A dual function of the furanocoumarin chalepensin in inhibiting Cyp2a and inducing Cyp2b in mice: the protein stabilization and receptor-mediated activation.

abstract：:Lead (Pb) exposure of consumers and the environment has been reduced over the past decades. Despite all measures taken, immission of Pb onto agricultural soils still occurs, with fertilizer application, lead shot from hunting activities, and Pb from air deposition representing major sources. Little is known about the ...

journal_title：Archives of toxicology

authors： Schupp T,Damm G,Foth H,Freyberger A,Gebel T,Gundert-Remy U,Hengstler JG,Mangerich A,Partosch F,Röhl C,Wollin KM

更新日期：2020-07-01 00:00:00

abstract：:Inhabitants of a private home suffered from symptoms possibly due to dichloroacetylene intoxication. Subsequent anamnesis revealed that abundant amounts of trichloroethylene had been used to remove a wax coating from a concrete-lined stone floor. This prompted us to examine whether dichloroacetylene could have been fo...

journal_title：Archives of toxicology

authors： Greim H,Wolff T,Höfler M,Lahaniatis E

更新日期：1984-12-01 00:00:00

abstract：:With the development of nanotechnology, myriad types of novel materials have been discovered at the nanoscale, among which the most interesting material is graphene. However, the toxicity data available on graphene are extremely limited. In this study, we explored toxic response of commercially available graphene nano...

journal_title：Archives of toxicology

authors： Park EJ,Lee GH,Han BS,Lee BS,Lee S,Cho MH,Kim JH,Kim DW

更新日期：2015-09-01 00:00:00

abstract：:The peroxisome proliferator class of non-genotoxic rodent hepatocarcinogens cause hepatocyte DNA synthesis, peroxisome proliferation and liver tumours when administered to rats and mice, but fail to induce S-phase or peroxisome proliferation in hepatocytes from other species including guinea-pigs, dogs, and primates i...

journal_title：Archives of toxicology

authors： Tugwood JD,Holden PR,James NH,Prince RA,Roberts RA

更新日期：1998-02-01 00:00:00

abstract：:Cytochrome P4502E1 (CYP2E1) gene shows genetic polymorphisms that vary markedly in frequency among different ethnic and racial groups. We studied the genotype distributions and allele frequencies of three CYP2E1 polymorphisms: CYP2E1*5B (RsaI/PstI RFLP, C-1053T/G-1293C SNP, rs2031920 /rs3813867), CYP2E1*6 (DraI RFLP, ...

journal_title：Archives of toxicology

authors： Ulusoy G,Arinç E,Adali O

更新日期：2007-10-01 00:00:00

abstract：:203Pb(NO3)2 was administered i.v. to pregnant C57BL mice at different stages, from day 8 to day 18 of gestation. The whole animals or excised uteri were subjected to autoradiography or were autopsied for scintillation counting of excised organs. Lead appeared in embryonic and fetal tissues at all stages of gestation. ...

journal_title：Archives of toxicology

authors： Danielsson BR,Dencker L,Lindgren A

更新日期：1983-10-01 00:00:00

abstract：:The use of nanotechnology is increasing exponentially, whereas the possible adverse health effects of engineered nanoparticles (NPs) are so far less known. Standardized mouse bioassay was used to study sensory and pulmonary irritation, airflow limitation, and inflammation potency of nanosized TiO(2). Single exposure (...

journal_title：Archives of toxicology

authors： Leppänen M,Korpi A,Miettinen M,Leskinen J,Torvela T,Rossi EM,Vanhala E,Wolff H,Alenius H,Kosma VM,Joutsensaari J,Jokiniemi J,Pasanen P

更新日期：2011-07-01 00:00:00

abstract：:Rats were exposed to single periods of inhalation of fumes generated by arc welding. Two processes were compared: either manual metal arc (MMA) using flux-coated mild steel (MS) electrodes or metal inert-gas (MIG) welding with stainless steel (SS). Widespread but small deposits of fume particles were cleared effective...

journal_title：Archives of toxicology

authors： Hicks R,Lam HF,Al-Shamma KJ,Hewitt PJ

更新日期：1984-03-01 00:00:00

abstract：:Sodium diethyldithiocarbamate (DETC) is the main metabolite of disulfiram. Recently, we reported that mechanism of disulfiram cytotoxicity in V79 cells might be partially connected with thiol redox-state imbalance. Here, we examined the effect of DETC on the level of intracellular glutathione (GSH), protein oxidation ...

journal_title：Archives of toxicology

authors： Rahden-Staroń I,Grosicka-Maciąg E,Kurpios-Piec D,Czeczot H,Grzela T,Szumiło M

更新日期：2012-12-01 00:00:00

abstract：:The responsiveness of the hepatic supernatant NAD+-dependent aldehyde dehydrogenase with a high Km value (high Km-AldDH) to phenobarbital (PB) and 3-methylcholanthrene (3-MC) treatment was studied in male rats of three strains; Wistar, Long-Evans, and Sprague-Dawley. A remarkable strain difference in the response of t...

