Control of some aspects of cis-platinum nephrotoxicity.


:The elevations of blood urea nitrogen and serum creatinine caused by cis-platinum in rats can be prevented by a combination of procedures centered around the administration of sodium N-methyl-N-dithiocarboxyglucamine (NaG), before and very soon after the cis-platinum is administered in hypertonic (4.5%) saline. Elevations in-blood urea nitrogen and serum creatinine levels subsequent to such treatment are largely eliminated. These same procedures appear to have no effect on the anti-tumor action of the cis-platinum, as measured by tumor size and mass and by survival times, in female Sprague-Dawley rats inoculated with the Walker 256 carcinoma. The degree of myelosuppression, as measured by the white blood cell count is also slightly reduced. White blood cell counts returned to normal values more rapidly in animals treated with NaG than in those treated with cis-platinum alone. An examination of the dose-response curve for the suppression of cis-platinum nephrotoxicity by NaG shows that this can be achieved with mole ratios of NaG: cis-platinum as low as 1:1 given after appropriate pretreatment. A preliminary structure-activity study on the suppression of cis-platinum induced elevations in blood urea nitrogen and serum creatinine by four closely related dithiocarbamates shows that this can also be achieved effectively by several dithiocarbamates in which the nitrogen atom bears polar substituents.


Arch Toxicol


Archives of toxicology


Jones MM,Basinger MA,Craft WD,Domingo JL,Llobet JM




Has Abstract


1986-10-01 00:00:00












  • Selectivity of plasma membrane calcium ATPase (PMCA)-mediated extrusion of toxic divalent cations in vitro and in cultured cells.

    abstract::In the recent years, the toxicity of certain divalent cations has been associated with the alteration of intracellular Ca2+ homeostasis. Among other mechanisms, these cations may affect the functionality of certain Ca2+-binding proteins and/or Ca2+ pumps. The plasma membrane calcium pump (PMCA) maintains Ca2+ homeosta...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Ferreira-Gomes MS,Mangialavori IC,Ontiveros MQ,Rinaldi DE,Martiarena J,Verstraeten SV,Rossi JPFC

    更新日期:2018-01-01 00:00:00

  • 3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo.

    abstract::Liver disease is an escalating global health issue. While liver transplantation is an effective mode of therapy, patient mortality has increased due to the shortage of donor organs. Developing renewable sources of human liver tissue is therefore attractive. Pluripotent stem cell-derived liver tissue represents a poten...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Rashidi H,Luu NT,Alwahsh SM,Ginai M,Alhaque S,Dong H,Tomaz RA,Vernay B,Vigneswara V,Hallett JM,Chandrashekran A,Dhawan A,Vallier L,Bradley M,Callanan A,Forbes SJ,Newsome PN,Hay DC

    更新日期:2018-10-01 00:00:00

  • Effects of cadmium on carbonic anhydrase activity and hemoglobin content of rat testes.

    abstract::The cadmilm-induced (Cd) damage of mammalian testes is thought to be correlated with an inhibition of carbonic anhydrase (CAH) by Cd. Since Cd causes dose-dependent changes in blood flow of the testes, an inhibition of CAH in the testes could be simulated by a decrease of CAH-rich erythrocytes. Therefore, CAH activiti...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Alsen C,Köpcke C,Ohnesorge FK,Schneider J

    更新日期:1976-12-23 00:00:00

  • FK506 (Tacrolimus) decreases the cytotoxicity of cyclosporin A in rat hepatocytes in primary culture: implication of CYP3A induction.

    abstract::Tacrolimus (FK506) and cyclosporin A (CsA) are two potent immunosuppressants mainly metabolized by hepatic cytochrome P-450 3A (CYP3A) monooxygenase. The aim of this study was to compare the toxic effects of the two drugs on hepatocytes in primary culture as a function of their metabolism and to explore the variations...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Ellouk-Achard S,Martin C,Duc HT,Dutertre-Catella H,Thevenin M,Warnet JM,Claude JR

    更新日期:1998-04-01 00:00:00

  • Penetration of beta-naphthylamine and o-toluidine through human skin in vitro.

    abstract::Several aromatic amines (AAs) are known to be carcinogens for humans. AAs are considered to be substantially absorbed through the skin. However, the database for dermal absorption of AAs in general is limited and no specific studies on dermal absorption of beta-naphthylamine (BNA) and o-toluidine (OT) have been publis...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Lüersen L,Wellner T,Koch HM,Angerer J,Drexler H,Korinth G

    更新日期:2006-10-01 00:00:00

  • The effects of sodium diethyldithiocarbamate in fibroblasts V79 cells in relation to cytotoxicity, antioxidative enzymes, glutathione, and apoptosis.

