Effect of alpha-tocopherol and di-butyl-hydroxytoluene (BHT) on UV-A-induced photobinding of 8-methoxypsoralen to Wistar rat epidermal biomacromolecules in vivo.

abstract：:The significance of urinary trehalase as a possible early indicator of renal disorder was examined using Cd-treated rabbits, which received 1 mg/kg Cd thrice weekly for 3 months subcutaneously. The results showed that urinary trehalase increased significantly from 1 week after treatment, earlier than LAP, ALP, protein...

journal_title：Archives of toxicology

authors： Nishimura N,Oshima H,Nakano M

更新日期：1986-12-01 00:00:00

abstract：:Several studies have explored the negative effects of cigarette smoke on bone healing; however, the complex pathogenesis still remains unclear. One crucial and primary factor determining effective fracture repair is the recruitment and differentiation of mesenchymal stem cells (MSCs) into bone-forming cells. Recently,...

journal_title：Archives of toxicology

authors： Sreekumar V,Aspera-Werz R,Ehnert S,Strobel J,Tendulkar G,Heid D,Schreiner A,Arnscheidt C,Nussler AK

更新日期：2018-04-01 00:00:00

abstract：:Rats were coexposed to lead (Pb) and Copper (Cu) through drinking water and intraperitoneally, respectively, for a period of 21 days. Neurochemical studies in these rats showed significant reduction in the activity of adenosine triphosphatase, cytochrome-c-oxidase, diaphorase and in the levels of biogenic amines in th...

journal_title：Archives of toxicology

authors： Malhotra KM,Shukla GS,Chandra SV

更新日期：1982-03-01 00:00:00

abstract：:In the present study the toxicological potential of a tumor-inhibiting dinuclear platinum(II) complex (bis(acetato)diammine-bis-micro-acetato diplatinum(II) dihydrate (BAP)) was evaluated, utilizing in vitro models of nephrotoxicity, myelosuppression and neurotoxicity. Regarding the discrepancies between the hallmark ...

journal_title：Archives of toxicology

authors： Momekov G,Ferdinandov D,Bakalova A,Zaharieva M,Konstantinov S,Karaivanova M

更新日期：2006-09-01 00:00:00

abstract：:Membrane transporters play an important role in the absorption, distribution, metabolism and excretion of drugs. The cellular accumulation of many drugs is the result of the net function of efflux and influx transporters. Efflux transporters such as P-glycoprotein/ABCB1 have been shown to confer multidrug resistance i...

journal_title：Archives of toxicology

authors： Windt T,Tóth S,Patik I,Sessler J,Kucsma N,Szepesi Á,Zdrazil B,Özvegy-Laczka C,Szakács G

更新日期：2019-04-01 00:00:00

abstract：:Cyclic AMP (c-AMP), added on its own to rat hepatocyte cultures, caused a marked accumulation of coproporphyrin III. The results obtained by comparing the effect of c-AMP to that of exogenous 5-aminolevulinate (ALA), and from adding c-AMP and ALA together, indicated that the coproporphyrinogen III metabolism was block...

journal_title：Archives of toxicology

authors： De Matteis F,Harvey C

更新日期：2005-07-01 00:00:00

abstract：:The uncertainties that surround the methods used for risk assessment of exposure to carcinogens have been highlighted by a recent document advocating an approach based on the T25 dose (the dose giving a 25% incidence of cancer in an appropriately designed animal experiment). This method relies on derivation of the T25...

journal_title：Archives of toxicology

authors： Roberts RA,Crump KS,Lutz WK,Wiegand HJ,Williams GM,Harrison PT,Purchase IF

更新日期：2001-11-01 00:00:00

abstract：:Previous studies indicate that benzanthrone, an anthraquinone dye intermediate, caused significant depletion of ascorbic acid (AsA). In this investigation the effect of benzanthrone on the status of different forms of AsA and other bio-antioxidants such as glutathione (GSH) was studied. Oral administration of benzanth...

journal_title：Archives of toxicology

authors： Dwivedi N,Das M,Khanna SK

更新日期：2001-06-01 00:00:00

abstract：:Rats were exposed to black tea (2.5% w/v) as their sole drinking liquid for either 1 day or 1 month, while controls were maintained on water. After this treatment period, all animals received a single oral dose IQ (2-amino-3-methylimidazo-[4,5-f]quinoline), and urine was collected for 48 h. Mutagenic activity of the u...

journal_title：Archives of toxicology

authors： Yoxall VR,Parker DA,Kentish PA,Ioannides C

更新日期：2004-08-01 00:00:00

abstract：:O,O,S-Trimethyl phosphorothioate (OOS-TMP) is known to induce unique symptoms, which are characterized by hypophagia, progressive weight loss, and hypothermia. To determine whether there is the possibility of a causal relationship between these toxic symptoms and a direct action of OOS-TMP on the central nervous syste...