journal_title：Archives of toxicology

authors： Nakanishi S,Shiohara E,Tsukada M,Yamazaki H,Nishiguchi K,Saladin R

更新日期：1979-12-01 00:00:00

abstract：:The in vitro DNA strand breaking activity of metallothionein (MT) containing Cd2+ and Zn2+ in a molar ratio of 5:2 is described. Studies with radical scavengers and electron paramagnetic resonance spectroscopy indicate that the DNA damage might be caused by a radical species formed by the native protein (i.e., MT) cha...

journal_title：Archives of toxicology

authors： Müller T,Schuckelt R,Jaenicke L

更新日期：1991-01-01 00:00:00

abstract：:In vitro assays are often used for the hazard characterisation of compounds, but their application for quantitative risk assessment purposes is limited. This is because in vitro assays cannot provide a complete in vivo dose-response curve from which a point of departure (PoD) for risk assessment can be derived, like t...

journal_title：Archives of toxicology

authors： Strikwold M,Spenkelink B,Woutersen RA,Rietjens IM,Punt A

更新日期：2013-09-01 00:00:00

abstract：:Rats were administered a sublethal dose of thallium (12.35 mg/kg as aqueous thallous sulfate, Tl2SO4, equivalent to 10 mg Tl+/kg per os) on day 0. Urine and feces were collected separately every day for 8 days and analyzed by atomic absorption spectroscopy. Based on information in the literature, five antidotal treatm...

journal_title：Archives of toxicology

authors： Lehmann PA,Favari L

更新日期：1985-04-01 00:00:00

abstract：:Deoxynivalenol (DON) contamination in food is a public health concern; however, the effect of DON exposure on immune disorders including allergies remains unclear. The aim of this study is to elucidate the effect of oral exposure to DON on pro-inflammatory and pro-pruritic responses in a mouse model of allergic dermat...

journal_title：Archives of toxicology

authors： Aihara R,Ookawara T,Morimoto A,Iwashita N,Takagi Y,Miyasaka A,Kushiro M,Miyake S,Fukuyama T

更新日期：2020-12-01 00:00:00

abstract：:Although polybrominated naphthalenes (PBNs) are contaminants of the commercial fire retardant fireMaster BP-6, the individual PBN isomers have not been identified. In order to study PBNs possessing an analogous level of bromination to those found in fireMaster BP-6, three synthetic PBN mixtures, averaging 5.0, 5.3, an...

journal_title：Archives of toxicology

authors： Robertson LW,Thompson K,Parkinson A

更新日期：1984-07-01 00:00:00

abstract：:The effect of ethanol on metabolism of 20 nitriles was studied in vivo and in vitro in mice. The hepatic microsomal metabolizing activity for nitriles was at a maximum 13 h after ethanol dosing (4.0 g/kg). Using microsomes from mice pretreated with ethanol under the above conditions, enhancement of the in vitro metabo...

journal_title：Archives of toxicology

authors： Tanii H,Hashimoto K

更新日期：1986-02-01 00:00:00

abstract：:The implementation of the Chemical Weapon Convention (CWC), prohibiting the development, production, storage and use of chemical weapons by 192 nations and the ban of highly toxic OP pesticides, especially class I pesticides according to the WHO classification, by many countries constitutes a great success of the inte...

journal_title：Archives of toxicology

authors： Worek F,Wille T,Koller M,Thiermann H

更新日期：2016-09-01 00:00:00

abstract：:The effect of pretreatment with SKF-525A, which inhibits hepatic cytochrome P450 enzymes, on metabolism and hepatotoxicity was examined in mice orally administered tributyltin chloride (TBTC) or dibutyltin dichloride (DBTC) at a dose of 180 mumol/kg. Analysis of butyltin compounds showed that the main metabolites in l...

journal_title：Archives of toxicology

authors： Ueno S,Suzuki T,Susa N,Furukawa Y,Sugiyama M

更新日期：1997-01-01 00:00:00

abstract：:Garenoxacin is a des-F(6)-quinolone with a broad antibacterial spectrum, which has previously been shown to exhibit low chondrotoxicity in juvenile dogs compared with several other quinolones. A study was performed to determine whether the low chondrotoxicity observed in immature rats following garenoxacin treatment c...

journal_title：Archives of toxicology

authors： Kastner M,Rahm U,Baumann-Wilschke I,Bello A,Stahlmann R

更新日期：2004-02-01 00:00:00

abstract：:Menadione is a naphthoquinone used as a vitamin K source in animal feed that can generate reactive oxygen species (ROS) and cause apoptosis. Here, we examined whether menadione reduces development of preimplantation bovine embryos in a ROS-dependent process and tested the hypothesis that actions of menadione would be ...