    abstract::Sodium diethyldithiocarbamate (DETC) is the main metabolite of disulfiram. Recently, we reported that mechanism of disulfiram cytotoxicity in V79 cells might be partially connected with thiol redox-state imbalance. Here, we examined the effect of DETC on the level of intracellular glutathione (GSH), protein oxidation ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Rahden-Staroń I,Grosicka-Maciąg E,Kurpios-Piec D,Czeczot H,Grzela T,Szumiło M

    更新日期:2012-12-01 00:00:00

  • Investigation of species differences in isobutene (2-methylpropene) metabolism between mice and rats.

    abstract::Metabolism of isobutene (2-methylpropene) in rats (Sprague Dawley) and mice (B6C3F1) follows kinetics according to Michaelis-Menten. The maximal metabolic elimination rates are 340 mumol/kg/h for rats and 560 mumol/kg/h for mice. The atmospheric concentration at which Vmax/2 is reached is 1200 ppm for rats and 1800 pp...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Csanády GA,Freise D,Denk B,Filser JG,Cornet M,Rogiers V,Laib RJ

    更新日期:1991-01-01 00:00:00

  • Arsenite induced oxidative damage in mouse liver is associated with increased cytokeratin 18 expression.

    abstract::Cytokeratins (CK) constitute a family of cytoskeletal intermediate filament proteins that are typically expressed in epithelial cells. An abnormal structure and function are effects that are clearly related to liver diseases as non-alcoholic steatohepatitis, cirrhosis and hepatocellular carcinoma. We have previously o...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Gonsebatt ME,Del Razo LM,Cerbon MA,Zúñiga O,Sanchez-Peña LC,Ramírez P

    更新日期:2007-09-01 00:00:00

  • Effects of calcium channel blockers on the development of early rat postimplantation embryos in culture.

    abstract::Rat embryos (9.5-day-old) were cultured for 48 h in the presence of nifedipine (NIF), nimodipine (NIM), nitrendipine (NIT), gallopamil HCl (GAL), verapamil HCl (VER) and diltiazem HCl (DIL). The effects on growth and morphogenetic differentiation in vitro were monitored. Dose-response relationships were evaluated, inc...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Stein G,Srivastava MK,Merker HJ,Neubert D

    更新日期:1990-01-01 00:00:00

  • Pneumoconiotic effects of welding-fume particles from mild and stainless steel deposited in the lung of the rat.

    abstract::Rats were exposed to single periods of inhalation of fumes generated by arc welding. Two processes were compared: either manual metal arc (MMA) using flux-coated mild steel (MS) electrodes or metal inert-gas (MIG) welding with stainless steel (SS). Widespread but small deposits of fume particles were cleared effective...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Hicks R,Lam HF,Al-Shamma KJ,Hewitt PJ

    更新日期:1984-03-01 00:00:00

  • Survivors of soman poisoning: recovery of the soman LD50 to control value in the presence of extensive acetylcholinesterase inhibition.

    abstract::Initially, mice were pretreated with atropine (17.4 mg/kg; IP) and the oxime reactivator HI-6 (50 mg/kg; IP) 5 min prior to an injection of soman (287 micrograms/kg, SC); approximately 2.1 x LD50 dose). More than 95% of the mice survived this dose of soman with atropine and HI-6 pretreatment. In these survivors of som...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Clement JG

    更新日期:1989-01-01 00:00:00

  • Correction to: Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models.

    abstract::This article is published with the incorrect copyright holder name in the HTML article as "© Springer 2018". The correct copyright line should read "The Author(s) 2018" (as it appears in the article PDF). ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,已发布勘误


    authors: Oesch F,Fabian E,Landsiedel R

    更新日期:2018-11-01 00:00:00

  • Hibiscus protocatechuic acid inhibits lipopolysaccharide-induced rat hepatic damage.

    abstract::Hibiscus protocatechuic acid (PCA), a phenolic compound found in the dried flowers of Hibiscus sabdariffa L. (Malvaceae), was demonstrated to have an antioxidant effect in vitro and in vivo, and an antitumor property in our previous study. In the present study, we used lipopolysaccharide (LPS, an endotoxin) to induce ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Lin WL,Hsieh YJ,Chou FP,Wang CJ,Cheng MT,Tseng TH

    更新日期:2003-01-01 00:00:00

  • A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens.

    abstract::Alternative methods to detect non-genotoxic carcinogens are urgently needed, as this class of carcinogens goes undetected in the current testing strategy for carcinogenicity under REACH. A complicating factor is that non-genotoxic carcinogens act through several distinctive modes of action, which makes prediction of t...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Schaap MM,Wackers PF,Zwart EP,Huijskens I,Jonker MJ,Hendriks G,Breit TM,van Steeg H,van de Water B,Luijten M

