当前位置： SCI文献检索 > ARCHIVES OF TOXICOLOGY期刊下所有文献 > Trenbolone growth promotant: covalent DNA binding in rat liver and in Salmonella typhimurium, and mutagenicity in the Ames test.

Trenbolone growth promotant: covalent DNA binding in rat liver and in Salmonella typhimurium, and mutagenicity in the Ames test.

Abstract：

:DNA binding in vivo: [6,7-3H]beta-trenbolone (beta-TBOH) was administered p.o. and i.p. to rats. After 8 or 16 h, DNA was isolated from the livers and purified to constant specific radioactivity. Enzymatic digestion to deoxyribonucleotides and separation by HPLC revealed about 90% of the DNA radioactivity eluting in the form of possible TBOH-nucleotide adducts. The extent of this genotoxicity, expressed in units of the Covalent Binding Index, CBI = (mumol TBOH bound per mol nucleotide)/(mmol TBOH administered per kg body weight) spanned from 8 to 17, i.e. was in the range found with weak genotoxic carcinogens. Ames test: low doses of beta-TBOH increased the number of revertants in Salmonella strain TA100 reproducibly and in a dose-dependent manner. The mutagenic potency was 0.2 revertants per nmol after preincubation of the bacteria (20 min at 37 degrees C) with doses between 30 and 60 micrograms per plate (47 and 94 micrograms/ml preincubation mixture). Above this dose, the number of revertants decreased to control values, accompanied by a reduction in survival. The addition of rat liver S9 inhibited the mutagenicity. DNA binding in vitro: calf thymus DNA was incubated with tritiated beta-TBOH with and without rat liver S9. Highest DNA radioactivities were determined in the absence of the "activation" system. Addition of inactive S9 (without cofactors) reduced the DNA binding by a factor of up to 20. Intermediate results were found with active S9. DNA binding in Salmonella: beta-TBOH was irreversibly bound to DNA isolated from S. typhimurium TA100 after incubation of bacteria with [3H]beta-TBOH.

journal_name

Arch Toxicol

journal_title

Archives of toxicology

authors

Lutz WK,Deuber R,Caviezel M,Sagelsdorff P,Friederich U,Schlatter C

doi

10.1007/BF00570127

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

103-9

issue

2-3

eissn

0340-5761

issn

1432-0738

journal_volume

62

pub_type

杂志文章

相关文献

ARCHIVES OF TOXICOLOGY文献大全
  • Exposure to multi-walled carbon nanotubes results in aggravation of airway inflammation and remodeling and in increased production of epithelium-derived innate cytokines in a mouse model of asthma.

    abstract：:With the development of nanotechnologies, the potential adverse effects of nanomaterials such as multi-walled carbon nanotubes (MWCNT) on the respiratory tract of asthmatics are questioned. Furthermore, investigations are necessary to understand how these effects might arise. In the present study, we hypothesized that...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-013-1116-3

    authors： Ronzani C,Casset A,Pons F

    更新日期：2014-02-01 00:00:00

  • Activation of autophagic flux and the Nrf2/ARE signaling pathway by hydrogen sulfide protects against acrylonitrile-induced neurotoxicity in primary rat astrocytes.

    abstract：:Hydrogen sulfide (H2S), the third gasotransmitter, has been shown to act as a neuroprotective factor in numerous pathological processes; however, its underlying mechanism(s) of action remain unclear. It is widely accepted that activation of moderate autophagy and the Nrf2/ARE signaling pathway play important roles in ...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-018-2208-x

    authors： Yang B,Bai Y,Yin C,Qian H,Xing G,Wang S,Li F,Bian J,Aschner M,Lu R

    更新日期：2018-06-01 00:00:00

  • Epigenetic properties of the diarrhetic marine toxin okadaic acid: inhibition of the gap junctional intercellular communication in a human intestine epithelial cell line.

    abstract：:Okadaic acid (OA) is produced by several types of dinoflagellates (marine plankton) and has been implicated as the causative agent of diarrhetic shellfish syndrome. Previous studies have shown that okadaic acid is a tumor promoter and a specific potent inhibitor of protein phosphatases and protein synthesis. These eff...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-003-0460-0

    authors： Traoré A,Baudrimont I,Dano S,Sanni A,Larondelle Y,Schneider YJ,Creppy EE

