Comparative study of activities in reactive oxygen species production/defense system in mitochondria of rat brain and liver, and their susceptibility to methylmercury toxicity.

Abstract:

:The involvement of oxidative stress has been suggested as a mechanism for neurotoxicity caused by methylmercury (MeHg), but the mechanism for MeHg selective toxicity in the central nervous system is still unclear. In this research, to clarify the mechanism of selective neurotoxicity caused by MeHg, the oxygen consumption levels, the reactive oxygen species (ROS) production rates and several antioxidant levels in mitochondria were compared among the cerebrum, cerebellum and liver of male Wistar rats. In addition, the alterations of these indexes were examined in MeHg-intoxicated rats (oral administration of 10 mg/kg day, for 5 days). Although the cerebrum and cerebellum in intact rats showed higher mitochondrial oxygen consumption levels and ROS production rates than the liver, glutathione peroxidase (GPX) and superoxide dismutase (SOD) activities were much lower in the cerebrum and cerebellum than in the liver. Especially, the cerebellum showed the highest oxygen consumption and ROS production rate and the lowest mitochondrial glutathione (GSH) levels among the tissues examined. In the MeHg-treated rats, decrease in the oxygen consumption and increase in the ROS generation were found only in the cerebellum mitochondria, despite a lower Hg accumulation in the mitochondrial fraction compared to the liver. Since MeHg treatment produced an enhancement of ROS generation in cerebellum mitochondria supplemented with succinate substrates, MeHg-induced oxidative stress might affect the complex II-III mediated pathway in the electron transfer chain in the cerebellum mitochondria. Our study suggested that inborn factors, high production system activity and low defense system activity of ROS in the brain, would relate to the high susceptibility of the central nervous system to MeHg toxicity.

journal_name

Arch Toxicol

journal_title

Archives of toxicology

authors

Mori N,Yasutake A,Hirayama K

doi

10.1007/s00204-007-0209-2

subject

Has Abstract

pub_date

2007-11-01 00:00:00

pages

769-76

issue

11

eissn

0340-5761

issn

1432-0738

journal_volume

81

pub_type

杂志文章
  • Oxime-type acetylcholinesterase reactivators in pregnancy: an overview.

    abstract::Oxime-type acetylcholinesterase reactivators (oxime-AChER) are used as an adjunct in the treatment for organophosphorus anticholinesterase poisoning. Because of the widespread usage and exposure of organophosphorus compounds (OPCs), its poisoning and fatalities is obvious in pregnant women, embryos and fetuses. OPCs i...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,评审

    doi:10.1007/s00204-013-1160-z

    authors: Nurulain SM,Kornelia T,Naqvi SN,Sharma C,Ojha S,Adem A

    更新日期:2014-03-01 00:00:00

  • [Chloroform poisoning in a young drug consumer. Analysis and distribution of chloroform in human body].

    abstract::A young drug consumer died after sniffing and drinking chloroform. The method to determine chloroform in body fluids and tissues is described. The influence of the oral and pulmonary absorption in the view to cause of death is discussed. ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/BF00294994

    authors: Iffland R,Ramme H

    更新日期:1983-08-01 00:00:00

  • Oxidatively damaged guanosine in white blood cells and in urine of welders: associations with exposure to welding fumes and body iron stores.

    abstract::The International Agency for Research on Cancer considers the carcinogenicity of welding fume of priority for re-evaluation. Genotoxic effects in experimental animals are still inconclusive. Here, we investigated the association of personal exposure to metals in respirable welding fumes during a working shift with oxi...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-014-1319-2

    authors: Pesch B,Lotz A,Koch HM,Marczynski B,Casjens S,Käfferlein HU,Welge P,Lehnert M,Heinze E,Van Gelder R,Hahn JU,Behrens T,Raulf M,Hartwig A,Weiss T,Brüning T

    更新日期:2015-08-01 00:00:00

  • Neurotoxicology of vincristine in the cat. Electrophysiological studies.

