Abstract：
:The effects of six iv infusions of an emulsion containing the plasticizer di(2-ethylhexyl) phthalate (DEHP) on the liver and testes were investigated in 40-day-old rats. Groups of five to six animals received the emulsion every other day in doses of 0, 5, 50 or 500 mg DEHP/kg body weight. Liver effects were studied by histological examination and by measuring bromosulfophthalein clearance, peroxisomal proliferation and certain enzymes in serum. Testicular effects were evaluated by light and electron microscopy. To investigate the possibility of an age-related effect on the testis, five 25-day-old rats were given six infusions of 500 mg DEHP/kg. Compared with control animals, the high-dose group showed a 36% increase in relative liver weight and a 41% increase in the number of peroxisomes. In Epon-embedded testicular material from animals given the highest dose, which is about 100 times the highest estimated human exposure, some altered Sertoli cells and some degenerated primary spermatocytes were observed. No age-related effect on the testis similar to that found following oral administration of DEHP was observed in this study.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Sjöberg P,Lindquist NG,Montin G,Plöen Ldoi
10.1007/BF00348313subject
Has Abstractpub_date
1985-12-01 00:00:00pages
78-83issue
2eissn
0340-5761issn
1432-0738journal_volume
58pub_type
杂志文章abstract：:Metabolic activation of the heterocyclic amine 3-amino -1,4-dimethyl-5 H-pyrido[4,3-b]indole (Trp-P-1) and 7-ethoxyresorufin O-deethylase (EROD) activity were examined in the chorioallantoic membrane (CAM) of 15-day-old chicken and 18-day-old eider duck embryos. The embryos were pretreated with an Ah receptor agonist,...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040000128
更新日期：2000-08-01 00:00:00
abstract：:The assay of neurotoxic esterase (NTE) in brains taken from dosed hens enables potential neurotoxicity of organophosphate pesticides, plasticers, etc. to be assessed. The original assay [Johnson, M.K. Biochem. J. 114, 711-717 (1969)] has been simplified to eliminate centrifugation and transfer steps and both the selec...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00293860
更新日期：1977-06-18 00:00:00
abstract：:A predictive test using mice for the identification of contact sensitizing chemicals was developed. Contact sensitizing activity is measured as a function of draining lymph node activation following application of test chemical. Experimental conditions for assessment of induced lymph node cell (LNC) responses have bee...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01974070
更新日期：1993-01-01 00:00:00
abstract：:The use of silver nanoparticles is one of the fastest growing product categories in the nanotechnology industry, with a focus on antimicrobial activity. However, thus far, toxicity data for silver nanoparticles are limited. In this study, we investigated the cytotoxic effects of silver nanoparticles (Ag NPs) and the p...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-011-0714-1
更新日期：2011-12-01 00:00:00
abstract：:The cytotoxicity of trivalent and pentavalent inorganic arsenic salts was determined in mouse fibroblasts in vitro. Concentrations of As (III) in the microM range led to a reduction of proliferation and viability with a concomitant increase in LDH release and stimulation of lactic acid production. Similar effects were...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00290882
更新日期：1985-08-01 00:00:00
abstract：:Tributyltin (TBT) has been shown to disrupt the ability of natural killer (NK) cells to destroy tumor targets in vitro even at exposures of 25 nM for 24 h, but cell viability was not significantly impacted. Thus, evaluation of intracellular molecular events that regulate cell viability in TBT exposed NK cells are of i...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0155-4
更新日期：2007-04-01 00:00:00
abstract：:As previously demonstrated, chronic administration of phenobarbital (0.05% in the drinking water) and of nafenopin (0.1% in the diet) increases the incidence and the kinetics of appearance of liver cancers. If bile acids play a key role in liver carcinogenesis, it might thus be expected that treatments like phenobarbi...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050087
更新日期：1994-01-01 00:00:00
