当前位置： SCI文献检索 > ARCHIVES OF TOXICOLOGY期刊下所有文献 > Differential effects of diabetes on CYP2E1 and CYP2B4 proteins and associated drug metabolizing enzyme activities in rabbit liver.

Differential effects of diabetes on CYP2E1 and CYP2B4 proteins and associated drug metabolizing enzyme activities in rabbit liver.

Abstract：

:The effects of diabetes on cytochrome P450 (CYP)-dependent drug metabolizing enzymes are yet to be clarified. The most widely used animals in these studies have been rats, and information on the effects of diabetes on rabbit liver drug metabolizing enzymes have been unavailable until now. In this study, for the first time, a significant induction of liver CYP2E1 is demonstrated via immunoblot analysis in alloxan-induced rabbits. The CYP2E1 content of diabetic microsomes was highly correlated with the activities of liver aniline 4-hydroxylase (r=0.82, p<0.05), and p-nitrophenol hydroxylase (r=0.86, p<0.01), and diabetes increased the activities of the enzymes associated with CYP2E1. The activities of aniline 4-hydroxylase and p-nitrophenol hydroxylase were significantly increased by 1.7 and 1.8-fold, respectively compared to those of control rabbits. In marked contrast, diabetes had no effect on the protein levels of CYP2B4 as determined by immunoblotting and on benzphetamine N-demethylase activity, which is known to be specifically metabolized by CYP2B4 in rabbit liver. The present study demonstrates that diabetes increases the activities of CYP2E1 and associated enzymes but does not change the activity levels of CYP2B4 and associated enzymes in diabetic rabbits. These findings are in contrast to those of mice, hamsters and rats, and that suggest the presence of species-dependent responses of CYP-dependent drug metabolizing enzymes to diabetes.

journal_name

Arch Toxicol

journal_title

Archives of toxicology

authors

Arinç E,Arslan S,Adali O

doi

10.1007/s00204-005-0654-8

keywords:

subject

Has Abstract

pub_date

2005-08-01 00:00:00

pages

427-33

issue

8

eissn

0340-5761

issn

1432-0738

journal_volume

79

pub_type

杂志文章

相关文献

ARCHIVES OF TOXICOLOGY文献大全
  • Species-specific pharmacokinetics of styrene in rat and mouse.

    abstract：:The pharmacokinetics of styrene were investigated in male Sprague-Dawley rats and male B6C3F1 mice using the closed chamber technique. Animals were exposed to styrene vapors of initial concentrations ranging from 550 to 5000 ppm, or received intraperitoneal (i.p.) doses of styrene from 20 to 340 mg/kg or oral (p.o.) d...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF01969264

    authors： Filser JG,Schwegler U,Csanády GA,Greim H,Kreuzer PE,Kessler W

    更新日期：1993-01-01 00:00:00

  • Increased copper concentrations in rat tissues after acute intoxication with 2,3,7,8-tetrachlorodibenzo-p-dioxin.

    abstract：:Recently, acutely toxic doses of the environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have been reported to affect the hepatic distribution of essential metals in the rat. However, the reduced food intake by TCDD was not taken into account. Therefore, metal concentrations were determined in different...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF02284268

    authors： Elsenhans B,Forth W,Richter E

    更新日期：1991-01-01 00:00:00

  • Upregulation of phosphoinositide 3-kinase prevents sunitinib-induced cardiotoxicity in vitro and in vivo.

    abstract：:Sunitinib (SNT) is a multi-targeted receptor tyrosine kinase inhibitor that has been approved by the FDA for cancer therapy. However, its cardiotoxicity has limited the clinical applicability with no effective therapeutic approach available. As a broadband kinase inhibitor, the function of several kinases that are ess...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-019-02448-z

    authors： Li C,Zou R,Zhang H,Wang Y,Qiu B,Qiu S,Wang W,Xu Y

    更新日期：2019-06-01 00:00:00

  • Ca(2+)-dependent suicidal erythrocyte death following zearalenone exposure.