    abstract::Cats were given vincristine sulfate (50 micrograms/kg i.v. every 4 days) and studied after 7-29 injections when neurological deficits became evident. The conduction velocity spectrum of individual afferent nerves from soleus muscles was shifted toward slower velocities. Relatively few functional muscle spindles or oth...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/BF00319653

    authors: Goldstein BD,Lowndes HE,Cho E

    更新日期:1981-11-01 00:00:00

  • Influence of testosterone on phase II metabolism and availability of soy isoflavones in male Wistar rats.

    abstract::Genistein and daidzein are the main isoflavones in soy. Their potential beneficial or adverse effects in males like the prevention of prostate cancer or the impact on reproductive functions are controversially discussed. Major determinants of their bioactivity are the absorption and biotransformation of isoflavones. I...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-016-1853-1

    authors: Soukup ST,Müller DR,Kurrat A,Diel P,Kulling SE

    更新日期:2017-04-01 00:00:00

  • Attenuation by methyl mercury and mercuric sulfide of pentobarbital induced hypnotic tolerance in mice through inhibition of ATPase activities and nitric oxide production in cerebral cortex.

    abstract::This study is aimed at exploring the possible mechanism of hypnosis-enhancing effect of HgS or cinnabar (a traditional Chinese medicine containing more than 95% HgS) in mice treated with pentobarbital. We also examined whether the effect of HgS is different from that of the well-known methyl mercury (MeHg). After a sh...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-007-0255-9

    authors: Chuu JJ,Huang ZN,Yu HH,Chang LH,Lin-Shiau SY

    更新日期:2008-06-01 00:00:00

  • Correction to: An evidence-based review of the genotoxic and reproductive effects of sulfur mustard.

    abstract::This is with reference to the note of the Editor-in-Chief of the Archives of Toxicology. ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s00204-018-2221-0

    authors: Khan F,Niaz K,Ismail Hassan F,Abdollahi M

    更新日期:2018-07-01 00:00:00

  • Sertoli cells proliferate in adult rats with prenatal exposure to 3,3',4,4',5-pentachlorobiphenyl.

    abstract::Sertoli cells play a critical role in spermatogenesis, and in adults, they are terminally differentiated with loss of proliferative activity. This study revealed Sertoli cell proliferation in 17-week-old Sprague-Dawley rats whose dams had been intragastrically administered 250 ng of 3,3',4,4',5-pentachlorobiphenyl/kg ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-011-0736-8

    authors: Wakui S,Muto T,Suzuki Y,Takahashi H,Hano H

    更新日期:2012-01-01 00:00:00

  • Polymyxin B causes DNA damage in HK-2 cells and mice.

    abstract::Increasing incidence of multidrug-resistant bacteria presents an imminent risk to global health. Polymyxins are 'last-resort' antibiotics against Gram-negative 'superbugs'; however, nephrotoxicity remains a key impediment in their clinical use. Molecular mechanisms underlying this nephrotoxicity remain poorly defined....

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-018-2192-1

    authors: Yun B,Zhang T,Azad MAK,Wang J,Nowell CJ,Kalitsis P,Velkov T,Hudson DF,Li J

    更新日期:2018-07-01 00:00:00

  • miR-138-1* regulates aflatoxin B1-induced malignant transformation of BEAS-2B cells by targeting PDK1.

    abstract::Environmental carcinogens-induced lung cancer and potential mechanisms have attracted widespread attention. Currently, microRNAs (miRNAs) have been recognized as key players in development of cancer, among which guide strand of miRNA has been well documented rather than its passenger strand (miRNA*). Our previous stud...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-015-1551-4

    authors: Wang Y,Zhang Z,Wang H,Zhang Y,Ji M,Xu H,Wang C,Sun Z,Gao W,Wang SL

    更新日期:2016-05-01 00:00:00

  • A genetic variant in miR-146a modifies colorectal cancer susceptibility in a Chinese population.

