Control of some aspects of cis-platinum nephrotoxicity.


:The elevations of blood urea nitrogen and serum creatinine caused by cis-platinum in rats can be prevented by a combination of procedures centered around the administration of sodium N-methyl-N-dithiocarboxyglucamine (NaG), before and very soon after the cis-platinum is administered in hypertonic (4.5%) saline. Elevations in-blood urea nitrogen and serum creatinine levels subsequent to such treatment are largely eliminated. These same procedures appear to have no effect on the anti-tumor action of the cis-platinum, as measured by tumor size and mass and by survival times, in female Sprague-Dawley rats inoculated with the Walker 256 carcinoma. The degree of myelosuppression, as measured by the white blood cell count is also slightly reduced. White blood cell counts returned to normal values more rapidly in animals treated with NaG than in those treated with cis-platinum alone. An examination of the dose-response curve for the suppression of cis-platinum nephrotoxicity by NaG shows that this can be achieved with mole ratios of NaG: cis-platinum as low as 1:1 given after appropriate pretreatment. A preliminary structure-activity study on the suppression of cis-platinum induced elevations in blood urea nitrogen and serum creatinine by four closely related dithiocarbamates shows that this can also be achieved effectively by several dithiocarbamates in which the nitrogen atom bears polar substituents.


Arch Toxicol


Archives of toxicology


Jones MM,Basinger MA,Craft WD,Domingo JL,Llobet JM




Has Abstract


1986-10-01 00:00:00












  • AhR-mediated changes in global gene expression in rat liver progenitor cells.

    abstract::Although the tumor-promoting effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), coplanar polychlorinated biphenyls (PCBs), and related compounds in liver tissue are primarily attributed to the activation of the aryl hydrocarbon receptor (AhR), the underlying molecular mechanisms are still unclear. Liver progenitor...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Faust D,Vondráček J,Krčmář P,Smerdová L,Procházková J,Hrubá E,Hulinková P,Kaina B,Dietrich C,Machala M

    更新日期:2013-04-01 00:00:00

  • Effect of cadmium on lung lysosomal enzymes in vitro.

    abstract::Labilization of lysosomal enzymes is often associated with the general process of inflammation. The present study investigated the effect of the pneumotoxin cadmium on the release and activity of two lung lysosomal enzymes. Incubation of rat lung lysosomes with cadmium resulted in the release of beta-glucuronidase but...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Giri SN,Hollinger MA

    更新日期:1995-01-01 00:00:00

  • Effects of cadmium on carbonic anhydrase activity and hemoglobin content of rat testes.

    abstract::The cadmilm-induced (Cd) damage of mammalian testes is thought to be correlated with an inhibition of carbonic anhydrase (CAH) by Cd. Since Cd causes dose-dependent changes in blood flow of the testes, an inhibition of CAH in the testes could be simulated by a decrease of CAH-rich erythrocytes. Therefore, CAH activiti...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Alsen C,Köpcke C,Ohnesorge FK,Schneider J

    更新日期:1976-12-23 00:00:00

  • The effects of sodium diethyldithiocarbamate in fibroblasts V79 cells in relation to cytotoxicity, antioxidative enzymes, glutathione, and apoptosis.

    abstract::Sodium diethyldithiocarbamate (DETC) is the main metabolite of disulfiram. Recently, we reported that mechanism of disulfiram cytotoxicity in V79 cells might be partially connected with thiol redox-state imbalance. Here, we examined the effect of DETC on the level of intracellular glutathione (GSH), protein oxidation ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Rahden-Staroń I,Grosicka-Maciąg E,Kurpios-Piec D,Czeczot H,Grzela T,Szumiło M

    更新日期:2012-12-01 00:00:00

  • Reduction of cisplatin toxicity in cultured renal tubular cells by the bioflavonoid quercetin.

    abstract::Quercetin (QC), a polyphenolic compound widely distributed in fruits and vegetables has recently gained interest due to its cisplatin (CP) sensitizing properties in cancer cells. It is currently unknown, whether quercetin also increases the susceptibility of the kidneys to cisplatin toxicity. We studied the effects of...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Kuhlmann MK,Horsch E,Burkhardt G,Wagner M,Köhler H

    更新日期:1998-07-01 00:00:00

  • Transfer and accumulation of cadmium, and the level of metallothionein in perfused human placentae.

    abstract::The purpose of the present study was to investigate the effect of perfusion with a medium containing 12 or 24 micrograms Cadmium (as CdCl2) per ml on this metal's accumulation, transfer rate and metallothionein (MT) level. The experiments were performed with an isolated lobule of a dually-perfused human term placenta....