    更新日期：2003-11-01 00:00:00

  • Deficit in learning and memory of rats with chronic fluorosis correlates with the decreased expressions of M1 and M3 muscarinic acetylcholine receptors.

    abstract：:To reveal the molecular mechanism of deficit in learning and memory induced by chronic fluorosis, the expression of muscarinic acetylcholine receptors (mAChRs) and oxidative stress were investigated. Sixty Sprague-Dawley (SD) rats were divided randomly into two groups (30 cases in each), i.e., the control group (<0.5 ...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-014-1408-2

    authors： Dong YT,Wang Y,Wei N,Zhang QF,Guan ZZ

    更新日期：2015-11-01 00:00:00

  • Quinolone-induced cartilage lesions are not reversible in rats.

    abstract：:The reversibility of quinolone-induced cartilage lesions has not been studied in detail. We treated five groups of five to seven juvenile Wistar rats (male and female; age: 5 weeks) with 2 x 600 mg ofloxacin/kg by gastric intubation on 1 day only (9:00 a.m. and 5:00 p.m.) and studied the knee joints histologically 3 d...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s002040050301

    authors： Förster C,Kociok K,Shakibaei M,Merker HJ,Stahlmann R

    更新日期：1996-01-01 00:00:00

  • Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells.

    abstract：:Etoposide (ETP) and anthracyclines are applied for wide anti-cancer treatments. However, the ETP-induced cardiotoxicity remains to be a major safety issue and the underlying cardiotoxic mechanisms are not well understood. This study is aiming to unravel the cardiotoxicity profile of ETP in comparison to anthracyclines...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-018-2170-7

    authors： Nemade H,Chaudhari U,Acharya A,Hescheler J,Hengstler JG,Papadopoulos S,Sachinidis A

    更新日期：2018-04-01 00:00:00

  • Chemical-induced contact allergy: from mechanistic understanding to risk prevention.

    abstract：:Chemical allergens are small molecules able to form a sensitizing complex once they bound to proteins. One of the most frequent manifestations of chemical allergy is contact hypersensitivity, which can have serious impact on quality of life. Allergic contact dermatitis is a predominantly CD8 + T cell-mediated immune d...

    journal_title：Archives of toxicology

    pub_type： 杂志文章,评审

    doi：10.1007/s00204-018-2283-z

    authors： Corsini E,Engin AB,Neagu M,Galbiati V,Nikitovic D,Tzanakakis G,Tsatsakis AM

    更新日期：2018-10-01 00:00:00

  • FK506 (Tacrolimus) decreases the cytotoxicity of cyclosporin A in rat hepatocytes in primary culture: implication of CYP3A induction.

    abstract：:Tacrolimus (FK506) and cyclosporin A (CsA) are two potent immunosuppressants mainly metabolized by hepatic cytochrome P-450 3A (CYP3A) monooxygenase. The aim of this study was to compare the toxic effects of the two drugs on hepatocytes in primary culture as a function of their metabolism and to explore the variations...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s002040050499

    authors： Ellouk-Achard S,Martin C,Duc HT,Dutertre-Catella H,Thevenin M,Warnet JM,Claude JR

    更新日期：1998-04-01 00:00:00

  • Effects of bisphenol A on breast cancer and its risk factors.

    abstract：:The incidence of breast cancer in Korea has been increasing for the last two decades (1983-2005), and now, breast cancer is ranked the leading cause of cancer in Korean women. Along with other endocrine disrupting chemicals (EDCs), bisphenol A (BPA) has been suspected as a potential risk factor for breast cancer. We s...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-008-0364-0

    authors： Yang M,Ryu JH,Jeon R,Kang D,Yoo KY

    更新日期：2009-03-01 00:00:00

  • Silver nanoparticles induce apoptosis and G2/M arrest via PKCζ-dependent signaling in A549 lung cells.