    abstract::MicroRNAs (miRNAs) are a family of endogenous, small, noncoding RNA molecules that involved in a wide range of biological processes including differentiation, proliferation, and apoptosis. A polymorphism G>C (rs2910164) is located in the stem region opposite to the mature miR-146a sequence. In our study, we investigat...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-012-1004-2

    authors: Ma L,Zhu L,Gu D,Chu H,Tong N,Chen J,Zhang Z,Wang M

    更新日期:2013-05-01 00:00:00

  • Glyphosate impairs male offspring reproductive development by disrupting gonadotropin expression.

    abstract::Sexual differentiation in the brain takes place from late gestation to the early postnatal days. This is dependent on the conversion of circulating testosterone into estradiol by the enzyme aromatase. The glyphosate was shown to alter aromatase activity and decrease serum testosterone concentrations. Thus, the aim of ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-011-0788-9

    authors: Romano MA,Romano RM,Santos LD,Wisniewski P,Campos DA,de Souza PB,Viau P,Bernardi MM,Nunes MT,de Oliveira CA

    更新日期:2012-04-01 00:00:00

  • Prevention by steroids of cerium hepatotoxicity.

    abstract::In female rats, the lethality and hepatotoxicity of cerous chloride (CeCl3) were significantly altered by pretreatment with steroidal and nonsteroidal compounds (pregnenolone-16alpha-carbonitrile "PCN", dexamethasone, spironolactone, phenobarbital) that stimulate hepatic drug-metabolizine enzyme activity and by estrad...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/BF00372765

    authors: Salas M,Tuchweber B

    更新日期:1976-03-11 00:00:00

  • Comparative studies on the nephrotoxicity of 2-bromoethanamine hydrobromide in the Fischer 344 rat and the multimammate desert mouse (Mastomys natalensis).

    abstract::Renal papillary necrosis (RPN) was induced in Fischer 344 (F344) rats (n = 4) using 2-bromoethanamine hydrobromide (BEA) dosed at 150 mg/kg, and in multimammate desert mice (Mastomys natalensis) at 150 and 250 mg/kg (n = 4 per group). Control rats and Mastomys were dosed with 0.9% saline (n = 4 per group). Urine was c...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/BF02733668

    authors: Holmes E,Bonner FW,Nicholson JK

    更新日期:1995-01-01 00:00:00

  • Hormonal activity of combinations of genistein, bisphenol A and 17beta-estradiol in the female Wistar rat.

    abstract::Phytoestrogens have been described as weak estrogens, selective estrogen receptor mediators (SERMs) or to exhibit antiestrogenic properties. However, information about their activity in combination with xenoestrogens and 17beta-estradiol in vivo, is limited. Therefore, the combinatory activity of the phytoestrogen gen...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-006-0102-4

    authors: Schmidt S,Degen GH,Seibel J,Hertrampf T,Vollmer G,Diel P

    更新日期:2006-12-01 00:00:00

  • Acetylation of putative arylamine and alkylaniline carcinogens in immortalized human fibroblasts transfected with rapid and slow acetylator N-acetyltransferase 2 haplotypes.

    abstract::Exposure to alkylanilines found in tobacco smoke and indoor air is associated with risk of bladder cancer. Genetic factors significantly influence the metabolism of arylamine carcinogens and the toxicological outcomes that result from exposure. We utilized nucleotide excision repair (NER)-deficient immortalized human ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-020-02901-4

    authors: Leggett CS,Doll MA,States JC,Hein DW

    更新日期:2021-01-01 00:00:00

  • Darbepoetin inhibits proliferation of hepatic cancer cells in the presence of TGF-β.

    abstract::Darbepoetin (DPO), an erythropoietin (EPO) derivative, was licensed in 2002 to treat patients with solid tumors suffering from chemotherapy-dependent anemia, although various tumors express EPO to improve vascularization, thus favoring tumor growth and spreading. Therefore, we wanted to investigate direct effects of D...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-013-1094-5

    authors: Ehnert S,Freude T,Eicher C,Burkhardt B,Martínez Sánchez JJ,Neumann J,Mühl-Benninghaus R,Dooley S,Pscherer S,Nussler AK

