Comparative hepatotoxicity and metabolism of N-methylformamide in rats and mice.

abstract：:5-Hydroxymethylfurfural (HMF) and furfuryl alcohol (FFA) are moderately potent rodent carcinogens that are present in thermally processed foodstuffs. The carcinogenic effects were hypothesized to originate from sulfotransferase (SULT)-mediated bioactivation yielding DNA-reactive and mutagenic sulfate esters, a confirm...

journal_title：Archives of toxicology

authors： Sachse B,Meinl W,Sommer Y,Glatt H,Seidel A,Monien BH

更新日期：2016-01-01 00:00:00

abstract：:Chalepensin, a furanocoumarin, is present in several medicinal Rutaceae plants and causes a mechanism-based inhibition of human and mouse cytochrome P450 (P450, CYP) 2A in vitro. To address the in vivo effect, we investigated the effects of chalepensin on multiple hepatic P450 enzymes in C57BL/6JNarl mice. Oral admini...

journal_title：Archives of toxicology

authors： Lo WS,Lim YP,Chen CC,Hsu CC,Souček P,Yun CH,Xie W,Ueng YF

更新日期：2012-12-01 00:00:00

abstract：:The use of new psychoactive substances (NPSs) as a substitute for illegal drugs is increasing rapidly and is a serious threat to public health. 25C-NBF is a newly synthesized phenethylamine-type NPS that acts as a 5-hydroxyindoleacetic acid (5-HT) receptor agonist, but little is known about its pharmacological effects...

journal_title：Archives of toxicology

authors： Hur KH,Kim SE,Lee BR,Ko YH,Seo JY,Kim SK,Ma SX,Kim YJ,Jeong Y,Pham DT,Trinh QD,Shin EJ,Kim HC,Lee YS,Lee SY,Jang CG

更新日期：2020-07-01 00:00:00

abstract：:Insulin-exposed rat mammary cancer cells were flow sorted based on a c-myc reporter plasmid encoding a destabilized green fluorescent protein. Sorted cells exhibited gradual increases in c-myc levels. Cells overexpressing c-myc by only 10% exhibited phenotypic changes attributable to c-myc overexpression, such as cell...

journal_title：Archives of toxicology

authors： Knudsen KJ,Nelander Holm GM,Krabbe JS,Listov-Saabye N,Kiehr B,Dufva M,Svendsen JE,Oleksiewicz MB

更新日期：2009-12-01 00:00:00

abstract：:The aim was to study the long-term response in the olfactory mucosa of NMRI mice after exposure to the olfactory toxicants dichlobenil (a herbicide) or methimazole (an antithyroid drug). Three and six months after exposure to dichlobenil (2x or 1 x 25 mg/kg i.p.), the dorsomedial part of the olfactory region showed a ...

journal_title：Archives of toxicology

authors： Bergman U,Ostergren A,Gustafson AL,Brittebo B

更新日期：2002-03-01 00:00:00

abstract：:The mycotoxins altertoxin I and II (ATX I and II) are secondary metabolites produced by Alternaria alternata fungi and may occur as food and feed contaminants, especially after long storage periods. Although the toxic potential of altertoxins has been previously investigated, little is known about the pathways that pl...

journal_title：Archives of toxicology

authors： Jarolim K,Del Favero G,Pahlke G,Dostal V,Zimmermann K,Heiss E,Ellmer D,Stark TD,Hofmann T,Marko D

更新日期：2017-01-01 00:00:00

abstract：:To explain the mechanism of renal injury caused by liver ischemia-reperfusion, we investigated biochemical and morphological changes in the liver and kidney in rats. After reperfusion following 60 min of liver ischemia, numerous changes were found. The level of serum transaminases and lipid peroxide formation in the l...

journal_title：Archives of toxicology

authors： Kudo Y,Egashira T,Takayama F,Yamanaka Y,Shimada T

更新日期：1993-01-01 00:00:00

abstract：:In the present study the toxicological potential of a tumor-inhibiting dinuclear platinum(II) complex (bis(acetato)diammine-bis-micro-acetato diplatinum(II) dihydrate (BAP)) was evaluated, utilizing in vitro models of nephrotoxicity, myelosuppression and neurotoxicity. Regarding the discrepancies between the hallmark ...

journal_title：Archives of toxicology

authors： Momekov G,Ferdinandov D,Bakalova A,Zaharieva M,Konstantinov S,Karaivanova M

更新日期：2006-09-01 00:00:00

abstract：:To clarify whether oxidative stress is involved in the development of hepatocellular preneoplastic foci induced by fenofibrate (FF), a peroxisome proliferator-activated receptor alpha agonist, male F344/N rats were fed a diet containing 6,000, 3,000, or 0 ppm of FF for 13 weeks after N-diethylnitrosamine initiation. T...

journal_title：Archives of toxicology

authors： Nishimura J,Dewa Y,Okamura T,Muguruma M,Jin M,Saegusa Y,Umemura T,Mitsumori K

