Abstract：
:The in vitro DNA strand breaking activity of metallothionein (MT) containing Cd2+ and Zn2+ in a molar ratio of 5:2 is described. Studies with radical scavengers and electron paramagnetic resonance spectroscopy indicate that the DNA damage might be caused by a radical species formed by the native protein (i.e., MT) charged with the heavy metal ions. No DNA strand breaks are detectable with the heat-denatured MT or with Cd2+ or Zn2+ alone. Inhibition studies using EDTA as a metal ion chelator or N-ethylmaleimide to alkylate sulfhydryl groups suggest that both the bound heavy metal ions as well as the SH groups of the various cysteine residues of MT may be involved in the MT-dependent DNA cleavage. Further characterization showed that the DNA cleavage is more likely random than sequence- or base-specific. These observations may provide a clue in the search for initial events in Cd-related carcinogenicity.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Müller T,Schuckelt R,Jaenicke Ldoi
10.1007/BF01973498keywords:
subject
Has Abstractpub_date
1991-01-01 00:00:00pages
20-6issue
1eissn
0340-5761issn
1432-0738journal_volume
65pub_type
杂志文章abstract：:A new class of potent anticancer drugs, alkylphosphocholines has been recognized lately. Miltefosine (Hexadecylphosphochlorine, HPC) has been found to express select antineoplastic effect on human breast cancer skin metastases with simultaneous preservation of bone marrow proliferative activity and low clastogenicity....
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-005-0010-z
更新日期：2006-01-01 00:00:00
abstract：:This study investigated whether paraquat (Pq)-induced lipidic peroxidation (LP) is accompanied by changes in blood pressure and heart rate (HR) in rats. Groups of adult male Wistar rats were studied 2 and 12 h after Pq (35 mg/kg, i.p.) administration. The LP was evaluated by monitoring thiobarbituric acid reactive sub...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-005-0660-x
更新日期：2005-09-01 00:00:00
abstract：:Although polybrominated naphthalenes (PBNs) are contaminants of the commercial fire retardant fireMaster BP-6, the individual PBN isomers have not been identified. In order to study PBNs possessing an analogous level of bromination to those found in fireMaster BP-6, three synthetic PBN mixtures, averaging 5.0, 5.3, an...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00346051
更新日期：1984-07-01 00:00:00
abstract：:The effects of acetaldehyde (ACD) on dopamine (DA) and DA-derived salsolinol (SAL) levels were investigated in the striatum of freely moving rats. Dialysate levels of DA and SAL were determined using in vivo reverse microdialysis coupled with high-performance liquid chromatography with an electrochemical detector. Per...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0131-z
更新日期：2007-02-01 00:00:00
abstract：:The rodenticide tetramethylenedisulfotetramine (TETS) is a potent convulsant (lethal dose in humans 7-10 mg) that is listed as a possible threat agent by the United States Department of Homeland Security. TETS has previously been studied in vivo for toxicity and in vitro in binding assays, with the latter demonstratin...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-017-2089-4
更新日期：2018-02-01 00:00:00
abstract：:The effect of acetone pretreatment (5% in drinking water for 10 days on rat liver metabolism and toxicity of thiobenzamide (TB) was investigated. Hepatic microsomes from acetone-pretreated rats showed a significant increase of TB-S-oxidation rate which, on the basis of selective thermal inactivation of FAD-containing ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01974397
更新日期：1990-01-01 00:00:00
abstract：:The effect of Co(NO3)2, CdSO4, NiSO4, ZnSO4, and HgCl2 (given repeatedly in subtoxic doses in the drinking water for 30 days) on rat liver monooxygenases was studied in experiments on male Wistar rats. The salts of Co, Cd, and Zn increased the activity of benzphetamine-N-demethylase, the content of cytochrome P-450 an...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00333421
更新日期：1985-01-01 00:00:00
abstract：:The cardiovascular effects were investigated after acute and subacute treatment with chlorodibromomethane (CDBM; 0.4 to 3.2 mmol/kg p.o.), trichloromethane (TCM; 0.31 and 1.25 mmol/kg p.o.) and mixtures of CDBM and TCM (acute, 0.8 mmol CDBM/kg + 1.25 mmol TCM/kg p.o.; subacute, 0.4 mmol CDBM/kg + 0.31 mmol TCM/kg p.o....