    更新日期:2014-01-01 00:00:00

  • Induction of peroxisomal beta-oxidation and P-450 4A-dependent activities by pivalic and trichloroacetic acid in rat liver and kidney.

    abstract::The influence of pivalic acid (PIV), a compound often used to make pro-drugs, and of the structurally related trichloroacetic acid (TCA), on several hepatic and renal enzymes was investigated in Sprague-Dawley rats, following a 4-day treatment period. The PIV and TCA treatments resulted in a similar and selective indu...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s002040050253

    authors: Zanelli U,Puccini P,Acerbi D,Ventura P,Gervasi PG

    更新日期:1996-01-01 00:00:00

  • Acute and subacute oral administration of mycotoxin deoxynivalenol exacerbates the pro-inflammatory and pro-pruritic responses in a mouse model of allergic dermatitis.

    abstract::Deoxynivalenol (DON) contamination in food is a public health concern; however, the effect of DON exposure on immune disorders including allergies remains unclear. The aim of this study is to elucidate the effect of oral exposure to DON on pro-inflammatory and pro-pruritic responses in a mouse model of allergic dermat...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-020-02875-3

    authors: Aihara R,Ookawara T,Morimoto A,Iwashita N,Takagi Y,Miyasaka A,Kushiro M,Miyake S,Fukuyama T

    更新日期:2020-12-01 00:00:00

  • A toll-like receptor 9 agonist sensitizes mice to mitochondrial dysfunction-induced hepatic apoptosis via the Fas/FasL pathway.

    abstract::Early hepatocyte death occurs in most liver injury cases and triggers liver inflammation, which in combination with other risk factors leads to the development of liver disease. However, the pathogenesis of early phase hepatocyte death remains poorly understood. Here, C57BL/6J mice were treated with the hepatotoxic dr...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-019-02454-1

    authors: Song B,Aoki S,Liu C,Ito K

    更新日期:2019-06-01 00:00:00

  • Dual-label time-resolved fluoroimmunoassay for simultaneous detection of aflatoxin B1 and ochratoxin A.

    abstract::A dual-label time-resolved fluoroimmunoassay (TRFIA) for simultaneous quantification of aflatoxin B1 (AFB1) and ochratoxin A (OTA) is described. For this, microtitration wells were coated with AFB1-horse radish peroxidase (HRP) and OTA-bovine serum albumin. The standards and samples were loaded on the coated plates, a...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-009-0410-6

    authors: Huang B,Xiao H,Zhang J,Zhang L,Yang H,Zhang Y,Jin J

    更新日期:2009-06-01 00:00:00

  • Role of phospholipase D in regulation of testicular Leydig cell hyperplasia in Sprague-Dawley rats treated with di(2-ethylhexyl) phthalate.

    abstract::This study was conducted to determine the functional role of phospholipase D (PLD) involved in testicular Leydig cell damage caused by di (2-ethylhexyl) phthalate (DEHP) in Sprague-Dawley rats. DEHP (500 mg/kg/day) was administered orally to prepubertal rats for 1, 7, 14, 21 or 28 days. After 7 days of exposure, DEHP ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-010-0618-5

    authors: Lee YJ,Ahn MY,Kim HS,Kwack SJ,Park KL,Yoon S,Min D

    更新日期:2011-08-01 00:00:00

  • Serum carboxylesterase activity in various strains of rats: sensitivity to inhibition by CBDP (2-/o-cresyl/4H:1:3:2-benzodioxaphosphorin-2-oxide).

    abstract::Rodents are relatively insensitive to the neurotoxic effects of various organophosphorus compounds. The purpose of this investigation was to determine if differences in inactivation of CBDP could explain the strain differences in the sensitivity to neurotoxicity following administration of TOCP (tri-o-cresyl phosphate...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/BF01973466

    authors: Clement JG,Erhardt N

    更新日期:1990-01-01 00:00:00

  • Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells.