journal_title：Archives of toxicology

authors： Ohtaka K,Hamade N,Yamazaki Y,Suzuki M,Koizumi A

更新日期：1995-01-01 00:00:00

abstract：:The in vitro DNA strand breaking activity of metallothionein (MT) containing Cd2+ and Zn2+ in a molar ratio of 5:2 is described. Studies with radical scavengers and electron paramagnetic resonance spectroscopy indicate that the DNA damage might be caused by a radical species formed by the native protein (i.e., MT) cha...

journal_title：Archives of toxicology

authors： Müller T,Schuckelt R,Jaenicke L

更新日期：1991-01-01 00:00:00

abstract：:Doppler and M-mode echocardiography (EC) were used to investigate the effects of minoxidil on the cardiac function of the dog and potentially to clarify the pathogenesis of cardiac lesions, in particular the necrotic lesion in the left ventricle and the haemorrhagic lesion in the right atrium. Groups of three dogs wer...

journal_title：Archives of toxicology

authors： Hanton G,Gautier M,Bonnet P

更新日期：2004-01-01 00:00:00

abstract：:4-Nonylphenol (para-nonylphenol, 4-NP), metabolites including linear and branched isoforms of nonylphenol (n-NP and t-NP, respectively), has been considered an endocrine disrupting substance resulting in reproductive dysfunction and increasing reactive oxygen species production in testis, liver, kidney, and brain. How...

journal_title：Archives of toxicology

authors： Hsieh CY,Miaw CL,Hsieh CC,Tseng HC,Yang YH,Yen CH

更新日期：2009-10-01 00:00:00

abstract：:This study is aimed at exploring the possible mechanism of hypnosis-enhancing effect of HgS or cinnabar (a traditional Chinese medicine containing more than 95% HgS) in mice treated with pentobarbital. We also examined whether the effect of HgS is different from that of the well-known methyl mercury (MeHg). After a sh...

journal_title：Archives of toxicology

authors： Chuu JJ,Huang ZN,Yu HH,Chang LH,Lin-Shiau SY

更新日期：2008-06-01 00:00:00

abstract：:Female C57/BL/6 x DBA/2 hybrid mice were exposed to two concentrations (270 and 135 ppm) of tetrachloroethylene (PER) in inhalation chambers for 6 h/day, 5 days per week, up to 11.5 weeks (270 ppm) and 7.5 weeks (135 ppm), respectively, followed by a 3-week exposure-free period. In the peripheral blood a reduction of ...

journal_title：Archives of toxicology

authors： Seidel HJ,Weber L,Barthel E

更新日期：1992-01-01 00:00:00

abstract：:The effects of intravenously (i.v.) administered or inhaled amyl nitrite (AN) were followed under chloralose anaesthesia in intact and cyanide-poisoned, spontaneously breathing beagles. The i.v. doses of AN were 0.03 and 0.15 mmol/kg and the i.v. dose of KCN was 0.06 mmol/kg. AN was inhaled in a closed system at 0.15 ...

journal_title：Archives of toxicology

authors： Klimmek R,Krettek C

更新日期：1988-01-01 00:00:00

abstract：:Rat embryos (9.5-day-old) were cultured for 48 h in the presence of nifedipine (NIF), nimodipine (NIM), nitrendipine (NIT), gallopamil HCl (GAL), verapamil HCl (VER) and diltiazem HCl (DIL). The effects on growth and morphogenetic differentiation in vitro were monitored. Dose-response relationships were evaluated, inc...

journal_title：Archives of toxicology

authors： Stein G,Srivastava MK,Merker HJ,Neubert D

更新日期：1990-01-01 00:00:00

abstract：:A method is outlined to estimate from hemodialysis or hemoperfusion data, respectively, the rate constants, the distribution volume in the beta-phase, and other pharmacokinetic parameters of toxic substances. All calculations are based on the assumption that the usual linear open two-compartment system is also the app...

journal_title：Archives of toxicology

authors： Wellhöner HH

更新日期：1983-05-01 00:00:00

abstract：:A method is described for the determination of lorazepam plasma levels involving extraction from the sample and analysis of the intact lorazepam by electron capture gas-liquid chromatography. Using mass spectrometry it is demonstrated, that lorazepam shows a thermal rearrangement under gas chromatographic conditions. ...

journal_title：Archives of toxicology

authors： de Groot G,Maes RA,Lemmens HH

更新日期：1976-06-08 00:00:00

abstract：:Bisphenol A (BPA) is a chemical in widespread use that is under scientific discussion due to its endocrine activity. Controversies exist about how to interpret reportedly high blood concentrations measured in uncontrolled situations. Physiologically based pharmaco-/toxicokinetic modelling resulted in 10-100-fold lower...