    abstract：:The use of silver nanoparticles is one of the fastest growing product categories in the nanotechnology industry, with a focus on antimicrobial activity. However, thus far, toxicity data for silver nanoparticles are limited. In this study, we investigated the cytotoxic effects of silver nanoparticles (Ag NPs) and the p...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-011-0714-1

    authors： Lee YS,Kim DW,Lee YH,Oh JH,Yoon S,Choi MS,Lee SK,Kim JW,Lee K,Song CW

    更新日期：2011-12-01 00:00:00

  • New insights into the organ-specific adverse effects of fumonisin B1: comparison between lung and liver.

    abstract：:Fumonisin B1 (FB1) is a well-known inhibitor of de novo sphingolipid biosynthesis, due to its ability to inhibit ceramide synthases (CerS) activity. In mammals, this toxin triggers broad clinical symptoms with multi-organ dysfunction such as hepatotoxicity or pulmonary edema. The molecular mechanism of CerS inhibition...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-014-1323-6

    authors： Loiseau N,Polizzi A,Dupuy A,Therville N,Rakotonirainy M,Loy J,Viadere JL,Cossalter AM,Bailly JD,Puel O,Kolf-Clauw M,Bertrand-Michel J,Levade T,Guillou H,Oswald IP

    更新日期：2015-09-01 00:00:00

  • Quantification of tetrabromo benzoic acid and tetrabromo phthalic acid in rats exposed to the flame retardant Uniplex FPR-45.

    abstract：:The first withdrawal of certain polybrominated diphenyl ethers flame retardants from the US market occurred in 2004. Since then, use of brominated non-PBDE compounds such as bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate (BEH-TEBP) and 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB) in commercial formulations has incr...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-015-1489-6

    authors： Silva MJ,Hilton D,Furr J,Gray LE,Preau JL,Calafat AM,Ye X

    更新日期：2016-03-01 00:00:00

  • Modifications of liver bile acids pool during modulation of rat hepatocarcinogenesis by phenobarbital and nafenopin.

    abstract：:As previously demonstrated, chronic administration of phenobarbital (0.05% in the drinking water) and of nafenopin (0.1% in the diet) increases the incidence and the kinetics of appearance of liver cancers. If bile acids play a key role in liver carcinogenesis, it might thus be expected that treatments like phenobarbi...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s002040050087

    authors： Delzenne NM,Taper HS,Roberfroid M

    更新日期：1994-01-01 00:00:00

  • [Delayed implantation and early developmental defects in the mouse caused by PCB: 2,2'-dichlorobiphenyl (author's transl)].

    abstract：:Pregnant mice administered per os during the days 1--3 (plug day = day 0) post conception (p.c.) with 375 mg 2,2'-dichlorobiphenyl/kilograms/day revealed on day 18 p.c. increased number of resorptions and doses up from 500 milligrams/kilograms/day led to a substantial retardation of the prenatal development. Based on ...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF00310329

    authors： Török P

    更新日期：1978-08-09 00:00:00

  • The role of SerpinB2 in human bronchial epithelial cells responses to particulate matter exposure.

    abstract：:Exposure to particulate matter (PM) has been related to the onset of adverse health effects including lung cancer, but the underlying molecular mechanisms are still under investigation. Epithelial-to-mesenchymal transition (EMT) is regarded as a crucial step in cancer progression. In a previous study, we reported EMT-...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-018-2259-z

    authors： Longhin E,Camatini M,Bersaas A,Mantecca P,Mollerup S

    更新日期：2018-09-01 00:00:00

  • Standardisation of defined approaches for skin sensitisation testing to support regulatory use and international adoption: position of the International Cooperation on Alternative Test Methods.

    abstract：:Skin sensitisation is the regulatory endpoint that has been at the centre of concerted efforts to replace animal testing in recent years, as demonstrated by the Organisation for Economic Co-operation and Development (OECD) adoption of five non-animal methods addressing mechanisms under the first three key events of th...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-017-2097-4

    authors： Casati S,Aschberger K,Barroso J,Casey W,Delgado I,Kim TS,Kleinstreuer N,Kojima H,Lee JK,Lowit A,Park HK,Régimbald-Krnel MJ,Strickland J,Whelan M,Yang Y,Zuang V