    更新日期:2015-12-01 00:00:00

  • Time course of lung retention and toxicity of inhaled particles: short-term exposure to nano-Ceria.

    abstract::Two Ceria nanomaterials (NM-211 and NM-212) were tested for inhalation toxicity and organ burdens in order to design a chronic and carcinogenicity inhalation study (OECD TG No. 453). Rats inhaled aerosol concentrations of 0.5, 5, and 25 mg/m(3) by whole-body exposure for 6 h/day on 5 consecutive days for 1 or 4 weeks ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Keller J,Wohlleben W,Ma-Hock L,Strauss V,Gröters S,Küttler K,Wiench K,Herden C,Oberdörster G,van Ravenzwaay B,Landsiedel R

    更新日期:2014-11-01 00:00:00

  • Electrophysiologic changes associated with chronic administration of organophosphates.

    abstract::Changes in the electrophysiologic activity of the rat sciatic nerve were examined after repeated dosing with either of two organophosphate insecticides, parathion, and trichlorfon. Although the parathion treated animals showed overt signs of systemic toxicity, there were no significant changes in any of the measured p...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Averbook BJ,Anderson RJ

    更新日期:1983-03-01 00:00:00

  • The role of epoxide hydrolases in health and disease.

    abstract::Epoxide hydrolases (EH) are ubiquitously expressed in all living organisms and in almost all organs and tissues. They are mainly subdivided into microsomal and soluble EH and catalyze the hydration of epoxides, three-membered-cyclic ethers, to their corresponding dihydrodiols. Owning to the high chemical reactivity of...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,评审


    authors: El-Sherbeni AA,El-Kadi AO

    更新日期:2014-11-01 00:00:00

  • Long-term and low-dose malathion exposure causes cognitive impairment in adult mice: evidence of hippocampal mitochondrial dysfunction, astrogliosis and apoptotic events.

    abstract::The organophosphorus (OP) pesticide malathion is a neurotoxic compound whose acute toxicity is primarily caused by the inhibition of acetylcholinesterase (AChE), leading to cholinergic syndrome-related symptoms. Some lines of evidence indicate that long-term exposure to low levels of OP may produce neuropsychiatric an...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: dos Santos AA,Naime AA,de Oliveira J,Colle D,dos Santos DB,Hort MA,Moreira EL,Suñol C,de Bem AF,Farina M

    更新日期:2016-03-01 00:00:00

  • Renal toxicity of aristolochic acid in rats as an example of nephrotoxicity testing in routine toxicology.

    abstract::The nephrotoxic action of aristolochic acid (AA) was investigated in female Wistar rats given single doses of 10, 50 or 100 mg/kg by gastric tube. Renal lesions developed within 3 days, the effect being dose-dependent. Histologically, there was evidence of necrosis of the epithelium of the renal tubules, and functiona...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Mengs U,Stotzem CD

    更新日期:1993-01-01 00:00:00

  • Cadmium, zinc and copper relationships in kidney and liver of humans exposed to environmental cadmium.

    abstract::Cadmium, copper and zinc have been determined in kidney cortex, kidney medulla and liver from 51 cadmium-polluted and 122 nonpolluted autopsied subjects. Liver cadmium and zinc were significantly higher in the cadmium-polluted subjects than in the nonpolluted subjects. Kidney cadmium, copper and zinc were lower in the...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Honda R,Nogawa K

    更新日期:1987-04-01 00:00:00

  • Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in cold-adapted rats.

    abstract::The toxicity of 60 micrograms/kg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) given IP in corn oil/5% acetone was examined in male Sprague-Dawley rats adapted to 25 degrees C or 4 degrees C ambient temperature. Cold exposure significantly reduced mean time to death and tended to increase mortality. Body weight at the ti...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Rozman K,Greim H

    更新日期:1986-12-01 00:00:00

  • Metabolism of acrylamide to glycidamide and their cytotoxicity in isolated rat hepatocytes: protective effects of GSH precursors.

    abstract::Acrylamide (AA) is a widely studied industrial chemical that is neurotoxic, mutagenic to somatic and germ cells, and carcinogenic in rodents. The recent discovery of AA at ppm levels in a wide variety of commonly consumed foods has energized research efforts worldwide to define toxicity and prevention. Metabolism and ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Kurebayashi H,Ohno Y

    更新日期:2006-12-01 00:00:00

  • Reactivating potency of obidoxime, pralidoxime, HI 6 and HLö 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds.