journal_title：Archives of toxicology

authors： Partosch F,Mielke H,Gundert-Remy U

更新日期：2013-07-01 00:00:00

abstract：:Tacrolimus (FK506) and cyclosporin A (CsA) are two potent immunosuppressants mainly metabolized by hepatic cytochrome P-450 3A (CYP3A) monooxygenase. The aim of this study was to compare the toxic effects of the two drugs on hepatocytes in primary culture as a function of their metabolism and to explore the variations...

journal_title：Archives of toxicology

authors： Ellouk-Achard S,Martin C,Duc HT,Dutertre-Catella H,Thevenin M,Warnet JM,Claude JR

更新日期：1998-04-01 00:00:00

abstract：:Exposure to bisphenolic chemicals during pregnancy occurs in > 90% of pregnancies. Bisphenolic compounds can cross the placental barrier reaching fetal circulation. However, the effects of emerging bisphenolic compounds, such as bisphenol S (BPS), on placental function remain untested. The aim was to determine if bisp...

journal_title：Archives of toxicology

authors： Gingrich J,Pu Y,Roberts J,Karthikraj R,Kannan K,Ehrhardt R,Veiga-Lopez A

更新日期：2018-05-01 00:00:00

abstract：:Aliphatic nitriles are a class of chemicals used in high volumes in the production of plastics and elastomers, in organic synthesis, and in production of a number of food packaging containers. Toxicity and metabolism of acrylonitrile (AN) are well characterized. On the other hand, minimal information is available on t...

journal_title：Archives of toxicology

authors： Burka LT,Sanchez IM,Ahmed AE,Ghanayem BI

更新日期：1994-01-01 00:00:00

abstract：:Okadaic acid (OA) is produced by several types of dinoflagellates (marine plankton) and has been implicated as the causative agent of diarrhetic shellfish syndrome. Previous studies have shown that okadaic acid is a tumor promoter and a specific potent inhibitor of protein phosphatases and protein synthesis. These eff...

journal_title：Archives of toxicology

authors： Traoré A,Baudrimont I,Dano S,Sanni A,Larondelle Y,Schneider YJ,Creppy EE

更新日期：2003-11-01 00:00:00

abstract：:This article is published with the incorrect copyright holder name in the HTML article as "© Springer 2018". The correct copyright line should read "The Author(s) 2018" (as it appears in the article PDF). ...

journal_title：Archives of toxicology

authors： Oesch F,Fabian E,Landsiedel R

更新日期：2018-11-01 00:00:00

abstract：:3-Chloro-1,2-propanediol (3-MCPD) fatty acid esters are formed upon thermal processing of fat-containing foods in the presence of chloride ions. Upon hydrolytic cleavage, these substances could release free 3-MCPD. This compound is toxicologically well characterised and displayed cancerogenic potential in rodent model...

journal_title：Archives of toxicology

authors： Buhrke T,Weisshaar R,Lampen A

更新日期：2011-10-01 00:00:00

abstract：:The mycotoxins altertoxin I and II (ATX I and II) are secondary metabolites produced by Alternaria alternata fungi and may occur as food and feed contaminants, especially after long storage periods. Although the toxic potential of altertoxins has been previously investigated, little is known about the pathways that pl...

journal_title：Archives of toxicology

authors： Jarolim K,Del Favero G,Pahlke G,Dostal V,Zimmermann K,Heiss E,Ellmer D,Stark TD,Hofmann T,Marko D

更新日期：2017-01-01 00:00:00

abstract：:Chronic ethanol consumption is a strong risk factor for the development of liver disease. Multiple mechanisms are involved in ethanol-mediated liver injury; oxidative stress being pointed has an important factor. However, it should be noted that moderate consumption of red wine has been associated with hepatoprotectiv...

journal_title：Archives of toxicology

authors： Silva P,Fernandes E,Carvalho F

更新日期：2015-10-01 00:00:00

abstract：:We analyzed adverse events in a clinical phase I trial to assess dose-dependent metabolic effects of St. John's wort co-administered with rifampicin in 12 healthy volunteers. Within 3-6 days after increasing the St. John's wort dose from 300 to 600 mg TID, five of six female participants developed ambient temperature-...

journal_title：Archives of toxicology

authors： Hohmann N,Maus A,Carls A,Haefeli WE,Mikus G

更新日期：2016-04-01 00:00:00

abstract：:Drug-induced liver injuries have been a major focus of current research in drug development, and are also one of the major reasons for the failure and withdrawal of drugs in development. Drug-induced liver injuries have been systematically recorded in many public databases, which have become valuable resources in this...

journal_title：Archives of toxicology

authors： Luo G,Shen Y,Yang L,Lu A,Xiang Z

更新日期：2017-09-01 00:00:00