Epigenetic properties of the diarrhetic marine toxin okadaic acid: inhibition of the gap junctional intercellular communication in a human intestine epithelial cell line.

abstract：:The mycotoxin ochratoxin A (OTA) and its metabolite ochratoxin alpha (OT-alpha) were investigated, to examine their potency to induce sister chromatid exchanges (SCE) in cultured porcine urinary bladder epithelial cells (PUBEC) (primary culture). Serum-free cultured PUBEC were incubated for 5 h with either OTA or OT-a...

journal_title：Archives of toxicology

authors： Föllmann W,Hillebrand IE,Creppy EE,Bolt HM

更新日期：1995-01-01 00:00:00

abstract：:The amphetamine-derived designer drugs have been illegally used worldwide as recreational drugs, some of which are known to be hepatotoxic in humans. To compare their cytotoxic effects, 3,4-methylenedioxy-N-methamphetamine (MDMA) and its related analogues, N-methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine (MBDB), 3,4...

journal_title：Archives of toxicology

authors： Nakagawa Y,Suzuki T,Tayama S,Ishii H,Ogata A

更新日期：2009-01-01 00:00:00

abstract：:In anaesthetized and artificially ventilated rabbits an intravenous infusion of paraoxon (0.8 mg/kg) was given over 30 min. The effects on cardiac output, blood flow to various vascular beds, and on the mass discharge of the postganglionic sympathetic efferents to the spleen and kidney were monitored. Immediately foll...

journal_title：Archives of toxicology

authors： Kullmann R,Reinsberg J,Amirmanssouri M

更新日期：1982-09-01 00:00:00

abstract：:Acute toxicity of bis (tributyltin) oxide in the sweat glands in the rat footpad was investigated by electron microscopy and an energy-dispersive X-ray microanalyzer. Male Wistar rats received an intramuscular injection of 0.5 ml/kg bis (tributyltin) oxide. After 6-8 h, swelling of mitochondria appeared in the secreto...

journal_title：Archives of toxicology

authors： Yamamoto O,Doi Y,Kudo H,Yoshizuka M,Fujimoto S

更新日期：2000-12-01 00:00:00

abstract：:Rat embryos (9.5-day-old) were cultured for 48 h in the presence of nifedipine (NIF), nimodipine (NIM), nitrendipine (NIT), gallopamil HCl (GAL), verapamil HCl (VER) and diltiazem HCl (DIL). The effects on growth and morphogenetic differentiation in vitro were monitored. Dose-response relationships were evaluated, inc...

journal_title：Archives of toxicology

authors： Stein G,Srivastava MK,Merker HJ,Neubert D

更新日期：1990-01-01 00:00:00

abstract：:To reveal the molecular mechanism of deficit in learning and memory induced by chronic fluorosis, the expression of muscarinic acetylcholine receptors (mAChRs) and oxidative stress were investigated. Sixty Sprague-Dawley (SD) rats were divided randomly into two groups (30 cases in each), i.e., the control group (<0.5 ...

journal_title：Archives of toxicology

authors： Dong YT,Wang Y,Wei N,Zhang QF,Guan ZZ

更新日期：2015-11-01 00:00:00

abstract：:Aliphatic nitriles are a class of chemicals used in high volumes in the production of plastics and elastomers, in organic synthesis, and in production of a number of food packaging containers. Toxicity and metabolism of acrylonitrile (AN) are well characterized. On the other hand, minimal information is available on t...

journal_title：Archives of toxicology

authors： Burka LT,Sanchez IM,Ahmed AE,Ghanayem BI

更新日期：1994-01-01 00:00:00

abstract：:Female Wistar rats were treated with various doses of progesterone orally via the diet or via the SC route. Oral treatment resulted in enhanced progesterone levels in the liver as measured by radioimmunoassay. There were up to 3-fold increases in activity of ethylmorphine demethylation by isolated microsomes; metaboli...

journal_title：Archives of toxicology

authors： Ochs H,Düsterberg B,Schulte-Hermann R

更新日期：1986-10-01 00:00:00

abstract：:Cadmium (Cd), a highly toxic heavy metal, is distributed widely in the general environment of today. The characteristic clinical manifestations of chronic Cd intoxication include renal proximal tubular dysfunction, general osteomalacia with severe pains, and anemia. We have recently reported that the serum level of er...

journal_title：Archives of toxicology

authors： Horiguchi H,Sato M,Konno N,Fukushima M

更新日期：1996-01-01 00:00:00

abstract：:The kinetics of vitamin E was followed in serum, liver and kidney of 10- and 55-day-old rats after the administration of a single i.m. dose of 100 mg alpha-tocopherol acetate/100 g body wt. The basal levels without vitamin E administration were significantly higher in serum and liver of 10- than 55-day-old rats. The e...