更新日期：2008-09-01 00:00:00

abstract：:Several structurally different metal chelating agents were screened for their relative efficacy in counteracting acute manganese intoxication in mice. Polyaminocarboxylic acids with nitrogen and oxygen as metal binding sites were more effective than certain sulfhydryl chelating agents and common drugs in preventing mo...

journal_title：Archives of toxicology

authors： Tandon SK,Khandelwal S

更新日期：1982-05-01 00:00:00

abstract：:A number of studies have evaluated the possibility that stress-induced changes in blood-brain barrier permeability enhanced the central effects of the carbamate acetylcholinesterase inhibitor, pyridostigmine. We previously found relatively little evidence of stress-induced changes in the acute toxicity of pyridostigmi...

journal_title：Archives of toxicology

authors： Baireddy P,Mirajkar N,Nallapaneni A,Singleton N,Pope CN

更新日期：2007-04-01 00:00:00

abstract：:The ethylene oxide adduct formed on the N-terminal valine in haemoglobin was investigated as a biological monitor of tobacco smoke intake. The modified method developed for the determination of the hydroxyethylvaline adduct (HOEtVal) involved reaction of globin with pentafluorophenyl isothiocyanate, extraction of the ...

journal_title：Archives of toxicology

authors： Bailey E,Brooks AG,Dollery CT,Farmer PB,Passingham BJ,Sleightholm MA,Yates DW

更新日期：1988-01-01 00:00:00

abstract：:As a potential endocrine disruptor, tris(2,3-dibromopropyl) isocyanurate (TBC) has previously been demonstrated to reduce expression of estrogen-dependent vitellogenin (vtg) mRNA in adult zebrafish. However, the underlying toxicity pathways and molecular mechanisms involved in TBC-induced endocrine disruption remain e...

journal_title：Archives of toxicology

authors： Cao H,Li X,Zhang W,Wang L,Pan Y,Zhou Z,Chen M,Zhang A,Liang Y,Song M

更新日期：2018-04-01 00:00:00

abstract：:The use of nanotechnology is increasing exponentially, whereas the possible adverse health effects of engineered nanoparticles (NPs) are so far less known. Standardized mouse bioassay was used to study sensory and pulmonary irritation, airflow limitation, and inflammation potency of nanosized TiO(2). Single exposure (...

journal_title：Archives of toxicology

authors： Leppänen M,Korpi A,Miettinen M,Leskinen J,Torvela T,Rossi EM,Vanhala E,Wolff H,Alenius H,Kosma VM,Joutsensaari J,Jokiniemi J,Pasanen P

更新日期：2011-07-01 00:00:00

abstract：:Sexual differentiation in the brain takes place from late gestation to the early postnatal days. This is dependent on the conversion of circulating testosterone into estradiol by the enzyme aromatase. The glyphosate was shown to alter aromatase activity and decrease serum testosterone concentrations. Thus, the aim of ...

journal_title：Archives of toxicology

authors： Romano MA,Romano RM,Santos LD,Wisniewski P,Campos DA,de Souza PB,Viau P,Bernardi MM,Nunes MT,de Oliveira CA

更新日期：2012-04-01 00:00:00

abstract：:The evaluation of developmental and reproductive toxicity of food contact materials (FCMs) is an important task for food safety. Since traditional experiments are both time-consuming and labor-intensive, only a small number of FCMs have sufficient toxicological data for evaluating their effects on human health. While ...

journal_title：Archives of toxicology

authors： Tung CW,Cheng HJ,Wang CC,Wang SS,Lin P

更新日期：2020-02-01 00:00:00

abstract：:The present experiments were performed to test the possibility of interrupting the enterohepatic circulation of arsenic (As). Therefore the efficacy of adsorbents to bind As and/or As-DMPS adducts in vitro and their effect on the excretion of As into the feces and urine in vivo were investigated after injection of As2...

journal_title：Archives of toxicology

authors： Reichl FX,Hunder G,Liebl B,Fichtl B,Forth W

更新日期：1995-01-01 00:00:00

abstract：:The effect of acute and chronic cadmium administration on hepatic drug metabolism was investigated in the male rat. 3 days after the acute administration of cadmium by either the intraperitoneal (0.84 mg Cd/kg) or the oral (greater than 80 mg Cd/kg) route, there was a significant potentiation in duration of hexobarbit...

journal_title：Archives of toxicology

authors： Schnell RC,Yuhas EM,Pence DH,Means JR,Roberts SA,Yau ET,Miya TS,Mennear JH

更新日期：1978-08-09 00:00:00

abstract：:The tetrahydroxylated biphenyl-ketone 2,2',4,4'-tetrahydroxybenzophenone (BP2), one of twelve benzophenone-derived UV-filters, is used in cosmetic products and in packaging materials to protect these products from light induced damage. Recently published studies showed that BP2 exerts estrogenic activity; thus, it is ...

journal_title：Archives of toxicology

authors： Schlecht C,Klammer H,Wuttke W,Jarry H

更新日期：2006-10-01 00:00:00

abstract：:Acetaminophen (APAP) is a widely-used analgesic and a known hepatotoxic agent. Vascular endothelial growth factor (VEGF) is a growth factor with multiple functional roles. VEGF plays an important role in angiogenesis and hepatic regeneration. The aim of this study was to determine the expression of VEGF isoforms and i...

