Determination of urinary thymidine glycol using affinity chromatography, HPLC and post-column reaction detection: a biomarker of oxidative DNA damage upon kidney transplantation.

abstract：:In the recent years, the toxicity of certain divalent cations has been associated with the alteration of intracellular Ca2+ homeostasis. Among other mechanisms, these cations may affect the functionality of certain Ca2+-binding proteins and/or Ca2+ pumps. The plasma membrane calcium pump (PMCA) maintains Ca2+ homeosta...

journal_title：Archives of toxicology

authors： Ferreira-Gomes MS,Mangialavori IC,Ontiveros MQ,Rinaldi DE,Martiarena J,Verstraeten SV,Rossi JPFC

更新日期：2018-01-01 00:00:00

abstract：:New strategies are needed to address the data gap between the bioactivity of chemicals in the environment versus existing hazard information. We address whether a high-throughput screening (HTS) system using a vertebrate organism (embryonic zebrafish) can characterize chemical-elicited behavioral responses at an early...

journal_title：Archives of toxicology

authors： Reif DM,Truong L,Mandrell D,Marvel S,Zhang G,Tanguay RL

更新日期：2016-06-01 00:00:00

abstract：:Previously we reported that exposure of mouse and human mast cells to aryl hydrocarbon receptor (AhR) ligands resulted in reactive oxygen species (ROS)- and calcium (Ca2+)-dependent activation of mast cells in vitro and in vivo. However, the mechanisms through which the AhR-ligand axis mediates stress response, Ca2+ s...

journal_title：Archives of toxicology

authors： Wang HC,Zhou Y,Huang SK

更新日期：2017-04-01 00:00:00

abstract：:The urinary and faecal excretion of chrysene and its phenolic metabolites after oral, intraperitoneal, intratracheal, and intrapulmonary administration to rats have been studied by means of gas chromatography/mass spectrometry. The metabolite profile was found to depend on the mode of excretion and on the route of adm...

journal_title：Archives of toxicology

authors： Grimmer G,Brune H,Dettbarn G,Heinrich U,Jacob J,Mohtashamipur E,Norpoth K,Pott F,Wenzel-Hartung R

更新日期：1988-01-01 00:00:00

abstract：:3-(Phenylamino)alanine (PAA), a contaminant found in L-tryptophan tablets, has been discussed as a possible cause of eosinophilia-myalgia syndrome (EMS). We administered PAA (100 mg/kg) by gastric gavage to Wistar rats to determine its distribution and metabolism. We developed a purification procedure, using Bond Elut...

journal_title：Archives of toxicology

authors： Adachi J,Mio T,Ueno Y,Naito T,Nishimura A,Fujiwara S,Sumino K,Tatsuno Y

更新日期：1994-01-01 00:00:00

abstract：:The aim of this study was to investigate the genotoxic potential of DNA adducts and to compare DNA adduct levels and patterns in petroleum vacuum distillates, coal tar distillate, bitumen fume condensates, and related substances that have a wide range of boiling temperatures. An in vitro assay was used for DNA adduct ...

journal_title：Archives of toxicology

authors： Akkineni LK,Zeisig M,Baranczewski P,Ekström LG,Möller L

更新日期：2001-01-01 00:00:00

abstract：:Pathological changes induced by cadmium aerosol had features common to the changes evoked by oxidants. Female rats were exposed to fumes of lead, antimony, zinc and cadmium (15-100 nmoles/m3). One hour after termination of exposure, superoxide dismutase (SOD) activity in erythrocytes of the exposed rats lowered by 15-...

journal_title：Archives of toxicology

authors： Minami M,Koshi K,Homma K,Suzuki Y

更新日期：1982-03-01 00:00:00

abstract：:Berberine, a main protoberberine component of Coptidis Rhizoma, was studied for the mechanism of its inhibitory effects on the tert-butyl hydroperoxide (t-BHP)-induced cytotoxicity and lipid peroxidation in rat liver. In the preliminary study, berberine expressed an antioxidant property by its capacity for quenching t...

journal_title：Archives of toxicology

authors： Hwang JM,Wang CJ,Chou FP,Tseng TH,Hsieh YS,Lin WL,Chu CY

更新日期：2002-11-01 00:00:00

abstract：:Particle-induced carcinogenicity is not well understood, but might involve inflammation. The proinflammatory cytokine tumor necrosis factor (TNF) is considered to be an important mediator in inflammation. We investigated its role in particle-induced inflammation and DNA damage in mice with and without TNF signaling. T...

journal_title：Archives of toxicology

authors： Saber AT,Bornholdt J,Dybdahl M,Sharma AK,Loft S,Vogel U,Wallin H

更新日期：2005-03-01 00:00:00

abstract：:Microsomal and soluble epoxide hydrolase (mEH and sEH) fulfill apparently distinct roles: Whereas mEH detoxifies xenobiotics, sEH hydrolyzes fatty acid (FA) signaling molecules and is thus implicated in a variety of physiological functions. These epoxy FAs comprise epoxyeicosatrienoic acids (EETs) and epoxy-octadeceno...