abstract：:The responsiveness of the hepatic supernatant NAD+-dependent aldehyde dehydrogenase with a high Km value (high Km-AldDH) to phenobarbital (PB) and 3-methylcholanthrene (3-MC) treatment was studied in male rats of three strains; Wistar, Long-Evans, and Sprague-Dawley. A remarkable strain difference in the response of t...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00333620
更新日期：1979-12-01 00:00:00
abstract：:Sulfites whether ingested or produced through the sulfur-containing amino acids metabolism of the animal are very active molecules and can cause cellular toxicity. Sulfite oxidase (SOX), a heme- and molybdenum containing mitochondrial enzyme, prevents mammalian cells from adverse effects of sulfite toxicity by metabol...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0125-x
更新日期：2006-10-01 00:00:00
abstract：:A number of studies have evaluated the possibility that stress-induced changes in blood-brain barrier permeability enhanced the central effects of the carbamate acetylcholinesterase inhibitor, pyridostigmine. We previously found relatively little evidence of stress-induced changes in the acute toxicity of pyridostigmi...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0144-7
更新日期：2007-04-01 00:00:00
abstract：:Pulmonary fibrosis is a poorly understood pathologic condition. Carbon nanotubes (CNTs) are nanomaterials with potentials for broad applications. CNTs can induce pulmonary fibrosis in animals, a cause for concern for exposed workers and consumers. Given the large number of CNTs available on the market and the seemingl...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2306-9
更新日期：2018-11-01 00:00:00
abstract：:The aim was to study the long-term response in the olfactory mucosa of NMRI mice after exposure to the olfactory toxicants dichlobenil (a herbicide) or methimazole (an antithyroid drug). Three and six months after exposure to dichlobenil (2x or 1 x 25 mg/kg i.p.), the dorsomedial part of the olfactory region showed a ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-002-0321-2
更新日期：2002-03-01 00:00:00
abstract：:This discussion of the NEL presents some thoughts how toxicologists could be encouraged to use more sophisticated modern techniques for the study of various environmental chemicals. It is proposed to use the concept of the NEL only for data obtained by conventional techniques in routine toxicity experiments. Informati...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00695868
更新日期：1979-10-01 00:00:00
abstract：:Aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor, has been studied extensively in carcinogenesis through the genomic pathway. In recent years, AHR has also been reported to exert positive or negative effects on epithelial-mesenchymal transition (EMT), the crucial step in tumor malignant progres...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1870-0
更新日期：2017-05-01 00:00:00
abstract：:MDMA-induced impairments of memory performance have been reported in different human and animal studies. However, the correlation between spatial memory impairment, brain mitochondrial function, and concentrations of MDMA and its metabolites has not yet been investigated despite it being needed for comparison with hum...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02673-x
更新日期：2020-03-01 00:00:00
abstract：:The first step in the oxidative metabolism of cocaine is N-demethylation to norcocaine, which is further N-hydroxylated to more toxic N-hydroxynorcocaine. In this study we examined the kinetics of norcocaine N-hydroxylation mediated by cytochrome P450 (CYP) in mouse and human liver microsomes. N-hydroxynorcocaine was ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040000154
更新日期：2000-11-01 00:00:00
abstract：:Treatment of tuberculosis (TB) has been a therapeutic challenge because of not only the naturally high resistance level of Mycobacterium tuberculosis to antibiotics but also the newly acquired mutations that confer further resistance. Currently standardized regimens require patients to daily ingest up to four drugs un...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-016-1727-6
更新日期：2016-07-01 00:00:00
abstract：:The cardiovascular effects were investigated after acute and subacute treatment with chlorodibromomethane (CDBM; 0.4 to 3.2 mmol/kg p.o.), trichloromethane (TCM; 0.31 and 1.25 mmol/kg p.o.) and mixtures of CDBM and TCM (acute, 0.8 mmol CDBM/kg + 1.25 mmol TCM/kg p.o.; subacute, 0.4 mmol CDBM/kg + 0.31 mmol TCM/kg p.o....
