Abstract:
:A wide variety of immunosuppressive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in experimental animals has been documented. In contrast, the impact of dioxin on the human immune system remains controversial, although adverse health effects have been reported in humans after occupational or accidental exposure to dioxin. Recently, Neubert et al. (1991) found that a dose-dependent decrease of peripheral blood lymphocyte (PBL) subpopulations in humans and non-human primates, including helper-inducer/memory cells (CD4+CD29+) and B cells (CD20+) occurred in pokeweed mitogen (PWM) stimulated cultures at concentrations as low as 10(-12)-10(-14) M TCDD. Therefore, the direct effects of dioxin on human PBL subpopulations have been studied, in order to determine their usefulness as sensitive biomarkers for human dioxin exposure. Lymphocyte cultures from healthy individuals were treated with 10(-7) M-10(-14) M TCDD in the absence and presence of stimulation with pokeweed mitogen (PWM) or anti-CD3 monoclonal antibody (moAb; OKT3) for 3 days. Cytochrome P450 (CYP1A1) enzyme induction, one of the best studied direct biological effects of TCDD on numerous cell types, was assayed in parallel by ethoxyresorufin-O-deethylase (EROD) activity. Percentages of the different lymphocytes subsets, including CD2 (T cells); CD4; CD45 RA (suppressor-inducer/virgin T cells); CD4 CD29; CD8; CD19 (B cells) as well as interleukin 2 (IL-2) receptor (CD25) and class II antigen (HLA-DR) expression, were analyzed by flow cytometry. DNA synthesis was determined by 3H-thymidine uptake after 3 days of culture.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Lang DS,Becker S,Clark GC,Devlin RB,Koren HSdoi
10.1007/s002040050072subject
Has Abstractpub_date
1994-01-01 00:00:00pages
296-302issue
5eissn
0340-5761issn
1432-0738journal_volume
68pub_type
杂志文章abstract::The effect of methantheline, a quaternary ammonium compound, on the reactivation by HI 6 of soman-inhibited human erythrocyte acetylcholinesterase (AChE) was investigated in vitro using purified human erythrocyte AChE or washed human erythrocytes. Methantheline itself was found to be a mixed competitive/non-competitiv...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050243
更新日期:1995-01-01 00:00:00
abstract::Phytoestrogens have been described as weak estrogens, selective estrogen receptor mediators (SERMs) or to exhibit antiestrogenic properties. However, information about their activity in combination with xenoestrogens and 17beta-estradiol in vivo, is limited. Therefore, the combinatory activity of the phytoestrogen gen...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-006-0102-4
更新日期:2006-12-01 00:00:00
abstract::Genistein and daidzein are the main isoflavones in soy. Their potential beneficial or adverse effects in males like the prevention of prostate cancer or the impact on reproductive functions are controversially discussed. Major determinants of their bioactivity are the absorption and biotransformation of isoflavones. I...
journal_title:Archives of toxicology
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doi:10.1007/s00204-016-1853-1
更新日期:2017-04-01 00:00:00
abstract::Changes in the urinary excretion of hippuric acid (HIA) and phenaceturic acid (PUA) as well as their metabolic precursors, i.e. benzoic (BA) and phenylacetic acid (PAA), in rats housed in glass metabolic cages for 4 days were monitored using gas-liquid chromatography. The amount of HIA excreted was 128 +/- 63 mumol/kg...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00324554
更新日期:1987-01-01 00:00:00
abstract::Levels of glutathione and activity of glutamine synthetase were assayed in organs of rats following inhalation of a heterogeneous solvent mixture containing both aliphatic and aromatic hydrocarbons. This mixture was administered for 3 weeks (6 h daily) at two levels in the inhaled air (400 and 800 ppm) to young adult ...
journal_title:Archives of toxicology
pub_type: 杂志文章
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abstract::The nephrotoxic action of aristolochic acid (AA) was investigated in female Wistar rats given single doses of 10, 50 or 100 mg/kg by gastric tube. Renal lesions developed within 3 days, the effect being dose-dependent. Histologically, there was evidence of necrosis of the epithelium of the renal tubules, and functiona...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01973700
更新日期:1993-01-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章,评审
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更新日期:2016-12-01 00:00:00
abstract::Cadmium chloride was administered by gavage to female rats 5 days a week for 5 weeks, then during mating and gestation periods at doses of 0.04, 0.4, and 4 mg Cd/kg/day. Treatment with cadmium neither affected the survival and fertility of females, nor produced overt fetotoxic effects. Fetal cadmium concentration was ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01234482
更新日期:1983-12-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00293687
更新日期:1988-01-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-011-0657-6
更新日期:2011-10-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00372765
更新日期:1976-03-11 00:00:00
abstract::Exposure to bisphenolic chemicals during pregnancy occurs in > 90% of pregnancies. Bisphenolic compounds can cross the placental barrier reaching fetal circulation. However, the effects of emerging bisphenolic compounds, such as bisphenol S (BPS), on placental function remain untested. The aim was to determine if bisp...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-018-2191-2
更新日期:2018-05-01 00:00:00
abstract::Occupational and environmental asbestos exposure is the main determinant of malignant pleural mesothelioma (MPM), however, the mechanisms by which its fibres contribute to cell toxicity and transformation are not completely clear. Aberrant DNA methylation is a common event in cancer but epigenetic modifications involv...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-018-2179-y
更新日期:2018-05-01 00:00:00
abstract::Cannabis use has become a hot topic in several countries due to the debate about its legalization for medical purposes. However, data are limited regarding adverse events, safety and potential impact on reproductive health. Cannabis consumption during pregnancy has been associated with gestational disorders such as pr...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-019-02389-7
更新日期:2019-03-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01973712
更新日期:1991-01-01 00:00:00
abstract::Increasing incidence of multidrug-resistant bacteria presents an imminent risk to global health. Polymyxins are 'last-resort' antibiotics against Gram-negative 'superbugs'; however, nephrotoxicity remains a key impediment in their clinical use. Molecular mechanisms underlying this nephrotoxicity remain poorly defined....
