当前位置： SCI文献检索 > ARCHIVES OF TOXICOLOGY期刊下所有文献 > Calpain-2 promotes MKP-1 expression protecting cardiomyocytes in both in vitro and in vivo mouse models of doxorubicin-induced cardiotoxicity.

Calpain-2 promotes MKP-1 expression protecting cardiomyocytes in both in vitro and in vivo mouse models of doxorubicin-induced cardiotoxicity.

Abstract：

:We recently reported that doxorubicin decreased the expression of calpain-1/2, while inhibition of calpain activity promoted doxorubicin-induced cardiac injury in mice. In this study, we investigated whether and how elevation of calpain-2 could affect doxorubicin-triggered cardiac injury. Transgenic mice with inducible cardiomyocyte-specific expression of calpain-2 were generated. An acute cardiotoxicity was induced in both transgenic mice and their relevant wild-type littermates by injection of a single dose of doxorubicin (20 mg/kg) and cardiac injury was analyzed 5 days after doxorubicin injection. Cardiomyocyte-specific up-regulation of calpain-2 did not induce any adverse cardiac phenotypes under physiological conditions by age 3 months, but significantly reduced myocardial injury and improved myocardial function in doxorubicin-treated mice. Cardiac protection of calpain-2 up-regulation was also observed in a mouse model of chronic doxorubicin cardiotoxicity. Up-regulation of calpain-2 increased the protein levels of mitogen activated protein kinase phosphatase-1 (MKP-1) in cultured mouse cardiomyocytes and heart tissues. Over-expression of MKP-1 prevented, whereas knockdown of MKP-1 augmented doxorubicin-induced apoptosis in cultured cardiomyocytes. Moreover, knockdown of MKP-1 offset calpain-2-elicited protective effects against doxorubicin-induced injury in cultured cardiomyocytes. Mechanistically, up-regulation of calpain-2 reduced the protein levels of phosphatase and tensin homolog and consequently promoted Akt activation, leading to increased MKP-1 protein steady-state levels by inhibiting its degradation. Collectively, this study reveals a new role of calpain-2 in promoting MKP-1 expression via phosphatase and tensin homolog/Akt signaling. This study also suggests that calpain-2/MKP-1 signaling may represent new therapeutic targets for doxorubicin-induced cardiac injury.

journal_name

Arch Toxicol

journal_title

Archives of toxicology

authors

Zheng D,Su Z,Zhang Y,Ni R,Fan GC,Robbins J,Song LS,Li J,Peng T

doi

10.1007/s00204-019-02405-w

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

1051-1065

issue

4

eissn

0340-5761

issn

1432-0738

pii

10.1007/s00204-019-02405-w

journal_volume

93

pub_type

杂志文章

相关文献

ARCHIVES OF TOXICOLOGY文献大全
  • Changes in the excretion of endogenous glycine conjugate as a possible artifact in toxicological experiments.

    abstract：:Changes in the urinary excretion of hippuric acid (HIA) and phenaceturic acid (PUA) as well as their metabolic precursors, i.e. benzoic (BA) and phenylacetic acid (PAA), in rats housed in glass metabolic cages for 4 days were monitored using gas-liquid chromatography. The amount of HIA excreted was 128 +/- 63 mumol/kg...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF00324554

    authors： Linhart I,Smejkal J

    更新日期：1987-01-01 00:00:00

  • Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on maternal immune response during pregnancy.

    abstract：:Whether pregnancy-induced immunosuppression when combined with exposure to 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) could exacerbate immunotoxicity has not been previously investigated. The current study evaluated the immune status of C57BL/6 pregnant and virgin mice following exposure to TCDD. To this end, syngene...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-003-0538-8

    authors： Camacho IA,Nagarkatti M,Nagarkatti PS

    更新日期：2004-05-01 00:00:00

  • Changes of the activities of superoxide dismutase after exposure to the fume of heavy metals and the significance of zinc in the tissue.

