Influence of arsenate and arsenite on signal transduction pathways: an update.

Abstract:

:Arsenic has been a recognized contaminant and toxicant, as well as a medicinal compound throughout human history. Populations throughout the world are exposed to arsenic and these exposures have been associated with a number of human cancers. Not much is known about the role of arsenic as a human carcinogen and more recently its role in non-cancerous diseases, such as cardiovascular disease, hypertension and diabetes mellitus have been uncovered. The health effects associated with arsenic are numerous and the association between arsenic exposure and human disease has intensified the search for molecular mechanisms that describe the biological activity of arsenic in humans and leads to the aforementioned disease states. Arsenic poses a human health risk due in part to the regulation of cellular signal transduction pathways and over the last few decades, some cellular mechanisms that account for arsenic toxicity, as well as, signal transduction pathways have been discovered. However, given the ubiquitous nature of arsenic in the environment, making sense of all the data remains a challenge. This review will focus on our knowledge of signal transduction pathways that are regulated by arsenic.

journal_name

Arch Toxicol

journal_title

Archives of toxicology

authors

Druwe IL,Vaillancourt RR

doi

10.1007/s00204-010-0554-4

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

585-96

issue

8

eissn

0340-5761

issn

1432-0738

journal_volume

84

pub_type

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