Induction of skin sensitization is augmented in Nrf2-deficient mice.

abstract：:The cholestatic effect of the newly developed oestradiol sulphamate (J995) was compared with that of the natural oestrogen oestradiol (E) and of the cholestatic standard oestrogen ethinyloestradiol (EE). Female ovariectomized rats were orally treated for 7 days with oestrogen doses molar equivalent to 0.01, 0.1, 1, an...

journal_title：Archives of toxicology

authors： Barth A,Elger W,Schneider B,Schwarz S

更新日期：1997-01-01 00:00:00

abstract：:Hydrogen sulfide (H2S), the third gasotransmitter, has been shown to act as a neuroprotective factor in numerous pathological processes; however, its underlying mechanism(s) of action remain unclear. It is widely accepted that activation of moderate autophagy and the Nrf2/ARE signaling pathway play important roles in ...

journal_title：Archives of toxicology

authors： Yang B,Bai Y,Yin C,Qian H,Xing G,Wang S,Li F,Bian J,Aschner M,Lu R

更新日期：2018-06-01 00:00:00

abstract：:The effects of diabetes on cytochrome P450 (CYP)-dependent drug metabolizing enzymes are yet to be clarified. The most widely used animals in these studies have been rats, and information on the effects of diabetes on rabbit liver drug metabolizing enzymes have been unavailable until now. In this study, for the first ...

journal_title：Archives of toxicology

authors： Arinç E,Arslan S,Adali O

更新日期：2005-08-01 00:00:00

abstract：:O,O,S-Trimethyl phosphorothioate (OOS-TMP) is known to induce unique symptoms, which are characterized by hypophagia, progressive weight loss, and hypothermia. To determine whether there is the possibility of a causal relationship between these toxic symptoms and a direct action of OOS-TMP on the central nervous syste...

journal_title：Archives of toxicology

authors： Ohtaka K,Hamade N,Yamazaki Y,Suzuki M,Koizumi A

更新日期：1995-01-01 00:00:00

abstract：:The development of metabolically competent in vitro models is of utmost importance for predicting adverse drug reactions, thereby preventing attrition-related economical and clinical burdens. Using the antiretroviral drug nevirapine (NVP) as a model, this work aimed to validate rat hepatocyte 3D spheroid cultures as c...

journal_title：Archives of toxicology

authors： Pinheiro PF,Pereira SA,Harjivan SG,Martins IL,Marinho AT,Cipriano M,Jacob CC,Oliveira NG,Castro MF,Marques MM,Antunes AMM,Miranda JP

更新日期：2017-03-01 00:00:00

abstract：:The first step in the oxidative metabolism of cocaine is N-demethylation to norcocaine, which is further N-hydroxylated to more toxic N-hydroxynorcocaine. In this study we examined the kinetics of norcocaine N-hydroxylation mediated by cytochrome P450 (CYP) in mouse and human liver microsomes. N-hydroxynorcocaine was ...

journal_title：Archives of toxicology

authors： Pellinen P,Kulmala L,Konttila J,Auriola S,Pasanen M,Juvonen R

更新日期：2000-11-01 00:00:00

abstract：:Acetaminophen (APAP) overdose is the leading cause of acute liver failure. Yet the mechanisms underlying adaptive tolerance toward APAP-induced liver injury are not fully understood. To better understand molecular mechanisms contributing to adaptive tolerance to APAP is an underpinning foundation for APAP-related prec...

journal_title：Archives of toxicology

authors： Yu D,Wu L,Gill P,Tolleson WH,Chen S,Sun J,Knox B,Jin Y,Xiao W,Hong H,Wang Y,Ren Z,Guo L,Mei N,Guo Y,Yang X,Shi L,Chen Y,Zeng L,Dreval K,Tryndyak V,Pogribny I,Fang H,Shi T,McCullough S,Bhattacharyya S,S

更新日期：2018-02-01 00:00:00

abstract：:Pulmonary fibrosis is a poorly understood pathologic condition. Carbon nanotubes (CNTs) are nanomaterials with potentials for broad applications. CNTs can induce pulmonary fibrosis in animals, a cause for concern for exposed workers and consumers. Given the large number of CNTs available on the market and the seemingl...

journal_title：Archives of toxicology

authors： Hindman B,Ma Q

更新日期：2018-11-01 00:00:00

abstract：:Long-term exposure of rats to cadmium (Cd) resulted in a marked suppression of erythropoietin (Epo) mRNA expression in the kidneys and the development of severe anemia. A recent report revealed that Cd inhibited hypoxia-inducible factor 1 (HIF-1) binding activity and Epo mRNA expression and protein production. However...

journal_title：Archives of toxicology

authors： Obara N,Imagawa S,Nakano Y,Suzuki N,Yamamoto M,Nagasawa T

更新日期：2003-05-01 00:00:00

abstract：:Many carcinogens and mutagens are electrophilic in nature and will react with nucleophilic sites in protein and nucleic acid. Determination of the extent of formation of these adducts of genotoxic agents with protein provides a practical method of monitoring human exposure and of determining the possible risk associat...