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050459
更新日期：1997-01-01 00:00:00
abstract：:203Pb(NO3)2 was administered i.v. to pregnant C57BL mice at different stages, from day 8 to day 18 of gestation. The whole animals or excised uteri were subjected to autoradiography or were autopsied for scintillation counting of excised organs. Lead appeared in embryonic and fetal tissues at all stages of gestation. ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01261379
更新日期：1983-10-01 00:00:00
abstract：:Cats were given vincristine sulfate (50 micrograms/kg i.v. every 4 days) and studied after 7-29 injections when neurological deficits became evident. The conduction velocity spectrum of individual afferent nerves from soleus muscles was shifted toward slower velocities. Relatively few functional muscle spindles or oth...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00319653
更新日期：1981-11-01 00:00:00
abstract：:The mechanical properties of the bones of young, adult and old rats administered various concentrations of cadmium were measured to prove the direct effect of cadmium on the bones of young rats. The young rats were divided into three subgroups, which were administered 0 (control), 5 and 10 ppm cadmium, respectively. T...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00278646
更新日期：1989-01-01 00:00:00
abstract：:The US Environmental Protection Agency's ToxCast program has generated toxicity data for thousands of chemicals but does not adequately assess potential neurotoxicity. Networks of neurons grown on microelectrode arrays (MEAs) offer an efficient approach to screen compounds for neuroactivity and distinguish between com...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-019-02636-x
更新日期：2020-02-01 00:00:00
abstract：:Chronic exposure to propiverine, a frequently prescribed pharmaceutical for treatment of overactive bladder and incontinence, provokes massive protein accumulation in the cytosol and nucleus of renal proximal tubule epithelial cells in rats. Previously, the accumulating protein was identified as D-amino acid oxidase (...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1685-z
更新日期：2017-01-01 00:00:00
abstract：:DNA damage induced by methylmethane sulfonate, cyclophosphamide, doxorubicin and procarbazine in male germ cells was assessed in rabbits by the demonstration of unscheduled DNA synthesis (UDS), in meiotic and postmeiotic phases of maturation. Immediately after treatment by the intravenous route tritiated thymidine was...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00361252
更新日期：1980-11-01 00:00:00
abstract：:The organophosphorus compound trichlorfon, dimethyl (2,2,2-trichloro-1-hydroxyethyl) phosphonate, was administered by stomach tube (100 mg/kg) to pregnant guinea pigs at two different stages of gestation (days 36, 37, 38 and 51, 52, 53). The pups developed locomotory disturbances, and post mortem examination revealed ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00263954
更新日期：1986-05-01 00:00:00
abstract：:Glucose is a major energy source for the entire body, while fructose metabolism occurs mainly in the liver. Fructose consumption has increased over the last decade globally and is suspected to contribute to the increased incidence of non-alcoholic fatty liver disease (NAFLD). NAFLD is a manifestation of metabolic synd...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-016-1892-7
更新日期：2017-04-01 00:00:00
abstract：:The present study has investigated the ability of amitraz, a widely used formamidine pesticide, to modulate serum concentrations and liver microsomal metabolism of 17beta-estradiol (E2) and testosterone in rats. Amitraz was administered intraperitoneally to male rats for 4 days and to intact female rats or ovariectomi...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-008-0288-8
更新日期：2008-10-01 00:00:00
abstract：:This review summarises the current state of knowledge regarding the physiology and control of production of thyroid hormones, the effects of chemicals in perturbing their synthesis and release that result in thyroid cancer. It does not consider the potential neurodevelopmental consequences of low thyroid hormones. The...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-020-02961-6
更新日期：2021-01-05 00:00:00
abstract：:Cannabis use has become a hot topic in several countries due to the debate about its legalization for medical purposes. However, data are limited regarding adverse events, safety and potential impact on reproductive health. Cannabis consumption during pregnancy has been associated with gestational disorders such as pr...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-019-02389-7