    abstract：:Zearalenone, a cereal mycotoxin with mycoestrogen activity and effect on fertility, is known to trigger apoptosis of a variety of nucleated cell types including hematopoietic progenitor cells. In analogy to apoptosis of nucleated cells, eryptosis, the suicidal death of erythrocytes, leads to cell shrinkage and cell me...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-013-1037-1

    authors： Jilani K,Lang F

    更新日期：2013-10-01 00:00:00

  • Sister chromatid exchange frequency in cultured isolated porcine urinary bladder epithelial cells (PUBEC) treated with ochratoxin A and alpha.

    abstract：:The mycotoxin ochratoxin A (OTA) and its metabolite ochratoxin alpha (OT-alpha) were investigated, to examine their potency to induce sister chromatid exchanges (SCE) in cultured porcine urinary bladder epithelial cells (PUBEC) (primary culture). Serum-free cultured PUBEC were incubated for 5 h with either OTA or OT-a...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s002040050171

    authors： Föllmann W,Hillebrand IE,Creppy EE,Bolt HM

    更新日期：1995-01-01 00:00:00

  • Synthesis, characterization and biologic effects of polybrominated naphthalenes.

    abstract：:Although polybrominated naphthalenes (PBNs) are contaminants of the commercial fire retardant fireMaster BP-6, the individual PBN isomers have not been identified. In order to study PBNs possessing an analogous level of bromination to those found in fireMaster BP-6, three synthetic PBN mixtures, averaging 5.0, 5.3, an...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF00346051

    authors： Robertson LW,Thompson K,Parkinson A

    更新日期：1984-07-01 00:00:00

  • Influence of subchronic administration of oestradiol, ethinyloestradiol and oestradiol sulphamate on bile flow, bile acid excretion, and liver and biliary glutathione status in rats.

    abstract：:The cholestatic effect of the newly developed oestradiol sulphamate (J995) was compared with that of the natural oestrogen oestradiol (E) and of the cholestatic standard oestrogen ethinyloestradiol (EE). Female ovariectomized rats were orally treated for 7 days with oestrogen doses molar equivalent to 0.01, 0.1, 1, an...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s002040050409

    authors： Barth A,Elger W,Schneider B,Schwarz S

    更新日期：1997-01-01 00:00:00

  • Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans.

    abstract：:Acetaminophen (APAP) overdose is the leading cause of acute liver failure. Yet the mechanisms underlying adaptive tolerance toward APAP-induced liver injury are not fully understood. To better understand molecular mechanisms contributing to adaptive tolerance to APAP is an underpinning foundation for APAP-related prec...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-017-2090-y

    authors： Yu D,Wu L,Gill P,Tolleson WH,Chen S,Sun J,Knox B,Jin Y,Xiao W,Hong H,Wang Y,Ren Z,Guo L,Mei N,Guo Y,Yang X,Shi L,Chen Y,Zeng L,Dreval K,Tryndyak V,Pogribny I,Fang H,Shi T,McCullough S,Bhattacharyya S,S

    更新日期：2018-02-01 00:00:00

  • Occupational exposure to some synthetic pyrethroids (permethrin and fenvalerate).

    abstract：:In a two-step study on exposure control method for occupational handling of permethrin was developed. Air sampling on a filter can be used in case of exposure to permethrin in powder form. The detection limit is 0.001 mg/m3. If biological sampling is used, the acid metabolite moiety in the urine must be monitored. How...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF00569234

    authors： Kolmodin-Hedman B,Swensson A,Akerblom M

    更新日期：1982-05-01 00:00:00

  • Toxicokinetics of soman in cerebrospinal fluid and blood of anaesthetized pigs.