journal_title：Archives of toxicology

authors： Appenroth D,Fröb S,Kersten L,Splinter FK,Winnefeld K

更新日期：1997-01-01 00:00:00

abstract：:Orally administered meso-2,3-dimercaptosuccinic acid (DMSA) is an effective antagonist for acute oral cadmium chloride (1 mmol/kg) intoxication in mice when administered up to 8 h after cadmium ingestion. Administration of sodium N-benzyl-N-dithiocarboxy-D-glucamine (NaB) i.p. along with DMSA p.o. resulted in kidney a...

journal_title：Archives of toxicology

authors： Jones MM,Basinger MA,Topping RJ,Gale GR,Jones SG,Holscher MA

更新日期：1988-08-01 00:00:00

abstract：:Hibiscus protocatechuic acid (PCA), a phenolic compound found in the dried flowers of Hibiscus sabdariffa L. (Malvaceae), was demonstrated to have an antioxidant effect in vitro and in vivo, and an antitumor property in our previous study. In the present study, we used lipopolysaccharide (LPS, an endotoxin) to induce ...

journal_title：Archives of toxicology

authors： Lin WL,Hsieh YJ,Chou FP,Wang CJ,Cheng MT,Tseng TH

更新日期：2003-01-01 00:00:00

abstract：:Previous studies have shown the antidotal efficacy of topical iodine at 15 and 30 min post-exposure to sulfur mustard (SM). Here we demonstrate efficacy at longer intervals (20, 30, 45, and 60 min, respectively, for data) using an improved topical povidone-iodine preparation termed N66, which contains steroidal and no...

journal_title：Archives of toxicology

authors： Wormser U,Sintov A,Brodsky B,Casillas RP,Nyska A

更新日期：2004-03-01 00:00:00

abstract：:We investigated the hepatotoxicity induced by AQ using a glutathione (GSH)-depleted mice model. Although sole administration of either AQ or L-buthionine-S,R-sulfoxinine (BSO), a well-known GSH synthesis inhibitor, produced no significant hepatotoxicity, combined administration of AQ with BSO induced hepatotoxicity ch...

journal_title：Archives of toxicology

authors： Shimizu S,Atsumi R,Itokawa K,Iwasaki M,Aoki T,Ono C,Izumi T,Sudo K,Okazaki O

更新日期：2009-07-01 00:00:00

abstract：:We have used the minipig as a prospective animal model for human risk characterization to study primary biochemical alterations upon oral contaminant intake. The effects of three orally administered soils containing polycyclic aromatic hydrocarbons (PAH) on the expression pattern of the cytochrome P450 enzyme CYP1A1 i...

journal_title：Archives of toxicology

authors： Roos PH,Tschirbs S,Welge P,Hack A,Theegarten D,Mogilevski G,Wilhelm M

更新日期：2002-06-01 00:00:00

abstract：:A young drug consumer died after sniffing and drinking chloroform. The method to determine chloroform in body fluids and tissues is described. The influence of the oral and pulmonary absorption in the view to cause of death is discussed. ...

journal_title：Archives of toxicology

authors： Iffland R,Ramme H

更新日期：1983-08-01 00:00:00

abstract：:Diet is directly related with physiological alterations occurring at a cell and subcellular level. However, the role of diet manipulation on mitochondrial physiology is still largely unexplored. Aiming at correlating diet with alterations of mitochondrial membrane composition and bioenergetics, Wistar-Han male rats we...

journal_title：Archives of toxicology

authors： Monteiro JP,Pereira CV,Silva AM,Maciel E,Baldeiras I,Peixoto F,Domingues MR,Jurado AS,Oliveira PJ

更新日期：2013-12-01 00:00:00

abstract：:4, 4'-Methylenedianiline (MDA) is used extensively as a curing agent in the production of elastomers and is classified as reasonably anticipated to be a human carcinogen based on sufficient evidence in animal experiments. Human N-acetyltransferase 1 (NAT1) and 2 (NAT2) catalyze the N-acetylation of aromatic amines and...

journal_title：Archives of toxicology

authors： Salazar-González RA,Zhang X,Doll MA,Lykoudi A,Hein DW

更新日期：2019-08-01 00:00:00

abstract：:The cholestatic effect of the newly developed oestradiol sulphamate (J995) was compared with that of the natural oestrogen oestradiol (E) and of the cholestatic standard oestrogen ethinyloestradiol (EE). Female ovariectomized rats were orally treated for 7 days with oestrogen doses molar equivalent to 0.01, 0.1, 1, an...

journal_title：Archives of toxicology

authors： Barth A,Elger W,Schneider B,Schwarz S

更新日期：1997-01-01 00:00:00

abstract：:The current management of rodent pest populations is based on second-generation anticoagulant rodenticides (SGAR). These molecules, of which difethialone is part, are much more efficient than the first generation. Nevertheless, this efficiency comes with a major drawback, SGARs are tissue persistent that increases the...

