Abstract：
:The kinetics of vitamin E was followed in serum, liver and kidney of 10- and 55-day-old rats after the administration of a single i.m. dose of 100 mg alpha-tocopherol acetate/100 g body wt. The basal levels without vitamin E administration were significantly higher in serum and liver of 10- than 55-day-old rats. The effect of vitamin E on cisplatin (CP; 0.6 mg/100 g body wt., i.p.) nephrotoxicity was investigated by determining urinary volume and protein excretion, as well as the concentration of blood urea nitrogen (BUN) and lipid peroxides in renal tissue (LPO). Previously described age differences in CP nephrotoxicity were confirmed. The administration of vitamin E, 12 h prior to CP, diminished the toxic effect of CP in young and adult rats. This effect could not be enhanced by a second administration of vitamin E. The simultaneous administration of vitamin E and C 12 h prior to CP intensified the protective effect of a single administration of vitamin E in 10- and 55-day-old rats without influencing the concentration of platinum in renal tissue.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Appenroth D,Fröb S,Kersten L,Splinter FK,Winnefeld Kdoi
10.1007/s002040050444subject
Has Abstractpub_date
1997-01-01 00:00:00pages
677-83issue
11eissn
0340-5761issn
1432-0738journal_volume
71pub_type
杂志文章abstract：:The reversibility of quinolone-induced cartilage lesions has not been studied in detail. We treated five groups of five to seven juvenile Wistar rats (male and female; age: 5 weeks) with 2 x 600 mg ofloxacin/kg by gastric intubation on 1 day only (9:00 a.m. and 5:00 p.m.) and studied the knee joints histologically 3 d...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050301
更新日期：1996-01-01 00:00:00
abstract：:Organophosphorus (OP) pesticides and nerve agents still pose a threat to the population. Treatment of OP poisoning is an ongoing challenge and burden for medical services. Standard drug treatment consists of atropine and an oxime as reactivator of OP-inhibited acetylcholinesterase and is virtually unchanged since more...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-020-02797-0
更新日期：2020-07-01 00:00:00
abstract：:False-negative judgment due to poor chemical solubility is a problem with in vitro skin sensitisation tests. Water-insoluble chemicals are typically dissolved in DMSO in most sensitisation tests but precipitate when diluted with medium beyond their solubility in water. Such tests lack procedures to rule out false-nega...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02934-9
更新日期：2020-10-17 00:00:00
abstract：:The kinetic analysis of esterase inhibition by acylating compounds (organophosphorus carbamates and sulfonyl fluorides) is sometimes unable to yield consistent results by fitting simple inhibition kinetic models to experimental data of complex systems. In this work, kinetic data were obtained for phenylmethylsulfonyl ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-012-0817-3
更新日期：2012-05-01 00:00:00
abstract：:As a potential endocrine disruptor, tris(2,3-dibromopropyl) isocyanurate (TBC) has previously been demonstrated to reduce expression of estrogen-dependent vitellogenin (vtg) mRNA in adult zebrafish. However, the underlying toxicity pathways and molecular mechanisms involved in TBC-induced endocrine disruption remain e...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2159-2
更新日期：2018-04-01 00:00:00
abstract：:Glyphosate (G) is the largest selling herbicide worldwide; the most common formulations (Roundup, R) contain polyoxyethyleneamine as main surfactant. Recent findings indicate that G exposure may cause DNA damage and cancer in humans. Aim of this investigation was to study the cytotoxic and genotoxic properties of G an...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-012-0804-8
更新日期：2012-05-01 00:00:00
abstract：:In female rats, the lethality and hepatotoxicity of cerous chloride (CeCl3) were significantly altered by pretreatment with steroidal and nonsteroidal compounds (pregnenolone-16alpha-carbonitrile "PCN", dexamethasone, spironolactone, phenobarbital) that stimulate hepatic drug-metabolizine enzyme activity and by estrad...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00372765
更新日期：1976-03-11 00:00:00
abstract：:Certain populations of the mosquitofish (Gambusia affinis) are highly resistant to cyclodiene and cyclodiene-type insecticides that competitively interact with the picrotoxinin binding site of the gamma-aminobutyric acid (GABA) receptor-ionophore complex in the central nervous system. Resistance involves a reduction i...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00332493
更新日期：1988-01-01 00:00:00
abstract：:The first withdrawal of certain polybrominated diphenyl ethers flame retardants from the US market occurred in 2004. Since then, use of brominated non-PBDE compounds such as bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate (BEH-TEBP) and 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB) in commercial formulations has incr...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-015-1489-6