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050459
更新日期：1997-01-01 00:00:00
abstract：:The asexual freshwater planarian Dugesia japonica has emerged as a medium-throughput alternative animal model for neurotoxicology. We have previously shown that D. japonica are sensitive to organophosphorus pesticides (OPs) and characterized the in vitro inhibition profile of planarian cholinesterase (DjChE) activity ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-017-2130-7
更新日期：2018-03-01 00:00:00
abstract：:Organotin compounds such as tributyltin (TBT) and triphenyltin can induce diabetes and insulin resistance. However, the development of diabetes caused by organotins and its underlying mechanisms remain unclear. In the present study, male KM mice were orally administered with TBT (0.5, 5, and 50 μg/kg) once every 3 day...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-017-1961-6
更新日期：2017-10-01 00:00:00
abstract：:Quantitative structure-activity relationships (QSAR) have suggested the importance of hydrogen bonding in relation to activation of the sensory irritant receptor by nonreactive volatile organic chemicals. To investigate this possibility further, three model compounds with different hydrogen bond acidity, trifluoroetha...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050281
更新日期：1996-01-01 00:00:00
abstract：:The inhibitory effect and mechanism of action of nicotinamide to paraquat toxicity were studied in male Sprague-Dawley rats. Proteins of submitochondrial particles (SMP), especially of mol. wt. 25-30 kDa, in rat lungs were destroyed by paraquat radicals, and aggregated protein bands approximately 100 kDa were observed...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050437
更新日期：1997-01-01 00:00:00
abstract：:Fifteen patients who were severely poisoned with either hypnotic drugs or salicylate were treated by charcoal haemoperfusion. The device contained 100g of activated charcoal immobilised by fixation to a polyester film. Two patients showed no response and eventually died. The remainder showed marked lightening of coma ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01270911
更新日期：1980-07-01 00:00:00
abstract：:The effect of N-benzyl-D-glucamine dithiocarbamate (BGD) on the renal toxicity induced by acute exposure to cadmium-metallothionein (Cd-MT) in rats was studied. Rats were injected intraperitoneally with BGD (400 mumol/kg) 6, 12, or 24 h after intraperitoneal injection of Cd-MT (1.78 mumol Cd as Cd-MT/kg) and thereafte...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01974392
更新日期：1990-01-01 00:00:00
abstract：:Some nucleoside analogues are used to treat herpes simplex and other viral infections. They are known to impair spermatogenesis, but published data are scarce. We studied the effects of four nucleosides on SerW3 cells, a rat Sertoli cell line. Cells were cultured for 3 days in DMEM supplemented with four different con...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1743-6
更新日期：2016-08-01 00:00:00
abstract：:The neurological effects of four synthetic pyrethroids resmethrin, permethrin, cypermethrin, and deltamethrin have been investigated in the rat to establish whether there is a correlation between the clinical-functional status of the animal and peripheral nerve damage as measured biochemically. Neuromuscular dysfuncti...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00294995
更新日期：1983-08-01 00:00:00
abstract：:We recently reported that doxorubicin decreased the expression of calpain-1/2, while inhibition of calpain activity promoted doxorubicin-induced cardiac injury in mice. In this study, we investigated whether and how elevation of calpain-2 could affect doxorubicin-triggered cardiac injury. Transgenic mice with inducibl...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-019-02405-w
更新日期：2019-04-01 00:00:00
abstract：:In a two-step study on exposure control method for occupational handling of permethrin was developed. Air sampling on a filter can be used in case of exposure to permethrin in powder form. The detection limit is 0.001 mg/m3. If biological sampling is used, the acid metabolite moiety in the urine must be monitored. How...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00569234
更新日期：1982-05-01 00:00:00
abstract：:Experimental and/or epidemiological studies suggest that prenatal exposure to bisphenol A (BPA) may delay fetal lung development and maturation and increase the susceptibility to childhood respiratory disease. However, the underlying mechanisms remain to be elucidated. In our previous study with cultured human fetal l...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-017-2150-3
更新日期：2018-04-01 00:00:00
abstract：:The present study was designed to compare the nephrotoxicity induced by the three platinum compounds cisplatin (CDDP), carboplatin (CBDCA) and transplatin (TDDP) in vitro and to obtain information to elucidate the mechanism of platinum compound-induced nephrotoxicity. Rat or rabbit renal cortical slices were incubated...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01973462
更新日期：1990-01-01 00:00:00
