Abstract:
:Di(2-ethylhexyl)phthalate (DEHP) and mono-(2-ethylhexyl)phthalate (MEHP) were administered PO or IP to pregnant ICR mice at varying doses on days 7, 8, and 9 of gestation. In groups given DEHP orally, resorptions and malformed fetuses increased significantly at 1,000 mg/kg. Fetal weights were also significantly suppressed. Anterior neural tube defects (anencephaly and exencephaly) were the malformations most commonly produced. No teratogenic effects were revealed by IP doses of DEHP and PO or IP doses of MEHP, although high doses were abortifacient and lethal to pregnant females. Thus DEHP is highly embryotoxic and teratogenic in mice when given PO but not IP. The difference in metabolism, disposition, or excretion by the route of administration may be responsible for the difference in DEHP teratogenicity. Although MEHP is a principal metabolite of DEHP and is several times more toxic than DEHP to adult mice, it seems that MEHP and its metabolites are not teratogenic in ICR mice.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Shiota K,Mima Sdoi
10.1007/BF00295165subject
Has Abstractpub_date
1985-02-01 00:00:00pages
263-6issue
4eissn
0340-5761issn
1432-0738journal_volume
56pub_type
杂志文章abstract::Nine bispyridinium oximes containing two pyridinium rings linked by dimethylether were synthesised. Each compound had on one of the pyridinium rings a hydroxyiminomethyl group in position 2 or 4, while the other ring was unsubstituted or had a methyl or a hydroxyiminomethyl group in position 2 or 4. The reactivating p...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00296900
更新日期:1979-02-23 00:00:00
abstract::Bolesatine, a glycoprotein from Boletus satanas Lenz, has previously been shown to be mitogenic to rat and human lymphocytes at very low concentrations, whereas higher concentrations inhibit protein synthesis in vitro and in several in vivo systems. The mechanism whereby this mitogenic activity occurs was previously u...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050223
更新日期:1995-01-01 00:00:00
abstract::During aerobic incubation of trichloroethylene with rabbit liver microsomes and NADPH a difference absorption peak appears at 451-452 nm. Trichloroethylene does not form a ligand absorption spectrum with hepatic microsomes reduced by dithionite, or in anaerobic incubates in the presence of NADPH. Addition of trichloro...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00293858
更新日期:1977-06-18 00:00:00
abstract::To evaluate the developmental neurotoxicity of arsenic in offspring rats by transplacental and early life exposure to sodium arsenite in drinking water, the pregnant rats or lactating dams, and weaned pups were given free access to drinking water, which contained arsenic at concentrations of 0, 10, 50, 100 mg/L from G...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-009-0403-5
更新日期:2009-06-01 00:00:00
abstract::3-monochloropropane-1,2-diol (3-MCPD), a rat renal and testicular carcinogen, has been reported to occur in various foods and food ingredients as free or esterified forms. Since reports about toxicity of 3-MCPD esters are limited, we conducted a 13-week rat subchronic toxicity study of 3-MCPD esters (palmitate diester...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-013-1190-6
更新日期:2014-04-01 00:00:00
abstract::Reduced gluconeogenesis due to decreased activity of key gluconeogenic enzymes in liver, together with feed refusal, has been suggested to play an important role in 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD)-induced lethality in rats. This study was carried out to further analyse the toxicological significance of red...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050626
更新日期:1999-08-01 00:00:00
abstract::Targeted therapies against cancer have improved both survival and quality of life of patients. However, metabolic rewiring evokes cellular mechanisms that reduce therapeutic mightiness. Resistant cells generate more glutathione, elicit nuclear factor erythroid 2-related factor 2 (NRF2) activation, and overexpress many...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-020-02838-8
更新日期:2020-08-01 00:00:00
abstract::Breast cancer is the most commonly diagnosed malignancy in females, the etiology being multifactorial and includes the role of lifestyle exposure to DNA-damaging chemicals such as dietary carcinogens benzo (a) pyrene (BaP) and 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP). Both compounds require cytochrome...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-019-02558-8
更新日期:2019-10-01 00:00:00
abstract::A wide variety of immunosuppressive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in experimental animals has been documented. In contrast, the impact of dioxin on the human immune system remains controversial, although adverse health effects have been reported in humans after occupational or accidental exposu...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050072
更新日期:1994-01-01 00:00:00
abstract::Chronic ciprofibrate administration resulted in distinct differences in hepatic responses between the two species examined. In the rat, hepatomegaly was observed with the coordinate induction of carnitine acetyltransferase, peroxisomal beta-oxidation and cytochrome P450IVA1 activities. The latter induction of cytochro...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF02034935
更新日期:1991-01-01 00:00:00
abstract::The toxic effect of cyclophosphamide on the proliferative cell population of hair follicles plucked from the human scalp was examined by the in vivo nuclear aberration assay. Patients participating in an independent clinical trial received oral low dose cyclophosphamide, intravenous high dose cyclophosphamide or oral ...
