Abstract:
:Forty-eight hours after a single dose of 14C-imipramine to rats, 14C-radioactivity could be measured in the following organs: liver greater than kidney greater than serum greater than fat greater than spleen greater than duodenum greater than lung greater than muscle and brain. Liver microsomes contained the main part of radioactivity derived from 14C-imipramine. After exhaustive extraction, only the proteins of liver, kidney, spleen, lung and serum contained measurable amounts of radioactive labeling. The greatest amount of 14C-imipramine irreversibly bound to proteins was detected in liver microsomes. The question, as to whether the irreversible protein binding of imipramine, if it occurs during therapy, results in toxic side-effects, is discussed.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Kappus Hdoi
10.1007/BF00353357keywords:
subject
Has Abstractpub_date
1976-12-23 00:00:00pages
75-80issue
1eissn
0340-5761issn
1432-0738journal_volume
37pub_type
杂志文章abstract::The elevations of blood urea nitrogen and serum creatinine caused by cis-platinum in rats can be prevented by a combination of procedures centered around the administration of sodium N-methyl-N-dithiocarboxyglucamine (NaG), before and very soon after the cis-platinum is administered in hypertonic (4.5%) saline. Elevat...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00316327
更新日期:1986-10-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00373398
更新日期:1982-07-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-005-0022-8
更新日期:2006-03-01 00:00:00
abstract::Many in the welding industry suffer from bronchitis, lung function changes, metal fume fever, and diseases related to respiratory damage. These phenomena are associated with welding fumes; however, the mechanism behind these findings remains to be elucidated. In this study, the lungs of cynomolgus monkeys were exposed...
journal_title:Archives of toxicology
pub_type: 杂志文章
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00347879
更新日期:1982-03-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050024
更新日期:1994-01-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00353240
更新日期:1975-02-14 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
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更新日期:2006-10-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
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更新日期:2020-10-27 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-003-0503-6
更新日期:2004-01-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-018-2376-8
更新日期:2019-03-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-016-1685-z
更新日期:2017-01-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1007/s00204-019-02387-9
更新日期:2019-03-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00351975
更新日期:1976-10-28 00:00:00
abstract::Tacrolimus (FK506) and cyclosporin A (CsA) are two potent immunosuppressants mainly metabolized by hepatic cytochrome P-450 3A (CYP3A) monooxygenase. The aim of this study was to compare the toxic effects of the two drugs on hepatocytes in primary culture as a function of their metabolism and to explore the variations...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050499
更新日期:1998-04-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01973308
更新日期:1993-01-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章,评审
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journal_title:Archives of toxicology
pub_type: 杂志文章
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更新日期:1995-01-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-019-02454-1
更新日期:2019-06-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-009-0482-3
更新日期:2010-02-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040100277
更新日期:2001-12-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00340977
更新日期:1986-02-01 00:00:00
abstract::Exposure to particulate matter (PM) has been related to the onset of adverse health effects including lung cancer, but the underlying molecular mechanisms are still under investigation. Epithelial-to-mesenchymal transition (EMT) is regarded as a crucial step in cancer progression. In a previous study, we reported EMT-...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-018-2259-z
更新日期:2018-09-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-016-1675-1
更新日期:2017-01-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050072
更新日期:1994-01-01 00:00:00
abstract::The object of this study was to compare the relative sensitivity of markers of exposure and effects in the lung of rats exposed to polymeric diphenyl-methane-4,4'-diisocyanate (pMDI) aerosol. Rats were repeatedly exposed to 12.9 mg pMDI/m(3) (6 h/day, 5 days/week for 14 days; exposure was from days 0--17 followed by a...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-001-0301-y
更新日期:2002-02-01 00:00:00