Archives of toxicology

authors： Aichinger G,Dellafiora L,Pantazi F,Del Favero G,Galaverna G,Dall'Asta C,Marko D

更新日期：2020-06-01 00:00:00

abstract：:Polyclonal antibodies raised toward a debrisoquine 4-hydroxylating cytochrome P-450 species purified from rat liver (P-450UT-A) were used to determine which monooxygenase reactions are linked to debrisoquine hydroxylation in human liver. Anti P-450UT-A did not inhibit the oxidation of dimethylnitrosamine, morphine, di...

journal_title：Archives of toxicology

authors： Wolff T,Distlerath LM,Worthington MT,Guengerich FP

更新日期：1987-01-01 00:00:00

abstract：:The first step in the oxidative metabolism of cocaine is N-demethylation to norcocaine, which is further N-hydroxylated to more toxic N-hydroxynorcocaine. In this study we examined the kinetics of norcocaine N-hydroxylation mediated by cytochrome P450 (CYP) in mouse and human liver microsomes. N-hydroxynorcocaine was ...

journal_title：Archives of toxicology

authors： Pellinen P,Kulmala L,Konttila J,Auriola S,Pasanen M,Juvonen R

更新日期：2000-11-01 00:00:00

abstract：:Rats were administered a sublethal dose of thallium (12.35 mg/kg as aqueous thallous sulfate, Tl2SO4, equivalent to 10 mg Tl+/kg per os) on day 0. Urine and feces were collected separately every day for 8 days and analyzed by atomic absorption spectroscopy. Based on information in the literature, five antidotal treatm...

journal_title：Archives of toxicology

authors： Lehmann PA,Favari L

更新日期：1985-04-01 00:00:00

abstract：:Interactions between chemicals in a mixture and interactions of mixture components with the skin can significantly alter the rate and extent of percutaneous absorption, as well as the cutaneous disposition of a topically applied chemical. The predictive ability of dermal absorption models, and consequently the dermal ...

journal_title：Archives of toxicology

authors： Riviere JE,Qiao G,Baynes RE,Brooks JD,Mumtaz M

更新日期：2001-08-01 00:00:00

abstract：:The immunotoxic potential of many classes of environmental contaminants has been well established in laboratory studies, with much attention being focussed on aryl hydrocarbon (Ah)-receptor binding polychlorinated biphenyl (PCB), polychlorinated dibenzo-p-dioxin (PCDD), and polychlorinated dibenzofuran (PCDF) congener...

journal_title：Archives of toxicology

authors： Ross PS,Van Loveren H,de Swart RL,van der Vliet H,de Klerk A,Timmerman HH,van Binnendijk R,Brouwer A,Vos JG,Osterhaus AD

更新日期：1996-01-01 00:00:00

abstract：:Primary hepatocytes are a widely used cell model to analyse the expression and regulation of hepatic cytochrome P450 (CYP) isoenzymes. Transforming growth factor-beta1 (TGF-beta1) was previously shown to inhibit constitutive and induced CYP1 expression in human cell lines and primary hepatocytes but not in rat cells. ...

journal_title：Archives of toxicology

authors： Müller GF,Döhr O,El-Bahay C,Kahl R,Abel J

更新日期：2000-05-01 00:00:00

abstract：:The antidepressants, imipramine and mianserin, have been reported to cause liver damage. We investigated a role of cytochrome P450 (CYP)-mediated formation of a reactive metabolite in antidepressant-induced acute cell injury using hepatocytes isolated from male and female Wistar rats, and male Dark Agouti rats, which ...

journal_title：Archives of toxicology

authors： Masubuchi Y,Konishi M,Horie T

更新日期：1999-04-01 00:00:00

abstract：:Early hepatocyte death occurs in most liver injury cases and triggers liver inflammation, which in combination with other risk factors leads to the development of liver disease. However, the pathogenesis of early phase hepatocyte death remains poorly understood. Here, C57BL/6J mice were treated with the hepatotoxic dr...

journal_title：Archives of toxicology

authors： Song B,Aoki S,Liu C,Ito K

更新日期：2019-06-01 00:00:00

abstract：:A series of experiments was set up to elucidate the effects of pollution on marine and estuarine fish health, since the European flounder (Platichthys flesus) has shown a relatively high prevalence of (pre)neoplastic liver lesions and lymphocystis virus disease in Dutch coastal and estuarine waters. The hypothesis of ...

journal_title：Archives of toxicology

authors： Grinwis GC,van den Brandhof EJ,Engelsma MY,Kuiper RV,Vaal MA,Vethaak AD,Wester PW,Vos JG

更新日期：2001-04-01 00:00:00

abstract：:The effect of pretreatment with cadmium (Cd) complexes on the distribution and accumulation of Cd in the liver and kidneys was examined for the Cd complexes that are reabsorbed site-selectively at the renal proximal tubules of rats. Cd was administered simultaneously with excess cysteine or as metallothionein (MT) and...

journal_title：Archives of toxicology

authors： Suzuki KT,Takahara T,Watanabe H,Nishikawa M,Yamamura M,Murakami M

更新日期：1986-04-01 00:00:00