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Boadi WY,Yannai S,Urbach J,Brandes JM,Summer KH

    更新日期:1991-01-01 00:00:00

  • Toxicokinetics of soman in cerebrospinal fluid and blood of anaesthetized pigs.

    abstract::The toxicokinetics of the four stereoisomers of the nerve agent C(+/-)P(+/-)-soman was analysed in cerebrospinal fluid (CSF) and blood in anaesthetized, spontaneously breathing pigs during a 90-min period after injection of soman. The pigs were challenged with different intravenous (i.v.) doses of C(+/-)P(+/-)-soman c...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Göransson-Nyberg A,Fredriksson SA,Karlsson B,Lundström M,Cassel G

    更新日期:1998-07-01 00:00:00

  • Protective effects of vitamin E and C on cisplatin nephrotoxicity in developing rats.

    abstract::The kinetics of vitamin E was followed in serum, liver and kidney of 10- and 55-day-old rats after the administration of a single i.m. dose of 100 mg alpha-tocopherol acetate/100 g body wt. The basal levels without vitamin E administration were significantly higher in serum and liver of 10- than 55-day-old rats. The e...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Appenroth D,Fröb S,Kersten L,Splinter FK,Winnefeld K

    更新日期:1997-01-01 00:00:00

  • Hepatocyte CREBH deficiency aggravates inflammatory liver injury following chemokine-dependent neutrophil infiltration through upregulation of NF-κB p65 in mice.

    abstract::Fulminant hepatitis is a serious inflammatory condition of the liver characterized by massive necrosis of liver parenchyma following excessive immune cell infiltration into the liver, and possibly causing sudden hepatic failure and medical emergency. However, the underlying mechanisms are not fully understood. Here, w...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Noh JR,Kim JH,Na SY,Lee IB,Seo YJ,Choi JH,Seo Y,Lee TG,Choi HS,Kim YH,Lee CH

    更新日期:2020-02-01 00:00:00

  • Inhibition, reactivation and aging kinetics of cyclohexylmethylphosphonofluoridate-inhibited human cholinesterases.

    abstract::Cyclohexylmethylphosphonofluoridate (cyclosarin) is a highly toxic organophosphate, which was shown to be rather resistant to conventional oxime therapy. To give more insight into the inhibition, reactivation and aging kinetics, human acetyl-(AChE) and butyrylcholinesterase (BChE) were inhibited by cyclosarin (k2 of 7...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Worek F,Eyer P,Szinicz L

    更新日期:1998-09-01 00:00:00

  • The effect of 1-deamino-2-tyr(ethyl) oxytocin upon peri- and postnatal development of the rat: growth retardation of the offspring.

    abstract::The effect of 1-deamino-2-tyr(ethyl) oxytocin (dEtOT) upon peri- and postnatal development of the rat was studied in two experiments when administered between day 15 of pregnancy and the day of parturition. The investigation showed that dEtOT did not affect the pups at birth, that dEtOT caused a dose-related growth re...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Magnusson G,Melin P

    更新日期:1985-09-01 00:00:00

  • Nanosized TiO₂ caused minor airflow limitation in the murine airways.

    abstract::The use of nanotechnology is increasing exponentially, whereas the possible adverse health effects of engineered nanoparticles (NPs) are so far less known. Standardized mouse bioassay was used to study sensory and pulmonary irritation, airflow limitation, and inflammation potency of nanosized TiO(2). Single exposure (...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Leppänen M,Korpi A,Miettinen M,Leskinen J,Torvela T,Rossi EM,Vanhala E,Wolff H,Alenius H,Kosma VM,Joutsensaari J,Jokiniemi J,Pasanen P

    更新日期:2011-07-01 00:00:00

  • Classifying the adverse mitogenic mode of action of insulin analogues using a novel mechanism-based genetically engineered human breast cancer cell panel.

    abstract::Insulin analogues are widely used in clinical practice. Modifications on the insulin molecular structure can affect the affinity and activation towards two closely related receptor tyrosine kinases: the insulin receptor (INSR) and the insulin-like growth factor 1 receptor (IGF1R). A switch towards higher IGF1R affinit...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: ter Braak B,Siezen CL,Kannegieter N,Koedoot E,van de Water B,van der Laan JW

    更新日期:2014-04-01 00:00:00

  • A sensitive mouse lymph node assay with two application phases for detection of contact allergens.