journal_title：Archives of toxicology

authors： Lefebvre S,Fourel I,Chatron N,Caruel H,Benoit E,Lattard V

更新日期：2020-03-01 00:00:00

abstract：:The elevations of blood urea nitrogen and serum creatinine caused by cis-platinum in rats can be prevented by a combination of procedures centered around the administration of sodium N-methyl-N-dithiocarboxyglucamine (NaG), before and very soon after the cis-platinum is administered in hypertonic (4.5%) saline. Elevat...

journal_title：Archives of toxicology

authors： Jones MM,Basinger MA,Craft WD,Domingo JL,Llobet JM

更新日期：1986-10-01 00:00:00

abstract：:Sulfites whether ingested or produced through the sulfur-containing amino acids metabolism of the animal are very active molecules and can cause cellular toxicity. Sulfite oxidase (SOX), a heme- and molybdenum containing mitochondrial enzyme, prevents mammalian cells from adverse effects of sulfite toxicity by metabol...

journal_title：Archives of toxicology

authors： Oztürk OH,Küçükatay V,Yönden Z,Ağar A,Bağci H,Delibaş N

更新日期：2006-10-01 00:00:00

abstract：:Mycotoxins are the most frequently occurring natural contaminants in human and animal diet. Among them, deoxynivalenol (DON), produced by Fusarium, is one of the most prevalent and thus represents an important health risk. Recent detection methods revealed new mycotoxins and new molecules derivated from the "native" m...

journal_title：Archives of toxicology

authors： Payros D,Alassane-Kpembi I,Pierron A,Loiseau N,Pinton P,Oswald IP

更新日期：2016-12-01 00:00:00

abstract：:A method is outlined to estimate from hemodialysis or hemoperfusion data, respectively, the rate constants, the distribution volume in the beta-phase, and other pharmacokinetic parameters of toxic substances. All calculations are based on the assumption that the usual linear open two-compartment system is also the app...

journal_title：Archives of toxicology

authors： Wellhöner HH

更新日期：1983-05-01 00:00:00

abstract：:Since teratogenicity testing in mammals is a particular challenge from an animal welfare perspective, there is a great need for the development of alternative test systems. In this context, the zebrafish (Danio rerio) embryo has received increasing attention as a non-protected embryonic vertebrate in vivo model. The p...

journal_title：Archives of toxicology

authors： Brotzmann K,Wolterbeek A,Kroese D,Braunbeck T

更新日期：2020-10-27 00:00:00

abstract：:In the isolated liver transient perfusion without calcium results in cholestasis which was characterized by an increased efflux rate across the sinusoidal membrane and inhibition of the concentrative transport of bromosulfophthalein to the canalicular side of the cell. Cholestasis could not be reversed within the usua...

journal_title：Archives of toxicology

authors： Höke H,Krell H,Pfaff E

更新日期：1980-03-01 00:00:00

abstract：:A new class of potent anticancer drugs, alkylphosphocholines has been recognized lately. Miltefosine (Hexadecylphosphochlorine, HPC) has been found to express select antineoplastic effect on human breast cancer skin metastases with simultaneous preservation of bone marrow proliferative activity and low clastogenicity....

journal_title：Archives of toxicology

authors： Martinova Y,Topashka-Ancheva M,Konstantinov S,Petkova S,Karaivanova M,Berger M

更新日期：2006-01-01 00:00:00

abstract：:The pharmacokinetics of styrene were investigated in male Sprague-Dawley rats and male B6C3F1 mice using the closed chamber technique. Animals were exposed to styrene vapors of initial concentrations ranging from 550 to 5000 ppm, or received intraperitoneal (i.p.) doses of styrene from 20 to 340 mg/kg or oral (p.o.) d...

journal_title：Archives of toxicology

authors： Filser JG,Schwegler U,Csanády GA,Greim H,Kreuzer PE,Kessler W

更新日期：1993-01-01 00:00:00

abstract：:Several studies have explored the negative effects of cigarette smoke on bone healing; however, the complex pathogenesis still remains unclear. One crucial and primary factor determining effective fracture repair is the recruitment and differentiation of mesenchymal stem cells (MSCs) into bone-forming cells. Recently,...

journal_title：Archives of toxicology

authors： Sreekumar V,Aspera-Werz R,Ehnert S,Strobel J,Tendulkar G,Heid D,Schreiner A,Arnscheidt C,Nussler AK

更新日期：2018-04-01 00:00:00

abstract：:Capillary gas chromatography coupled to mass spectrometry was employed to quantify ethylmorphine in biological fluids and tissues in a death attributed to oral ethylmorphine ingestion. The femoral blood concentration of the drug was 488 ng/ml. Hair analysis revealed the individual's drug abuse pattern, particularly th...

journal_title：Archives of toxicology

authors： Kintz P,Jamey C,Mangin P

更新日期：1994-01-01 00:00:00