journal_title：Archives of toxicology

authors： Marowsky A,Meyer I,Erismann-Ebner K,Pellegrini G,Mule N,Arand M

更新日期：2017-11-01 00:00:00

abstract：:The hepatotoxicity of acetaminophen (APAP) overdose depends on metabolic activation to a toxic reactive metabolite via hepatic mixed function oxidase. In vitro studies have indicated that APAP may also be cooxidized by prostaglandin H synthetase. The present experiments were designed to assess the possible contributio...

journal_title：Archives of toxicology

authors： Ben-Zvi Z,Weissman-Teitellman B,Katz S,Danon A

更新日期：1990-01-01 00:00:00

abstract：:Chronic exposure to carbon disulfide (CS2) can induce polyneuropathy in occupational worker and experimental animals, but underlying mechanism for CS2 neurotoxicity is currently unknown. In the present study, male Wistar rats were randomly divided into two experimental groups and one control group. The rats in two exp...

journal_title：Archives of toxicology

authors： Song F,Zhang C,Wang Q,Zeng T,Xie K

更新日期：2009-06-01 00:00:00

abstract：:The toxicokinetics of the four stereoisomers of the nerve agent C(+/-)P(+/-)-soman was analysed in cerebrospinal fluid (CSF) and blood in anaesthetized, spontaneously breathing pigs during a 90-min period after injection of soman. The pigs were challenged with different intravenous (i.v.) doses of C(+/-)P(+/-)-soman c...

journal_title：Archives of toxicology

authors： Göransson-Nyberg A,Fredriksson SA,Karlsson B,Lundström M,Cassel G

更新日期：1998-07-01 00:00:00

abstract：:The involvement of oxidative stress has been suggested as a mechanism for neurotoxicity caused by methylmercury (MeHg), but the mechanism for MeHg selective toxicity in the central nervous system is still unclear. In this research, to clarify the mechanism of selective neurotoxicity caused by MeHg, the oxygen consumpt...

journal_title：Archives of toxicology

authors： Mori N,Yasutake A,Hirayama K

更新日期：2007-11-01 00:00:00

abstract：:The incidence of breast cancer in Korea has been increasing for the last two decades (1983-2005), and now, breast cancer is ranked the leading cause of cancer in Korean women. Along with other endocrine disrupting chemicals (EDCs), bisphenol A (BPA) has been suspected as a potential risk factor for breast cancer. We s...

journal_title：Archives of toxicology

authors： Yang M,Ryu JH,Jeon R,Kang D,Yoo KY

更新日期：2009-03-01 00:00:00

abstract：:The genotoxicity of the sensory irritant 2-chlorobenzylidene malonitrile (CS) to V79 Chinese hamster cells was investigated using the induction of gene mutations, micronuclei and DNA repair synthesis as biological endpoints. CS efficiently induced micronuclei and mutants resistant to 6-thioguanine in these cells, but ...

journal_title：Archives of toxicology

authors： Ziegler-Skylakakis K,Summer KH,Andrae U

更新日期：1989-01-01 00:00:00

abstract：:Exposure to toxic metals is a well-known problem in industrialized countries. Metals interfere with a number of physiological processes, including central nervous system (CNS), haematopoietic, hepatic and renal functions. In the evaluation of the toxicity of a particular metal it is crucial to consider many parameters...

journal_title：Archives of toxicology

authors： Sinicropi MS,Amantea D,Caruso A,Saturnino C

更新日期：2010-07-01 00:00:00

abstract：:Occupational exposure to benzene has been associated with leukemia, anemia, leukopenia, and thrombocytopenia. Genetic susceptibility to benzene toxicity in humans may be related to variations in benzene metabolizing genes. The main objective of this study was to ascertain whether polymorphism of GSTP1, GSTM1, GSTT1 an...

journal_title：Archives of toxicology

authors： Nourozi MA,Neghab M,Bazzaz JT,Nejat S,Mansoori Y,Shahtaheri SJ

更新日期：2018-06-01 00:00:00

abstract：:Most dietary flavonoids have antioxidant activity in vitro however, secondary mechanisms such as the ability to influence gene expression with the consequent modulation of specific enzymatic activities involved in the intracellular response against oxidative stress, are being realized. In the following study, we exami...

journal_title：Archives of toxicology

authors： Mitchell AE,Burns SA,Rudolf JL

更新日期：2007-11-01 00:00:00

abstract：:Chronic exposure to inorganic arsenic (As) [As(III) + As(V)], which affects millions of people, increases the incidence of some kinds of cancer and other non-carcinogenic pathologies. Although the oral pathway is the main form of exposure, in vivo studies have not been conducted to verify the intestinal toxicity of th...

