Abstract:
:Changes in the urinary excretion of hippuric acid (HIA) and phenaceturic acid (PUA) as well as their metabolic precursors, i.e. benzoic (BA) and phenylacetic acid (PAA), in rats housed in glass metabolic cages for 4 days were monitored using gas-liquid chromatography. The amount of HIA excreted was 128 +/- 63 mumol/kg for female and 79 +/- 43 mumol/kg for male rats in the first 24 h and decreased to 11 +/- 7 mumol/kg (p less than 0.01) for female and 3.2 +/- 2.4 mumol/kg (p less than 0.001) for male rats on the 2nd day. These values remained nearly at the same level until the end of the experiment. The amount of PUA decreased from 48 +/- 12 mumol/kg on the 1st day to 22 +/- 9 mumol/kg (p less than 0.05) on the 2nd day by male rats, whereas by the females the decrease from 30 +/- 9 mumol/kg to 21 +/- 8 mumol/kg was not significant. The decrease in the excretion of glycine conjugates was compensated by a parallel increase in the level of unconjugated BA and PAA.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Linhart I,Smejkal Jdoi
10.1007/BF00324554subject
Has Abstractpub_date
1987-01-01 00:00:00pages
83-5issue
1eissn
0340-5761issn
1432-0738journal_volume
61pub_type
杂志文章abstract::Using human neuroblastoma SH-SY5Y cells, effects of acrylamide on p53 protein and intracellular signal transducting pathways were examined. Acrylamide increased p53, phosphorylated p53, and p53-associated protein murine double minute 2 (MDM2). The phosphorylation of p53 was specific for the Ser15 site. Among mitogen-a...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-005-0022-8
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journal_title:Archives of toxicology
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:1999-02-01 00:00:00
abstract::Reactive oxygen species are generated during ischaemia-reperfusion of tissue. Oxidation of thymidine by hydroxyl radicals (HO) leads to the formation of 5,6-dihydroxy-5,6-dihydrothymidine (thymidine glycol). Thymidine glycol is excreted in urine and can be used as biomarker of oxidative DNA damage. Time dependent chan...
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journal_title:Archives of toxicology
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journal_title:Archives of toxicology
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050102
更新日期:1994-01-01 00:00:00
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更新日期:2003-07-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Archives of toxicology
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更新日期:2008-03-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
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更新日期:2007-05-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Archives of toxicology
pub_type: 杂志文章
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更新日期:1991-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/BF00310480
更新日期:1981-09-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF02035137
更新日期:1992-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-02-01 00:00:00
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journal_title:Archives of toxicology
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更新日期:1990-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF02098037
更新日期:1991-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1998-02-01 00:00:00