    更新日期：2018-02-01 00:00:00

  • Dietary fructose as a risk factor for non-alcoholic fatty liver disease (NAFLD).

    abstract：:Glucose is a major energy source for the entire body, while fructose metabolism occurs mainly in the liver. Fructose consumption has increased over the last decade globally and is suspected to contribute to the increased incidence of non-alcoholic fatty liver disease (NAFLD). NAFLD is a manifestation of metabolic synd...

    journal_title：Archives of toxicology

    pub_type： 杂志文章,评审

    doi：10.1007/s00204-016-1892-7

    authors： Alwahsh SM,Gebhardt R

    更新日期：2017-04-01 00:00:00

  • Human liver debrisoquine 4-hydroxylase: test for specificity toward various monooxygenase substrates and model of the active site.

    abstract：:Polyclonal antibodies raised toward a debrisoquine 4-hydroxylating cytochrome P-450 species purified from rat liver (P-450UT-A) were used to determine which monooxygenase reactions are linked to debrisoquine hydroxylation in human liver. Anti P-450UT-A did not inhibit the oxidation of dimethylnitrosamine, morphine, di...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF00296955

    authors： Wolff T,Distlerath LM,Worthington MT,Guengerich FP

    更新日期：1987-01-01 00:00:00

  • Commentary to Gebel 2012: A quantitative review should apply meta-analytical methods-and this applies also to quantitative toxicological reviews.

    abstract：:Gebel (In Arch Toxicol 87(5):923-924, 2013) replied to my Letter to the Editor (Morfeld in Arch Toxicol 87(5):921, 2013) in which I criticized the quantitative review of inhalation rat studies on the association of granular biopersistent dust exposures and lung cancer risk (Gebel in Arch Toxicol 86(7):995-1007, 2012)....

    journal_title：Archives of toxicology

    pub_type： 评论,信件

    doi：10.1007/s00204-013-1138-x

    authors： Morfeld P

    更新日期：2013-11-01 00:00:00

  • Overdose toxicity studies versus threshold: elements of biology must be incorporated into risk assessment.

    abstract：:The estimation of risk and evaluation of risk/benefit are traditionally and by necessity oriented at the current state of science and technology to ensure contemporary rights of safety. This demands a careful development in the methodology of hazard identification and risk assessment and its continuous updating and in...

    journal_title：Archives of toxicology

    pub_type： 杂志文章,评审

    doi：10.1007/BF00296984

    authors： Hildebrandt AG

    更新日期：1987-01-01 00:00:00

  • Biochemical and toxicological effects of short-term, intermittent xylene inhalation exposure and combined ethanol intake.

    abstract：:Intermittent inhalation of 300 ppm of xylene vapour 6 h daily for 2 weeks caused a marked accumulation of the solvent in the perirenal fat. Simultaneous ethanol ingestion reduced the solvent load significantly although the perirenal xylene concentration increased in both test groups between the first and second week o...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF00354091

    authors： Savolainen H,Vainio H,Helojoki M,Elovaara E

    更新日期：1978-12-28 00:00:00

  • Precision toxicology based on single cell sequencing: an evolving trend in toxicological evaluations and mechanism exploration.

    abstract：:In this review, we introduce a new concept, precision toxicology: the mode of action of chemical- or drug-induced toxicity can be sensitively and specifically investigated by isolating a small group of cells or even a single cell with typical phenotype of interest followed by a single cell sequencing-based analysis. P...

    journal_title：Archives of toxicology

    pub_type： 杂志文章,评审

    doi：10.1007/s00204-017-1971-4

    authors： Zhang B,Huang K,Zhu L,Luo Y,Xu W

    更新日期：2017-07-01 00:00:00

  • Interlaboratory comparison of total cytochrome P-450 and protein determinations in rat liver microsomes. Reinvestigation of assay conditions.