journal_title：Archives of toxicology

authors： Bailey E,Farmer PB,Shuker DE

更新日期：1987-01-01 00:00:00

abstract：:The effects of acetaldehyde (ACD) on dopamine (DA) and DA-derived salsolinol (SAL) levels were investigated in the striatum of freely moving rats. Dialysate levels of DA and SAL were determined using in vivo reverse microdialysis coupled with high-performance liquid chromatography with an electrochemical detector. Per...

journal_title：Archives of toxicology

authors： Wang W,Ameno K,Jamal M,Kumihashi M,Uekita I,Ameno S,Ijiri I

更新日期：2007-02-01 00:00:00

abstract：:3-(Phenylamino)alanine (PAA), a contaminant found in L-tryptophan tablets, has been discussed as a possible cause of eosinophilia-myalgia syndrome (EMS). We administered PAA (100 mg/kg) by gastric gavage to Wistar rats to determine its distribution and metabolism. We developed a purification procedure, using Bond Elut...

journal_title：Archives of toxicology

authors： Adachi J,Mio T,Ueno Y,Naito T,Nishimura A,Fujiwara S,Sumino K,Tatsuno Y

更新日期：1994-01-01 00:00:00

abstract：:The mycotoxins altertoxin I and II (ATX I and II) are secondary metabolites produced by Alternaria alternata fungi and may occur as food and feed contaminants, especially after long storage periods. Although the toxic potential of altertoxins has been previously investigated, little is known about the pathways that pl...

journal_title：Archives of toxicology

authors： Jarolim K,Del Favero G,Pahlke G,Dostal V,Zimmermann K,Heiss E,Ellmer D,Stark TD,Hofmann T,Marko D

更新日期：2017-01-01 00:00:00

abstract：:Cadmium, copper and zinc have been determined in kidney cortex, kidney medulla and liver from 51 cadmium-polluted and 122 nonpolluted autopsied subjects. Liver cadmium and zinc were significantly higher in the cadmium-polluted subjects than in the nonpolluted subjects. Kidney cadmium, copper and zinc were lower in the...

journal_title：Archives of toxicology

authors： Honda R,Nogawa K

更新日期：1987-04-01 00:00:00

abstract：:Since teratogenicity testing in mammals is a particular challenge from an animal welfare perspective, there is a great need for the development of alternative test systems. In this context, the zebrafish (Danio rerio) embryo has received increasing attention as a non-protected embryonic vertebrate in vivo model. The p...

journal_title：Archives of toxicology

authors： Brotzmann K,Wolterbeek A,Kroese D,Braunbeck T

更新日期：2020-10-27 00:00:00

abstract：:Chalepensin, a furanocoumarin, is present in several medicinal Rutaceae plants and causes a mechanism-based inhibition of human and mouse cytochrome P450 (P450, CYP) 2A in vitro. To address the in vivo effect, we investigated the effects of chalepensin on multiple hepatic P450 enzymes in C57BL/6JNarl mice. Oral admini...

journal_title：Archives of toxicology

authors： Lo WS,Lim YP,Chen CC,Hsu CC,Souček P,Yun CH,Xie W,Ueng YF

更新日期：2012-12-01 00:00:00

abstract：:Polyclonal antibodies raised toward a debrisoquine 4-hydroxylating cytochrome P-450 species purified from rat liver (P-450UT-A) were used to determine which monooxygenase reactions are linked to debrisoquine hydroxylation in human liver. Anti P-450UT-A did not inhibit the oxidation of dimethylnitrosamine, morphine, di...

journal_title：Archives of toxicology

authors： Wolff T,Distlerath LM,Worthington MT,Guengerich FP

更新日期：1987-01-01 00:00:00

abstract：:The immunotoxic potential of many classes of environmental contaminants has been well established in laboratory studies, with much attention being focussed on aryl hydrocarbon (Ah)-receptor binding polychlorinated biphenyl (PCB), polychlorinated dibenzo-p-dioxin (PCDD), and polychlorinated dibenzofuran (PCDF) congener...

journal_title：Archives of toxicology

authors： Ross PS,Van Loveren H,de Swart RL,van der Vliet H,de Klerk A,Timmerman HH,van Binnendijk R,Brouwer A,Vos JG,Osterhaus AD

更新日期：1996-01-01 00:00:00

abstract：:In a previous study, we showed that bisphenol A (BPA) had oestrogen-like effects in bird embryos, causing malformations of the oviducts in Japanese quail (Coturnix japonica) and feminisation of the left testis in chicken (Gallus domesticus). In this study, uptake and distribution of BPA and tetrabromobisphenol A (TBBP...