    abstract::Etoposide (ETP) and anthracyclines are applied for wide anti-cancer treatments. However, the ETP-induced cardiotoxicity remains to be a major safety issue and the underlying cardiotoxic mechanisms are not well understood. This study is aiming to unravel the cardiotoxicity profile of ETP in comparison to anthracyclines...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-018-2170-7

    authors: Nemade H,Chaudhari U,Acharya A,Hescheler J,Hengstler JG,Papadopoulos S,Sachinidis A

    更新日期:2018-04-01 00:00:00

  • Mutagenicity testing of organic extracts of diesel exhaust particles after spiking with polycyclic aromatic hydrocarbons (PAH).

    abstract::In the present study, spiking was used as a strategy to evaluate the mutagenicity of individual compounds in a mixture. Mutagenicity of individual polycyclic aromatic hydrocarbons (PAH) was evaluated in an organic extract of diesel exhaust particles (DEP). The particles were extracted with dichloromethane (DCM). After...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s002040050555

    authors: Bostrøm E,Engen S,Eide I

    更新日期:1998-10-01 00:00:00

  • Synthetic cannabinoid CP-55,940 induces apoptosis in a human skeletal muscle model via regulation of CB1 receptors and L-type Ca2+ channels.

    abstract::Rhabdomyolysis has been reported in patients who abuse synthetic cannabinoids. However, no studies have yet assessed whether these cases reflect the direct cytotoxicity of synthetic cannabinoids on skeletal muscle, a possibility that the present study sought to address. Specifically, this study investigated the cytoto...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-020-02944-7

    authors: Tomiyama KI,Funada M

    更新日期:2020-11-10 00:00:00

  • Resveratrol protects primary cilia integrity of human mesenchymal stem cells from cigarette smoke to improve osteogenic differentiation in vitro.

    abstract::Several studies have explored the negative effects of cigarette smoke on bone healing; however, the complex pathogenesis still remains unclear. One crucial and primary factor determining effective fracture repair is the recruitment and differentiation of mesenchymal stem cells (MSCs) into bone-forming cells. Recently,...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-017-2149-9

    authors: Sreekumar V,Aspera-Werz R,Ehnert S,Strobel J,Tendulkar G,Heid D,Schreiner A,Arnscheidt C,Nussler AK

    更新日期:2018-04-01 00:00:00

  • Culprit or correlate? An application of the Bradford Hill criteria to Vitamin E acetate.

    abstract::Vitamin E acetate (VEA) has come under significant scrutiny due to its association with e-cigarette, or vaping, product use-associated lung injury (EVALI). In 1965, Sir Austin Bradford Hill proposed a set of criteria used to critically assess an association for causality. In this article, we apply the Bradford Hill ca...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,评审

    doi:10.1007/s00204-020-02770-x

    authors: Feldman R,Meiman J,Stanton M,Gummin DD

    更新日期:2020-06-01 00:00:00

  • Identification of the human liver UDP-glucuronosyltransferase involved in the metabolism of p-ethoxyphenylurea (dulcin).

    abstract::Dulcin (DL), now banned, was once a widely used artificial sweetener. DL possesses an ureido group that is metabolized by direct glucuronidation in rabbit liver microsomes. Dulcin N-glucuronide (DNG) is the only type of ureido N-glucuronide known to date; ureido glucuronidation in humans has not been previously report...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-006-0138-5

    authors: Uesawa Y,Staines AG,Lockley D,Mohri K,Burchell B

    更新日期:2007-03-01 00:00:00

  • Toxicity of PCB-126 in European flounder (Platichthys flesus) with emphasis on histopathology and cytochrome P4501A induction in several organ systems.

    abstract::A series of experiments was set up to elucidate the effects of pollution on marine and estuarine fish health, since the European flounder (Platichthys flesus) has shown a relatively high prevalence of (pre)neoplastic liver lesions and lymphocystis virus disease in Dutch coastal and estuarine waters. The hypothesis of ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s002040100213

    authors: Grinwis GC,van den Brandhof EJ,Engelsma MY,Kuiper RV,Vaal MA,Vethaak AD,Wester PW,Vos JG

    更新日期:2001-04-01 00:00:00