journal_title：Archives of toxicology

authors： Chiocchetti GM,Domene A,Kühl AA,Zúñiga M,Vélez D,Devesa V,Monedero V

更新日期：2019-08-01 00:00:00

abstract：:In vivo screening methods for detection of thyroid function modulators are now under development in many research laboratories. We assessed the applicability of the Hershberger assay protocol to screen for thyroid function modulators. In experiment 1, castrated male BrlHan WIST@Jcl (GALAS) rats were administered a pot...

journal_title：Archives of toxicology

authors： Noda S,Muroi T,Takakura S,Sakamoto S,Takatsuki M,Yamasaki K,Tateyama S,Yamaguchi R

更新日期：2005-11-01 00:00:00

abstract：:Due to its unique physical structure and chemical properties, graphene family nanomaterials (GFNs) and derived commodities have been widely used in commercial products, particularly biomedical applications, which has significantly increased the risk of human exposure. There exists significant evidence that GFNs are ac...

journal_title：Archives of toxicology

authors： Xiaoli F,Qiyue C,Weihong G,Yaqing Z,Chen H,Junrong W,Longquan S

更新日期：2020-06-01 00:00:00

abstract：:We have used the minipig as a prospective animal model for human risk characterization to study primary biochemical alterations upon oral contaminant intake. The effects of three orally administered soils containing polycyclic aromatic hydrocarbons (PAH) on the expression pattern of the cytochrome P450 enzyme CYP1A1 i...

journal_title：Archives of toxicology

authors： Roos PH,Tschirbs S,Welge P,Hack A,Theegarten D,Mogilevski G,Wilhelm M

更新日期：2002-06-01 00:00:00

abstract：:Trichloroethylene (TCE)-induced liver toxicity and carcinogenesis is believed to be mediated in part by activation of the peroxisome proliferator-activated receptor α (PPARα). However, the contribution of the two TCE metabolites, dichloroacetate (DCA) and trichloroacetate (TCA) to the toxicity of TCE, remains unclear....

journal_title：Archives of toxicology

authors： Fang ZZ,Krausz KW,Tanaka N,Li F,Qu A,Idle JR,Gonzalez FJ

更新日期：2013-11-01 00:00:00

abstract：:We recently reported that doxorubicin decreased the expression of calpain-1/2, while inhibition of calpain activity promoted doxorubicin-induced cardiac injury in mice. In this study, we investigated whether and how elevation of calpain-2 could affect doxorubicin-triggered cardiac injury. Transgenic mice with inducibl...

journal_title：Archives of toxicology

authors： Zheng D,Su Z,Zhang Y,Ni R,Fan GC,Robbins J,Song LS,Li J,Peng T

更新日期：2019-04-01 00:00:00

abstract：:Nine bispyridinium oximes containing two pyridinium rings linked by dimethylether were synthesised. Each compound had on one of the pyridinium rings a hydroxyiminomethyl group in position 2 or 4, while the other ring was unsubstituted or had a methyl or a hydroxyiminomethyl group in position 2 or 4. The reactivating p...

journal_title：Archives of toxicology

authors： Simeon V,Wilhelm K,Granov A,Besarović-Lazarev S,Buntić A,Fajdetić A,Binenfeld Z

更新日期：1979-02-23 00:00:00

abstract：:The significance of elevated excretion of metallothionein in urine of women living in cadmium-polluted areas of Japan was studied with respect to renal dysfunction. The relationships between the concentrations of metallothionein in urine and those of other non-specific urinary indices of renal dysfunction, i.e., total...

journal_title：Archives of toxicology

authors： Tohyama C,Shaikh ZA,Nogawa K,Kobayashi E,Honda R

更新日期：1982-07-01 00:00:00

abstract：:N-Methyl-2-pyrrolidone (NMP) is a versatile organic solvent frequently used for surface cleaning such as paint stripping or graffiti removal. Liquid NMP is rapidly absorbed through the skin but dermal vapour phase absorption might also play an important role for the uptake of the solvent. This particular aspect was in...

journal_title：Archives of toxicology

authors： Bader M,Wrbitzky R,Blaszkewicz M,Schäper M,van Thriel C

更新日期：2008-01-01 00:00:00

abstract：:The disposition, elimination, and metabolism of 50 mg/kg (1.36 muCi/animal) of tri-o-cresyl [phenyl-U-14C] phosphate after ten daily oral doses was investigated in adult male Fischer 344 rats. Groups of three treated animals were killed at intervals of 24, 48, 72, and 96 h after the last administrations. Generally, th...

journal_title：Archives of toxicology

authors： Somkuti SG,Abou-Donia MB

更新日期：1990-01-01 00:00:00

abstract：:To explain the mechanism of renal injury caused by liver ischemia-reperfusion, we investigated biochemical and morphological changes in the liver and kidney in rats. After reperfusion following 60 min of liver ischemia, numerous changes were found. The level of serum transaminases and lipid peroxide formation in the l...

journal_title：Archives of toxicology

authors： Kudo Y,Egashira T,Takayama F,Yamanaka Y,Shimada T

更新日期：1993-01-01 00:00:00