journal_title：Archives of toxicology

authors： Halldin K,Berg C,Bergman A,Brandt I,Brunström B

更新日期：2001-12-01 00:00:00

abstract：:This study was performed to assess the relation between occupational exposure to N,N-dimethylformamide after an 8 h work shift in the acrylic fibre industry and its three biological markers N-methylformamide (NMFtotal), N-acetyl-S-(N-methylcarbamoyl)cysteine (AMCC), and N-methylcarbamoyl adduct at haemoglobin (MCVal)....

journal_title：Archives of toxicology

authors： Seitz M,Kilo S,Eckert E,Müller J,Drexler H,Göen T

更新日期：2018-07-01 00:00:00

abstract：:5-Hydroxymethylfurfural (HMF) and furfuryl alcohol (FFA) are moderately potent rodent carcinogens that are present in thermally processed foodstuffs. The carcinogenic effects were hypothesized to originate from sulfotransferase (SULT)-mediated bioactivation yielding DNA-reactive and mutagenic sulfate esters, a confirm...

journal_title：Archives of toxicology

authors： Sachse B,Meinl W,Sommer Y,Glatt H,Seidel A,Monien BH

更新日期：2016-01-01 00:00:00

abstract：:The effect of lindane and heptachlor on haem metabolism was studied with the aim to elucidate the mechanism of their porphyrinogenic action. The effects of these compounds on delta-aminolaevulinate synthase (ALA-S) and ferrochelatase were evaluated and the mechanism of increase of ALA-S activity was especially studied...

journal_title：Archives of toxicology

authors： Taira MC,San Martín de Viale LC

更新日期：1998-11-01 00:00:00

abstract：:The effect of duration of employment at a North American cadmium smelter on urinary metallothionein (MT), total protein, beta 2-microglobulin (beta 2-MG), glucose, cadmium, copper and zinc of 53 men was studied. The levels of all urinary parameters increased with the duration of employment. Smoking history did not aff...

journal_title：Archives of toxicology

authors： Shaikh ZA,Tohyama C,Nolan CV

更新日期：1987-02-01 00:00:00

abstract：:Cyclic AMP (c-AMP), added on its own to rat hepatocyte cultures, caused a marked accumulation of coproporphyrin III. The results obtained by comparing the effect of c-AMP to that of exogenous 5-aminolevulinate (ALA), and from adding c-AMP and ALA together, indicated that the coproporphyrinogen III metabolism was block...

journal_title：Archives of toxicology

authors： De Matteis F,Harvey C

更新日期：2005-07-01 00:00:00

abstract：:Chronic ethanol consumption is a strong risk factor for the development of liver disease. Multiple mechanisms are involved in ethanol-mediated liver injury; oxidative stress being pointed has an important factor. However, it should be noted that moderate consumption of red wine has been associated with hepatoprotectiv...

journal_title：Archives of toxicology

authors： Silva P,Fernandes E,Carvalho F

更新日期：2015-10-01 00:00:00

abstract：:This article is published with the incorrect copyright holder name in the HTML article as "© Springer 2018". The correct copyright line should read "The Author(s) 2018" (as it appears in the article PDF). ...

journal_title：Archives of toxicology

authors： Oesch F,Fabian E,Landsiedel R

更新日期：2018-11-01 00:00:00

abstract：:Teratogenic effects caused by a new nitroimidazopyridazine were examined in Wistar (WU) rats after repeated oral administration of 0, 2.5, 10, and 40 mg/kg, given on days 6-17 post coitum (p.c.) (Day of mating = Day 0) in a regular study on embryo-fetal development according to ICH S5A. At day 20 p.c., fetuses were re...

journal_title：Archives of toxicology

authors： Woehrmann T,Volland J,Tuch K,Bode G,Hübel U

更新日期：2006-07-01 00:00:00

abstract：:Previous studies in our laboratory identified retinoid-induced defects that are mediated by RAR-RXR heterodimerization using interaction of synthetic ligands selective for the retinoid receptors RAR and RXR in mice (Elmazar et al. 1997, Toxicol Appl Pharmacol 146:21-28; Elmazar et al. 2001, Toxicol Appl Pharmacol 170:...

journal_title：Archives of toxicology

authors： Elmazar MM,Nau H

更新日期：2004-11-01 00:00:00

abstract：:We studied the incorporation of cocaine (COC), benzoylecgonine (BE) and ecgonine methyl ester (EME) into hair from blood. At first, the time courses of three drugs in rat plasma following i.p. administration of cocaine were investigated over 360 min. AUCs of COC, BE and EME in plasma were 14.2, 60.7 and 53.4 microgram...

journal_title：Archives of toxicology

authors： Nakahara Y,Ochiai T,Kikura R

更新日期：1992-01-01 00:00:00

abstract：:Chlorpyrifos (CPF) is a widely used organophosphorus pesticide. Earlier work from our laboratory and others has demonstrated that the sensitivity to CPF exposure changes markedly during maturation. A number of studies suggest that in addition to inhibiting acetylcholinesterase (AChE), CPF oxon may also interact direct...

journal_title：Archives of toxicology

authors： Zhang H,Liu J,Pope CN

更新日期：2002-01-01 00:00:00