Abstract：
:Experimental manganese lymphadenopathy was produced by guinea pigs by intratracheal inoculation of manganese dioxide (50 mg/300 g body weight) and histopathologic changes in the tracheobronchial lymph nodes were studied up to 180 days. There was slow extracellular transport of manganese dust into the nodes, which did not provoke any significant reaction at early periods. However, at later periods the nodes exhibited a significant increase in the density of dust particles and the reaction consisted of phagocytosis, degeneration of dust laden macrophages, slight proliferation of fibroblasts, together with some reticulinosis corresponding to deposits of dust particles. The significance of these findings have been discussed from the chronic toxicity viewpoint.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Shanker R,Dogra RK,Sahu AP,Zaidi SHdoi
10.1007/BF00351975keywords:
subject
Has Abstractpub_date
1976-10-28 00:00:00pages
151-7issue
2eissn
0340-5761issn
1432-0738journal_volume
36pub_type
杂志文章abstract：:The highly directional maternal-to-fetal transfer of essential fatty acids (EFAs) across the placenta plays a critical role in guiding proper fetal development. Exposure to xenobiotics that may alter the fetal supply of EFAs/lipids could lead to fetal toxicity. Since the placenta is the first fetal arising organ that ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-005-0047-z
更新日期：2006-05-01 00:00:00
abstract：:People living in damp buildings are typically exposed to spore and mycelial fragments of the fungi that grow on damp building materials. There is experimental evidence that this exposure to triple-helical (1, 3)-β-D glucan and low molecular weight toxins may be associated with non-atopic asthma observed in damp and mo...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-013-1042-4
更新日期：2013-10-01 00:00:00
abstract：:Chronic ciprofibrate administration resulted in distinct differences in hepatic responses between the two species examined. In the rat, hepatomegaly was observed with the coordinate induction of carnitine acetyltransferase, peroxisomal beta-oxidation and cytochrome P450IVA1 activities. The latter induction of cytochro...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF02034935
更新日期：1991-01-01 00:00:00
abstract：:Pregnant mice administered per os during the days 1--3 (plug day = day 0) post conception (p.c.) with 375 mg 2,2'-dichlorobiphenyl/kilograms/day revealed on day 18 p.c. increased number of resorptions and doses up from 500 milligrams/kilograms/day led to a substantial retardation of the prenatal development. Based on ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00310329
更新日期：1978-08-09 00:00:00
abstract：:Intravenous administration of lead acetate to rabbits for 10 weeks at 2 week intervals resulted in significantly elevated blood lead levels, slight anemia with marked microspherocytosis and moderate basophilic stippling, and marked depression of red cell delta-aminolevulinic acid (ALA) dehydratase activity. However th...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00695874
更新日期：1979-10-01 00:00:00
abstract：:In order to study the mechanisms of acute n-hexane intoxication, the effects of n-hexane and its metabolites 2-hexanol, methyl-n-butyl ketone, 2,5-hexanediol and 2,5-hexanedione on the cloned voltage-operated potassium channels Kv1.1, Kv1.4, Kv2.1 and Kv3.4 were investigated with electrophysiological techniques in the...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050382
更新日期：1997-01-01 00:00:00
abstract：:Aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor, has been studied extensively in carcinogenesis through the genomic pathway. In recent years, AHR has also been reported to exert positive or negative effects on epithelial-mesenchymal transition (EMT), the crucial step in tumor malignant progres...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1870-0
更新日期：2017-05-01 00:00:00
abstract：:The present study was carried out to elucidate the mechanisms behind an increase in the incidence of malignant or multiple mammary tumors as a result of oral administration of rolipram in a 104-week carcinogenicity study. The organs and tissues of Sprague-Dawley (SD) rats of both sexes, which had been subjected to a 1...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-005-0016-6
更新日期：2006-02-01 00:00:00