journal_title：Archives of toxicology

authors： Papastefanou VP,Bozas E,Mykoniatis MG,Grypioti A,Garyfallidis S,Bartsocas CS,Nicolopoulou-Stamati P

更新日期：2007-10-01 00:00:00

abstract：:Changes in the electrophysiologic activity of the rat sciatic nerve were examined after repeated dosing with either of two organophosphate insecticides, parathion, and trichlorfon. Although the parathion treated animals showed overt signs of systemic toxicity, there were no significant changes in any of the measured p...

journal_title：Archives of toxicology

authors： Averbook BJ,Anderson RJ

更新日期：1983-03-01 00:00:00

abstract：:Several in vitro DNA microarray studies have shown the importance of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in skin sensitization. Nevertheless, the exact in vivo role of the Nrf2-Keap1 pathway during the induction of skin sensitization remains unknown. To study the function of Nrf2, a local lymph node ass...

journal_title：Archives of toxicology

authors： van der Veen JW,Gremmer ER,Vermeulen JP,van Loveren H,Ezendam J

更新日期：2013-04-01 00:00:00

abstract：:The possible formation of singlet oxygen via photoexcited psoralens has been associated with the occurrence of, amongst others, erythema. Therefore it has been suggested to combine PUVA with the topical or systemic administration of antioxidants. However, the effect of these antioxidants on the photobinding of psorale...

journal_title：Archives of toxicology

authors： Schoonderwoerd SA,Beijersbergen van Henegouwen GM,Persons KC

更新日期：1991-01-01 00:00:00

abstract：:Chronic ciprofibrate administration resulted in distinct differences in hepatic responses between the two species examined. In the rat, hepatomegaly was observed with the coordinate induction of carnitine acetyltransferase, peroxisomal beta-oxidation and cytochrome P450IVA1 activities. The latter induction of cytochro...

journal_title：Archives of toxicology

authors： Makowska JM,Bonner FW,Gibson GG

更新日期：1991-01-01 00:00:00

abstract：:Dose-dependent excretion of p,p'DDE in rats was investigated. p,p'DDE itself was the major excreta in rats. But some o,p'isomer of DDE was detected in feces by GC-MS analysis. The excretion of p,p'DDE after a single administration was modified by its dose level. The time pattern of p,p'DDE excretion agrees well with t...

journal_title：Archives of toxicology

authors： Ando M

更新日期：1982-01-01 00:00:00

abstract：:Ochratoxin A (OTA) is a toxin produced by fungi such as Aspergillus spp. and Penicillium spp. The key target organ of OTA toxicity is the kidney, and it is known that epithelial-to-mesenchymal transition (EMT) leading to fibrosis is enhanced after long-term exposure of the kidney to OTA. However, the mechanisms respon...

journal_title：Archives of toxicology

authors： Pyo MC,Chae SA,Yoo HJ,Lee KW

更新日期：2020-09-01 00:00:00

abstract：:Degradation of neurofilament (NF) proteins by Ca2+-activated neutral protease (CANP) was studied in the nervous system of rats treated with neurotoxic or non-neurotoxic compounds. In the tibial nerve, the degradation of NF 68K was depressed by five neurotoxic compounds: acrylamide, N-hydroxymetylacrylamide, N-isopropy...

journal_title：Archives of toxicology

authors： Tanii H,Hayashi M,Hashimoto K

更新日期：1988-08-01 00:00:00

abstract：:Nine bispyridinium oximes containing two pyridinium rings linked by dimethylether were synthesised. Each compound had on one of the pyridinium rings a hydroxyiminomethyl group in position 2 or 4, while the other ring was unsubstituted or had a methyl or a hydroxyiminomethyl group in position 2 or 4. The reactivating p...

journal_title：Archives of toxicology

authors： Simeon V,Wilhelm K,Granov A,Besarović-Lazarev S,Buntić A,Fajdetić A,Binenfeld Z

更新日期：1979-02-23 00:00:00

abstract：:Quantitative structure-activity relationships (QSAR) have suggested the importance of hydrogen bonding in relation to activation of the sensory irritant receptor by nonreactive volatile organic chemicals. To investigate this possibility further, three model compounds with different hydrogen bond acidity, trifluoroetha...

journal_title：Archives of toxicology

authors： Nielsen GD,Abraham MH,Hansen LF,Hammer M,Cooksey CJ,Andonian-Haftvan J,Alarie Y

更新日期：1996-01-01 00:00:00

abstract：:The neurotoxicity of "ecstasy" (3,4-methylenedioxymethamphetamine, MDMA) is thought to involve hepatic metabolism, though its real contribution is not completely understood. Most in vitro neurotoxicity studies concern isolated exposures of MDMA or its metabolites, at high concentrations, not considering their mixture,...

journal_title：Archives of toxicology

authors： Barbosa DJ,Capela JP,Silva R,Vilas-Boas V,Ferreira LM,Branco PS,Fernandes E,Bastos Mde L,Carvalho F

更新日期：2014-02-01 00:00:00