    abstract：:Assay conditions in determining total cytochrome P-450 in four laboratories were compared. Although the determination was derived from the original Omura and Sato method in each laboratory, the four standard protocols differed slightly, resulting in considerable differences in the results. Since the cytochrome P-450 c...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF00324544

    authors： Rutten AA,Falke HE,Catsburg JF,Topp R,Blaauboer BJ,van Holsteijn I,Doorn L,van Leeuwen FX

    更新日期：1987-01-01 00:00:00

  • [Cardiotoxicity of bromethylbutyramide (carbromide) (author's transl)].

    abstract：:Bromethylbutyramide (Carbromide), a quantitatively important metabolite of carbromal, diminished the contractility of electrically driven and the frequency of spontaneously beating guinea-pig atria. The negative inotropic action of bromethylbutyramide occurred at concentrations which are reached in human carbromal poi...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF01891970

    authors： Strubelt O

    更新日期：1978-04-27 00:00:00

  • Selective cytotoxicity associated with in vitro exposure of fresh rat renal fragments and continuous cell lines to atractyloside.

    abstract：:The consumption of plants containing the diterpenoid atractyloside (ATR) causes selective proximal tubule injury, renal failure and death in humans. We have compared the effects of ATR in freshly isolated renal proximal tubules and glomeruli from rat and also in cell lines: NRK, derived from the proximal tubules, and ...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s002040050362

    authors： Obatomi DK,Bach PH

    更新日期：1996-01-01 00:00:00

  • Effect of bolesatine on phospholipid/calcium dependent protein kinase in Vero cells and in rat thymus.

    abstract：:Bolesatine, a glycoprotein from Boletus satanas Lenz, has previously been shown to be mitogenic to rat and human lymphocytes at very low concentrations, whereas higher concentrations inhibit protein synthesis in vitro and in several in vivo systems. The mechanism whereby this mitogenic activity occurs was previously u...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s002040050223

    authors： Ennamany R,Kretz O,Creppy EE

    更新日期：1995-01-01 00:00:00

  • Association between polymorphism of GSTP1, GSTT1, GSTM1 and CYP2E1 genes and susceptibility to benzene-induced hematotoxicity.

    abstract：:Occupational exposure to benzene has been associated with leukemia, anemia, leukopenia, and thrombocytopenia. Genetic susceptibility to benzene toxicity in humans may be related to variations in benzene metabolizing genes. The main objective of this study was to ascertain whether polymorphism of GSTP1, GSTM1, GSTT1 an...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-017-2104-9

    authors： Nourozi MA,Neghab M,Bazzaz JT,Nejat S,Mansoori Y,Shahtaheri SJ

    更新日期：2018-06-01 00:00:00

  • Correction to: Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models.

    abstract：:This article is published with the incorrect copyright holder name in the HTML article as "© Springer 2018". The correct copyright line should read "The Author(s) 2018" (as it appears in the article PDF). ...

    journal_title：Archives of toxicology

    pub_type： 杂志文章,已发布勘误

    doi：10.1007/s00204-018-2301-1

    authors： Oesch F,Fabian E,Landsiedel R

    更新日期：2018-11-01 00:00:00

  • Dose-response of promotion by polychlorinated biphenyls and chloroform in rat liver foci bioassay.

    abstract：:Using the rat liver foci bioassay a dose-response relationship was evaluated for the promoting activity of the ubiquitous and persistent environmental pollutants polychlorinated biphenyls (PCBs) and chloroform. Initiation of liver foci was performed by oral administration of a single dose of 8 mg/kg body wt of diethyl...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF00296982

    authors： Deml E,Oesterle D

    更新日期：1987-01-01 00:00:00

  • Maintenance of drug metabolism and transport functions in human precision-cut liver slices during prolonged incubation for 5 days.

    abstract：:Human precision-cut liver slices (hPCLS) are a valuable ex vivo model that can be used in acute toxicity studies. However, a rapid decline in metabolic enzyme activity limits their use in studies that require a prolonged xenobiotic exposure. The aim of the study was to extend the viability and function of hPCLS to 5 d...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-016-1865-x

    authors： Starokozhko V,Vatakuti S,Schievink B,Merema MT,Asplund A,Synnergren J,Aspegren A,Groothuis GMM

    更新日期：2017-05-01 00:00:00