abstract：:Melanin is a polyanionic pigment that colors, e.g., the hair, skin and eyes. The pigment neuromelanin is closely related to melanin and is mainly produced in specific neurons of the substantia nigra. Certain drugs and chemicals bind to melanin/neuromelanin and are retained in pigment cells for long periods. This speci...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-016-1757-0
更新日期：2016-08-01 00:00:00
abstract：:Mouse liver CYP2A5 is induced by several structurally unrelated compounds. In intact mouse liver, pyrazole (PYR) and 4-hydroxypyrazole (4-OH) induce selectively the expression of CYP2A5 while expression of other CYPs is decreased. In this study we exposed mouse primary hepatocytes to PYR, 4-OH, 4-methylpyrazole (4Me; ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050511
更新日期：1998-05-01 00:00:00
abstract：:pp'DDT (600 mg/kg, orally) produced an increase in the level of free ammonia and a decrease of acetylcholine in the corpus striatum of rats. These effects were maximal 5 h after the administration of pp'DDT. The animals showed tremors after 2 h, mild or moderate convulsions after 3.5 h and severe convulsions 5 h after...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00303292
更新日期：1980-05-01 00:00:00
abstract：:Several structurally different metal chelating agents were screened for their relative efficacy in counteracting acute manganese intoxication in mice. Polyaminocarboxylic acids with nitrogen and oxygen as metal binding sites were more effective than certain sulfhydryl chelating agents and common drugs in preventing mo...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00569233
更新日期：1982-05-01 00:00:00
abstract：:The inhibitory effect and mechanism of action of nicotinamide to paraquat toxicity were studied in male Sprague-Dawley rats. Proteins of submitochondrial particles (SMP), especially of mol. wt. 25-30 kDa, in rat lungs were destroyed by paraquat radicals, and aggregated protein bands approximately 100 kDa were observed...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050437
更新日期：1997-01-01 00:00:00
abstract：:The elevations of blood urea nitrogen and serum creatinine caused by cis-platinum in rats can be prevented by a combination of procedures centered around the administration of sodium N-methyl-N-dithiocarboxyglucamine (NaG), before and very soon after the cis-platinum is administered in hypertonic (4.5%) saline. Elevat...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00316327
更新日期：1986-10-01 00:00:00
abstract：:A recent intervention study demonstrated the occurrence of irilone as second most abundant isoflavone next to daidzein in human plasma after consumption of a red clover-based dietary supplement (RCDS) containing predominately formononetin ≫ biochanin A > irilone (12 % of these isoflavones). To elucidate the relevance ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-013-1114-5
更新日期：2014-02-01 00:00:00
abstract：:Gene expression analysis has been established as a tool for the characterization of genotoxic mechanisms of chemical mutagens. It has been suggested that expression analysis is capable of distinguishing compounds that cause DNA damage from those that interfere with mitotic spindle function. Formaldehyde (FA) is known ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-013-1060-2
更新日期：2013-11-01 00:00:00
abstract：:Engineered amorphous silica nanoparticles (nanosilica) are widely used in industry yet can induce adverse effects, which might be classified according to the oxidative stress model. However, the underlying mechanisms as well as the potential interactions of the three postulated different tiers of toxicity-i.e. oxidati...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2223-y
更新日期：2018-07-01 00:00:00
abstract：:Dulcin (DL), now banned, was once a widely used artificial sweetener. DL possesses an ureido group that is metabolized by direct glucuronidation in rabbit liver microsomes. Dulcin N-glucuronide (DNG) is the only type of ureido N-glucuronide known to date; ureido glucuronidation in humans has not been previously report...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0138-5
更新日期：2007-03-01 00:00:00
abstract：:Metabolic activation of the heterocyclic amine 3-amino -1,4-dimethyl-5 H-pyrido[4,3-b]indole (Trp-P-1) and 7-ethoxyresorufin O-deethylase (EROD) activity were examined in the chorioallantoic membrane (CAM) of 15-day-old chicken and 18-day-old eider duck embryos. The embryos were pretreated with an Ah receptor agonist,...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040000128
更新日期：2000-08-01 00:00:00