    abstract::A predictive test using mice for the identification of contact sensitizing chemicals was developed. Contact sensitizing activity is measured as a function of draining lymph node activation following application of test chemical. Experimental conditions for assessment of induced lymph node cell (LNC) responses have bee...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Ikarashi Y,Tsuchiya T,Nakamura A

    更新日期:1993-01-01 00:00:00

  • In vivo evaluation of the effect of arsenite on the intestinal epithelium and associated microbiota in mice.

    abstract::Chronic exposure to inorganic arsenic (As) [As(III) + As(V)], which affects millions of people, increases the incidence of some kinds of cancer and other non-carcinogenic pathologies. Although the oral pathway is the main form of exposure, in vivo studies have not been conducted to verify the intestinal toxicity of th...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Chiocchetti GM,Domene A,Kühl AA,Zúñiga M,Vélez D,Devesa V,Monedero V

    更新日期:2019-08-01 00:00:00

  • New designer phenethylamines 2C-C and 2C-P have abuse potential and induce neurotoxicity in rodents.

    abstract::2C (2C-x) is the general name for the family of phenethylamines containing two methoxy groups at the 2 and 5 positions of the benzene ring. The abuse of 2C family drugs has grown rapidly, although the abuse potential and neurotoxic properties of 2C drugs have not yet been fully investigated. In this study, we investig...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Kim YJ,Ma SX,Hur KH,Lee Y,Ko YH,Lee BR,Kim SK,Sung SJ,Kim KM,Kim HC,Lee SY,Jang CG

    更新日期:2021-01-30 00:00:00

  • The role of epoxide hydrolases in health and disease.

    abstract::Epoxide hydrolases (EH) are ubiquitously expressed in all living organisms and in almost all organs and tissues. They are mainly subdivided into microsomal and soluble EH and catalyze the hydration of epoxides, three-membered-cyclic ethers, to their corresponding dihydrodiols. Owning to the high chemical reactivity of...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,评审


    authors: El-Sherbeni AA,El-Kadi AO

    更新日期:2014-11-01 00:00:00

  • Carcinogenic risk of copper gluconate evaluated by a rat medium-term liver carcinogenicity bioassay protocol.

    abstract::Carcinogenic risk and molecular mechanisms underlying the liver tumor-promoting activity of copper gluconate, an additive of functional foods, were investigated using a rat medium-term liver carcinogenicity bioassay protocol (Ito test) and a 2-week short-term administration experiment. In the medium-term liver bioassa...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Abe M,Usuda K,Hayashi S,Ogawa I,Furukawa S,Igarashi M,Nakae D

    更新日期:2008-08-01 00:00:00

  • Mechanisms involved in the transport of mercuric ions in target tissues.

    abstract::Mercury exists in the environment in various forms, all of which pose a risk to human health. Despite guidelines regulating the industrial release of mercury into the environment, humans continue to be exposed regularly to various forms of this metal via inhalation or ingestion. Following exposure, mercuric ions are t...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,评审


    authors: Bridges CC,Zalups RK

    更新日期:2017-01-01 00:00:00

  • Testicular toxicity of dietary 2,2-bis(4-hydroxyphenyl)propane (bisphenol A) in F344 rats.

    abstract::Male F344/DuCrj (Fischer) rats were given bisphenol A (BPA) in the diet at levels of 0 (control), 0.25, 0.50 and 1.00%, equivalent to 0, 235, 466 and 950 mg/kg per day, respectively, for 44 days. Body weight gains were depressed dose-dependently in BPA-treated rats, and those of 0.50 and 1.00% groups were significant....

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Takahashi O,Oishi S

    更新日期:2001-03-01 00:00:00

  • Dual effect of red wine on liver redox status: a concise and mechanistic review.

    abstract::Chronic ethanol consumption is a strong risk factor for the development of liver disease. Multiple mechanisms are involved in ethanol-mediated liver injury; oxidative stress being pointed has an important factor. However, it should be noted that moderate consumption of red wine has been associated with hepatoprotectiv...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,评审


    authors: Silva P,Fernandes E,Carvalho F

    更新日期:2015-10-01 00:00:00

  • Anti-apoptotic, anti-inflammatory, and immunomodulatory activities of 3,3'-diselenodipropionic acid in mice exposed to whole body γ-radiation.

    abstract::The present study was designed to evaluate the possible protective effects of 3,3'-diselenodipropionic acid (DSePA), a potent radioprotector, against oxidative organ damage induced by whole body γ-irradiation and explore its mechanistic effects. The mice were subjected to whole body γ-irradiation at 5 Gy for the detec...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Kunwar A,Bag PP,Chattopadhyay S,Jain VK,Priyadarsini KI