journal_title：Archives of toxicology

authors： Moss JI,Pontes E,Hansen PJ

更新日期：2009-11-01 00:00:00

abstract：:Steatosis, also known as fatty liver disease (FLD), is a disorder in which the lipid metabolism of the liver is disturbed, leading to the abnormal retention of lipids in hepatocytes. FLD can be induced by several drugs, and although it is mostly asymptomatic, it can lead to steatohepatitis, which is associated with li...

journal_title：Archives of toxicology

authors： Rodrigues RM,Branson S,De Boe V,Sachinidis A,Rogiers V,De Kock J,Vanhaecke T

更新日期：2016-03-01 00:00:00

abstract：:Arsenic has been a recognized contaminant and toxicant, as well as a medicinal compound throughout human history. Populations throughout the world are exposed to arsenic and these exposures have been associated with a number of human cancers. Not much is known about the role of arsenic as a human carcinogen and more r...

journal_title：Archives of toxicology

authors： Druwe IL,Vaillancourt RR

更新日期：2010-08-01 00:00:00

abstract：:New strategies are needed to address the data gap between the bioactivity of chemicals in the environment versus existing hazard information. We address whether a high-throughput screening (HTS) system using a vertebrate organism (embryonic zebrafish) can characterize chemical-elicited behavioral responses at an early...

journal_title：Archives of toxicology

authors： Reif DM,Truong L,Mandrell D,Marvel S,Zhang G,Tanguay RL

更新日期：2016-06-01 00:00:00

abstract：:In this review, we introduce a new concept, precision toxicology: the mode of action of chemical- or drug-induced toxicity can be sensitively and specifically investigated by isolating a small group of cells or even a single cell with typical phenotype of interest followed by a single cell sequencing-based analysis. P...

journal_title：Archives of toxicology

authors： Zhang B,Huang K,Zhu L,Luo Y,Xu W

更新日期：2017-07-01 00:00:00

abstract：:The nephrotoxicity of 4-amino-3-S-glutathionylphenol (PAP-GSH), a known metabolite of 4-amino-phenol (PAP), was determined in male Fischer 344 rats. Administration of a single dose of 40 or 60 mumol kg-1 caused a marked elevation in blood urea nitrogen and an increase in the urinary excretion of glucose, protein and g...

journal_title：Archives of toxicology

authors： Fowler LM,Foster JR,Lock EA

更新日期：1994-01-01 00:00:00

abstract：:Intermittent inhalation of 300 ppm of xylene vapour 6 h daily for 2 weeks caused a marked accumulation of the solvent in the perirenal fat. Simultaneous ethanol ingestion reduced the solvent load significantly although the perirenal xylene concentration increased in both test groups between the first and second week o...

journal_title：Archives of toxicology

authors： Savolainen H,Vainio H,Helojoki M,Elovaara E

更新日期：1978-12-28 00:00:00

abstract：:The effects of six iv infusions of an emulsion containing the plasticizer di(2-ethylhexyl) phthalate (DEHP) on the liver and testes were investigated in 40-day-old rats. Groups of five to six animals received the emulsion every other day in doses of 0, 5, 50 or 500 mg DEHP/kg body weight. Liver effects were studied by...

journal_title：Archives of toxicology

authors： Sjöberg P,Lindquist NG,Montin G,Plöen L

更新日期：1985-12-01 00:00:00

abstract：:Exposure to particulate matter (PM) has been related to the onset of adverse health effects including lung cancer, but the underlying molecular mechanisms are still under investigation. Epithelial-to-mesenchymal transition (EMT) is regarded as a crucial step in cancer progression. In a previous study, we reported EMT-...

journal_title：Archives of toxicology

authors： Longhin E,Camatini M,Bersaas A,Mantecca P,Mollerup S

更新日期：2018-09-01 00:00:00

abstract：:The α,β-unsaturated carbonyl group is recognized as alert for mutagenicity, attributed to (1) its direct reaction with DNA, counteractable by glutathione (GSH), and (2) oxidative stress caused indirectly by GSH depletion. Accordingly, the α,β,γ,δ-unsaturated lactone patulin (PAT), a mycotoxin detected in fruits and pr...

journal_title：Archives of toxicology

authors： Pfenning C,Esch HL,Fliege R,Lehmann L

更新日期：2016-02-01 00:00:00

abstract：:Quantitative structure-activity relationships (QSAR) have suggested the importance of hydrogen bonding in relation to activation of the sensory irritant receptor by nonreactive volatile organic chemicals. To investigate this possibility further, three model compounds with different hydrogen bond acidity, trifluoroetha...

journal_title：Archives of toxicology

authors： Nielsen GD,Abraham MH,Hansen LF,Hammer M,Cooksey CJ,Andonian-Haftvan J,Alarie Y

更新日期：1996-01-01 00:00:00