Urinary and faecal excretion of chrysene and chrysene metabolites by rats after oral, intraperitoneal, intratracheal or intrapulmonary application.

abstract：:In his Nobel Prize Lecture of December 12, 1946, Hermann J. Muller argued that the dose-response for radiation-induced germ cell mutations was linear and that there was "no escape from the conclusion that there is no threshold". However, assessment of correspondence between Muller and Curt Stern 1 month prior to his N...

journal_title：Archives of toxicology

authors： Calabrese EJ

更新日期：2011-12-01 00:00:00

abstract：:Rats were exposed to nickel sulfate (NiSO4) either by intratracheal (IT) instillation or by acute aerosol inhalation, and pulmonary clearance of Ni and pulmonary inflammatory responses were studied. The half-time of Ni in the lung (initial lung burden = 50 micrograms Ni/rat) was about 32 h in both the IT instillation ...

journal_title：Archives of toxicology

authors： Hirano S,Shimada T,Osugi J,Kodama N,Suzuki KT

更新日期：1994-01-01 00:00:00

abstract：:Renal papillary necrosis (RPN) was induced in Fischer 344 (F344) rats (n = 4) using 2-bromoethanamine hydrobromide (BEA) dosed at 150 mg/kg, and in multimammate desert mice (Mastomys natalensis) at 150 and 250 mg/kg (n = 4 per group). Control rats and Mastomys were dosed with 0.9% saline (n = 4 per group). Urine was c...

journal_title：Archives of toxicology

authors： Holmes E,Bonner FW,Nicholson JK

更新日期：1995-01-01 00:00:00

abstract：:Certain esterase inhibitors such as O-(2-chloro-2,3,3-trifluorocyclobutyl) O-ethyl S-propyl phosphorothioate (KBR-2822) and phenylmethanesulfonyl fluoride (PMSF) cause exacerbation (promotion) of toxic and traumatic axonopathies. Although these chemicals are capable of inhibiting neuropathy target esterase (NTE), whic...

journal_title：Archives of toxicology

authors： Jokanovic M,Moretto A,Lotti M

更新日期：1998-01-01 00:00:00

abstract：:Purified phenobarbital-induced rat liver cytochrome P-450 was incorporated in a reconstituted system containing NADPH-cytochrome P-450 reductase, dilauroyl phosphatidyl choline and sodium cholate. This system was added to organ cultures of limb buds from mouse embryos on day 11 of gestation. Cyclophosphamide (100 micr...

journal_title：Archives of toxicology

authors： Kastner M,Blankenburg G,Schulz T,Schack G,Neubert D

更新日期：1988-01-01 00:00:00

abstract：:Chemical formation of dichlorvos (2, 2-dichlorovinyl dimethyl phosphate) was found to occur in mouse brain after i.p. injection of metrifonate (2, 2, 2-trichloro-1-hydroxyethyl dimethyl phosphonate). A mass fragmentographic technique was used. Different isotopic variants were used both as internal standards and to com...

journal_title：Archives of toxicology

authors： Nordgren I,Bergström M,Holmstedt B,Sandoz M

更新日期：1978-10-13 00:00:00

abstract：:Cats were given vincristine sulfate (50 micrograms/kg i.v. every 4 days) and studied after 7-29 injections when neurological deficits became evident. The conduction velocity spectrum of individual afferent nerves from soleus muscles was shifted toward slower velocities. Relatively few functional muscle spindles or oth...

journal_title：Archives of toxicology

authors： Goldstein BD,Lowndes HE,Cho E

更新日期：1981-11-01 00:00:00

abstract：:Iron (Fe) plays essential roles in biological processes, whereas cadmium (Cd) is a toxic and non-essential metal. Two metal transporters, divalent metal transporter 1 (DMT1) and metal transporter protein 1 (MTP1), are responsible for Fe transport in mammals. Here, we studied the effect of dietary Fe on the expression ...

journal_title：Archives of toxicology

authors： Kim DW,Kim KY,Choi BS,Youn P,Ryu DY,Klaassen CD,Park JD

更新日期：2007-05-01 00:00:00

abstract：:Perfluoroalkyl acids are widely used in numerous industrial and commercial applications due to their unique physical and chemical characteristics. Although perfluorooctanoic acid (PFOA) is associated with hepatomegaly through peroxisome proliferator-activated receptor α (PPARα) activation, liver fat accumulation and c...

journal_title：Archives of toxicology

authors： Yan S,Wang J,Dai J

更新日期：2015-09-01 00:00:00

abstract：:The effects of cadmium exposure during pregnancy (by means of daily subcutaneous injections of 4.4 mumol/kg to the mother) on the neonates were investigated. No effect was observed on fetal or neonatal body weights, nor on neonatal liver weights. These parameters were examined up to 5 weeks after birth. The weight of ...