journal_title:Archives of toxicology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01974396
更新日期:1990-01-01 00:00:00
abstract::This is with reference to the note of the Editor-in-Chief of the Archives of Toxicology. ...
journal_title:Archives of toxicology
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00204-018-2221-0
更新日期:2018-07-01 00:00:00
abstract::Cadmium chloride was administered by gavage to female rats 5 days a week for 5 weeks, then during mating and gestation periods at doses of 0.04, 0.4, and 4 mg Cd/kg/day. Treatment with cadmium neither affected the survival and fertility of females, nor produced overt fetotoxic effects. Fetal cadmium concentration was ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01234482
更新日期:1983-12-01 00:00:00
abstract::O,O,S-Trimethyl phosphorothioate (OOS-TMP) is known to induce unique symptoms, which are characterized by hypophagia, progressive weight loss, and hypothermia. To determine whether there is the possibility of a causal relationship between these toxic symptoms and a direct action of OOS-TMP on the central nervous syste...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050212
更新日期:1995-01-01 00:00:00
abstract::The protective effects of various chelating agents such as D-penicillamine (D-PEN), 2,3-dimercaptosuccinic acid (DMSA), 2,3-dimercaptopropane sulphonate (DMPS), and N-(2-mercapto-2-methylpropanoyl)-L-cysteine (bucillamine), on the renal damage induced by gold sodium thiomalate (AuTM) in rats were studied. Rats were in...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01973712
更新日期:1991-01-01 00:00:00
abstract::Garenoxacin is a des-F(6)-quinolone with a broad antibacterial spectrum, which has previously been shown to exhibit low chondrotoxicity in juvenile dogs compared with several other quinolones. A study was performed to determine whether the low chondrotoxicity observed in immature rats following garenoxacin treatment c...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-003-0514-3
更新日期:2004-02-01 00:00:00
abstract::Pregnant mice administered per os during the days 1--3 (plug day = day 0) post conception (p.c.) with 375 mg 2,2'-dichlorobiphenyl/kilograms/day revealed on day 18 p.c. increased number of resorptions and doses up from 500 milligrams/kilograms/day led to a substantial retardation of the prenatal development. Based on ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00310329
更新日期:1978-08-09 00:00:00
abstract::MicroRNAs (miRNAs) are a family of endogenous, small, noncoding RNA molecules that involved in a wide range of biological processes including differentiation, proliferation, and apoptosis. A polymorphism G>C (rs2910164) is located in the stem region opposite to the mature miR-146a sequence. In our study, we investigat...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-012-1004-2
更新日期:2013-05-01 00:00:00
abstract::4-Nonylphenol (para-nonylphenol, 4-NP), metabolites including linear and branched isoforms of nonylphenol (n-NP and t-NP, respectively), has been considered an endocrine disrupting substance resulting in reproductive dysfunction and increasing reactive oxygen species production in testis, liver, kidney, and brain. How...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-009-0447-6
更新日期:2009-10-01 00:00:00
abstract::Monolayers of L6 rat skeletal myoblast cells formed surface binding isotherms with the purified tobacco leaf glycoprotein TGP1 and the enriched cigarette tar glycoprotein TGP2. Scatchard analysis showed that the binding in the range of the limited concentrations tested was to a single class molecule and the calculated...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050151
更新日期:1995-01-01 00:00:00
abstract::Whether pregnancy-induced immunosuppression when combined with exposure to 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) could exacerbate immunotoxicity has not been previously investigated. The current study evaluated the immune status of C57BL/6 pregnant and virgin mice following exposure to TCDD. To this end, syngene...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-003-0538-8
