Abstract:
:Rats were exposed to nickel sulfate (NiSO4) either by intratracheal (IT) instillation or by acute aerosol inhalation, and pulmonary clearance of Ni and pulmonary inflammatory responses were studied. The half-time of Ni in the lung (initial lung burden = 50 micrograms Ni/rat) was about 32 h in both the IT instillation and inhalation groups. Ni retention in the lung tissue following IT instillation of NiSO4 was saturable with reference to dose, suggesting that clearance rate of Ni from the rat lung depends on lung burden of Ni. Lung inflammatory responses were evaluated by biochemical, elemental and cytological indicators in bronchoalveolar lavage fluid (BALF) following IT instillation of NiSO4. Activities of lactate dehydrogenase and beta-glucuronidase, contents of lysozyme, protein, sulfur and calcium, and the number of polymorphonuclear leukocytes were increased with a peak at 2-3 days post-instillation, while BALF alkaline phosphatase (ALP) activity was significantly decreased after IT instillation of NiSO4. Lung tissue ALP activity was also decreased by NiSO4. Because Ni does not inhibit ALP directly, the decrease in ALP activity is probably due to functional changes of type II cells (a major source of BALF ALP). Thiobarbituric acid reacting substances in the lung tissue were not changed by NiSO4, suggesting that lipid peroxidation plays a minimal, if any role, in the Ni-induced inflammation in the rat lung.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Hirano S,Shimada T,Osugi J,Kodama N,Suzuki KTdoi
10.1007/s002040050112subject
Has Abstractpub_date
1994-01-01 00:00:00pages
548-54issue
9eissn
0340-5761issn
1432-0738journal_volume
68pub_type
杂志文章abstract::Aluminum phosphide (AlP), one of the most commonly used pesticides worldwide, has been the leading cause of self-poisoning mortalities among many Asian countries. The heart is the main organ affected in AlP poisoning. Melatonin has been previously shown to be beneficial in reversing toxic changes in the heart. The pre...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-1998-6
更新日期:2017-09-01 00:00:00
abstract::N-methylformamide (NMF) produced dose-dependent zone 3 haemorrhagic necrosis in mice; the threshold dose was 100-200 mg/kg. In rats a dose of 1000 mg/kg caused hepatic damage in some animals and slight elevations of plasma transaminases. A species difference in susceptibility to NMF-induced hepatotoxicity is clearly i...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00570135
更新日期:1988-01-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1340-5
更新日期:2015-11-01 00:00:00
abstract::Using human neuroblastoma SH-SY5Y cells, effects of acrylamide on p53 protein and intracellular signal transducting pathways were examined. Acrylamide increased p53, phosphorylated p53, and p53-associated protein murine double minute 2 (MDM2). The phosphorylation of p53 was specific for the Ser15 site. Among mitogen-a...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-005-0022-8
更新日期:2006-03-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章,评审
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更新日期:2020-07-01 00:00:00
abstract::Chemical formation of dichlorvos (2, 2-dichlorovinyl dimethyl phosphate) was found to occur in mouse brain after i.p. injection of metrifonate (2, 2, 2-trichloro-1-hydroxyethyl dimethyl phosphonate). A mass fragmentographic technique was used. Different isotopic variants were used both as internal standards and to com...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00351767
更新日期:1978-10-13 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1268-9
更新日期:2015-04-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00324544
更新日期:1987-01-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-020-02944-7
更新日期:2020-11-10 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01974392
更新日期:1990-01-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050499
更新日期:1998-04-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-020-02938-5
更新日期:2021-01-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-004-0586-8
更新日期:2004-11-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050171
更新日期:1995-01-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00346051
更新日期:1984-07-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00334632
更新日期:1989-01-01 00:00:00
abstract::Cadmium (Cd), a highly toxic heavy metal, is distributed widely in the general environment of today. The characteristic clinical manifestations of chronic Cd intoxication include renal proximal tubular dysfunction, general osteomalacia with severe pains, and anemia. We have recently reported that the serum level of er...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050352