    abstract：:Pathological changes induced by cadmium aerosol had features common to the changes evoked by oxidants. Female rats were exposed to fumes of lead, antimony, zinc and cadmium (15-100 nmoles/m3). One hour after termination of exposure, superoxide dismutase (SOD) activity in erythrocytes of the exposed rats lowered by 15-...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF00347869

    authors： Minami M,Koshi K,Homma K,Suzuki Y

    更新日期：1982-03-01 00:00:00

  • Determination of urinary thymidine glycol using affinity chromatography, HPLC and post-column reaction detection: a biomarker of oxidative DNA damage upon kidney transplantation.

    abstract：:Reactive oxygen species are generated during ischaemia-reperfusion of tissue. Oxidation of thymidine by hydroxyl radicals (HO) leads to the formation of 5,6-dihydroxy-5,6-dihydrothymidine (thymidine glycol). Thymidine glycol is excreted in urine and can be used as biomarker of oxidative DNA damage. Time dependent chan...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s002040050638

    authors： Thier R,Brüning T,Kocher K,Blaszkewicz M,Makropoulos V,Sundberg A,Bolt HM

    更新日期：1999-11-01 00:00:00

  • Silver nanoparticles induce apoptosis and G2/M arrest via PKCζ-dependent signaling in A549 lung cells.

    abstract：:The use of silver nanoparticles is one of the fastest growing product categories in the nanotechnology industry, with a focus on antimicrobial activity. However, thus far, toxicity data for silver nanoparticles are limited. In this study, we investigated the cytotoxic effects of silver nanoparticles (Ag NPs) and the p...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-011-0714-1

    authors： Lee YS,Kim DW,Lee YH,Oh JH,Yoon S,Choi MS,Lee SK,Kim JW,Lee K,Song CW

    更新日期：2011-12-01 00:00:00

  • Long-term arsenite exposure induces premature senescence in B cell lymphoma A20 cells.

    abstract：:Chronic arsenite exposure induces immunosuppression, but the precise mechanisms remain elusive. Our previous studies demonstrated that arsenite exposure for 24 h induces G0/G1 arrest in mouse B lymphoma A20 cells and the arrest is caused through induction of cyclin-dependent kinase inhibitor p16(INK4a) followed by acc...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-015-1500-2

    authors： Okamura K,Nohara K

    更新日期：2016-04-01 00:00:00

  • Detrimental effects of prenatal exposure to filtered diesel exhaust on mouse spermatogenesis.

    abstract：:We recently showed that prenatal exposure to diesel exhaust (DE) disrupts spermatogenesis in mouse offspring. This study was undertaken to determine whether filtered DE in which 99.97% of diesel exhaust particles >0.3 microm in diameter were removed affects spermatogenesis in growing mice. After prenatal exposure to f...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-008-0302-1

    authors： Ono N,Oshio S,Niwata Y,Yoshida S,Tsukue N,Sugawara I,Takano H,Takeda K

    更新日期：2008-11-01 00:00:00

  • Epigenetic properties of the diarrhetic marine toxin okadaic acid: inhibition of the gap junctional intercellular communication in a human intestine epithelial cell line.

    abstract：:Okadaic acid (OA) is produced by several types of dinoflagellates (marine plankton) and has been implicated as the causative agent of diarrhetic shellfish syndrome. Previous studies have shown that okadaic acid is a tumor promoter and a specific potent inhibitor of protein phosphatases and protein synthesis. These eff...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-003-0460-0

    authors： Traoré A,Baudrimont I,Dano S,Sanni A,Larondelle Y,Schneider YJ,Creppy EE

    更新日期：2003-11-01 00:00:00

  • Effect of cadmium or magnesium on calcium-dependent central function that reduces blood pressure.

    abstract：:The effect of intracerebroventricular (i.c.v.) administration of cadmium or magnesium on central calcium-dependent blood pressure regulation was investigated. The systolic blood pressure of spontaneously hypertensive rats (SHR; male, 13 weeks of age) decreased following i.c.v. administration of cadmium chloride (20 nm...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s002040050644

    authors： Sutoo D,Akiyama K

    更新日期：2000-03-01 00:00:00

  • Toxicology data of graphene-family nanomaterials: an update.