abstract：:Drugs may cause serotonin toxicity by a number of different mechanisms including inhibition of serotonin uptake and metabolism, increased serotonin synthesis and release, activation of serotonin receptors, and inhibition of cytochrome P450 oxidases. Some drug interactions involving opioids can increase intrasynaptic l...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-018-2244-6
更新日期：2018-08-01 00:00:00
abstract：:The effect of Co(NO3)2, CdSO4, NiSO4, ZnSO4, and HgCl2 (given repeatedly in subtoxic doses in the drinking water for 30 days) on rat liver monooxygenases was studied in experiments on male Wistar rats. The salts of Co, Cd, and Zn increased the activity of benzphetamine-N-demethylase, the content of cytochrome P-450 an...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00333421
更新日期：1985-01-01 00:00:00
abstract：:A number of studies have evaluated the possibility that stress-induced changes in blood-brain barrier permeability enhanced the central effects of the carbamate acetylcholinesterase inhibitor, pyridostigmine. We previously found relatively little evidence of stress-induced changes in the acute toxicity of pyridostigmi...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0144-7
更新日期：2007-04-01 00:00:00
abstract：:Garenoxacin is a des-F(6)-quinolone with a broad antibacterial spectrum, which has previously been shown to exhibit low chondrotoxicity in juvenile dogs compared with several other quinolones. A study was performed to determine whether the low chondrotoxicity observed in immature rats following garenoxacin treatment c...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-003-0514-3
更新日期：2004-02-01 00:00:00
abstract：:Acrylamide (AA) is a widely studied industrial chemical that is neurotoxic, mutagenic to somatic and germ cells, and carcinogenic in rodents. The recent discovery of AA at ppm levels in a wide variety of commonly consumed foods has energized research efforts worldwide to define toxicity and prevention. Metabolism and ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0109-x
更新日期：2006-12-01 00:00:00
abstract：:The present study was performed to investigate the potential toxic effects of prenatal exposure to 4-tert-octylphenol (OP) on liver, kidney, spleen, and hematologic parameters of male and female rats in adult life. The rats were treated with OP subcutaneously in utero at doses of control (vehicle, corn oil), 100 or 25...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-008-0354-2
更新日期：2009-04-01 00:00:00
abstract：:The effects of equimolar doses of the triphenylethylene antiestrogens tamoxifen and toremifene on female Sprague-Dawley rat liver were studied in a 52-week toxicity study which included a 13-week recovery period. Liver tumors were found in four out of five rats at the highest dose level of tamoxifen (45 mg/kg per day)...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF02072035
更新日期：1993-01-01 00:00:00
abstract：:This study was performed to assess the relation between occupational exposure to N,N-dimethylformamide after an 8 h work shift in the acrylic fibre industry and its three biological markers N-methylformamide (NMFtotal), N-acetyl-S-(N-methylcarbamoyl)cysteine (AMCC), and N-methylcarbamoyl adduct at haemoglobin (MCVal)....
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2219-7
更新日期：2018-07-01 00:00:00
abstract：:Di(2-ethylhexyl)phthalate (DEHP) and mono-(2-ethylhexyl)phthalate (MEHP) were administered PO or IP to pregnant ICR mice at varying doses on days 7, 8, and 9 of gestation. In groups given DEHP orally, resorptions and malformed fetuses increased significantly at 1,000 mg/kg. Fetal weights were also significantly suppre...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00295165
更新日期：1985-02-01 00:00:00
abstract：:The estimation of risk and evaluation of risk/benefit are traditionally and by necessity oriented at the current state of science and technology to ensure contemporary rights of safety. This demands a careful development in the methodology of hazard identification and risk assessment and its continuous updating and in...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/BF00296984
更新日期：1987-01-01 00:00:00
abstract：:Nanoparticles (NP) have a tendency to agglomerate after dispersion in physiological media, which can be prevented by the addition of serum. This may however result in modification of the toxic potential of particles due to the formation of protein corona. Our study aimed to analyze the role of serum that is added to i...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1673-3
更新日期：2017-01-01 00:00:00