更新日期:1996-01-01 00:00:00
abstract::The effects of acetone on liver, kidney, and lung monooxygenases were studied using hamsters administered 8% acetone in drinking water. Binding of aniline to liver microsomes induced a type II difference spectrum, and the spectral binding was enhanced in hamsters pretreated with acetone. Administration of acetone caus...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01973502
更新日期:1991-01-01 00:00:00
abstract::Spin trapping in vivo was first achieved in the author's laboratory and is shown to be a feasible method for demonstrating that highly reactive free radical intermediates are generated in the tissues of intact animals as a result of the exposure to certain toxic compounds and to ionizing radiation. The method is based...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/BF00296966
更新日期:1987-01-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-013-1060-2
更新日期:2013-11-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00296900
更新日期:1979-02-23 00:00:00
abstract::2C (2C-x) is the general name for the family of phenethylamines containing two methoxy groups at the 2 and 5 positions of the benzene ring. The abuse of 2C family drugs has grown rapidly, although the abuse potential and neurotoxic properties of 2C drugs have not yet been fully investigated. In this study, we investig...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-021-02980-x
更新日期:2021-01-30 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050429
更新日期:1997-01-01 00:00:00
abstract::The objective of this study was to evaluate the role of apoptosis in the development of the newborn cochlear structures and hearing loss caused by prenatal cis-diaminedichloroplatinum (cisplatin) exposure. Pregnant albino guinea pigs were intraperitoneally injected with 1.5 mg/kg body weight cisplatin once a day for s...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-010-0543-7
更新日期:2011-01-01 00:00:00
abstract::Tributyltin (TBT) has been shown to disrupt the ability of natural killer (NK) cells to destroy tumor targets in vitro even at exposures of 25 nM for 24 h, but cell viability was not significantly impacted. Thus, evaluation of intracellular molecular events that regulate cell viability in TBT exposed NK cells are of i...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-006-0155-4
更新日期:2007-04-01 00:00:00
abstract::Between 0.25-25 micrograms of an aqueous solution of either mercuric chloride or methyl mercuric acetate was injected directly into the sciatic nerve of 28 adult Wistar rats. The resultant pathological changes in the nerve were examined by teasing individual fibres and by light and electron microscopy. In most respect...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00310442
更新日期:1980-12-01 00:00:00
abstract::Unsaturated compounds are known to cause false-positive reactions in the local lymph node assay (LLNA) but not in the guinea pig maximization test. We have tested a panel of substances (succinic acid, undecylenic acid, 1-octyn-3-ol, fumaric acid, maleic acid, linoleic acid, oleic acid, alpha-linolenic acid, squalene, ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-015-1527-4
更新日期:2016-04-01 00:00:00
abstract::Gebel (In Arch Toxicol 87(5):923-924, 2013) replied to my Letter to the Editor (Morfeld in Arch Toxicol 87(5):921, 2013) in which I criticized the quantitative review of inhalation rat studies on the association of granular biopersistent dust exposures and lung cancer risk (Gebel in Arch Toxicol 86(7):995-1007, 2012)....
journal_title:Archives of toxicology
pub_type: 评论,信件
doi:10.1007/s00204-013-1138-x
更新日期:2013-11-01 00:00:00
abstract::Occupational and environmental asbestos exposure is the main determinant of malignant pleural mesothelioma (MPM), however, the mechanisms by which its fibres contribute to cell toxicity and transformation are not completely clear. Aberrant DNA methylation is a common event in cancer but epigenetic modifications involv...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-018-2179-y
更新日期:2018-05-01 00:00:00
abstract::The significance of elevated excretion of metallothionein in urine of women living in cadmium-polluted areas of Japan was studied with respect to renal dysfunction. The relationships between the concentrations of metallothionein in urine and those of other non-specific urinary indices of renal dysfunction, i.e., total...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00373398
更新日期:1982-07-01 00:00:00