    abstract：:Due to its unique physical structure and chemical properties, graphene family nanomaterials (GFNs) and derived commodities have been widely used in commercial products, particularly biomedical applications, which has significantly increased the risk of human exposure. There exists significant evidence that GFNs are ac...

    journal_title：Archives of toxicology

    pub_type： 杂志文章,评审

    doi：10.1007/s00204-020-02717-2

    authors： Xiaoli F,Qiyue C,Weihong G,Yaqing Z,Chen H,Junrong W,Longquan S

    更新日期：2020-06-01 00:00:00

  • Comparative metabolism and disposition of acrylonitrile and methacrylonitrile in rats.

    abstract：:Aliphatic nitriles are a class of chemicals used in high volumes in the production of plastics and elastomers, in organic synthesis, and in production of a number of food packaging containers. Toxicity and metabolism of acrylonitrile (AN) are well characterized. On the other hand, minimal information is available on t...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF03208340

    authors： Burka LT,Sanchez IM,Ahmed AE,Ghanayem BI

    更新日期：1994-01-01 00:00:00

  • The role of epoxide hydrolases in health and disease.

    abstract：:Epoxide hydrolases (EH) are ubiquitously expressed in all living organisms and in almost all organs and tissues. They are mainly subdivided into microsomal and soluble EH and catalyze the hydration of epoxides, three-membered-cyclic ethers, to their corresponding dihydrodiols. Owning to the high chemical reactivity of...

    journal_title：Archives of toxicology

    pub_type： 杂志文章,评审

    doi：10.1007/s00204-014-1371-y

    authors： El-Sherbeni AA,El-Kadi AO

    更新日期：2014-11-01 00:00:00

  • Testicular atrophy induced by di(2-ethylhexyl)phthalate: changes in histology, cell specific enzyme activities and zinc concentrations in rat testis.

    abstract：:Daily administration of 2g/kg/day di(2-ethylhexyl)phthalate (DEHP) to immature rats was found to cause testicular atrophy and reduce zinc concentration. Specific activities of testicular enzymes associated with postmeiotic spermatogenic cells, such as lactate dehydrogenase isozyme-X, hyaluronidase and sorbitol dehydro...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF00290553

    authors： Oishi S

    更新日期：1986-12-01 00:00:00

  • Effect of lindane and heptachlor on delta-aminolaevulinate synthase and its regulation.

    abstract：:The effect of lindane and heptachlor on haem metabolism was studied with the aim to elucidate the mechanism of their porphyrinogenic action. The effects of these compounds on delta-aminolaevulinate synthase (ALA-S) and ferrochelatase were evaluated and the mechanism of increase of ALA-S activity was especially studied...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s002040050566

    authors： Taira MC,San Martín de Viale LC

    更新日期：1998-11-01 00:00:00

  • Tumor necrosis factor is not required for particle-induced genotoxicity and pulmonary inflammation.

    abstract：:Particle-induced carcinogenicity is not well understood, but might involve inflammation. The proinflammatory cytokine tumor necrosis factor (TNF) is considered to be an important mediator in inflammation. We investigated its role in particle-induced inflammation and DNA damage in mice with and without TNF signaling. T...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-004-0613-9

    authors： Saber AT,Bornholdt J,Dybdahl M,Sharma AK,Loft S,Vogel U,Wallin H

    更新日期：2005-03-01 00:00:00

  • Gene expression profiling in the lung tissue of cynomolgus monkeys in response to repeated exposure to welding fumes.

    abstract：:Many in the welding industry suffer from bronchitis, lung function changes, metal fume fever, and diseases related to respiratory damage. These phenomena are associated with welding fumes; however, the mechanism behind these findings remains to be elucidated. In this study, the lungs of cynomolgus monkeys were exposed...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-009-0486-z

    authors： Heo JD,Oh JH,Lee K,Kim CY,Song CW,Yoon S,Han JS,Yu IJ

    更新日期：2010-03-01 00:00:00

  • Protective effect of topical iodine containing anti-inflammatory drugs against sulfur mustard-induced skin lesions.