    abstract：:The toxicokinetics of the four stereoisomers of the nerve agent C(+/-)P(+/-)-soman was analysed in cerebrospinal fluid (CSF) and blood in anaesthetized, spontaneously breathing pigs during a 90-min period after injection of soman. The pigs were challenged with different intravenous (i.v.) doses of C(+/-)P(+/-)-soman c...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s002040050529

    authors： Göransson-Nyberg A,Fredriksson SA,Karlsson B,Lundström M,Cassel G

    更新日期：1998-07-01 00:00:00

  • Effect of bolesatine on phospholipid/calcium dependent protein kinase in Vero cells and in rat thymus.

    abstract：:Bolesatine, a glycoprotein from Boletus satanas Lenz, has previously been shown to be mitogenic to rat and human lymphocytes at very low concentrations, whereas higher concentrations inhibit protein synthesis in vitro and in several in vivo systems. The mechanism whereby this mitogenic activity occurs was previously u...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s002040050223

    authors： Ennamany R,Kretz O,Creppy EE

    更新日期：1995-01-01 00:00:00

  • Selective cytotoxicity associated with in vitro exposure of fresh rat renal fragments and continuous cell lines to atractyloside.

    abstract：:The consumption of plants containing the diterpenoid atractyloside (ATR) causes selective proximal tubule injury, renal failure and death in humans. We have compared the effects of ATR in freshly isolated renal proximal tubules and glomeruli from rat and also in cell lines: NRK, derived from the proximal tubules, and ...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s002040050362

    authors： Obatomi DK,Bach PH

    更新日期：1996-01-01 00:00:00

  • Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates.

    abstract：:Standard treatment of poisoning by organophosphates (OP) includes the administration of an antimuscarinic agent, e.g. atropine, and of an acetylcholinesterase (AChE) reactivator (oxime). The presently available oximes, obidoxime and pralidoxime (2-PAM), are considered to be insufficient for highly toxic OPs, e.g. sari...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-002-0375-1

    authors： Worek F,Reiter G,Eyer P,Szinicz L

    更新日期：2002-09-01 00:00:00

  • Irreversible protein binding of 14C-imipramine in rats in vivo.

    abstract：:Forty-eight hours after a single dose of 14C-imipramine to rats, 14C-radioactivity could be measured in the following organs: liver greater than kidney greater than serum greater than fat greater than spleen greater than duodenum greater than lung greater than muscle and brain. Liver microsomes contained the main part...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF00353357

    authors： Kappus H

    更新日期：1976-12-23 00:00:00

  • Maintenance of drug metabolism and transport functions in human precision-cut liver slices during prolonged incubation for 5 days.

    abstract：:Human precision-cut liver slices (hPCLS) are a valuable ex vivo model that can be used in acute toxicity studies. However, a rapid decline in metabolic enzyme activity limits their use in studies that require a prolonged xenobiotic exposure. The aim of the study was to extend the viability and function of hPCLS to 5 d...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-016-1865-x

    authors： Starokozhko V,Vatakuti S,Schievink B,Merema MT,Asplund A,Synnergren J,Aspegren A,Groothuis GMM

    更新日期：2017-05-01 00:00:00

  • St. John's wort treatment in women bears risks beyond pharmacokinetic drug interactions.

    abstract：:We analyzed adverse events in a clinical phase I trial to assess dose-dependent metabolic effects of St. John's wort co-administered with rifampicin in 12 healthy volunteers. Within 3-6 days after increasing the St. John's wort dose from 300 to 600 mg TID, five of six female participants developed ambient temperature-...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-015-1532-7

    authors： Hohmann N,Maus A,Carls A,Haefeli WE,Mikus G

    更新日期：2016-04-01 00:00:00

  • Genotype and allele frequencies of polymorphic CYP2E1 in the Turkish population.

    abstract：:Cytochrome P4502E1 (CYP2E1) gene shows genetic polymorphisms that vary markedly in frequency among different ethnic and racial groups. We studied the genotype distributions and allele frequencies of three CYP2E1 polymorphisms: CYP2E1*5B (RsaI/PstI RFLP, C-1053T/G-1293C SNP, rs2031920 /rs3813867), CYP2E1*6 (DraI RFLP, ...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-007-0200-y

    authors： Ulusoy G,Arinç E,Adali O

    更新日期：2007-10-01 00:00:00

  • Urinary trehalase as an early indicator of cadmium-induced renal tubular damage in rabbit.

