Abstract：
:The effect of isosorbide diuresis on gentamicin excretion and tissue accumulation as well as gentamicin-induced histopathologic changes in renal tissue were examine in rats. Gentamicin (30, 60, 120, 160 mg/kg) was administered s.c. for 10 consecutive days with or without isosorbide pretreatment. Osmotic diuresis with isosorbide did not significantly reduce the dose-dependent extent of gentamicin accumulation in renal tissues in comparison to nondiuresed rats. Although the urinary concentration of gentamicin was reduced in the diuresed animals, total gentamicin excretion remained unaffected. In addition, diuresis altered neither the renal excretion of the proximal tubular cell marker enzyme, N-acetyl-B-glucosaminidase, nor the severity of pathologic damage as determined by light microscopic examination of renal tissues. It appears that osmotically-induced diuresis alone is insufficient to prevent or significantly reduce gentamicin nephrotoxicity in rats. This is in contrast to other forms of diuretic therapy, such as furosemide, which have been shown to effectively reduce renal accumulation and resultant renal toxicity of aminoglycoside administration.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Newman RA,Weinstock LB,Gump DW,Hacker MP,Yates JWdoi
10.1007/BF02419001subject
Has Abstractpub_date
1980-09-01 00:00:00pages
213-21issue
3eissn
0340-5761issn
1432-0738journal_volume
45pub_type
杂志文章abstract：:The development and application of high throughput in vitro assays is an important development for risk assessment in the twenty-first century. However, there are still significant challenges to incorporate in vitro assays into routine toxicity testing practices. In this paper, a robust learning approach was developed...
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更新日期：2018-03-01 00:00:00
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更新日期：1980-05-01 00:00:00
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更新日期：2017-09-01 00:00:00
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