    abstract：:Previous studies have shown the antidotal efficacy of topical iodine at 15 and 30 min post-exposure to sulfur mustard (SM). Here we demonstrate efficacy at longer intervals (20, 30, 45, and 60 min, respectively, for data) using an improved topical povidone-iodine preparation termed N66, which contains steroidal and no...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-003-0523-2

    authors： Wormser U,Sintov A,Brodsky B,Casillas RP,Nyska A

    更新日期：2004-03-01 00:00:00

  • Oxidatively damaged guanosine in white blood cells and in urine of welders: associations with exposure to welding fumes and body iron stores.

    abstract：:The International Agency for Research on Cancer considers the carcinogenicity of welding fume of priority for re-evaluation. Genotoxic effects in experimental animals are still inconclusive. Here, we investigated the association of personal exposure to metals in respirable welding fumes during a working shift with oxi...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-014-1319-2

    authors： Pesch B,Lotz A,Koch HM,Marczynski B,Casjens S,Käfferlein HU,Welge P,Lehnert M,Heinze E,Van Gelder R,Hahn JU,Behrens T,Raulf M,Hartwig A,Weiss T,Brüning T

    更新日期：2015-08-01 00:00:00

  • Opioid analgesic drugs and serotonin toxicity (syndrome): mechanisms, animal models, and links to clinical effects.

    abstract：:Drugs may cause serotonin toxicity by a number of different mechanisms including inhibition of serotonin uptake and metabolism, increased serotonin synthesis and release, activation of serotonin receptors, and inhibition of cytochrome P450 oxidases. Some drug interactions involving opioids can increase intrasynaptic l...

    journal_title：Archives of toxicology

    pub_type： 杂志文章,评审

    doi：10.1007/s00204-018-2244-6

    authors： Baldo BA

    更新日期：2018-08-01 00:00:00

  • Induction of peroxisomal beta-oxidation and P-450 4A-dependent activities by pivalic and trichloroacetic acid in rat liver and kidney.

    abstract：:The influence of pivalic acid (PIV), a compound often used to make pro-drugs, and of the structurally related trichloroacetic acid (TCA), on several hepatic and renal enzymes was investigated in Sprague-Dawley rats, following a 4-day treatment period. The PIV and TCA treatments resulted in a similar and selective indu...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s002040050253

    authors： Zanelli U,Puccini P,Acerbi D,Ventura P,Gervasi PG

    更新日期：1996-01-01 00:00:00

  • Heat shock protein 70 in the rat nasal cavity: localisation and response to hyperthermia.

    abstract：:Heat shock proteins (HSPs) are a group of proteins that are rapidly induced in response to physiological stress, including hyperthermia and exposure to toxicants. Thus they may provide a useful index of toxicity in in vitro systems for screening for toxicity. We have recently developed a rat nasal explant system for i...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-004-0541-8

    authors： Simpson SA,Alexander DJ,Reed CJ

    更新日期：2004-06-01 00:00:00

  • A new metabolic pathway of arsenite: arsenic-glutathione complexes are substrates for human arsenic methyltransferase Cyt19.

    abstract：:The metabolism of arsenic is generally accepted to proceed by repetitive reduction and oxidative methylation; the latter is mediated by arsenic methyltransferase (Cyt19). In human urine, the major metabolites of inorganic arsenicals such as arsenite (iAsIII) and arsenate (iAsV) are monomethylarsonic acid (MMA(V)) and ...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-004-0620-x

    authors： Hayakawa T,Kobayashi Y,Cui X,Hirano S

    更新日期：2005-04-01 00:00:00

  • Learning, memory and the expression of cholinergic components in mice are modulated by the pesticide chlorpyrifos depending upon age at exposure and apolipoprotein E (APOE) genotype.

    abstract：:Polymorphisms of the apolipoprotein E (APOE) gene differentially affect neurobiological functions and cognitive performance and confer different vulnerabilities to subclinical exposures to chlorpyrifos (CPF), a pesticide used worldwide. The data reported on this topic suggest a complex interaction between cholinergic ...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-019-02387-9

    authors： Basaure P,Guardia-Escote L,Cabré M,Peris-Sampedro F,Sánchez-Santed F,Domingo JL,Colomina MT