    更新日期:2011-11-01 00:00:00

  • Inhibition of ferrochelatase and accumulation of porphyrins in mouse hepatocyte cultures exposed to porphyrinogenic chemicals.

    abstract::The ability of 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC), 3,5-diethoxycarbonyl-4-ethyl-1,4-dihydro-2,6-dimethylpyridine (EDDC) and griseofulvin to induce porphyria in primary cultures of mouse hepatocytes has been examined. Exposure of cultured mouse hepatocytes to DDC, EDDC or griseofulvin resulted in a marked ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Brady AM,Lock EA

    更新日期:1992-01-01 00:00:00

  • Mutagenicity testing of organic extracts of diesel exhaust particles after spiking with polycyclic aromatic hydrocarbons (PAH).

    abstract::In the present study, spiking was used as a strategy to evaluate the mutagenicity of individual compounds in a mixture. Mutagenicity of individual polycyclic aromatic hydrocarbons (PAH) was evaluated in an organic extract of diesel exhaust particles (DEP). The particles were extracted with dichloromethane (DCM). After...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Bostrøm E,Engen S,Eide I

    更新日期:1998-10-01 00:00:00

  • On the mechanisms of melatonin in protection of aluminum phosphide cardiotoxicity.

    abstract::Aluminum phosphide (AlP), one of the most commonly used pesticides worldwide, has been the leading cause of self-poisoning mortalities among many Asian countries. The heart is the main organ affected in AlP poisoning. Melatonin has been previously shown to be beneficial in reversing toxic changes in the heart. The pre...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Asghari MH,Moloudizargari M,Baeeri M,Baghaei A,Rahimifard M,Solgi R,Jafari A,Aminjan HH,Hassani S,Moghadamnia AA,Ostad SN,Abdollahi M

    更新日期:2017-09-01 00:00:00

  • Inhibitory effect of berberine on tert-butyl hydroperoxide-induced oxidative damage in rat liver.

    abstract::Berberine, a main protoberberine component of Coptidis Rhizoma, was studied for the mechanism of its inhibitory effects on the tert-butyl hydroperoxide (t-BHP)-induced cytotoxicity and lipid peroxidation in rat liver. In the preliminary study, berberine expressed an antioxidant property by its capacity for quenching t...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Hwang JM,Wang CJ,Chou FP,Tseng TH,Hsieh YS,Lin WL,Chu CY

    更新日期:2002-11-01 00:00:00

  • Application of ESR spectroscopy in toxicology.

    abstract::Spin trapping in vivo was first achieved in the author's laboratory and is shown to be a feasible method for demonstrating that highly reactive free radical intermediates are generated in the tissues of intact animals as a result of the exposure to certain toxic compounds and to ionizing radiation. The method is based...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,评审


    authors: McCay PB

    更新日期:1987-01-01 00:00:00

  • Interleukin-6 selectively induces drug metabolism to potentiate the genotoxicity of dietary carcinogens in mammary cells.

    abstract::Breast cancer is the most commonly diagnosed malignancy in females, the etiology being multifactorial and includes the role of lifestyle exposure to DNA-damaging chemicals such as dietary carcinogens benzo (a) pyrene (BaP) and 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP). Both compounds require cytochrome...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Malik DE,David RM,Gooderham NJ

    更新日期:2019-10-01 00:00:00

  • Chelation in metal intoxication. XII. Antidotal efficacy of chelating agents on acute toxicity of manganese.

    abstract::Several structurally different metal chelating agents were screened for their relative efficacy in counteracting acute manganese intoxication in mice. Polyaminocarboxylic acids with nitrogen and oxygen as metal binding sites were more effective than certain sulfhydryl chelating agents and common drugs in preventing mo...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Tandon SK,Khandelwal S

    更新日期:1982-05-01 00:00:00

  • Acute and subacute inhalation toxicity of dichlorosilane in male ICR mice.

    abstract::Using male ICR mice, the LC50 and acute and subacute inhalation toxicity of dichlorosilane (SiH2Cl2, DCS) and the fate of DCS released into the air were investigated. DCS resolved and minute particles including silicon and chloride were observed, when DCS was released into the air. Most particles were under 1 micron i...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Nakashima H,Omae K,Takebayashi T,Ishizuka C,Sakurai H,Yamazaki K,Nakaza M,Shibata T,Kudo M,Koshi S

    更新日期:1996-01-01 00:00:00