    abstract：:The significance of urinary trehalase as a possible early indicator of renal disorder was examined using Cd-treated rabbits, which received 1 mg/kg Cd thrice weekly for 3 months subcutaneously. The results showed that urinary trehalase increased significantly from 1 week after treatment, earlier than LAP, ALP, protein...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF00290547

    authors： Nishimura N,Oshima H,Nakano M

    更新日期：1986-12-01 00:00:00

  • Serum carboxylesterase activity in various strains of rats: sensitivity to inhibition by CBDP (2-/o-cresyl/4H:1:3:2-benzodioxaphosphorin-2-oxide).

    abstract：:Rodents are relatively insensitive to the neurotoxic effects of various organophosphorus compounds. The purpose of this investigation was to determine if differences in inactivation of CBDP could explain the strain differences in the sensitivity to neurotoxicity following administration of TOCP (tri-o-cresyl phosphate...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF01973466

    authors： Clement JG,Erhardt N

    更新日期：1990-01-01 00:00:00

  • Dietary fructose as a risk factor for non-alcoholic fatty liver disease (NAFLD).

    abstract：:Glucose is a major energy source for the entire body, while fructose metabolism occurs mainly in the liver. Fructose consumption has increased over the last decade globally and is suspected to contribute to the increased incidence of non-alcoholic fatty liver disease (NAFLD). NAFLD is a manifestation of metabolic synd...

    journal_title：Archives of toxicology

    pub_type： 杂志文章,评审

    doi：10.1007/s00204-016-1892-7

    authors： Alwahsh SM,Gebhardt R

    更新日期：2017-04-01 00:00:00

  • Use of the dog as non-rodent test species in the safety testing schedule associated with the registration of crop and plant protection products (pesticides): present status.

    abstract：:The results from a survey of the expert information that is publicly accessible on the use of the dog as test species during the regulatory evaluation of agricultural chemicals and pesticides are reported. Methods that are being used or considered in order to reduce the number of dogs used for this purpose are describ...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-005-0678-0

    authors： Box RJ,Spielmann H

    更新日期：2005-11-01 00:00:00

  • Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum.

    abstract：:Trichloroethylene (TCE)-induced liver toxicity and carcinogenesis is believed to be mediated in part by activation of the peroxisome proliferator-activated receptor α (PPARα). However, the contribution of the two TCE metabolites, dichloroacetate (DCA) and trichloroacetate (TCA) to the toxicity of TCE, remains unclear....

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-013-1053-1

    authors： Fang ZZ,Krausz KW,Tanaka N,Li F,Qu A,Idle JR,Gonzalez FJ

    更新日期：2013-11-01 00:00:00

  • Induction of CYP2A5 by pyrazole and its derivatives in mouse primary hepatocytes.

    abstract：:Mouse liver CYP2A5 is induced by several structurally unrelated compounds. In intact mouse liver, pyrazole (PYR) and 4-hydroxypyrazole (4-OH) induce selectively the expression of CYP2A5 while expression of other CYPs is decreased. In this study we exposed mouse primary hepatocytes to PYR, 4-OH, 4-methylpyrazole (4Me; ...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s002040050511

    authors： Kojo A,Viitala P,Pasanen M,Pelkonen O,Raunio H,Juvonen R

    更新日期：1998-05-01 00:00:00

  • Interlaboratory comparison of total cytochrome P-450 and protein determinations in rat liver microsomes. Reinvestigation of assay conditions.