    abstract::The treatment of poisoning by highly toxic organophosphorus compounds (nerve agents) is unsatisfactory. Until now, the efficacy of new potential antidotes has primarily been evaluated in animals. However, the extrapolation of these results to humans is hampered by species differences. Since oximes are believed to act ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Worek F,Widmann R,Knopff O,Szinicz L

    更新日期:1998-03-01 00:00:00

  • Human liver debrisoquine 4-hydroxylase: test for specificity toward various monooxygenase substrates and model of the active site.

    abstract::Polyclonal antibodies raised toward a debrisoquine 4-hydroxylating cytochrome P-450 species purified from rat liver (P-450UT-A) were used to determine which monooxygenase reactions are linked to debrisoquine hydroxylation in human liver. Anti P-450UT-A did not inhibit the oxidation of dimethylnitrosamine, morphine, di...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Wolff T,Distlerath LM,Worthington MT,Guengerich FP

    更新日期:1987-01-01 00:00:00

  • In utero exposure to nicotine and chlorpyrifos alone, and in combination produces persistent sensorimotor deficits and Purkinje neuron loss in the cerebellum of adult offspring rats.

    abstract::This study was carried out to investigate the effect of in utero exposure to the cholinotoxicants, nicotine and chlorpyrifos, alone or in combination on neurobehavioral alterations and neuronal morphology latter in adult age. In the present study, 90 days old (corresponding to a human adult age) male and female offspr...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Abou-Donia MB,Khan WA,Dechkovskaia AM,Goldstein LB,Bullman SL,Abdel-Rahman A

    更新日期:2006-09-01 00:00:00

  • The protective role of NAD(P)H:quinone oxidoreductase 1 on acetaminophen-induced liver injury is associated with prevention of adenosine triphosphate depletion and improvement of mitochondrial dysfunction.

    abstract:UNLABELLED:An overdose of acetaminophen (APAP) causes hepatotoxicity due to its metabolite, N-acetyl-p-benzoquinone imine. NAD(P)H:quinone oxidoreductase 1 (NQO1) is an important enzyme for detoxification, because it catabolizes endogenous/exogenous quinone to hydroquinone. Although various studies have suggested the ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Hwang JH,Kim YH,Noh JR,Gang GT,Kim KS,Chung HK,Tadi S,Yim YH,Shong M,Lee CH

    更新日期:2015-11-01 00:00:00

  • Effects of acetone administration on cytochrome P-450-dependent monooxygenases in hamster liver, kidney, and lung.

    abstract::The effects of acetone on liver, kidney, and lung monooxygenases were studied using hamsters administered 8% acetone in drinking water. Binding of aniline to liver microsomes induced a type II difference spectrum, and the spectral binding was enhanced in hamsters pretreated with acetone. Administration of acetone caus...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Ueng TH,Tsai JN,Ju JM,Ueng YF,Iwasaki M,Guengerich FP

    更新日期:1991-01-01 00:00:00

  • Aluminum interaction with phosphoinositide-associated signal transduction.

    abstract::Concerning molecular and cellular mechanisms of aluminum toxicity, recent studies support the hypothesis that interactions of aluminum ions with elements of signal transduction pathways are apparently primary events in cells. In the case of the phosphoinositide-associated signalling pathway of neuroblastoma cells, gua...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,评审


    authors: Haug A,Shi B,Vitorello V

    更新日期:1994-01-01 00:00:00

  • Bioactivation of food genotoxicants 5-hydroxymethylfurfural and furfuryl alcohol by sulfotransferases from human, mouse and rat: a comparative study.

    abstract::5-Hydroxymethylfurfural (HMF) and furfuryl alcohol (FFA) are moderately potent rodent carcinogens that are present in thermally processed foodstuffs. The carcinogenic effects were hypothesized to originate from sulfotransferase (SULT)-mediated bioactivation yielding DNA-reactive and mutagenic sulfate esters, a confirm...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Sachse B,Meinl W,Sommer Y,Glatt H,Seidel A,Monien BH

    更新日期:2016-01-01 00:00:00

  • Alterations in neurofilaments content and calpains activity of sciatic nerve of carbon disulfide-treated rats.

    abstract::Chronic exposure to carbon disulfide (CS2) can induce polyneuropathy in occupational worker and experimental animals, but underlying mechanism for CS2 neurotoxicity is currently unknown. In the present study, male Wistar rats were randomly divided into two experimental groups and one control group. The rats in two exp...

    journal_title:Archives of toxicology

    pub_type: 杂志文章


    authors: Song F,Zhang C,Wang Q,Zeng T,Xie K

    更新日期:2009-06-01 00:00:00