更新日期：2016-03-01 00:00:00
abstract：:Bisphenol A (BPA) is a chemical in widespread use that is under scientific discussion due to its endocrine activity. Controversies exist about how to interpret reportedly high blood concentrations measured in uncontrolled situations. Physiologically based pharmaco-/toxicokinetic modelling resulted in 10-100-fold lower...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-013-1022-8
更新日期：2013-07-01 00:00:00
abstract：:Several in vitro DNA microarray studies have shown the importance of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in skin sensitization. Nevertheless, the exact in vivo role of the Nrf2-Keap1 pathway during the induction of skin sensitization remains unknown. To study the function of Nrf2, a local lymph node ass...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-012-0976-2
更新日期：2013-04-01 00:00:00
abstract：:The antidepressants, imipramine and mianserin, have been reported to cause liver damage. We investigated a role of cytochrome P450 (CYP)-mediated formation of a reactive metabolite in antidepressant-induced acute cell injury using hepatocytes isolated from male and female Wistar rats, and male Dark Agouti rats, which ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050599
更新日期：1999-04-01 00:00:00
abstract：:Darbepoetin (DPO), an erythropoietin (EPO) derivative, was licensed in 2002 to treat patients with solid tumors suffering from chemotherapy-dependent anemia, although various tumors express EPO to improve vascularization, thus favoring tumor growth and spreading. Therefore, we wanted to investigate direct effects of D...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-013-1094-5
更新日期：2014-01-01 00:00:00
abstract：:Primary human hepatocytes (hHeps) are still gold standard to perform human drug metabolism studies, but their availability is limited by donor organ scarcity. Therefore, hepatoma cell lines are widely used as alternatives, although their phases I and II drug-metabolizing activities are substantially lower compared wit...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-011-0733-y
更新日期：2012-01-01 00:00:00
abstract：:The effect of methantheline, a quaternary ammonium compound, on the reactivation by HI 6 of soman-inhibited human erythrocyte acetylcholinesterase (AChE) was investigated in vitro using purified human erythrocyte AChE or washed human erythrocytes. Methantheline itself was found to be a mixed competitive/non-competitiv...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050243
更新日期：1995-01-01 00:00:00
abstract：:The highly directional maternal-to-fetal transfer of essential fatty acids (EFAs) across the placenta plays a critical role in guiding proper fetal development. Exposure to xenobiotics that may alter the fetal supply of EFAs/lipids could lead to fetal toxicity. Since the placenta is the first fetal arising organ that ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-005-0047-z
更新日期：2006-05-01 00:00:00
abstract：:The objective of this study was to evaluate the role of apoptosis in the development of the newborn cochlear structures and hearing loss caused by prenatal cis-diaminedichloroplatinum (cisplatin) exposure. Pregnant albino guinea pigs were intraperitoneally injected with 1.5 mg/kg body weight cisplatin once a day for s...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-010-0543-7
更新日期：2011-01-01 00:00:00
abstract：:Diet is directly related with physiological alterations occurring at a cell and subcellular level. However, the role of diet manipulation on mitochondrial physiology is still largely unexplored. Aiming at correlating diet with alterations of mitochondrial membrane composition and bioenergetics, Wistar-Han male rats we...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-013-1068-7
更新日期：2013-12-01 00:00:00
abstract：:Current developmental neurotoxicity (DNT) testing in animals faces major limitations, such as high cost and time demands as well as uncertainties in their methodology, evaluation and regulation. Therefore, the use of human-based 3D in vitro systems in combination with high-content image analysis (HCA) might contribute...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1852-2
更新日期：2017-04-01 00:00:00
abstract：:In anaesthetized and artificially ventilated rabbits an intravenous infusion of paraoxon (0.8 mg/kg) was given over 30 min. The effects on cardiac output, blood flow to various vascular beds, and on the mass discharge of the postganglionic sympathetic efferents to the spleen and kidney were monitored. Immediately foll...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00310857
更新日期：1982-09-01 00:00:00
abstract：:A new class of potent anticancer drugs, alkylphosphocholines has been recognized lately. Miltefosine (Hexadecylphosphochlorine, HPC) has been found to express select antineoplastic effect on human breast cancer skin metastases with simultaneous preservation of bone marrow proliferative activity and low clastogenicity....