更新日期：2019-03-01 00:00:00
abstract：:Particle-induced carcinogenicity is not well understood, but might involve inflammation. The proinflammatory cytokine tumor necrosis factor (TNF) is considered to be an important mediator in inflammation. We investigated its role in particle-induced inflammation and DNA damage in mice with and without TNF signaling. T...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-004-0613-9
更新日期：2005-03-01 00:00:00
abstract：:Hexamoll® DINCH® (diisononyl-cyclohexane-1,2-dicarboxylate) is a new high molecular weight plasticizer and a non-aromatic phthalate substitute. In this follow-up study, we further investigated the extensive oxidative metabolism of Hexamoll® DINCH® after oral dosage of 50 mg to three male volunteers (0.552-0.606 mg/kg ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1688-9
更新日期：2017-01-01 00:00:00
abstract：:The inhibitory effect and mechanism of action of nicotinamide to paraquat toxicity were studied in male Sprague-Dawley rats. Proteins of submitochondrial particles (SMP), especially of mol. wt. 25-30 kDa, in rat lungs were destroyed by paraquat radicals, and aggregated protein bands approximately 100 kDa were observed...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050437
更新日期：1997-01-01 00:00:00
abstract：:The regional distribution of dopamine, norepinephrine and homovanillic acid was assessed in adult male rabbits exposed to styrene vapours. The turnover of dopamine and norepinephrine was also measured in several brain regions by the decay in endogenous catecholamines after inhibition of tyrosine hydroxylase by alpha-m...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00316123
更新日期：1984-09-01 00:00:00
abstract：:Sodium diethyldithiocarbamate (DETC) is the main metabolite of disulfiram. Recently, we reported that mechanism of disulfiram cytotoxicity in V79 cells might be partially connected with thiol redox-state imbalance. Here, we examined the effect of DETC on the level of intracellular glutathione (GSH), protein oxidation ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-012-0909-0
更新日期：2012-12-01 00:00:00
abstract：:As Drosophila melanogaster occupies an important position within the test battery for mutagens and carcinogens, it is of interest to study the xenobiotics metabolism of this insect. Likewise, the genetic control of these important enzyme systems falls within this interest. Our attempt was to get new strains, which sho...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00316345
更新日期：1984-11-01 00:00:00
abstract：:Pulmonary fibrosis is a poorly understood pathologic condition. Carbon nanotubes (CNTs) are nanomaterials with potentials for broad applications. CNTs can induce pulmonary fibrosis in animals, a cause for concern for exposed workers and consumers. Given the large number of CNTs available on the market and the seemingl...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2306-9
更新日期：2018-11-01 00:00:00
abstract：:Possible induction of chromosomal aberrations and/or sister chromatid exchanges by astemizole was studied in vitro on human lymphocytes. In vivo chromosomal damage was assessed by a micronucleus test on rats and a dominant lethal test on both male and female mice. All these tests yielded negative results for astemizol...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00373399
更新日期：1982-07-01 00:00:00
abstract：:The effect of 1-deamino-2-tyr(ethyl) oxytocin (dEtOT) upon peri- and postnatal development of the rat was studied in two experiments when administered between day 15 of pregnancy and the day of parturition. The investigation showed that dEtOT did not affect the pups at birth, that dEtOT caused a dose-related growth re...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00324786
更新日期：1985-09-01 00:00:00
abstract：:Although the tumor-promoting effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), coplanar polychlorinated biphenyls (PCBs), and related compounds in liver tissue are primarily attributed to the activation of the aryl hydrocarbon receptor (AhR), the underlying molecular mechanisms are still unclear. Liver progenitor...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-012-0979-z
更新日期：2013-04-01 00:00:00
abstract：:Perfluorocarboxylic acids (PFCAs) including perfluorooctanoic acid (PFOA) are environmental pollutants showing high accumulation, thermochemical stability and hepatocarcinogenicity. Peroxisome proliferator-activated receptor α is suggested to mediate their toxicities, but the precise mechanism remains unclear. Previou...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1888-3
更新日期：2017-06-01 00:00:00