更新日期:2004-05-01 00:00:00
abstract::The EU-EuroMix project adopted the strategy of the European Food Safety Authority (EFSA) for cumulative risk assessment, which limits the number of chemicals to consider in a mixture to those that induce a specific toxicological phenotype. These so-called cumulative assessment groups (CAGs) are refined at several leve...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-018-2320-y
更新日期:2018-12-01 00:00:00
abstract::To investigate the mechanism on photosensitive dermatitis caused by ketoprofen (KP) in humans, the following experiments were performed by topical application on guinea pigs. The phototoxicity study involving treatment with 10% solution of KP, its enantiomers (R-KP and S-KP), loxoprofen, and flurbiprofen revealed no p...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-006-0063-7
更新日期:2006-07-01 00:00:00
abstract::Several structurally different metal chelating agents were screened for their relative efficacy in counteracting acute manganese intoxication in mice. Polyaminocarboxylic acids with nitrogen and oxygen as metal binding sites were more effective than certain sulfhydryl chelating agents and common drugs in preventing mo...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00569233
更新日期:1982-05-01 00:00:00
abstract::The regional distribution of dopamine, norepinephrine and homovanillic acid was assessed in adult male rabbits exposed to styrene vapours. The turnover of dopamine and norepinephrine was also measured in several brain regions by the decay in endogenous catecholamines after inhibition of tyrosine hydroxylase by alpha-m...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00316123
更新日期:1984-09-01 00:00:00
abstract::The in ovo carcinogenicity assessing (IOCA) assay was used to examine the morphological changes in fetal turkey livers caused by the DNA-reactive carcinogen diethylnitrosamine (DEN). Fertilized turkey eggs were allocated into 3 groups: nondosed control (NDC), vehicle (water) control (VC) and DEN-dosed. At day 0, the f...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-010-0603-z
更新日期:2011-06-01 00:00:00
abstract::Assay conditions in determining total cytochrome P-450 in four laboratories were compared. Although the determination was derived from the original Omura and Sato method in each laboratory, the four standard protocols differed slightly, resulting in considerable differences in the results. Since the cytochrome P-450 c...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00324544
更新日期:1987-01-01 00:00:00
abstract::This review summarises the current state of knowledge regarding the physiology and control of production of thyroid hormones, the effects of chemicals in perturbing their synthesis and release that result in thyroid cancer. It does not consider the potential neurodevelopmental consequences of low thyroid hormones. The...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-020-02961-6
更新日期:2021-01-05 00:00:00
abstract::The reduction of 20 microM hexavalent chromium [chromium(VI)] by L-ascorbic acid (AsA) (0.06-2 mM) and/or glutathione (GSH) (2-15 mM) in buffer solutions, cell-free bronchoalveolar lavage fluids or soluble fractions of rat lungs was investigated at physiological pH (37 degrees C). The reduction in AsA solution was pse...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF02010721
更新日期:1990-01-01 00:00:00
abstract::The nephrotoxic action of aristolochic acid (AA) was investigated in female Wistar rats given single doses of 10, 50 or 100 mg/kg by gastric tube. Renal lesions developed within 3 days, the effect being dose-dependent. Histologically, there was evidence of necrosis of the epithelium of the renal tubules, and functiona...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01973700
更新日期:1993-01-01 00:00:00