journal_title：Archives of toxicology

authors： Hazelhoff Roelfzema W,Roelofsen AM,Leene W,Peereboom-Stegeman HJ

更新日期：1989-01-01 00:00:00

abstract：:The tissue distribution, metabolism and excretion of 14C-2,2',4,4',5-pentachlorodiphenyl ether (PCDE) were studied in the rat. Radioactivity was distributed in all tissues examined, with the highest concentrations being found in the fat followed by the skin, liver, kidney and muscle. Most of the radioactivity found in...

journal_title：Archives of toxicology

authors： Komsta E,Chu I,Villeneuve DC,Benoit FM,Murdoch D

更新日期：1988-01-01 00:00:00

abstract：:The peroxisome proliferator class of non-genotoxic rodent hepatocarcinogens cause hepatocyte DNA synthesis, peroxisome proliferation and liver tumours when administered to rats and mice, but fail to induce S-phase or peroxisome proliferation in hepatocytes from other species including guinea-pigs, dogs, and primates i...

journal_title：Archives of toxicology

authors： Tugwood JD,Holden PR,James NH,Prince RA,Roberts RA

更新日期：1998-02-01 00:00:00

abstract：:Hydrogen sulfide (H2S), the third gasotransmitter, has been shown to act as a neuroprotective factor in numerous pathological processes; however, its underlying mechanism(s) of action remain unclear. It is widely accepted that activation of moderate autophagy and the Nrf2/ARE signaling pathway play important roles in ...

journal_title：Archives of toxicology

authors： Yang B,Bai Y,Yin C,Qian H,Xing G,Wang S,Li F,Bian J,Aschner M,Lu R

更新日期：2018-06-01 00:00:00

abstract：:Gene expression analysis has been established as a tool for the characterization of genotoxic mechanisms of chemical mutagens. It has been suggested that expression analysis is capable of distinguishing compounds that cause DNA damage from those that interfere with mitotic spindle function. Formaldehyde (FA) is known ...

journal_title：Archives of toxicology

authors： Kuehner S,Holzmann K,Speit G

更新日期：2013-11-01 00:00:00

abstract：:Standard treatment of poisoning by organophosphates (OP) includes the administration of an antimuscarinic agent, e.g. atropine, and of an acetylcholinesterase (AChE) reactivator (oxime). The presently available oximes, obidoxime and pralidoxime (2-PAM), are considered to be insufficient for highly toxic OPs, e.g. sari...

journal_title：Archives of toxicology

authors： Worek F,Reiter G,Eyer P,Szinicz L

更新日期：2002-09-01 00:00:00

abstract：:Exposure to bisphenolic chemicals during pregnancy occurs in > 90% of pregnancies. Bisphenolic compounds can cross the placental barrier reaching fetal circulation. However, the effects of emerging bisphenolic compounds, such as bisphenol S (BPS), on placental function remain untested. The aim was to determine if bisp...

journal_title：Archives of toxicology

authors： Gingrich J,Pu Y,Roberts J,Karthikraj R,Kannan K,Ehrhardt R,Veiga-Lopez A

更新日期：2018-05-01 00:00:00

abstract：:With the development of nanotechnologies, the potential adverse effects of nanomaterials such as multi-walled carbon nanotubes (MWCNT) on the respiratory tract of asthmatics are questioned. Furthermore, investigations are necessary to understand how these effects might arise. In the present study, we hypothesized that...

journal_title：Archives of toxicology

authors： Ronzani C,Casset A,Pons F

更新日期：2014-02-01 00:00:00

abstract：:People living in damp buildings are typically exposed to spore and mycelial fragments of the fungi that grow on damp building materials. There is experimental evidence that this exposure to triple-helical (1, 3)-β-D glucan and low molecular weight toxins may be associated with non-atopic asthma observed in damp and mo...

journal_title：Archives of toxicology

authors： Rand TG,Robbins C,Rajaraman D,Sun M,Miller JD

更新日期：2013-10-01 00:00:00

abstract：:Ochratoxin A (OTA) is a toxin produced by fungi such as Aspergillus spp. and Penicillium spp. The key target organ of OTA toxicity is the kidney, and it is known that epithelial-to-mesenchymal transition (EMT) leading to fibrosis is enhanced after long-term exposure of the kidney to OTA. However, the mechanisms respon...

journal_title：Archives of toxicology

authors： Pyo MC,Chae SA,Yoo HJ,Lee KW

更新日期：2020-09-01 00:00:00

abstract：:Nucleotide excision repair (NER) is a versatile pathway that removes helix-distorting DNA lesions from the genomes of organisms across the evolutionary scale, from bacteria to humans. The serial steps in NER involve recognition of lesions, adducts or structures that disrupt the DNA double helix, removal of a short oli...