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-005-0010-z
更新日期：2006-01-01 00:00:00
abstract：:The organophosphorus (OP) pesticide malathion is a neurotoxic compound whose acute toxicity is primarily caused by the inhibition of acetylcholinesterase (AChE), leading to cholinergic syndrome-related symptoms. Some lines of evidence indicate that long-term exposure to low levels of OP may produce neuropsychiatric an...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-015-1466-0
更新日期：2016-03-01 00:00:00
abstract：:Perfluoroalkyl acids are widely used in numerous industrial and commercial applications due to their unique physical and chemical characteristics. Although perfluorooctanoic acid (PFOA) is associated with hepatomegaly through peroxisome proliferator-activated receptor α (PPARα) activation, liver fat accumulation and c...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-014-1322-7
更新日期：2015-09-01 00:00:00
abstract：:Selenium (Se) is an essential dietary component for animals including humans and is regarded as a protective agent against cancer. Although the mode of anticancer action of Se is not fully understood yet, several mechanisms, such as antioxidant protection by selenoenzymes, specific inhibition of tumor cell growth by S...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-010-0595-8
更新日期：2010-12-01 00:00:00
abstract：:Experimental manganese lymphadenopathy was produced by guinea pigs by intratracheal inoculation of manganese dioxide (50 mg/300 g body weight) and histopathologic changes in the tracheobronchial lymph nodes were studied up to 180 days. There was slow extracellular transport of manganese dust into the nodes, which did ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00351975
更新日期：1976-10-28 00:00:00
abstract：:The EU-EuroMix project adopted the strategy of the European Food Safety Authority (EFSA) for cumulative risk assessment, which limits the number of chemicals to consider in a mixture to those that induce a specific toxicological phenotype. These so-called cumulative assessment groups (CAGs) are refined at several leve...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2320-y
更新日期：2018-12-01 00:00:00
abstract：:When rats were dosed with 14 microgram/kg 3H-isoproterenol, 3H-radioactivity was measurable in the liver until 48 h. This amount was not different in livers of animals which have been pretreated with diethyl maleate. After exhaustive extraction, a significant amount of 3H-radioactivity from isoproterenol could be dete...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00343273
更新日期：1977-12-30 00:00:00
abstract：:The tissue distribution, metabolism and excretion of 14C-2,2',4,4',5-pentachlorodiphenyl ether (PCDE) were studied in the rat. Radioactivity was distributed in all tissues examined, with the highest concentrations being found in the fat followed by the skin, liver, kidney and muscle. Most of the radioactivity found in...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00332484
更新日期：1988-01-01 00:00:00
abstract：:Cannabis use has become a hot topic in several countries due to the debate about its legalization for medical purposes. However, data are limited regarding adverse events, safety and potential impact on reproductive health. Cannabis consumption during pregnancy has been associated with gestational disorders such as pr...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-019-02389-7
更新日期：2019-03-01 00:00:00
abstract：:Initially, mice were pretreated with atropine (17.4 mg/kg; IP) and the oxime reactivator HI-6 (50 mg/kg; IP) 5 min prior to an injection of soman (287 micrograms/kg, SC); approximately 2.1 x LD50 dose). More than 95% of the mice survived this dose of soman with atropine and HI-6 pretreatment. In these survivors of som...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00316438
更新日期：1989-01-01 00:00:00