    abstract：:Assay conditions in determining total cytochrome P-450 in four laboratories were compared. Although the determination was derived from the original Omura and Sato method in each laboratory, the four standard protocols differed slightly, resulting in considerable differences in the results. Since the cytochrome P-450 c...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF00324544

    authors： Rutten AA,Falke HE,Catsburg JF,Topp R,Blaauboer BJ,van Holsteijn I,Doorn L,van Leeuwen FX

    更新日期：1987-01-01 00:00:00

  • Human variability in isoform-specific UDP-glucuronosyltransferases: markers of acute and chronic exposure, polymorphisms and uncertainty factors.

    abstract：:UDP-glucuronosyltransferases (UGTs) are involved in phase II conjugation reactions of xenobiotics and differences in their isoform activities result in interindividual kinetic differences of UGT probe substrates. Here, extensive literature searches were performed to identify probe substrates (14) for various UGT isofo...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-020-02765-8

    authors： Kasteel EEJ,Darney K,Kramer NI,Dorne JLCM,Lautz LS

    更新日期：2020-08-01 00:00:00

  • A genetic variant in miR-146a modifies colorectal cancer susceptibility in a Chinese population.

    abstract：:MicroRNAs (miRNAs) are a family of endogenous, small, noncoding RNA molecules that involved in a wide range of biological processes including differentiation, proliferation, and apoptosis. A polymorphism G>C (rs2910164) is located in the stem region opposite to the mature miR-146a sequence. In our study, we investigat...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-012-1004-2

    authors： Ma L,Zhu L,Gu D,Chu H,Tong N,Chen J,Zhang Z,Wang M

    更新日期：2013-05-01 00:00:00

  • The modified IL-8 Luc assay, an in vitro skin sensitisation test, can significantly improve the false-negative judgment of lipophilic sensitizers with logKow values > 3.5.

    abstract：:False-negative judgment due to poor chemical solubility is a problem with in vitro skin sensitisation tests. Water-insoluble chemicals are typically dissolved in DMSO in most sensitisation tests but precipitate when diluted with medium beyond their solubility in water. Such tests lack procedures to rule out false-nega...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-020-02934-9

    authors： Kimura Y,Fujimura C,Aiba S

    更新日期：2020-10-17 00:00:00

  • Distribution of bisphenol A and tetrabromobisphenol A in quail eggs, embryos and laying birds and studies on reproduction variables in adults following in ovo exposure.

    abstract：:In a previous study, we showed that bisphenol A (BPA) had oestrogen-like effects in bird embryos, causing malformations of the oviducts in Japanese quail (Coturnix japonica) and feminisation of the left testis in chicken (Gallus domesticus). In this study, uptake and distribution of BPA and tetrabromobisphenol A (TBBP...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s002040100277

    authors： Halldin K,Berg C,Bergman A,Brandt I,Brunström B

    更新日期：2001-12-01 00:00:00

  • Mutagenicity testing of organic extracts of diesel exhaust particles after spiking with polycyclic aromatic hydrocarbons (PAH).

    abstract：:In the present study, spiking was used as a strategy to evaluate the mutagenicity of individual compounds in a mixture. Mutagenicity of individual polycyclic aromatic hydrocarbons (PAH) was evaluated in an organic extract of diesel exhaust particles (DEP). The particles were extracted with dichloromethane (DCM). After...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s002040050555

    authors： Bostrøm E,Engen S,Eide I

    更新日期：1998-10-01 00:00:00

  • Embryo lethality and teratogenicity of a new fluoroquinolone antibacterial DW-116 in rats.

    abstract：:DW-116, 1-(5-fluoro-2-pyridyl)-6-fluoro-7-(4-methyl-l-piperazinyl)-1, 4-dihydro-4-oxoquinolone-3-carboxylic acid hydrochloride, is a newly developed fluoroquinolone antibacterial. The potential of DW-116 to induce developmental toxicity was, investigated in Sprague-Dawley rats. DW-116 was administered by gavage to pre...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s002040050662

    authors： Kim JC,Yun HI,Shin HC,Han SS,Chung MK

    更新日期：2000-04-01 00:00:00