journal_title：Archives of toxicology

authors： Spivak G

更新日期：2016-11-01 00:00:00

abstract：:The organophosphorus compound trichlorfon, dimethyl (2,2,2-trichloro-1-hydroxyethyl) phosphonate, was administered by stomach tube (100 mg/kg) to pregnant guinea pigs at two different stages of gestation (days 36, 37, 38 and 51, 52, 53). The pups developed locomotory disturbances, and post mortem examination revealed ...

journal_title：Archives of toxicology

authors： Berge GN,Nafstad I,Fonnum F

更新日期：1986-05-01 00:00:00

abstract：:Airway smooth muscle (ASM) cell phenotypic switching played an important role in airway remodeling in asthma. In vitro platelet-derived growth factor (PDGF) induced ASM cell phenotypic switching from a mature to pro-remodeling phenotype, but the mechanism remained incompletely understood. This study was to explore the...

journal_title：Archives of toxicology

authors： Ning Y,Huang H,Dong Y,Sun Q,Zhang W,Xu W,Li Q

更新日期：2013-05-01 00:00:00

abstract：:Perfluorocarboxylic acids (PFCAs) including perfluorooctanoic acid (PFOA) are environmental pollutants showing high accumulation, thermochemical stability and hepatocarcinogenicity. Peroxisome proliferator-activated receptor α is suggested to mediate their toxicities, but the precise mechanism remains unclear. Previou...

journal_title：Archives of toxicology

authors： Abe T,Takahashi M,Kano M,Amaike Y,Ishii C,Maeda K,Kudoh Y,Morishita T,Hosaka T,Sasaki T,Kodama S,Matsuzawa A,Kojima H,Yoshinari K

更新日期：2017-06-01 00:00:00

abstract：:Melanin is a polyanionic pigment that colors, e.g., the hair, skin and eyes. The pigment neuromelanin is closely related to melanin and is mainly produced in specific neurons of the substantia nigra. Certain drugs and chemicals bind to melanin/neuromelanin and are retained in pigment cells for long periods. This speci...

journal_title：Archives of toxicology

authors： Karlsson O,Lindquist NG

更新日期：2016-08-01 00:00:00

abstract：:Blooms of cyanobacteria have been documented throughout history, all over the world. Mass populations of these organisms typically present hazards to human health and are known for the production of a wide range of highly toxic metabolites-cyanotoxins, of which among the most common and most investigated are the micro...

journal_title：Archives of toxicology

authors： Svirčev Z,Drobac D,Tokodi N,Mijović B,Codd GA,Meriluoto J

更新日期：2017-02-01 00:00:00

abstract：:Quercetin (QC), a polyphenolic compound widely distributed in fruits and vegetables has recently gained interest due to its cisplatin (CP) sensitizing properties in cancer cells. It is currently unknown, whether quercetin also increases the susceptibility of the kidneys to cisplatin toxicity. We studied the effects of...

journal_title：Archives of toxicology

authors： Kuhlmann MK,Horsch E,Burkhardt G,Wagner M,Köhler H

更新日期：1998-07-01 00:00:00

abstract：:A pharmacokinetic profile of [14C] leptophos was determined in laying hens following a single oral dose of 400 mg/kg (0.58 muCi). Most of the radioactivity was excreted into the urine and feces. After 15 days, the total radioactivity recovered in the combined urinary-fecal excretion was 73.5% of the administered dose....

journal_title：Archives of toxicology

authors： Abou-Donia MB

更新日期：1976-10-28 00:00:00

abstract：:A method is outlined to estimate from hemodialysis or hemoperfusion data, respectively, the rate constants, the distribution volume in the beta-phase, and other pharmacokinetic parameters of toxic substances. All calculations are based on the assumption that the usual linear open two-compartment system is also the app...

journal_title：Archives of toxicology

authors： Wellhöner HH

更新日期：1983-05-01 00:00:00

abstract：:The effect of acute and chronic cadmium administration on hepatic drug metabolism was investigated in the male rat. 3 days after the acute administration of cadmium by either the intraperitoneal (0.84 mg Cd/kg) or the oral (greater than 80 mg Cd/kg) route, there was a significant potentiation in duration of hexobarbit...

journal_title：Archives of toxicology

authors： Schnell RC,Yuhas EM,Pence DH,Means JR,Roberts SA,Yau ET,Miya TS,Mennear JH

更新日期：1978-08-09 00:00:00

abstract：:Evading apoptosis and chemo-resistance are considered as very important factors which help tumour progression and metastasis. Hence, to overcome chemo-resistance, there is an urgent requirement for emergence of more effective treatment options. Myricetin, a naturally occurring flavonoid, is present in various plant-de...

journal_title：Archives of toxicology

authors： Akhtar S,Najafzadeh M,Isreb M,Newton L,Gopalan RC,Anderson D

更新日期：2021-01-01 00:00:00