    更新日期：2019-03-01 00:00:00

  • In vitro assessment of drug-induced liver steatosis based on human dermal stem cell-derived hepatic cells.

    abstract：:Steatosis, also known as fatty liver disease (FLD), is a disorder in which the lipid metabolism of the liver is disturbed, leading to the abnormal retention of lipids in hepatocytes. FLD can be induced by several drugs, and although it is mostly asymptomatic, it can lead to steatohepatitis, which is associated with li...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-015-1483-z

    authors： Rodrigues RM,Branson S,De Boe V,Sachinidis A,Rogiers V,De Kock J,Vanhaecke T

    更新日期：2016-03-01 00:00:00

  • Effects of cadmium on carbonic anhydrase activity and hemoglobin content of rat testes.

    abstract：:The cadmilm-induced (Cd) damage of mammalian testes is thought to be correlated with an inhibition of carbonic anhydrase (CAH) by Cd. Since Cd causes dose-dependent changes in blood flow of the testes, an inhibition of CAH in the testes could be simulated by a decrease of CAH-rich erythrocytes. Therefore, CAH activiti...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF00353353

    authors： Alsen C,Köpcke C,Ohnesorge FK,Schneider J

    更新日期：1976-12-23 00:00:00

  • Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates.

    abstract：:Standard treatment of poisoning by organophosphates (OP) includes the administration of an antimuscarinic agent, e.g. atropine, and of an acetylcholinesterase (AChE) reactivator (oxime). The presently available oximes, obidoxime and pralidoxime (2-PAM), are considered to be insufficient for highly toxic OPs, e.g. sari...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-002-0375-1

    authors： Worek F,Reiter G,Eyer P,Szinicz L

    更新日期：2002-09-01 00:00:00

  • Impact of serum as a dispersion agent for in vitro and in vivo toxicological assessments of TiO2 nanoparticles.

    abstract：:Nanoparticles (NP) have a tendency to agglomerate after dispersion in physiological media, which can be prevented by the addition of serum. This may however result in modification of the toxic potential of particles due to the formation of protein corona. Our study aimed to analyze the role of serum that is added to i...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-016-1673-3

    authors： Vranic S,Gosens I,Jacobsen NR,Jensen KA,Bokkers B,Kermanizadeh A,Stone V,Baeza-Squiban A,Cassee FR,Tran L,Boland S

    更新日期：2017-01-01 00:00:00

  • Reactivating potency of obidoxime, pralidoxime, HI 6 and HLö 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds.

    abstract：:The treatment of poisoning by highly toxic organophosphorus compounds (nerve agents) is unsatisfactory. Until now, the efficacy of new potential antidotes has primarily been evaluated in animals. However, the extrapolation of these results to humans is hampered by species differences. Since oximes are believed to act ...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s002040050495

    authors： Worek F,Widmann R,Knopff O,Szinicz L

    更新日期：1998-03-01 00:00:00

  • [Delayed implantation and early developmental defects in the mouse caused by PCB: 2,2'-dichlorobiphenyl (author's transl)].

    abstract：:Pregnant mice administered per os during the days 1--3 (plug day = day 0) post conception (p.c.) with 375 mg 2,2'-dichlorobiphenyl/kilograms/day revealed on day 18 p.c. increased number of resorptions and doses up from 500 milligrams/kilograms/day led to a substantial retardation of the prenatal development. Based on ...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF00310329

    authors： Török P

    更新日期：1978-08-09 00:00:00

  • Toxic effects of A2E in human ARPE-19 cells were prevented by resveratrol: a potential nutritional bioactive for age-related macular degeneration treatment.

    abstract：:Age-related macular degeneration (AMD) is a late-onset retinal disease and the leading cause of central vision loss in the elderly. Degeneration of retinal pigment epithelial cells (RPE) is a crucial contributing factor responsible for the onset and progression of AMD. The toxic fluorophore N-retinyl-N-retinylidene et...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-019-02637-w

    authors： Alaimo A,Di Santo MC,Domínguez Rubio AP,Chaufan G,García Liñares G,Pérez OE

    更新日期：2020-02-01 00:00:00