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-018-2192-1
更新日期:2018-07-01 00:00:00
abstract::Nucleotide excision repair (NER) is a versatile pathway that removes helix-distorting DNA lesions from the genomes of organisms across the evolutionary scale, from bacteria to humans. The serial steps in NER involve recognition of lesions, adducts or structures that disrupt the DNA double helix, removal of a short oli...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-016-1820-x
更新日期:2016-11-01 00:00:00
abstract::Microsomal and soluble epoxide hydrolase (mEH and sEH) fulfill apparently distinct roles: Whereas mEH detoxifies xenobiotics, sEH hydrolyzes fatty acid (FA) signaling molecules and is thus implicated in a variety of physiological functions. These epoxy FAs comprise epoxyeicosatrienoic acids (EETs) and epoxy-octadeceno...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-2060-4
更新日期:2017-11-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章,评审
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更新日期:2016-09-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章,已发布勘误
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更新日期:2018-11-01 00:00:00
abstract::Exposure to particulate matter (PM) has been related to the onset of adverse health effects including lung cancer, but the underlying molecular mechanisms are still under investigation. Epithelial-to-mesenchymal transition (EMT) is regarded as a crucial step in cancer progression. In a previous study, we reported EMT-...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-018-2259-z
更新日期:2018-09-01 00:00:00
abstract::A number of studies have evaluated the possibility that stress-induced changes in blood-brain barrier permeability enhanced the central effects of the carbamate acetylcholinesterase inhibitor, pyridostigmine. We previously found relatively little evidence of stress-induced changes in the acute toxicity of pyridostigmi...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-006-0144-7
更新日期:2007-04-01 00:00:00
abstract::The International Agency for Research on Cancer considers the carcinogenicity of welding fume of priority for re-evaluation. Genotoxic effects in experimental animals are still inconclusive. Here, we investigated the association of personal exposure to metals in respirable welding fumes during a working shift with oxi...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1319-2
更新日期:2015-08-01 00:00:00
abstract::Steatosis, also known as fatty liver disease (FLD), is a disorder in which the lipid metabolism of the liver is disturbed, leading to the abnormal retention of lipids in hepatocytes. FLD can be induced by several drugs, and although it is mostly asymptomatic, it can lead to steatohepatitis, which is associated with li...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-015-1483-z
更新日期:2016-03-01 00:00:00
abstract::To reveal the molecular mechanism of deficit in learning and memory induced by chronic fluorosis, the expression of muscarinic acetylcholine receptors (mAChRs) and oxidative stress were investigated. Sixty Sprague-Dawley (SD) rats were divided randomly into two groups (30 cases in each), i.e., the control group (<0.5 ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1408-2
更新日期:2015-11-01 00:00:00
abstract::The ability of 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC), 3,5-diethoxycarbonyl-4-ethyl-1,4-dihydro-2,6-dimethylpyridine (EDDC) and griseofulvin to induce porphyria in primary cultures of mouse hepatocytes has been examined. Exposure of cultured mouse hepatocytes to DDC, EDDC or griseofulvin resulted in a marked ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01974011
更新日期:1992-01-01 00:00:00
abstract::In the recent years, the toxicity of certain divalent cations has been associated with the alteration of intracellular Ca2+ homeostasis. Among other mechanisms, these cations may affect the functionality of certain Ca2+-binding proteins and/or Ca2+ pumps. The plasma membrane calcium pump (PMCA) maintains Ca2+ homeosta...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-2031-9
更新日期:2018-01-01 00:00:00
abstract::Clark 1 (diphenylarsine chloride) and Clark 2 (diphenylarsine cyanide) were used as chemical weapon agents (CWA), and the soil contamination by these CWA and their degraded products, diphenyl and phenyl arsenicals, has been one of the most serious environmental issues. In a series of comparisons in toxicity between tr...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-004-0598-4
更新日期:2005-01-01 00:00:00
abstract::The goal of the present study was to obtain an in vivo relevant prioritization method for the endocrine potencies of different polycarbonate monomers, by combining in vitro bioassay data with physiologically based kinetic (PBK) modelling. PBK models were developed for a selection of monomers, including bisphenol A (BP...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-019-02479-6
更新日期:2019-07-01 00:00:00